Adding a certain compound to certain chemical reactions, such as: 63485-51-8, name is trans-Methyl 3-hydroxycyclobutanecarboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 63485-51-8, Computed Properties of C6H10O3
The 3 – [(1 R) -1 – phenyl ethyl] imidazole -4 – carboxylic acid (1 A) (1.0 g, 4.6 mmol) suspended in dichloromethane (20 ml) in, adding trans -3 – hydroxy-cyclobutyl carboxylic acid methyl ester (2 A) (0.9 g, 6.9 mmol), 1 – (3 – dimethylamino propyl) -3 – ethyl carbodiimide hydrochloride (1.3 g, 6.9 mmol), 4 – dimethylamino pyridine (0.85 g, 6.9 mmol), stirring at room temperature for 2 hours. The reaction solution for sequentially saturated sodium dihydrogen phosphate aqueous solution (30 ml × 2) and saturated salt water (30 ml × 1) washing, drying of the organic phase with anhydrous sodium sulfate, filtered, the filtrate is concentrated under reduced pressure, the residue separation and purification with silica gel column chromatography (ethyl acetate/petroleum ether (v/v)=1/20 – 1/5), to obtain the title compound trans – (3 – methoxy carbonyl cyclobutyl) 3 – [(1 R) -1 – phenethyl] imidazole -4 – carboxylic acid ester (compound 2), colorless oily matter (1.0 g, yield 66percent)
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, trans-Methyl 3-hydroxycyclobutanecarboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Sichuan Hai Sike Pharmaceutical Co., Ltd.; Qiu Guanpeng; Wei Yonggang; Lu Yonghua; Huang Qingping; Liao Pengfei; (17 pag.)CN107641105; (2018); A;,
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