Category: 63746-12-3

New learning discoveries about C10H11NO4

Application of 63746-12-3,Some common heterocyclic compound, 63746-12-3, name is Dimethyl 4-aminoisophthalate, molecular formula is C10H11NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Application of 63746-12-3,Some common heterocyclic compound, 63746-12-3, name is Dimethyl 4-aminoisophthalate, molecular formula is C10H11NO4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

According to another aspect, the intermediate compound of formula (III) may be prepared, in accordance with the synthetic process illustrated in Scheme 26 above, according to Method B, as illustrated in Synthetic Scheme [26/METHOD B] below: Scheme 26/Method B. 0 0 0 0 0 Toluene I, 11 2 Tnphosgene NS 0 O O Toluene 0 0- R2NH2 NH O NH R2 MeOH 0 0 0 R3 MeONa-‘-N 10 MeONa I N’ O N 0 H 0 0 O O LiOH gp I N-R2 unto Dioxane/H20 H (III) wherein [R2] is as defined above for Formula [I.]

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Dimethyl 4-aminoisophthalate, its application will become more common.

Reference:
Patent; WARNER-LAMBERT COMPANY LLC; WO2004/14384; (2004); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Introduction of a new synthetic route about Dimethyl 4-aminoisophthalate

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63746-12-3, name is Dimethyl 4-aminoisophthalate, A new synthetic method of this compound is introduced below., Quality Control of Dimethyl 4-aminoisophthalate

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63746-12-3, name is Dimethyl 4-aminoisophthalate, A new synthetic method of this compound is introduced below., Quality Control of Dimethyl 4-aminoisophthalate

To a mixture of (4-adamantan-1-yl-phenoxy)-acetic acid (229 mg, 0.8 mmol) and 4-aminoisophthalic acid dimethyl ester (301 mg, 1.4 mmol) were dissolved in DMF (5 mL), and EDCHCl (140 mg, 0.75 mmol), HOAt (163 mg, 1.2 mmol) and DIPEA (0.21 ml, 1.2 mmol) was added. The mixture was stirred overnight, and then partitioned between ethyl acetate and brine. The organic phase was dried (MgSO4 anh), and concentrated. The residue was purified by silica gel column chromatography (CH2Cl2:MeOH=50:1) to give 4-[2-(4-Adamantan-1-yl-phenoxy)acetyl-amino]-isophthalic acid dimethyl ester as a white solid (281 mg, 76.3% yield). 1H-NMR (CDCl3, 300 Hz) 12.00 (1H, s, NH), 9.40 (1H, d, J=1.8 Hz, aromatic), 8.12 (1H, d, J=7.8 Hz, aromatic), 7.78 (1H, dd, J=8.1 & 1.8 Hz, aromatic), 7.33 (2H, m, aromatic), 7.03 (2H, m, aromatic), 4.65 (2H, s, OCH2CO), 3.97 (3H, s, OCH3), 3.95 (3H, s, OCH3), 2.09 (3H, m, adamantyl), 1.89-1.90 (6H, m, adamantyl), 1.72-1.82 (6H, m, adamantyl).

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY; US2009/306078; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics