Category: 64123-77-9

These common heterocyclic compound, 64123-77-9, name is Methyl 2-(3-fluorophenyl)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Methyl 2-(3-fluorophenyl)acetate

General procedure: The oil was thendissolved in EtOH, and NH2NH2.H2O (3 eq) was added.The mixture was refluxed for 10 h. CH2Cl2 (30 mL) was thenadded and extracted with distilled H2O (3 × 20 mL). Theorganic phase was separated, dried on anhydrous Na2SO4,and evaporated under vacuum to afford correspondinghydrazide 7a in very good yield (white solid, 1.02g, 93%)

The synthetic route of Methyl 2-(3-fluorophenyl)acetate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Vu, Vu Van; Nhung, Trinh Thi; Thanh, Nguyen Thi; Chinh, Luu Van; Tien, Vu Dinh; Thuy, Vu Thu; Thi Thao, Do; Nam, Nguyen Hai; Koeckritz, Angela; Vu, Tran Khac; Journal of Chemistry; vol. 2017; (2017);,
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In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 64123-77-9 as follows. name: Methyl 2-(3-fluorophenyl)acetate

Methyl 2-(3-fluorophenyl)acetate (1.90 g, 1 1.3 mmol) and N-bromo succinimide (2.01 g, 1 1.3 mmol) were dissolved in CC14 (80 ml). HBr (64 ul,0.56 mmol) was added and the mixture was stirred under reflux overnight. The mixture was cooled at room temperature, diluted with DCM and washed with sat. NaHCO3, water and brine. The organic layer was dried (Na2SO4), filtered and evaporated obtaining intermediate 115 (2.68 g, 96% yield).

According to the analysis of related databases, 64123-77-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; AMARI, Gabriele; RICCABONI, Mauro; WO2011/160919; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 64123-77-9, name is Methyl 2-(3-fluorophenyl)acetate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 64123-77-9, Application In Synthesis of Methyl 2-(3-fluorophenyl)acetate

Compound 16 (5 g, 22.92 mmol, 1.0 eq.) Was dissolved in 50 mL of tetrahydrofuran in a 250 mL round bottom flask, LDA (17.19 mL, 34.38 mmol, 1.5 eq.) was added at minus 78 C and stirred at low temperature for 1 hour. To the above reaction system, a tetrahydrofuran solution (50 mL) of compound 15 (3.44 g, 22.92 mmol, 1.0 eq.) was slowly added dropwise. After the dropwise addition, the mixture was stirred at low temperature for 3 hours. Saturated aqueous NH4Cl, quenched with ethyl acetate (40 mL x 3). The combined organic phases were washed with saturated brine (50 mL x 2). The organic phase was dried, dried and purified on a silica gel column (PE: EA = 20: 1) to give a yellow oil 17 (1.0 g, yield: 11.8%).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Methyl 2-(3-fluorophenyl)acetate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Shanghai Yaoming Kant, Immanuel New Drug Development Co., Ltd.; Wu Xiangyang; Wang Fei; Ao Zhiyong; Yang Kanghui; Wan Shuangyi; Wang Lijuan; (24 pag.)CN106478590; (2017); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 64123-77-9, name is Methyl 2-(3-fluorophenyl)acetate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Formula: C9H9FO2

Methyl 2-(3-fluorophenyl)acetate (1.90 g, 11.3 mmol) and N-bromo succinimide (2.01 g, 11.3 mmol) are dissolved in CCl4 (80 mL). HBr (64 ul, 0.56 mmol) is added and the mixture is stirred under reflux overnight. The mixture is cooled at RT, diluted with DCM and washed with sat. NaHCO3, water and brine.The organic layer is dried (Na2SO4), filtered and evaporated obtaining intermediate 1144 as a yellow oil (2.68 g, 96% yield).

The synthetic route of 64123-77-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; CALIGIURI, Antonio; RICCABONI, Mauro; AMARI, Gabriele; WO2010/72338; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 64123-77-9, name is Methyl 2-(3-fluorophenyl)acetate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Quality Control of Methyl 2-(3-fluorophenyl)acetate

General procedure: The oil was thendissolved in EtOH, and NH2NH2.H2O (3 eq) was added.The mixture was refluxed for 10 h. CH2Cl2 (30 mL) was thenadded and extracted with distilled H2O (3 × 20 mL). Theorganic phase was separated, dried on anhydrous Na2SO4,and evaporated under vacuum to afford correspondinghydrazide 7a in very good yield (white solid, 1.02g, 93%)

The synthetic route of Methyl 2-(3-fluorophenyl)acetate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Vu, Vu Van; Nhung, Trinh Thi; Thanh, Nguyen Thi; Chinh, Luu Van; Tien, Vu Dinh; Thuy, Vu Thu; Thi Thao, Do; Nam, Nguyen Hai; Koeckritz, Angela; Vu, Tran Khac; Journal of Chemistry; vol. 2017; (2017);,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 64123-77-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 64123-77-9, name is Methyl 2-(3-fluorophenyl)acetate, This compound has unique chemical properties. The synthetic route is as follows.

Example 21: (R)-3-[l-(3-Fluoro-phenyl)-cycloheptanecarbonyloxy]-l-(5-phenyl- [l,3,4]oxadiazol-2-ylmethyl)-l-azonia-bicyclo[2.2.2]octane chloride a) 2-But-3-enyl-2-(3-fluoro-phenyl)-hex-5-enoic acid methyl ester (3-Fluoro-phenyl)-acetic acid methyl ester (4.30 g) was dissolved in tetrahydrofuran (20 mL) and cooled to -78C. Lithium zs(trimethylsilyl)amide (25.6 mL, IM THF solution) was added and the solution was stirred for 30 minutes. 4-Bromo-but-l-ene (2.60 mL) was added and the reaction was allowed to warm to room temperature and stirred for an hour. The reaction was again cooled to -78C. Lithium zs(trimethylsilyl)amide (25.6 mL, IM THF solution) was added and the solution was stirred for 30 minutes. 4-Bromo-l-butene (2.60 mL) was added and the reaction was allowed to warm to room temperature and stirred for an hour. The reaction was again cooled to -78C and further aliquots of Lithium zs(trimethylsilyl)amide (25.6 mL, IM THF solution) and 4-bromo-l-butene (2.60 mL) were added following the procedure outlined above. After stirring overnight, water (20 mL) was added and the reaction mixture extracted with diethyl ether (2 x 60 mL). The combined organic extracts were dried with magnesium sulfate and evaporated. The resulting liquid was purified by column chromatography on silica eluting with ethyl acetate / iso hexane (1 / 99) to afford the sub-titled compound (5.0 g).m/e 277 [M+H]+

The chemical industry reduces the impact on the environment during synthesis Methyl 2-(3-fluorophenyl)acetate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ASTRAZENECA AB; ARGENTA DISCOVERY Ltd.; FORD, Rhonan; WO2009/139709; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 64123-77-9,Some common heterocyclic compound, 64123-77-9, name is Methyl 2-(3-fluorophenyl)acetate, molecular formula is C9H9FO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

(ab) from methyl m-fluorophenylacetate and methyl formate there was obtained methyl 2-(m-fluorophenyl)-3-hydroxy-acrylate of b.p. 75-81/0.1 mm;

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Methyl 2-(3-fluorophenyl)acetate, its application will become more common.

Reference:
Patent; Hoffmann-La Roche Inc.; US4735940; (1988); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 64123-77-9, name is Methyl 2-(3-fluorophenyl)acetate, A new synthetic method of this compound is introduced below., Quality Control of Methyl 2-(3-fluorophenyl)acetate

Intermediate 99: Methyl 2-chlorosulfonyl-5-fluorophenylacetate Methyl 3-fluorophenylacetate (1.51g) was added dropwise to chlorosulphonic acid (7mL) with stirring and ice cooling. The cooling bath was removed and the mixture was allowed to warm to room temperature and left to stand for 16 hours. The mixture was added toa mixture of ice and ethyl acetate and the organic layer was separated, washed with water, dried (MgSO4) and filtered. The filtrate was concentrated in vacuo and the residue was purified by chromatography on silica, eluting with a mixture of ethyl acetate and cyclohexane, with a gradient of 0-20%, to give methyl 2-chlorosulfonyl-5-fluorophenylacetate (1.42g) as a white solid.j00636j ?HNMR(CDC13) : 8.16 (1H, dd), 7.29-7.16 (2H, m), 4.19 (2H, s), 3.76 (3H, s).

The synthetic route of 64123-77-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZAFGEN, INC.; PALLIN, Thomas, David; CRAMP, Susan, Mary; DYKE, Hazel, Joan; ZAHLER, Robert; WO2014/71369; (2014); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics