Category: 6279-86-3

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6279-86-3, name is Triethyl methanetricarboxylate, This compound has unique chemical properties. The synthetic route is as follows., 6279-86-3

1b) 6-Hydroxy-2-phenyl-3-(phenylmethyl)-4(3H)-pyrimidinone; A mixture of the compound from example 1(a) (0.342 g, 1.63 mmol), triethyl methanetricarboxylate (0.755 g, 3.25 mmol), methanolic sodium methoxide (0.378 mL of a 4.37 M solution, 1.65 mmol) and ethanol (3 mL) was stirred in a microwave reactor at 160 C. for 0.5 h, then cooled and poured into 1M aqueous hydrochloric acid (20 mL). The mixture was extracted with ethyl acetate, and the extracts washed with brine, dried (MgSO4) and evaporated under reduced pressure. The residue was chromatographed (silica gel, 5-10% methanol/dichloromethane) to give the title compound (0.320 g, 44%) as a foam. 1H NMR (400 MHz, DMSO-d6) delta ppm 5.05 (s, 2 H) 5.50 (s, 1 H) 6.87 (m, 2 H) 7.18-7.26 (m, 3 H) 7.36-7.43 (m,4H) 7.49 (m, 1 H) 11.64 (s, 1 H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; Shaw, Antony N.; Duffy, Kevin J.; Tedesco, Rosanna; Wiggall, Kenneth; US2008/171756; (2008); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 6279-86-3, name is Triethyl methanetricarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Triethyl methanetricarboxylate

10129] 14.5 parts (62.4 mmol) of triethyl carboxymalonate,11.4 parts (76.4 mmol) of 5-amino-2-benzimidazolinone and0.138 part (0.626 mmol) of 2,6-di-tert-butyl-p-cresol weredissolved in 141 parts (1.93 mol) of N,N-dimethylformamide, and reacted under heating and stirring at 800 C. for 6hours. After the reaction, N,N-dimethylformamide was distilled away under reduced pressure, and 300 parts (16.7 mol) of water was added to the obtained residue. The deposit was filtered to thereby obtain the intermediate (4).

The synthetic route of Triethyl methanetricarboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CANON KABUSHIKI KAISHA; CANON FINETECH INC.; Kubo, Haruko; Ueno, Suzuka; Chizuwa, Junko; Yamamoto, Tomoya; Itabashi, Hitoshi; Terui, Yuhei; Yoshida, Yu; Murai, Yasuaki; Toyoda, Takayuki; (26 pag.)US2016/130233; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6279-86-3, name is Triethyl methanetricarboxylate, A new synthetic method of this compound is introduced below., COA of Formula: C10H16O6

Example 2N-r(7-hvdroxy-5-oxo-4,5-dihvdropyrazolori,5-alpyrimidin-6-yl)carbonyllglvcine A mixture of lH-pyrazol-5-amine (0.20 g, 2.40 mmol), triethyl methanetricarboxylate (0.51 mL, 2.40 mmol), glycine (0.27 g, 3.60 mmol) and l,8-diazabicyclo[5.4.0]undec-7-ene (0.68 mL, 4.80 mmol) in ethanol (5.0 mL) was heated to 180 0C for 20 minutes in a Biotage Initiator microwave synthesizer. The mixture was purified via preparative HPLC (YMC 75 X 30 mm column, 0.1% TFA in water and 0.1% TFA in acetonitrile) to afford the title compound as a yellow solid (0.065 g, 11%). 1H NMR (400 MHz, OMSO-d6) delta ppm 13.0 (s, 2 H) 9.87 (t, J=5.6 Hz, 1 H) 7.85 (d, J=2.0 Hz, 1 H) 6.01 (d, J=LO Hz, 1 H) 4.16 (d, J=5.8 Hz, 2 H). MS(ES+) m/e 253 [M+H]+.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; SMITHKLINE BEECHAM CORPORATION; WO2009/39323; (2009); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 6279-86-3, A common heterocyclic compound, 6279-86-3, name is Triethyl methanetricarboxylate, molecular formula is C10H16O6, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of triethyl 1,1, 2-ethanetricarboxylate (3.51 mL, 15.30 mmol) and 2- (4-nitrophenyl)- ethanimidamide hydrochloride (46.95 g, 217.72 mmol) in anhydrous MeOH (300 mL) at room temperature was added NaOMe (3.8. 82 g, 718.49 mmol) and the resulting suspension was refluxed for 16 hours. After cooling to room temperature, the reaction mixture was chilled to 0C, acidified with 6N HCI, and the separated solids collected by suction and rinsed with cold water. Drying under high vacuum at 45C for 6 hours then gave methyl [4, 6-dihydroxy-2- (4-nitrobenzyl)- pyrimidin-5-yl] acetate (56.48 g, 81% yield) as a pale white powder.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BAYER HEALTHCARE AG; WO2005/73234; (2005); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

6279-86-3, name is Triethyl methanetricarboxylate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of Triethyl methanetricarboxylate

To a solution of tert-butyl [2-[1-(2-iodoethyl)cyclohexyl]ethoxy]diphenylsilane (540 mg) and ethyl methane tricarboxylate (727 mg) in N, N-dimethylformamide (5 ML) was added potassium carbonate (575 mg) at room temperature.. The solution was stirred at 110 C for 6 hours, to which water and 3N hydrochloric acid were added.. The solution was extracted with ethyl acetate.. The organic layer was washed in turn with a 1N aqueous sodium hydroxide solution, water and saturated aqueous sodium chloride solution, dried over anhydrous magnesium sulfate, and concentrated under reduced pressure.. The resulting residue was purified by chromatography (silica gel, hexane:ethyl acetate=85:15) to give the title compound (470 mg).1H-NMR (CDCl3) delta: 1.03 (s, 9H), 1.17-1.40 (m, 12H), 1.23 (t, 9H, J=6.8 Hz), 1.60 (t, 2H, J=8.0 Hz), 1.96-2.04 (m, 2H), 3.68 (t, 2H, J=8.0Hz), 4.18 (q, 6H, J=6. 8 Hz), 7.73-7.45 (m, 6H), 7.64-7.70 (m, 4H).

The synthetic route of 6279-86-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Kyorin Pharmaceutical Co., Ltd.; Nisshin Pharma Inc.; EP1443046; (2004); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 6279-86-3,Some common heterocyclic compound, 6279-86-3, name is Triethyl methanetricarboxylate, molecular formula is C10H16O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a well-stirred solution of (1R)- l-(4-chlorophenyl)ethanol (1.00 g, 6.38 mmol) and triethylmethanetricarboxylate (2.69 mL, 12.8 mmol) in dry toluene (12.8 mL) under dry nitrogen is added a 1M solution of trimethylphosphine in THF (12.8 mL, 12.8 mmol) via syringe. The mixture is cooled at -78 C and DIAD (2.51 mL, 12.8 mmol) is added slowly over a period of 15 min. The reaction is stirred at -78 C for lh, the bath is removed and stirring is continued as the bath warmed to rt for an additional 4 h. The reaction mixture is concentrated, dissolved in diethyl ether (100 mL) and washed with IN NaOH (2 x 50 mL) and IN HC1 (1 x 50 mL). The organics are dried with anhydrous sodium sulfate, concentrated and the residue is subjected to silica gel chromatography (230-400 mesh, 150 g, elution with 5 and 10% ethyl acetate/hexane) to give 1.90 g of triethyl (25)-2-(4- chlorophenyl)propane-l ,l , l-tricarboxylate as an oil. NMR (400 MHz, CDC13) delta ppm 1.20 (9 H, t), 1.47 (3 H, d), 3.82 (1 H, q), 4.17 (6 H, m), 7.24 (2 H, d), 7.36 (2 H, d); MS (ESI+) for Ci 8H23C106 m/z 371.1 (M+H)+; HPLC retention time: 5.20 min. (Method D).

The synthetic route of 6279-86-3 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BIORELIX, INC.; COISH, Philip, D., G.; DIXON, Brian, R.; OSTERMAN, David; ARISTOFF, Paul, Adrian; NAVIA, Manuel; SCIAVOLINO, Frank; AVOLA, Stephanie; BABOULAS, Nick; BELLIOTTI, Thomas, R.; BELLO, Angelica; BERMAN, Judd; CHRUSCIEL, Robert, A.; EVANS, Bruce, R.; KAUR, Harpreet; MOON, David; PHAM, Vinh; ROUGHTON, Andrew; WICKENS, Phil; WILSON, Jeffrey; WO2011/126567; (2011); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 6279-86-3, name is Triethyl methanetricarboxylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6279-86-3, category: esters-buliding-blocks

To a solution of 1.00 mL of the alcohol (A-lOa) (1.00 equiv., 7.94 mmol) and 3.44 mL of triethyl methanetricarboxylate (2.00 equiv., 15.9 mmol) in 30.0 mL of anhydrous toluene at room temperature, 15.9 mL of 1M trimethyl phosphine solution in toluene (1M, 2.00 equiv., 15.9 mmol) was added. The resulting solution was cooled to -78C. DIAD (3.13 mL, 2.00 equiv., 15.9 mmol) was added slowly at such a rate to maintain the temperature of the reaction at -75C to -77C. The reaction was then stirred at -78C for 0.5 hours and warmed to room temperature for 1-3 hours and was allowed to run overnight. Solvent was concentrated in vacuo to get crude. The crude was purified by column chromatography using hexane and ethyl acetate to yield compound (A-lOb) as clear oil (2.46 g, 92.1 %). 1H NMR (600MHz, CHLOROFORM- d) d = 4.45-7.43 (d, 2H), 7.30-7.20 (m, 3H), 4.22-4.13 (m, 6H), 1.23-1.19 (t, =7.2Hz, 9H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; EPIODYNE, INC.; MEDINA, Julio Cesar; MCGEE, Larry; WEI, Zhi-Liang; SADLOWSKI, Corinne; SEIDL, Frederick; BHATT, Ulhas; WANG, Xiaodong; NGUYEN, Thomas; SPERANDIO, David; DING, Pingyu; NERURKAR, Alok; LI, Yihong; DUQUETTE, Jason; (307 pag.)WO2019/195634; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 6279-86-3, The chemical industry reduces the impact on the environment during synthesis 6279-86-3, name is Triethyl methanetricarboxylate, I believe this compound will play a more active role in future production and life.

p-Methoxyaniline (123 mg, 1 mmol) was dissolved in dimethylformamide (1 ml).;Then, triethyl methanetricarboxylate (232 mg, 1 mmol) was added.;The mixture was heated for six hours at 170-190 C. The reaction was cooled to rt and treated with ethanol, filtered and washed with ethanol to yield 8 as a yellow solid (143 mg, 58%); mp 308-310 C; 1H NMR (500 MHz, DMSO-d6) delta 3.79 (s, 3H), 3.86 (s, 3H), 7.01 (d, J = 8.9 Hz, 2H), 7.40 (br s, 3H), 7.59 (d, J = 8.9 Hz, 2H), 12.01 (s, 1H), 12.63 (s, 1H), 16.67 (s, 1H); 13C NMR (125.7 MHz, DMSO-d6) delta 55.09, 55.38, 96.39, 104.22, 114.13, 114.51, 117.33, 122.13, 123.65, 129.58, 133.11, 154.53, 156.26, 161.98, 168.39, 171.37; Anal. for C18H16N2O5: Calcd C, 63.52; H, 4.74; N, 8.23. Found C, 63.66; H, 5.00; N, 8.09.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Triethyl methanetricarboxylate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Sabbah, Dima A.; Simms, Neka A.; Wang, Wang; Dong, Yuxiang; Ezell, Edward L.; Brattain, Michael G.; Vennerstrom, Jonathan L.; Zhong, Haizhen A.; Bioorganic and Medicinal Chemistry; vol. 20; 24; (2012); p. 7175 – 7183;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

These common heterocyclic compound, 6279-86-3, name is Triethyl methanetricarboxylate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Computed Properties of C10H16O6

10129] 14.5 parts (62.4 mmol) of triethyl carboxymalonate,11.4 parts (76.4 mmol) of 5-amino-2-benzimidazolinone and0.138 part (0.626 mmol) of 2,6-di-tert-butyl-p-cresol weredissolved in 141 parts (1.93 mol) of N,N-dimethylformamide, and reacted under heating and stirring at 800 C. for 6hours. After the reaction, N,N-dimethylformamide was distilled away under reduced pressure, and 300 parts (16.7 mol) of water was added to the obtained residue. The deposit was filtered to thereby obtain the intermediate (4).

The synthetic route of Triethyl methanetricarboxylate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; CANON KABUSHIKI KAISHA; CANON FINETECH INC.; Kubo, Haruko; Ueno, Suzuka; Chizuwa, Junko; Yamamoto, Tomoya; Itabashi, Hitoshi; Terui, Yuhei; Yoshida, Yu; Murai, Yasuaki; Toyoda, Takayuki; (26 pag.)US2016/130233; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 6279-86-3,Some common heterocyclic compound, 6279-86-3, name is Triethyl methanetricarboxylate, molecular formula is C10H16O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: 4.1.1.1 Ethyl 1-hexyl-1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxylate (2a); A mixture of N-hexylaniline (0.88g, 5mmol) and triethyl methanetricarboxylate 3 (3.48g, 15mmol) was irradiated with microwaves at the fixed power of 250 Watt (max temp 250C) for 20min in open vessel conditions. The crude mixture was directly purified by flash chromatography (PE/AcOEt 4:1) giving compound 2a as a yellow oil. (0.856g, 54% yield). 4.1.1.5 Ethyl 1-methyl-1,2-dihydro-4-hydroxy-2-oxo-quinoline-3-carboxylate (2e) Yield: 35%. 1H NMR: (200 MHz, CDCl3): delta 12.64 (bs, 1H), 7.30-7.26 (m, 4H), 4.35 (q, 2H, J = 7.3 Hz), 3.62 (s, 3H), 1.19 (t, 3H, J = 7.3 Hz). ES-MS: 270 [M+Na]+.

The synthetic route of 6279-86-3 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Manetti, Fabrizio; Petricci, Elena; Gabrielli, Annalisa; Mann, Andre; Faure, Helene; Gorojankina, Tatiana; Brasseur, Laurent; Hoch, Lucile; Ruat, Martial; Taddei, Maurizio; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 747 – 757;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics