Krause, H. W.’s team published research in Chirality in 1996 | CAS: 67877-95-6

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Category: esters-buliding-blocks They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

《Unusual amino acids VI. Substituted arylamino acids by asymmetric hydrogenation of N-Cbz and N-Boc protected dehydroamino acid derivatives》 was published in Chirality in 1996. These research results belong to Krause, H. W.; Kreuzfeld, H.-J.; Schmidt, U.; Dobler, Ch.; Michalik, M.; Taudien, S.; Fischer, Ch.. Category: esters-buliding-blocks The article mentions the following:

Substituted N-Cbz and N-Boc protected (arylamino)acrylic acids and esters were prepared and used in asym. hydrogenations catalyzed by PROPRAPHOS-Rh. Stereoselectivities >90% ee could be achieved, the rate of which is dependent on the position of the substituent in the aromatic ring. The N-Boc derivatives provide advantages compared with the N-Cbz analogs. The amino acid derivatives were fully characterized by 19F, 13C, and 1H NMR. In the part of experimental materials, we found many familiar compounds, such as H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6Category: esters-buliding-blocks)

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Category: esters-buliding-blocks They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Koning, Nicolas R.’s team published research in ACS Omega in 2022 | CAS: 67877-95-6

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Safety of H-D-Phe(4-NO2)-OMe.HCl

《A C-H Activation Approach to the Tricyclic Core of Glionitrin A and B》 was written by Koning, Nicolas R.; Strand, Daniel. Safety of H-D-Phe(4-NO2)-OMe.HCl And the article was included in ACS Omega on April 12 ,2022. The article conveys some information:

Synthesis of diketopiperazines has been of long-standing interest in both natural product synthesis and medicinal chem. Here, we present an operationally convenient and efficient approach to the fused indoline-diketopiperazine tricyclic core of glionitrin A/B and related structures using a Pd-catalyzed C-H activation reaction to form the indoline five-membered ring. Exploratory work aimed at elaborating the tricyclic structures into the corresponding natural products is discussed. Safety: handling and decontamination protocols required for toxic iodomethane. The results came from multiple reactions, including the reaction of H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6Safety of H-D-Phe(4-NO2)-OMe.HCl)

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones.Safety of H-D-Phe(4-NO2)-OMe.HCl

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xie, Yu’s team published research in Chemistry – A European Journal in 2007 | CAS: 67877-95-6

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.SDS of cas: 67877-95-6

In 2007,Chemistry – A European Journal included an article by Xie, Yu; Yu, Zhaopeng; Huang, Xiaoying; Wang, Zhiyong; Niu, Liwen; Teng, Maikun; Li, Jing. SDS of cas: 67877-95-6. The article was titled 《Rational design of MOFs constructed from modified aromatic amino acids》. The information in the text is summarized as follows:

Three Phe and Tyr derivatives, 2-amino-3-(4-aminophenyl)-propionic acid (AAP), 3E-[5-(2-amino-2-carboxyethyl)-2-methoxyphenyl]-acrylic acid (AMPA) and 3-(4-aminophenyl)-2-(carboxymethyl-amino)-propionic acid (ACP) were chosen as the ligands to construct four kinds of novel metal-organic frameworks (MOFs) (five structures). These structures are, [CdII{(R)-AAP}(Py)(H2O)]·(ClO4), (R-1); [CdII{(S)-AAP}(H2O)]·(ClO4), (S-2); [ZnII2{(R,S)-AMPA}(H2O)], (R,S-3); [ZnII2{(R)-ACP}(Py)3]·(ClO4)2, (R-4): and the inversion twin of (R-1). Rational design to adjust the depth and the width of ligands can mediate the size and the shape of the grids of these 2-dimensional layers. Addnl., among these compounds, three pure chiral coordination polymers were obtained, owing to the inducement of chirality by the modified amino acids. This property makes them potential NLO materials. After reading the article, we found that the author used H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6SDS of cas: 67877-95-6)

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils. They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.SDS of cas: 67877-95-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hinkes, Stefan’s team published research in Journal of Medicinal Chemistry in 2016 | CAS: 67877-95-6

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Product Details of 67877-95-6 Polyesters are important plastics, with monomers linked by ester moieties.

Hinkes, Stefan; Wuttke, Andre; Saupe, Sebastian M.; Ivanova, Teodora; Wagner, Sebastian; Knoerlein, Anna; Heine, Andreas; Klebe, Gerhard; Steinmetzer, Torsten published an article in Journal of Medicinal Chemistry. The title of the article was 《Optimization of Cyclic Plasmin Inhibitors: From Benzamidines to Benzylamines》.Product Details of 67877-95-6 The author mentioned the following in the article:

New macrocyclic plasmin inhibitors based on our previously optimized P2-P3 core segment have been developed. In the first series, the P4 residue was modified, whereas the 4-amidinobenzylamide in P1 position was maintained. The originally used P4 benzylsulfonyl residue could be replaced by various sulfonyl- or urethane-like protecting groups. In the second series, the P1 benzamidine was modified and a strong potency and excellent selectivity was retained by incorporation of p-xylenediamine. Several analogs inhibit plasmin in the subnanomolar range, and their potency against related trypsin-like serine proteases including trypsin itself could be further reduced. Selected derivatives have been tested in a plasma fibrinolysis assay and are more effective than the reference inhibitor aprotinin. The crystal structure of one inhibitor was determined in complex with trypsin. The binding mode reveals a sterical clash of the inhibitor’s linker segment with the 99-hairpin loop of trypsin, which is absent in plasmin. In the experiment, the researchers used H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6Product Details of 67877-95-6)

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Product Details of 67877-95-6 Polyesters are important plastics, with monomers linked by ester moieties.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tokutake, S.’s team published research in Molecular Crystals and Liquid Crystals in 1989 | CAS: 67877-95-6

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Computed Properties of C10H13ClN2O4 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Computed Properties of C10H13ClN2O4On May 31, 1989, Tokutake, S.; Imanishi, Y.; Sisido, M. published an article in Molecular Crystals and Liquid Crystals. The article was 《Efficiency of second harmonic generation from amino acids, peptides, and polypeptides carrying polarizable aromatic groups》. The article mentions the following:

The SHG (2nd harmonic generation) efficiencies of optically active amino acids, their monomeric derivatives, linear and cyclic dipeptides, tripeptides, and polypeptides carrying polarizable groups were tested. Among the 91 samples, L-valine-p-nitroanilide (Val-NA) showed the largest SHG [9.2 × I2ω(urea)]. Val-NA was phase-matchable and transparent at ≥420 nm. Monopeptide and dipeptide derivatives of p-nitrophenylalanine showed large SHG and were transparent at ≥420 nm. In the experiment, the researchers used many compounds, for example, H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6Computed Properties of C10H13ClN2O4)

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. They are important in biology, being one of the main classes of lipids and comprising the bulk of animal fats and vegetable oils.Computed Properties of C10H13ClN2O4 They perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Xiaowei’s team published research in Journal of the American Chemical Society in 2019 | CAS: 67877-95-6

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Quality Control of H-D-Phe(4-NO2)-OMe.HCl

Quality Control of H-D-Phe(4-NO2)-OMe.HClOn September 4, 2019 ,《Chiral Gating for Size- and Shape-Selective Asymmetric Catalysis》 was published in Journal of the American Chemical Society. The article was written by Li, Xiaowei; Zhao, Yan. The article contains the following contents:

A poor or mediocre stereoselectivity is a key roadblock for a chiral catalyst to find practical adoptions. We report a facile method to create a tunable chiral space near a chiral catalyst to augment its selectivity. The space was created rationally through templated polymerization within cross-linked micelles, using readily available amino acid derivatives It provided gated entrance of reactants to the catalyst, enabling a mediocre prolinamide to catalyze aldol condensation in water with excellent yields and ee, in a size- and shape-selective manner. In the part of experimental materials, we found many familiar compounds, such as H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6Quality Control of H-D-Phe(4-NO2)-OMe.HCl)

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Quality Control of H-D-Phe(4-NO2)-OMe.HCl

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Stress, Cedric J.’s team published research in Angewandte Chemie, International Edition in 2019 | CAS: 67877-95-6

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Product Details of 67877-95-6

The author of 《A DNA-Encoded Chemical Library Incorporating Elements of Natural Macrocycles》 were Stress, Cedric J.; Sauter, Basilius; Schneider, Lukas A.; Sharpe, Timothy; Gillingham, Dennis. And the article was published in Angewandte Chemie, International Edition in 2019. Product Details of 67877-95-6 The author mentioned the following in the article:

Here the authors show a seven-step chem. synthesis of a DNA-encoded macrocycle library (DEML) on DNA. Inspired by polyketide and mixed peptide-polyketide natural products, the library was designed to incorporate rich backbone diversity. Achieving this diversity, however, comes at the cost of the custom synthesis of bifunctional building block libraries. This study outlines the importance of careful retrosynthetic design in DNA-encoded libraries, while revealing areas where new DNA synthetic methods are needed. In the part of experimental materials, we found many familiar compounds, such as H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6Product Details of 67877-95-6)

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. Product Details of 67877-95-6

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gorecki, Marian’s team published research in Biochimica et Biophysica Acta, Protein Structure in 1978 | CAS: 67877-95-6

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Safety of H-D-Phe(4-NO2)-OMe.HCl They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

《Modulation of the catalytic properties of α-chymotrypsin by chemical modification at Tyr 146》 was published in Biochimica et Biophysica Acta, Protein Structure in 1978. These research results belong to Gorecki, Marian; Wilchek, Meir; Blumberg, Shmaryahu. Safety of H-D-Phe(4-NO2)-OMe.HCl The article mentions the following:

α-Chymotrypsin was modified with 3 different diazonium salts derived from D-phenylalanine. All 3 reagents reacted selectivity with tyrosine-146 on the surface of the enzyme. The spectral and enzymic properties of the azochymotrypsins were characteristic for each of the proteins. Depending on the structure of the reagent used for modification, the activity towards p-nitroanilide substrate was higher or about the same as that of the native enzyme. In addition to this study using H-D-Phe(4-NO2)-OMe.HCl, there are many other studies that have used H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6Safety of H-D-Phe(4-NO2)-OMe.HCl) was used in this study.

H-D-Phe(4-NO2)-OMe.HCl(cas: 67877-95-6) belongs to esters. Esters are more polar than ethers but less polar than alcohols. Safety of H-D-Phe(4-NO2)-OMe.HCl They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics