Category: 63106-93-4

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 63106-93-4, name is 1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one, A new synthetic method of this compound is introduced below., Application In Synthesis of 1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one

34 kg of aluminium chloride (255 moles) are suspended in 240 L of toluene and then 38.3 kg of diethylamine (523.5 moles) are added while maintaining the temperature between 15 and 300C. The lactone concentrate (38 kg) obtained earlier is poured on the medium maintained at 25C. The reaction medium is stirred for at least 1 hour 30 minutes. Formation of a precipitate is observed.This reaction medium is hydrolyzed with 345 L of water and then filtered after adding a filtration adjuvant. After decantation, the organic phase is washed twice with 235 L and 175 L of water and then concentrated until an amide-alcohol concentrate of 110 L is obtained.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; PIERRE FABRE MEDICAMENT; NICOLAS, Marc; HELLIER, Paul; DIARD, Catherine; SUBRA, Laurent; WO2010/86394; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 63106-93-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 63106-93-4, name is 1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step-2: Synthesis of compound 5: 5 [001.0].) 34 g of aluminium cbioride (0.255 moles) are suspended in 240 ml of toluene and then 38,3 g of diethylamine 4 (0.523 moles) are added while maintaining the temperature between 15 and 30C. The lactone 3 concentrate (38 g) obtained earlier step was poured into the reaction medium maintained at 2SQC. The reaction medium was stirred for at least 1 hour 30 minutes. Formation of a precipitate was observed. The reaction medium was hydro y zed with 345 mi of water and then filtered after adding a filtration adjuvant. After decantation, the organic phase was washed twice with 235 ml and 175 m of water and then concen trated to obtain the amide-alcohol intermediate 5.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; KANDULA, Mahesh; WO2013/168002; (2013); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

63106-93-4, name is 1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. 63106-93-4

Diethylamine (1 .56 g, 21 .3 mmol) is added dropwise to a suspension of aluminum trichloride (1 .38 g, 10.4 mmol) in toluene (9.6 mL), cooled to 0 C under magnetic stirring and in nitrogen atmosphere, checking that the internal temperature of the system does not exceed 15 C. The obtained solution is maintained at 25 C for about 30 minutes, then a toluene (2 mL) solution of lactone A (1 .50 g, 8.6 mmol) is slowly added. The mixture is maintained under magnetic stirring at 25 C up to complete conversion (about 2 hours), then poured into water (7.2 mL) previously cooled to 5 C, checking that the internal temperature does not exceed 25 C. The obtained phases are separated and the aqueous phase extracted with toluene. The organic phase is filtered on a panel of activated carbon and celite, and concentrated at reduced pressure until a residue of 2.50 g (containing about 2.10 g of the desired product) is obtained, which is used in the next step without any further purification.

Statistics shows that 63106-93-4 is playing an increasingly important role. we look forward to future research findings about 1-Phenyl-3-oxabicyclo[3.1.0]hexan-2-one.

Reference:
Patent; QUIMICA SINTETICA, S.A.; BARRECA, Giuseppe; ROMANO’, Bruno Gaetano; (16 pag.)WO2016/71303; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics