Category: 6520-83-8

Reference of 6520-83-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6520-83-8, name is Ethyl 2-methoxy-6-methylbenzoate, This compound has unique chemical properties. The synthetic route is as follows.

Example 12 5-(7-Methoxy-1-oxo-1,3-dihydro-isoindol-2-ylmethyl)-2-(oxalyl-amino)-4,5,6,7-tetrahydro-thieno[2,3-c]pyridine-3-carboxylic acid 2-Methoxy-6-methylbenzoic acid ethyl ester (500 mg, 2.67 mmol), N-bromosuccinimide (483.8 mg, 2.72 mmol) and 2,2′-azobis(2-methyl-propionitrile) (30.2 mg, 0.123 mmol) in carbon tetrachloride (10 ml) were heated to reflux. After 18 hours, the reaction mixture was evaporated to dryness in vacuo. The residue was dissolved in dichloromethane (100 ml) and washed with water (2*50 ml). The organic layer was dried (MgSO4), filtered and the solvent evaporated in vacuo. The residue (702 mg) was purified by column chromatography using a mixture of hexanes/dichloromethane (1:1) as eluent, which afforded 573 mg (85%) of 6-bromomethyl-2-methoxy-benzoic acid ethyl ester as an oil. 1H-NMR (CDCl3): delta7.37 (t, 1H, J=8.4 Hz), 7.01 (d, 1H, J=8.1 Hz), 6.90 (d, 1H, J=8.4 Hz), 4.54 (s, 2H), 4.45 (q, 2H, J=7.2 Hz), 3.82 (s, 3H), 1.42 (t, 3H, J=9 Hz).

The chemical industry reduces the impact on the environment during synthesis Ethyl 2-methoxy-6-methylbenzoate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Novo Nordisk A/S; Ontogen Corporation; US6410556; (2002); B1;,
Ester – Wikipedia,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6520-83-8, name is Ethyl 2-methoxy-6-methylbenzoate, A new synthetic method of this compound is introduced below., Product Details of 6520-83-8

Step 1 Ethyl 2-bromomethyl-6-methoxybenzoate 19.56 g of N-bromosuccinimide and 4.84 g of benzoyl peroxide were added to a solution of 19.40 g of ethyl 2-methoxy-6-methylbenzoate in 150 ml of carbon tetrachloride. The reaction medium was refluxed for 6 hours (no further change). The reaction medium was cooled to 5 C. and the succinimide was filtered. The organic phase was washed with a saturated sodium hydrogen carbonate solution (2*150 ml), dried over magnesium sulfate and evaporated. The residue was purified by chromatography on silica gel (column puriFlash, IR-50SI/800G, Spot II) eluted with heptane/ethyl acetate (gradient). 15.5 g of ethyl 2-bromomethyl-6-methoxybenzoate were obtained in the form of a yellow oil which later crystallizes. Yield=56%.

The synthetic route of 6520-83-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Musicki, Branislav; Aubert, Jerome; Boiteaux, Jean-Guy; Clary, Laurence; Rossio, Patricia; Schuppli-Nollet, Marlene; US2014/309208; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

6520-83-8, name is Ethyl 2-methoxy-6-methylbenzoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: Ethyl 2-methoxy-6-methylbenzoate

Ethyl 3-bromo-6-methoxy-2-methylbenzoate (13-2). To a methylene chloride solution (100 mL) of Ethyl 2-methoxy-6-mefhylbenzoate (13-1, 5 g, 25.8 mmol, TCI Ml 120) was added bromine (1.65 mL, 32.2 mmol, 1.25 equiv) at O 0C. The reaction was stirred at O 0C to 25 0C for 12 h and quenched with sodium thiosulfate solution (5%, 20 mL) and stirred for 20 min. The resulting mixture was extracted with methylene chloride. The combined methylene chloride extracts were dried(Na2SO4) and concentrated to give 7.2 g of 13-2: 1H NMR (400 MHz, CDCl3) delta 7.47 (d, J= 9.2 Hz, 1 H), 6.63 (d, J= 9.2 Hz, 1 H)5 4.38 (q, J= 7.3 Hz, 2 H), 3.78 (s, 3 H), 2.30 (s, 3 H), 1.35 (, J= 7.3 Hz, 3 H).

The synthetic route of 6520-83-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; TETRAPHASE PHARMACEUTICALS, INC.; DENG, Yonghong; PLAMONDON, Louis; SUN, Cuixiang; XIAO, Xiao-Yi; ZHOU, Jingye; SUTCLIFFE, Joyce, A.; RONN, Magnus, P.; WO2011/25982; (2011); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics