Related Products of 62456-15-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 62456-15-9, name is trans-Methyl 4-aminocyclohexanecarboxylate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.
Step 1: Methyl trans-4-(tert-butoxycarbonylamino)cyclohexanecarboxylate:Methyl trans-4-aminocyclohexanecarboxylate (43 g, 222 mmol) was added to MeOH(500 ml) to give a colourless solution. The solution was cooled to 10C and triethylamine (46.4 ml, 333 mmol) was added dropwise, followed by a solution of di- tert-butyldicarbonate (53.3 g, 244 mmol) in MeOH (400 ml) over 20 minutes. The reaction was allowed to warm to RT and stirred overnight. The mixture was evaporated to dryness under reduced pressure. The resulting colourless solid was dissolved in EtOAc (1000 ml) and the solution obtained was washed successively with 10% citric acid solution (100 ml), saturated sodium bicarbonate solution (2 x 100ml) and saturated brine (100 ml), dried (MgS04) and evaporated under reduced pressure to give a colourless solid.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, trans-Methyl 4-aminocyclohexanecarboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; ATKINSON Benjamin; BEATTIE David; CULSHAW Andrew James; DEVEREUX Nicholas James; MCKENNA Jeffrey; DALE James; WO2011/92293; A1; (2011);,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics