6274-50-6, name is Methyl 2-(4-methoxyphenyl)-2-methylpropanoate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 6274-50-6
To a solution of methyl 2-(4-methoxyphenyl)acetate (10.0 g, 48.00 mmol) in MeOH (20 mL) was added dropwise a solution of NaOH (7.69 g, 192.3 mmol) in water (50 mL). The reaction mixture was stirred at rt for 6 h. The MeOH was distilled off at reduced pressure and water (25 mL) was added. The aqueous layer was washed with Et20 and then acidified to pH=4 using 6.0 M HC1. The resultant precipitate was filtered, washed with hexanes, and dried. The resultant solid was dissolved in CH2CI2 (150 mL) and cooled to -78 C followed by the addition of BBr3 (1.0 M solution in CH2C12) (72.0 mL, 72.00 mmol) over 30 min. After the completion of the addition, the temperature was raised to 0 C, and the reaction mixture was stirred for an additional 30 min. Water was slowly added and the organic layer was separated, dried over Na2S04; and concentrated to provide the title compound (4.30 g, 50%). lU NMR (400 MHz, DMSO-d6) delta ppm 12.17 (br s, 1H), 9.31 (s, 1H), 7.14 (d, 2H), 6.71 (d, 2H), 1.42 (s, 6H).
The synthetic route of 6274-50-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TEMPERO PHARMACEUTICALS, INC.; BALOGLU, Erkan; BOHNERT, Gary, J.; GHOSH, Shomir; LOBERA, Mercedes; SCHMIDT, Darby, R.; SUNG, Leonard; WO2013/19682; (2013); A1;,
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