Category: 6259-76-3

Zeng, Lin published the artcileComparative Analysis of Volatile Compounds in Tieguanyin with Different Types Based on HS-SPME-GC-MS, Application In Synthesis of 6259-76-3, the main research area is Tieguanyin volatile compound HSSPME GCMS comparative analysis; Tieguanyin; aroma; oolong tea; volatile compounds.

Tieguanyin (TGY) is one kind of oolong tea that is widely appreciated for its aroma and taste. To study the difference of volatile compounds among different types of TGY and other oolong teas, solid-phase microextraction-gas chromatog.-mass spectrometry and chemometrics anal. were conducted in this experiment Based on variable importance in projection > 1 and aroma character impact > 1, the contents of heptanal (1.60-2.79μg/L), (E,E)-2,4-heptadienal (34.15-70.68μg/L), (E)-2-octenal (1.57-2.94μg/L), indole (48.44-122.21μg/L), and (E)-nerolidol (32.64-96.63μg/L) in TGY were higher than in other varieties. With the increase in tea fermentation, the total content of volatile compounds decreased slightly, mainly losing floral compounds Heavily fermented tea contained a higher content of monoterpenoids, whereas low-fermentation tea contained higher contents of sesquiterpenes and indole, which could well distinguish the degree of TGY fermentation Besides, the volatiles anal. of different grades of TGY showed that the special-grade tea contained more aroma compounds, mainly alcs. (28%). (E,E)-2,4-Heptadienal, (E)-2-octenal, benzeneacetaldehyde, and (E)-nerolidol were the key volatile compounds to distinguish different grades of TGY. The results obtained in this study could help enrich the theor. basis of aroma substances in TGY.

Foods published new progress about Fermentation. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, Application In Synthesis of 6259-76-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hwang, Jee-hyun published the artcileEmployment of cytology for in vitro skin irritation test using a reconstructed human epidermis model, Keraskin, Application In Synthesis of 6259-76-3, the main research area is skin irritation epidermis irritant model Keraskin; Cytology; Dermal toxicity; Reconstructed human epidermis model; Skin irritation.

Skin irritation tests using reconstructed human epidermis (RhE) employ viability as an endpoint, but color interference or borderline results are often problematic. We examined whether the cytol. of cells from treated RhE could determine skin irritancy. Six chems. (three irritants; DnP, 1-B, PH, three non-irritants; DP, APA, HS) were evaluated in a RhE, Keraskin. DP, HS, and PH were clearly classified with viability, but DnP, 1-B, and APA were often falsely determined, due to borderline values falling near the cutoff, 50%. In histol., the tissues treated with DnP, 1-B, and PH showed erosion of the stratum corneum, vacuolization, and necrosis in the basal layer. DP- and HS-treated tissues showed relatively normal morphol. but APA induced necrosis similar to irritants. Cytol. revealed that DnP, 1-B or PH depleted cells and induced irregular and abnormal cell shapes. In contrast, relatively regular and normal shapes and clear distinction between the nucleus and cytoplasm was observed for DP, APA and HS. To further confirm it, addnl. 10 substances, including false positives from OECD TG 439, were tested. Overall (16 substances in total), cytol.: total area predicted the skin irritancy of test chems. with the highest accuracy (87.5%) followed by cytol.: cell count (81.3%), histol. (75%) and viability (68.8%), confirming the utility of cytol. as an alternative endpoint in the skin irritation test using RhE.

Toxicology In Vitro published new progress about Cytotoxicity. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, Application In Synthesis of 6259-76-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fusco, Laura published the artcileSkin irritation potential of graphene-based materials using a non-animal test, Formula: C13H18O3, the main research area is graphene based material skin irritation potential health hazard.

Besides inhalation, skin contact may be considered one of the most relevant exposure routes to graphene-based materials (GBMs). However, very few data on the cutaneous toxicity of these materials are available, so far. This study is focused on skin irritation potential of a panel of GBMs: few-layer graphene (FLG), exfoliated by ball milling of graphite, FLG exfoliated by ultrasonication using sodium dodecyl sulfate (FLG-SDS) or sodium dodecylbenzenesulfonate (FLG-SDBS), CVD-graphene, obtained by chem. vapor deposition, graphene oxide (GO) and reduced GO (rGO). Skin irritation was assessed using the SkinEthic Reconstructed human Epidermis (RhE), following the Organization for Economic Co-operation and Development (OECD) Test Guideline (TG) 439. Even though not validated for nanomaterials, the OCED TG 439 turned out to be applicable also for GBM testing, since no interference with the methylthiazolyldiphenyl-tetrazolium bromide (MTT) reduction, used as a final readout, was found. Furthermore, direct epidermal exposure to powd. GBMs mimics the actual human exposure, avoiding interference by the cell culture medium (protein corona formation). Only GBMs prepared with irritant surfactants (FLG-SDS and FLG-SDBS), but not the others, reduced RhE viability at levels lower than those predicting skin irritation (�0%), suggesting irritant properties.

Nanoscale published new progress about Ball milling. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, Formula: C13H18O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mancuso, Raffaella published the artcileSynthesis, computational evaluation and pharmacological assessment of acetylsalicylic esters as anti-inflammatory agents, Safety of Hexyl 2-hydroxybenzoate, the main research area is aspirin acetylsalicylic ester antiinflammatory toxicity.

A convenient approach to the synthesis of alkyl esters of aspirin (ASA-OR) has been developed. The synthesis of ASA-OR has been realized in two steps: (1) direct esterification of salicylic acid with alcs. in the presence of dicyclohexylcarbodiimide to give alkyl salicylates (SAL-OR); (2) acetylation of SAL-OR with acetyl chloride to yield ASA-OR. Mol. mechanics simulations, performed to calculate the kinetic radii of several ASA-OR, indicated that the pentyl and hexyl acetylsalicylates possess the best properties to cross cell membranes. The in vitro biol. tests demonstrate their anti-inflammatory activity, superimposable to that of aspirin. The results of our study suggest that ASA-OR may be used as anti-inflammatory drugs for topical application.

Medicinal Chemistry Research published new progress about Cell membrane. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, Safety of Hexyl 2-hydroxybenzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Picone, Marco published the artcileFragrance materials (FMs) affect the larval development of the copepod Acartia tonsa: An emerging issue for marine ecosystems, SDS of cas: 6259-76-3, the main research area is Acartia tonsa marine ecosystem fragrance material; Acartia tonsa; Copepods; Fragrance materials (FMs); Larval development.

Fragrance materials (FMs) are used in a variety of detergents and cosmetics, including household and personal care products. Despite their widespread use and the growing evidence of their occurrence in surface waters worldwide, very little is known about their toxicity towards marine species, including a key component of the marine food webs such as copepods. Thus, we investigated the toxicity of six of the more long-lasting and stable com. fragrances, including Amyl Salicylate (AMY), Oranger Crystals (ORA), Hexyl Salicylate (HEX), Ambrofix (AMB), Peonile (PEO), and Benzyl Salicylate (BZS), to assess their ability to impair the larval development of the calanoid copepod Acartia tonsa. FMs inhibited the development of A. tonsa significantly at concentrations by far lower than the effect-concentrations reported in the literature for aquatic species. The more toxic FMs were HEX (EC50 = 57 ng L-1), AMY (EC50 = 131 ng L-1) and ORA (EC50 = 766 ng L-1), while the other three compounds exerted toxic effects at concentrations higher than 1000 ng L-1 (LOEC at 1000 ng L-1-1 for PEO and BZS, and at 10,000 ng L-1 for AMB). Early life-stage mortality was unaffected by FMs at all the tested concentrations A comparison with water concentrations of FMs reported in the literature confirmed that FMs, especially HEX and AMY, may act as contaminants of potential concern in many aquatic habitats, including urban areas and remote and polar environments.

Ecotoxicology and Environmental Safety published new progress about Acartia tonsa. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, SDS of cas: 6259-76-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sapozhnikova, Yelena published the artcileSuspect screening of chemicals in food packaging plastic film by comprehensive two-dimensional gas chromatography coupled to time-of-flight mass spectrometry, Name: Hexyl 2-hydroxybenzoate, the main research area is food packaging plastic film chem screening GC TOF MS.

In this study, chems. extracted from a food packaging plastic film with a series of organic solvents were tentatively identified with comprehensive two-dimensional gas chromatog. coupled to time-of-flight mass spectrometry (GC×GC-TOF-MS). A total of 91 compounds were tentatively identified in the film extracts, based on high mass spectral matching with the US National Institute of Standards and Technol. (NIST) mass spectral (MS) library. The tentatively identified chems. included common plasticizers: di(2-ethylhexyl) adipate (DEHA), di-Et and di-Bu phthalates; polymer and plastic additives: hexafluorobisphenol A (bisphenol AF), 2,4,7,9-tetramethyl-5-decyn-4,7-diol (TMDD), Me dehydroabietate, and 2,2,4-trimethyl-1,3-pentanediol diisobutyrate (TXIB); UV filters: homosalate, 2-ethyhexyl salicylate (octisalate); fragrances: cedrol and galaxolide, flavoring agents: n-hexyl salicylate and benzophenone. Addnl., representatives of polycyclic aromatic hydrocarbons (PAHs), alkylated naphthalenes, linear alkylbenzenes, and Ph, biphenyl, and di-Ph compounds were identified. Unexpected discovery of low chlorinated polychlorinated biphenyls (PCBs) in the film extracts suggests their source should be investigated further. The tentatively identified compounds were characterized based on use, source, chem. properties, and previously reported occurrences in plastic food packaging materials, food, or the environment.

LCGC North America published new progress about Food packaging. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, Name: Hexyl 2-hydroxybenzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bernardo, Naissa Previde published the artcileVolatile Composition of Sparkling Wines of cv. Chardonnay Cultivated under Different Training Systems in Serra da Mantiqueira (Brazil), SDS of cas: 6259-76-3, the main research area is sparkling wine training system volatile composition; GC-MS; GDC; HS-SPME; aroma; crop; lyre.

The grapevine is a climbing plant and allows for the manipulation of vegetative canopies to change the microclimate and exposure of leaves and clusters to solar radiation, affecting the primary and secondary metabolisms of plants. Thus, this work aimed to evaluate how the lyre and Geneva double-curtain (GDC) training systems could contribute to the volatile composition of sparkling wines in replicates of vinifications carried out in the Serra da Mantiqueira (Brazil) in two consecutive summer harvests (2017 and 2018). Fifty-four free volatile compounds were identified by HS-SPME/GC-MS in the wines in both systems and vintages. Multivariate anal. differentiated the vintages in component 1 (22.7%) and the training systems in component 2 (7.1%). The crops were differentiated by aldehydes in 2017 and in 2018 by isoamyl acetate ester, probably derived from the amino acid leucine, the season having been more humid, with lower temperatures and less radiation. For the training systems, besides the alc. compounds, the GDC was differentiated by the terpenoid compounds geranylacetone and β-damascenone, which may contribute more pleasant aromas to sparkling wines. This work promotes addnl. research and enables winegrowers, through the management of their vineyards, to achieve sparkling wines with different volatile compositions

Foods published new progress about Soils, vineyard. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, SDS of cas: 6259-76-3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Alepee, Nathalie published the artcileUsefulness of the EpiSkin reconstructed human epidermis model within Integrated Approaches on Testing and Assessment (IATA) for skin corrosion and irritation, Category: esters-buliding-blocks, the main research area is EpiSkin skin corrosion corrosive irritant irritation.

Predictive capacity of the EpiSkin model was evaluated on 87 chems. using the Bottom-Up and the Top-Down testing approaches recommended within Integrated Approach on Testing and Assessment for the identification of both skin irritation and corrosion hazards. Classified (UN GHS Cat. 1 and Cat. 2) chems. were identified with a very high sensitivity (�4%) and the non-classified (UN GHS Cat. 3 and No Cat.) chems. with an appropriate specificity (70%). Very high sensitivities were obtained for the identification of Cat. 1 chems. (�8%), very high specificities for non-Cat. 1 chems. (93%), and accuracies of -95% for the identification of skin corrosives vs. non-corrosives by both approaches. Overall accuracies of 72% were found for predicting the single (sub)categories: non-classified, Cat. 2, Subcat. 1B/1C and Subcat. 1A. Results indicated the testing strategies to be more predictive than the individual assays on a conservative safety approach. Finally, no extreme misclassifications (no under-prediction of in vivo Subcat. 1A as non-Cat. 1, and no over-prediction of non-classified chem. as Subcat. 1A) occur. These findings, independently of the approach used, confirm the usefulness of the EpiSkin in vitro model for a safe prediction of the skin irritant and corrosive hazards of chems.

Toxicology In Vitro published new progress about Artificial skin. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cabanes, A. published the artcileNew methods to remove volatile organic compounds from post-consumer plastic waste, Recommanded Product: Hexyl 2-hydroxybenzoate, the main research area is volatile organic compound plastic waste hot air stripping extraction; Contaminant; Deodorization; NIA; Odor; Polyethylene; Smell.

While the annual European demand for polyolefins is 25 million tonnes, only 3 million tonnes of recycled polyolefins find their place in the market, despite collecting 15 million tonnes of post-consumer polyolefins every year. Brand owners of care products are showing their interest in using post-consumer recycled plastics for their packaging. However, there is a general concern in using these materials, as recycled polymers can contain unwanted substances that may expose the consumer to health risks or make the packaging unattractive. Accordingly, the presence of these contaminants narrows the market opportunity of recycled plastics to applications with low-quality requirements and in which the product is not in direct contact with the consumer. Though mech. recycling is the most widespread solution presents limitations in terms of decontamination, as only superficial substances are removed. Thereby, the volatile organic compounds (VOCs) migrated to the polymer matrix remain inside. Consequently, there is a need to find a solution to purify recycled plastics and increase their market share. This study focuses on removing VOCs from post-consumer recycled HDPE through two innovative methods applied for the first time in this field, steam stripping and polyethylene glycol (PEG) extraction The methodol. implemented to analyze the volatile organic compounds in HDPE was HS-SPME-GC/MS. Both methods showed a decrease above 70% in the VOCs content compared to extrusion-degassing. Moreover, these were compared to hot air stripping, a new technol. developed at an industrial scale for the removal of VOCs. As a result, steam stripping improved efficiency in reducing the overall VOCs compared to hot air stripping. The PEG extraction method lowered the volatile polar compounds further than using hot air stripping. Addnl., none of these technologies modified the HDPE melting flow index.

Science of the Total Environment published new progress about Biodegradability. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, Recommanded Product: Hexyl 2-hydroxybenzoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pang, Wenwen published the artcileAnticancer activities of Zanthoxylum bungeanum seed oil on malignant melanoma, COA of Formula: C13H18O3, the main research area is Zanthoxylum malignant melanoma seed oil anticancer; Cell cycle arrest; Invasion; Malignant melanoma; Seed oil Apoptosis; Zanthoxylum bungeanum.

Zanthoxylum bungeanum Maxim. (ZBM), a Chinese herb medicine and food additive, has been shown to have broad-spectrum beneficial effects. However, the anticancer activities of its seed have not been reported.for the first time investigated the anti-proliferation activity of seed oil of ZBM (ZBSO) on melanoma A375 cells as well as the underlying mechanisms. The chem. composition of ZBSO was analyzed by Ultra Performance Liquid Chromatog. A375 cells exposure at different concentrations of ZBSO to examine the selectivity vs. normal skin cells, invasion, apoptosis and cell cycle arrest. Furthermore, transcriptome anal. was employed to investigate potential anticancer mechanisms of ZBSO. Major compounds of ZBSO were identified and unsaturated fatty acid made up the major compound ZBSO-treated A375 cells showed more typical apoptotic morphol. features than normal cells. ZBSO can significantly inhibit invasion and proliferation of A375 cells by G1 phase arrest and induction of apoptosis. Transcriptome anal. showed that ZBSO may affect cell cycle and MAPK signaling pathway of A375 cells. ZBSO possessed anticancer activities that were selectively effective to A375 cells. This study support the hypothesis that ZBSO is a capable candidate for anti-melanoma agent, and provide new insights for future work on investigating the utilization of ZBSO in malignant melanoma treatment.

Journal of Ethnopharmacology published new progress about Antitumor agents. 6259-76-3 belongs to class esters-buliding-blocks, name is Hexyl 2-hydroxybenzoate, and the molecular formula is C13H18O3, COA of Formula: C13H18O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics