Category: 623-50-7

Yao, Yao; Chen, Kai; Yang, Xingyuan; Li, Jingming; Li, Xuewen published the artcile< Comparative study of the key aromatic compounds of Cabernet Sauvignon wine from the Xinjiang region of China>, Application In Synthesis of 623-50-7 , the main research area is Cabernet Sauvignon wine aromatic compound China; Cabernet Sauvignon wine; GC–MS; Heatmap cluster; Random forest; Sensory analysis; Volatile compounds.

Abstract: To determine the differences in the characteristic volatile compounds between winemaking areas in the Xinjiang region, this study was conducted by sampling Cabernet Sauvignon grapes from four winemaking areas in Xinjiang, named Tianshanbeilu, Yili, Yanqi, and Hami. After undergoing the same alc. fermentation treatment, the wines from the four areas were subjected to GC-MS and sensory anal. The results showed that fifty aromatic compounds (including higher alcs., esters, acids, terpenes, aldehydes/ketones, et al.) were identified and quantified. Interestingly, the terpene and phenylalanine derivative contents of the wines from northern Xinjiang were higher than those from the south. Addnl., four vineyards highly contributed to the development of key volatile compounds in the Xinjiang region. Sensory anal. showed that the wines from northern Xinjiang were impressive with a flowery and fruity aroma and the wines from southern Xinjiang had a stronger wine body and astringency.

Journal of Food Science and Technology (New Delhi, India) published new progress about Acidity (volatile). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Application In Synthesis of 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yasuno, Takumi; Ohe, Tomoyuki; Kataoka, Hiroki; Hashimoto, Kosho; Ishikawa, Yumiko; Furukawa, Keigo; Tateishi, Yasuhiro; Kobayashi, Toi; Takahashi, Kyoko; Nakamura, Shigeo; Mashino, Tadahiko published the artcile< Fullerene derivatives as dual inhibitors of HIV-1 reverse transcriptase and protease>, Electric Literature of 623-50-7 , the main research area is pyridinium fullerene preparation dual inhibitor HIV reverse transcriptase protease; piperidinium fullerene preparation dual inhibitor HIV reverse transcriptase protease; proline fullerene preparation dual inhibitor HIV reverse transcriptase protease; Fullerene; HIV protease; HIV reverse transcriptase.

In the present study, we newly synthesized three types of novel fullerene derivatives: pyridinium-type derivatives, piperidinium-type derivatives, and proline-type derivatives Among the assessed compounds, some were found to inhibit both HIV reverse transcriptase and HIV protease (HIV-PR), with IC50 values in the low micromolar range being observed Regarding HIV-PR inhibition activity, proline-type derivatives, bearing an alkyl chain between the hydroxylmethylcarbonyl (HMC) moiety and pyrrolidine ring, were more potent than other derivatives This result might indicate that connecting HMC moieties with proline-type fullerene derivatives through properly sized alkyl chain leads to improved HIV-PR inhibitory activity.

Bioorganic & Medicinal Chemistry Letters published new progress about AIDS (disease). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Electric Literature of 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Eduful, Benjamin J.; O’Byrne, Sean N.; Temme, Louisa; Asquith, Christopher R. M.; Liang, Yi; Picado, Alfredo; Pilotte, Joseph R.; Hossain, Mohammad Anwar; Wells, Carrow I.; Zuercher, William J.; Catta-Preta, Carolina M. C.; Zonzini Ramos, Priscila; Santiago, Andre de S.; Counago, Rafael M.; Langendorf, Christopher G.; Nay, Kevin; Oakhill, Jonathan S.; Pulliam, Thomas L.; Lin, Chenchu; Awad, Dominik; Willson, Timothy M.; Frigo, Daniel E.; Scott, John W.; Drewry, David H. published the artcile< Hinge Binder Scaffold Hopping Identifies Potent Calcium/Calmodulin-Dependent Protein Kinase Kinase 2 (CAMKK2) Inhibitor Chemotypes>, HPLC of Formula: 623-50-7 , the main research area is CAMKK2 inhibitor chemotype probe signaling.

CAMKK2 is a serine/threonine kinase and an activator of AMPK whose dysregulation is linked with multiple diseases. Unfortunately, STO-609, the tool inhibitor commonly used to probe CAMKK2 signaling, has limitations. To identify promising scaffolds as starting points for the development of high-quality CAMKK2 chem. probes, we utilized a hinge-binding scaffold hopping strategy to design new CAMKK2 inhibitors. Starting from the potent but promiscuous disubstituted 7-azaindole GSK650934, a total of 32 compounds, composed of single-ring, 5,6-, and 6,6-fused heteroaromatic cores, were synthesized. The compound set was specifically designed to probe interactions with the kinase hinge-binding residues. Compared to GSK650394 and STO-609, 13 compounds displayed similar or better CAMKK2 inhibitory potency in vitro, while compounds 13g and 45 had improved selectivity for CAMKK2 across the kinome. Our systematic survey of hinge-binding chemotypes identified several potent and selective inhibitors of CAMKK2 to serve as starting points for medicinal chem. programs.

Journal of Medicinal Chemistry published new progress about Crystal structure. 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, HPLC of Formula: 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Portnova, Svetlana V.; Yamshchikova, Yulia F.; Krasnykh, Eugene L.; Nikitin, Eugene D.; Popov, Alexander P.; Faizullin, Mars Z. published the artcile< Vapor Pressure, Vaporization Enthalpies, Critical Parameters, and Heat Capacities of Alkyl Glycolates>, HPLC of Formula: 623-50-7 , the main research area is vapor pressure vaporization enthalpy heat capacity alkyl glycolate.

Developing biotechnol. methods to produce glycolic acid and alkyl glycolates requires knowledge of thermophys. and thermodn. data. Vapor pressures of linear alkyl glycolates HO-CH2-COO-(CH2)n-H with n = 1-8 were determined by the transpiration method. Standard molar enthalpies of vaporization at exptl. temperature and at 298.15 K were derived from the temperature dependence of the vapor pressure. The critical temperatures and pressures of alkyl glycolates were measured by the pulse-heating method. The exptl. data were successfully checked for internal consistency. Molar heat capacity of atm. pressure for liquid esters was measured by the method of differential scanning calorimetry in the temperature range 303-423 K. The molar liquid heat capacities at 298.15 K and atm. pressure of alkyl glycolates were calculated from the result of this work. The measured values were used for estimating prediction capabilities of group-contribution methods by Constantinou and Gani, Marrero and Gani, and Hukkerikar et al. for critical properties and Chickos and Acree, Domalski and Hearing, and Ceriani et al. for heat capacity at 298.15 K. Results of this study could be used for the design and optimization of the chem. processes of the utilization of renewable feedstock.

Journal of Chemical & Engineering Data published new progress about Critical pressure. 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, HPLC of Formula: 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tanaka, Hiroaki; Negoro, Kenji; Koike, Takanori; Tsukamoto, Issei; Yokoyama, Kazuhiro; Maeda, Jun; Inagaki, Yusuke; Shimoshige, Yukinori; Ino, Katsutoshi; Ishizu, Kenichiro; Takahashi, Taisuke published the artcile< Discovery and structure-activity relationships study of positive allosteric modulators of the M3 muscarinic acetylcholine receptor>, Reference of 623-50-7 , the main research area is muscle contraction mAChR PAMs SAR HTS pharmacokinetics allosteric enhancers; Allosteric enhancers; M(3) muscarinic acetylcholine receptor; Positive allosteric modulators.

The M3 muscarinic acetylcholine receptor (mAChR) is a member of the family of mAChRs, which are associated with a variety of physiol. functions including the contraction of various smooth muscle tissues, stimulation of glandular secretion, and regulation of a range of cholinergic processes in the central nerve system. We report here the discovery and a comprehensive structure-activity relationships (SARs) study of novel pos. allosteric modulators (PAMs) of the M3 mAChR through a high throughput screening (HTS) campaign. Compound 9(I) exhibited potent in vitro PAM activity towards the M3 mAChR and significant enhancement of muscle contraction in a concentration-dependent manner when applied to isolated smooth muscle strips of rat bladder. Compound 9 also showed excellent subtype selectivity over other subtypes of mAChRs including M1, M2, and M4 mAChRs, and moderate selectivity over the M5 mAChR, indicating that compound 9 is an M3-preferring M3/M5 dual PAM. Moreover, compound 9 displayed acceptable pharmacokinetics profiles after oral dosing to rats. These results suggest that compound 9 may be a promising chem. probe for the M3 mAChR for further investigation of its pharmacol. function both in vitro and in vivo.

Bioorganic & Medicinal Chemistry published new progress about High-throughput screening. 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Reference of 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yao, Yao; Chen, Kai; Yang, Xingyuan; Li, Jingming; Li, Xuewen published the artcile< Comparative study of the key aromatic compounds of Cabernet Sauvignon wine from the Xinjiang region of China>, Application In Synthesis of 623-50-7 , the main research area is Cabernet Sauvignon wine aromatic compound China; Cabernet Sauvignon wine; GC–MS; Heatmap cluster; Random forest; Sensory analysis; Volatile compounds.

Abstract: To determine the differences in the characteristic volatile compounds between winemaking areas in the Xinjiang region, this study was conducted by sampling Cabernet Sauvignon grapes from four winemaking areas in Xinjiang, named Tianshanbeilu, Yili, Yanqi, and Hami. After undergoing the same alc. fermentation treatment, the wines from the four areas were subjected to GC-MS and sensory anal. The results showed that fifty aromatic compounds (including higher alcs., esters, acids, terpenes, aldehydes/ketones, et al.) were identified and quantified. Interestingly, the terpene and phenylalanine derivative contents of the wines from northern Xinjiang were higher than those from the south. Addnl., four vineyards highly contributed to the development of key volatile compounds in the Xinjiang region. Sensory anal. showed that the wines from northern Xinjiang were impressive with a flowery and fruity aroma and the wines from southern Xinjiang had a stronger wine body and astringency.

Journal of Food Science and Technology (New Delhi, India) published new progress about Acidity (volatile). 623-50-7 belongs to class esters-buliding-blocks, and the molecular formula is C4H8O3, Application In Synthesis of 623-50-7 .

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics