Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 623-53-0, name is Ethyl methyl carbonate, A new synthetic method of this compound is introduced below., Recommanded Product: Ethyl methyl carbonate
47 mmol of the above intermediate I, 3-trifluoromethyl-4-chloroaniline 47 mmol and 0.4 mmol of benzyltrimethylammonium hydroxide weredissolved in 100 mL of N-methylpyrrolidone, and ethyl methyl carbonate 50 mmol was added dropwise in portions. The temperature was raised to 50 C for 80 min, cooled to room temperature, and the reaction solution was added to a mixed solvent of 60 mL of water and 40 mL of ethyl acetate, stirred, layered, and the aqueous phase was extracted with ethyl acetate. The sodium chloride was washed, dried, and dried under vacuum at 40 C to obtain 20.99 g of crude sorafenib in a yield of 96.1%.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shandong Luoxin Pharmaceutical Group Hengxin Pharmaceutical Co., Ltd.; Liu Zhenteng; Hou Junkai; Liu Qingli; Tian Song; (13 pag.)CN108276327; (2018); A;,
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