Category: 623-50-7

Kim, Seong Ju published the artcileEffect of thermochemically fractionation before hydrothermal liquefaction of herbaceous biomass on biocrude characteristics, HPLC of Formula: 623-50-7, the main research area is Miscanthus kenaf phenol hydrothermal liquefaction high performance liquid chromatog.

Hydrothermal liquefaction (HTL) of fractionated two types herbaceous biomass (kenaf and miscanthus) by dilute acid, organosolv, alk., or demineralization process was carried out under ethanol water co-solvent at 350°C for 30 min to examine the biocrude yield and characteristics. The biocrude properties were comprehensively characterized by HPLC, elemental, GC-MS, and TGA anal. Fractionation technologies before HTL effectively increased biocrude yield up to 38% compared to that of untreated herbaceous biomass (31%), except for organosolv fractionation of miscanthus, especially, HTL after alk. fractionation showed high yield and energy recovery ratio up to 70%. Elemental anal. showed that HHV of biocrude was neg. affected by hydrolysis reaction of high lignin content after dilute acid fractionation. The GC-MS anal. revealed that carbohydrates-derived compound significantly increased in the biocrude obtained after organosolv and alk. fractionation due to holocellulose increases through fractionation process. Addnl., TGA results indicated that the ratio of high-boiling-point compounds in biocrude obtained after demineralization was expanded compared with untreated due to ash removal, which could act as a catalyst.

Renewable Energy published new progress about Biodiesel fuel. 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, HPLC of Formula: 623-50-7.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yasuno, Takumi published the artcileFullerene derivatives as dual inhibitors of HIV-1 reverse transcriptase and protease, COA of Formula: C4H8O3, the main research area is pyridinium fullerene preparation dual inhibitor HIV reverse transcriptase protease; piperidinium fullerene preparation dual inhibitor HIV reverse transcriptase protease; proline fullerene preparation dual inhibitor HIV reverse transcriptase protease; Fullerene; HIV protease; HIV reverse transcriptase.

In the present study, we newly synthesized three types of novel fullerene derivatives: pyridinium-type derivatives, piperidinium-type derivatives, and proline-type derivatives Among the assessed compounds, some were found to inhibit both HIV reverse transcriptase and HIV protease (HIV-PR), with IC50 values in the low micromolar range being observed Regarding HIV-PR inhibition activity, proline-type derivatives, bearing an alkyl chain between the hydroxylmethylcarbonyl (HMC) moiety and pyrrolidine ring, were more potent than other derivatives This result might indicate that connecting HMC moieties with proline-type fullerene derivatives through properly sized alkyl chain leads to improved HIV-PR inhibitory activity.

Bioorganic & Medicinal Chemistry Letters published new progress about AIDS (disease). 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, COA of Formula: C4H8O3.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Arslaner, Ayla published the artcileProbiotic ice cream with Malus floribunda fruit sauce: Quality properties, mineral, and volatile composition, Recommanded Product: Ethyl 2-hydroxyacetate, the main research area is Malus probiotic ice cream.

This study investigated the effect of Malus floribunda fruit sauce (MFS) on the quality properties, minerals, volatiles, and viability of Lactobacillus acidophilus La-5 in probiotic ice creams. The MFS increased the dry matter, acidity, total sugar, invert sugar, and calories while decreasing fat, protein, ash, sucrose contents, viscosity, overrun, first dripping, complete melting time, and the pH of samples. The heavy metal contents were within safe limits. The MFS increased the perception of a fruity taste/aroma due to the increase in the terpenes and terpenoids, which reflected pos. on the sensory scores. The highest taste and odor score (4.72) was seen in the MFIC sample. L. acidophilus La-5 counts (7.49 log cfu/g) and the survival rate (100.69%) of MFIC were significantly higher at the end of storage. Consequently, MFS may be used as a source of flavoring agents in ice cream and MFIC is a satisfactory vehicle for L. acidophilus La-5. Novelty impact statement : There is no study in the scientific literature on the use of Malus floribunda fruit sauce (MFS) as a potential functional ingredient in probiotic ice cream production MFS supplementation caused a significant change of volatile compounds in ice cream samples, which reflected pos. on the sensory scores. MFS enhanced survival rates of Lactobacillus acidophilus La-5 in ice creams during the 60 days of storage.

Journal of Food Processing and Preservation published new progress about Escherichia coli. 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, Recommanded Product: Ethyl 2-hydroxyacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mowery, Patricia published the artcileDiscovery of an indole-substituted furanone with tubulin polymerization inhibition activity, Application of Ethyl 2-hydroxyacetate, the main research area is indole furanone drug discovery synthesis anticancer tubulin polymerization inhibition; Anticancer; Furanone; Indole; Tubulin.

Analogs of diarylpyrrolinone lead compound I were prepared and tested for anti-proliferative activity in U-937 cancer cells. Alterations of I focused on modifying the two nitrogen atoms: the pyrrolinone nitrogen atom was substituted with a Pr group or replaced with an oxygen atom (furanone); and the substituents on the indole nitrogen were varied. These changes led to the discovery of a furanone analog II with sub-micromolar anti-cancer potency and tubulin polymerization inhibition activity.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents. 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, Application of Ethyl 2-hydroxyacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kim, Ho Shin published the artcileImprovement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M, HPLC of Formula: 623-50-7, the main research area is carcinoma DCN1 UBE2M interaction inhibitors NEDD8 pharmacokinetic oral bioavailability.

The cullin-RING ubiquitin ligases (CRLs) are ubiquitin E3 enzymes that play a key role in controlling proteasomal degradation and are activated by neddylation. We previously reported inhibitors that target CRL activation by disrupting the interaction of defective in cullin neddylation 1 (DCN1), a CRL neddylation co-E3, and UBE2M, a neddylation E2. Our first-generation inhibitors possessed poor oral bioavailability and fairly rapid clearance that hindered the study of acute inhibition of DCN-controlled CRL activity in vivo. Herein, we report studies to improve the pharmacokinetic performance of the pyrazolo-pyridone inhibitors. The current best inhibitor, 40 (I), inhibits the interaction of DCN1 and UBE2M, blocks NEDD8 transfer in biochem. assays, thermally stabilizes cellular DCN1, and inhibits anchorage-independent growth in a DCN1 amplified squamous cell carcinoma cell line. Addnl., we demonstrate that a single oral 50 mg/kg dose sustains plasma exposures above the biochem. IC90 for 24 h in mice.

Journal of Medicinal Chemistry published new progress about Antitumor agents. 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, HPLC of Formula: 623-50-7.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Portnova, Svetlana V. published the artcileVapor Pressure, Vaporization Enthalpies, Critical Parameters, and Heat Capacities of Alkyl Glycolates, HPLC of Formula: 623-50-7, the main research area is vapor pressure vaporization enthalpy heat capacity alkyl glycolate.

Developing biotechnol. methods to produce glycolic acid and alkyl glycolates requires knowledge of thermophys. and thermodn. data. Vapor pressures of linear alkyl glycolates HO-CH2-COO-(CH2)n-H with n = 1-8 were determined by the transpiration method. Standard molar enthalpies of vaporization at exptl. temperature and at 298.15 K were derived from the temperature dependence of the vapor pressure. The critical temperatures and pressures of alkyl glycolates were measured by the pulse-heating method. The exptl. data were successfully checked for internal consistency. Molar heat capacity of atm. pressure for liquid esters was measured by the method of differential scanning calorimetry in the temperature range 303-423 K. The molar liquid heat capacities at 298.15 K and atm. pressure of alkyl glycolates were calculated from the result of this work. The measured values were used for estimating prediction capabilities of group-contribution methods by Constantinou and Gani, Marrero and Gani, and Hukkerikar et al. for critical properties and Chickos and Acree, Domalski and Hearing, and Ceriani et al. for heat capacity at 298.15 K. Results of this study could be used for the design and optimization of the chem. processes of the utilization of renewable feedstock.

Journal of Chemical & Engineering Data published new progress about Critical pressure. 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, HPLC of Formula: 623-50-7.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reyes, Laura published the artcileAutocatalyzed and heterogeneously catalyzed esterification kinetics of glycolic acid with ethanol, Synthetic Route of 623-50-7, the main research area is glycolic acid ethanol amberlyst catalyst esterification kinetics.

The chem. equilibrium and reaction kinetics in homogeneously and heterogeneously catalyzed systems were investigated for the reversible esterification reaction of glycolic acid with ethanol. In a first approach, the thermodn. equilibrium of the reaction was established for temperatures between 50°C and 75°C. To differentiate catalytic from homogeneous contribution, the esterification was first studied without a catalyst and the data obtained were then used to model the autocatalyzed homogeneous reaction kinetics. The impact of different com. solid catalysts such as zeolites, oxides and ion exchange resins on the esterification reaction was also investigated. For the latter, the amount of total acid sites was quantified in order to correlate this parameter to the reaction rate and glycolic acid conversion. Finally, the effects of catalyst loading, temperature, presence of water and recyclability were examined for the most efficient catalyst, Amberlyst 70. Moreover, a kinetic adjustment of the exptl. results was carried out by fitting the data to a pseudo-homogeneous model and comparing to adsorption-based models.

Reaction Chemistry & Engineering published new progress about Activation energy. 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, Synthetic Route of 623-50-7.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hernandez-Ruiz, Raquel published the artcileMo-Catalyzed One-Pot Synthesis of N-Polyheterocycles from Nitroarenes and Glycols with Recycling of the Waste Reduction Byproduct. Substituent-Tuned Photophysical Properties, Related Products of esters-buliding-blocks, the main research area is polyheterocycle preparation green chem; nitroarene glycol tandem reduction imine formation intramol cyclization oxidation; dioxomolybdenum complex catalyst waste reuse; N-heterocycles; dioxomolybdenum; nitroaromatics; photophysical properties; reuse of waste.

A catalytic domino reduction-imine formation-intramol. cyclization-oxidation for the general synthesis of a wide variety of biol. relevant N-polyheterocycles, such as quinoxaline- and quinoline-fused derivatives, and phenanthridines, is reported. A simple, easily available, and environmentally friendly dioxomolybdenum(VI) complex has proven to be a highly efficient and versatile catalyst for transforming a broad range of starting nitroarenes involving several redox processes. Not only is this a sustainable, step-economical as well as air- and moisture-tolerant method, but also it is worth highlighting that the waste byproduct generated in the first step of the sequence is recycled and incorporated in the final target mol., improving the overall synthetic efficiency. Moreover, selected indoloquinoxalines have been photophys. characterized in cyclohexane and toluene with exceptional fluorescence quantum yields above 0.7 for the alkyl derivatives

Chemistry – A European Journal published new progress about Absorption spectra. 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, Related Products of esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yu, Haiyan published the artcileCharacterization of the volatile profile of Chinese rice wine by comprehensive two-dimensional gas chromatography coupled to quadrupole mass spectrometry, Safety of Ethyl 2-hydroxyacetate, the main research area is Chinese rice wine volatile profile 2D GC MS; Chinese rice wine; comprehensive two-dimensional gas chromatography coupled to quadrupole mass spectrometry; surrogate odor activity value; volatile compounds.

BACKGROUND : Chinese rice wine (CRW) is a kind of traditional fermentation wine in China. Aged CRW is more popular among consumers owing to its harmonious and pleasant flavor. The volatile profile of CRW has been extensively studied using gas chromatog./mass spectrometry (GC/MS). However, flavor components in CRW are far richer than those detected by GC/MS. To obtain more information about the volatile profile of fresh (5-yr) and aged (10-yr) CRW, a method based on comprehensive two-dimensional gas chromatog. coupled to quadrupole mass spectrometry (GC×GC/qMS) was developed. The major volatile compounds contributing to the characteristic aroma of fresh and aged CRW were identified by surrogate odor activity value (OAV). RESULTS : Ninety-eight volatile compounds were detected in the 5-yr CRW samples and 107 in the 10-yr samples by GC×GC/qMS. The numbers of compounds detected by GC×GC/qMS for the 5-yr and 10-yr samples were 71.4 and 65.4% higher than those detected by GC/MS. The aged wine had a more complex volatile profile than the fresh wine, with an increase in esters and aldehydes and a decrease in alcs. and organic acids. There were 22 volatile compounds with surrogate OAV > 1. Nine were the potent key aroma compounds in CRW: Et isovalerate (OAV 500-33 500), Et butyrate (OAV 84-334), Et isobutyrate (OAV 49-170), 2-nonenal (OAV 20-100), Et heptanoate (OAV 1-74), Et hexanoate (OAV 60-77), phenylethyl alc. (OAV 2-18), benzaldehyde (OAV 28-30) and hexanal (OAV 4-11). CONCLUSION : GC×GC/qMS showed better separation than GC/MS. The presented GC×GC/qMS method was suitable for characterization of the volatile profile of CRW. © 2019 Society of Chem. Industry.

Journal of the Science of Food and Agriculture published new progress about Alcohols Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, Safety of Ethyl 2-hydroxyacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Gasnot, Julien published the artcileTaming the Reactivity of Phosphiranium Salts: Site-Selective C-Centered Ring Opening for Direct Synthesis of Phosphinoethylamines, Safety of Ethyl 2-hydroxyacetate, the main research area is phosphiranium salt preparation nucleophilic ring opening aniline nitrogen nucleophile; phosphinoethylamine preparation; nucleophilic ring opening; phosphinoethyl amines; phosphiranium ions; selectivity; steric protection.

Advances in the field of P chem. are documented, by revealing the synthetic utility of previously underused quaternary phosphiranium salts (QPrS) as three-chain-atom electrophilic building blocks. Notably, control of their challenging C-centered electrophilicity is disclosed with an expedient synthesis of tertiary β-anilino phosphines as a proof-of-concept.

Angewandte Chemie, International Edition published new progress about Amines Role: SPN (Synthetic Preparation), PREP (Preparation) (phosphinoethylamines). 623-50-7 belongs to class esters-buliding-blocks, name is Ethyl 2-hydroxyacetate, and the molecular formula is C4H8O3, Safety of Ethyl 2-hydroxyacetate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics