Category: 680217-71-4

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 680217-71-4, name is Ethyl 2-(2,6-difluorophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows., HPLC of Formula: C10H10F2O2

General procedure: To a stirred solution of phenyl acetic acid ethyl ester 1a (1 g, 6.09 mmol) in THF (10 mL) was added LiHMDS (9.1 ml, 1 M sol. in THF, 7.31 mmol) at -78 C and the reaction mixture was stirred at this temperature for 30 min. Ethyl-1-imidazole carboxylate 2 (1.2 g, 9.146 mmol) in dry THF (3 ml) was added drop wise to the reaction mixture at -78 C and stirred at rt for 3 h. The reaction mixture was quenched with saturated ammonium chloride solution and extracted with ethyl acetate. The combined organic layer was washed with water, saturated brine solution, and dried over Na2SO4. The solvent was evaporated under reduced pressure and the crude product was chromatographed on a silica gel column. Elution with 4% ethyl acetate/pet ether gave the pure compound 3a (1.1 g, 81% yield) as a colorless liquid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 680217-71-4.

Reference:
Article; Behera, Manoranjan; Venkat Ragavan; Sambaiah; Erugu, Balaiah; Rama Krishna Reddy; Mukkanti; Yennam, Satyanarayana; Tetrahedron Letters; vol. 53; 9; (2012); p. 1060 – 1062;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Electric Literature of 680217-71-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 680217-71-4 as follows.

A mixture of scheme 27 compound 4 (1.4 g, 7.07 mmol) and (2,6-difluoro-phenyl)-acetic acid ethyl ester (2.63 g, 14.14 mmol), CS2CO3 (6.9 g, 21.2 mmol), were dissolved in DMF. The reaction mixture was heated to 110 C and stirred for 4h. The mixture was evaporated in vacuo, the residue was purified by silica gel column chromatography (DCM/MeOH = 100/1 to 10/1) to give the scheme 27 compound 5 (410 mg, 17%) as a yellow solid.

According to the analysis of related databases, 680217-71-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.; WO2014/52365; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 680217-71-4, name is Ethyl 2-(2,6-difluorophenyl)acetate, A new synthetic method of this compound is introduced below., Product Details of 680217-71-4

As in the scheme, a solution of scheme 28 compound 1 (1 g, 3.95 mmol), ester (1.47 g, 7.9 mmol) and CS2CO3 (3.86 g, 11.85 mmol) in DMF (30 mL) under N2 was added and stirred at 110 C for 4 h. The solvent then was evaporated and the remaining residue was diluted with water and extracted with CH2C12. The combined extracts were washed with brine, dried over Na2S04 and concentrated in vacuo. The crude product was purified by prep-HPLC to afford scheme 28 compound 2 (420 mg, 27.4%) as a brown solid.

The synthetic route of 680217-71-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.; WO2014/52365; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 680217-71-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 680217-71-4 as follows.

A mixture of scheme 27 compound 4 (1.4 g, 7.07 mmol) and (2,6-difluoro-phenyl)-acetic acid ethyl ester (2.63 g, 14.14 mmol), CS2CO3 (6.9 g, 21.2 mmol), were dissolved in DMF. The reaction mixture was heated to 110 C and stirred for 4h. The mixture was evaporated in vacuo, the residue was purified by silica gel column chromatography (DCM/MeOH = 100/1 to 10/1) to give the scheme 27 compound 5 (410 mg, 17%) as a yellow solid.

According to the analysis of related databases, 680217-71-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; MANNKIND CORPORATION; TOLERO PHARMACEUTICALS, INC.; ZENG, Qingping; FARIS, Mary; MOLLARD, Alexis; WARNER, Steven L.; FLYNN, Gary A.; WO2014/52365; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 680217-71-4, name is Ethyl 2-(2,6-difluorophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Ethyl 2-(2,6-difluorophenyl)acetate

General procedure: To a stirred solution of phenyl acetic acid ethyl ester 1a (1 g, 6.09 mmol) in THF (10 mL) was added LiHMDS (9.1 ml, 1 M sol. in THF, 7.31 mmol) at -78 C and the reaction mixture was stirred at this temperature for 30 min. Ethyl-1-imidazole carboxylate 2 (1.2 g, 9.146 mmol) in dry THF (3 ml) was added drop wise to the reaction mixture at -78 C and stirred at rt for 3 h. The reaction mixture was quenched with saturated ammonium chloride solution and extracted with ethyl acetate. The combined organic layer was washed with water, saturated brine solution, and dried over Na2SO4. The solvent was evaporated under reduced pressure and the crude product was chromatographed on a silica gel column. Elution with 4% ethyl acetate/pet ether gave the pure compound 3a (1.1 g, 81% yield) as a colorless liquid.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 680217-71-4.

Reference:
Article; Behera, Manoranjan; Venkat Ragavan; Sambaiah; Erugu, Balaiah; Rama Krishna Reddy; Mukkanti; Yennam, Satyanarayana; Tetrahedron Letters; vol. 53; 9; (2012); p. 1060 – 1062;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics