623-47-2 Archives - Page 9 of 12 - Esters-buliding-blocks

Amosova, Svetlana V.’s team published research in Beilstein Journal of Organic Chemistry in 2020 | CAS: 623-47-2

Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Category: esters-buliding-blocks

《Regio- and stereoselective synthesis of new ensembles of diversely functionalized 1,3-thiaselenol-2-ylmethyl selenides by a double rearrangement reaction》 was written by Amosova, Svetlana V.; Filippov, Andrey A.; Makhaeva, Nataliya A.; Albanov, Alexander I.; Potapov, Vladimir A.. Category: esters-buliding-blocks And the article was included in Beilstein Journal of Organic Chemistry in 2020. The article conveys some information:

The reaction of 2-(bromomethyl)-1,3-thiaselenole with potassium selenocyanate proceeded via a rearrangement with ring expansion, leading to a six-membered 2,3-dihydro-1,4-thiaselenin-2-yl selenocyanate (kinetic product) which in turn underwent rearrangement with ring contraction to a 1,3-thiaselenol-2-ylmethyl selenocyanate (thermodn. product). These rearrangements occurred by a nucleophilic attack of the selenocyanate anion at two different carbon atoms of the seleniranium intermediate. The efficient regioselective synthesis of alkyl, allyl, 2-propynyl, benzyl, 4-fluorobenzyl, and 2-pyridinylmethyl 1,3-thiaselenol-2-ylmethyl selenides was developed based on the generation of sodium 1,3-thiaselenol-2-ylmethylselenolate from 1,3-thiaselenol-2-ylmethyl selenocyanate or bis(1,3-thiaselenol-2-ylmethyl) diselenide followed by nucleophilic substitution reactions. Sodium 1,3-thiaselenol-2-ylmethylselenolate underwent nucleophilic addition to alkyl propiolates in a regio- and stereoselective manner affording 1,3-thiaselenol-2-ylmethyl vinyl selenides in high yields predominantly with Z-configuration. Not a single representative of the 1,3-thiaselenol-2-ylmethyl selenide scaffold has been previously described in the literature. The experimental process involved the reaction of Ethyl propiolate(cas: 623-47-2Category: esters-buliding-blocks)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hussein, Mohanad A.’s team published research in Angewandte Chemie, International Edition in 2020 | CAS: 623-47-2

《Halide Anion Triggered Reactions of Michael Acceptors with Tropylium Ion》 was written by Hussein, Mohanad A.; Tran, Uyen P. N.; Huynh, Vien T.; Ho, Junming; Bhadbhade, Mohan; Mayr, Herbert; Nguyen, Thanh V.. Synthetic Route of C5H6O2 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Tropylium bromide undergoes noncatalyzed, regioselective additions to a large variety of Michael acceptors. In this way, acrylic esters are converted into β-bromo-α-cycloheptatrienylpropionic esters. The reactions are interpreted as nucleophilic attack of bromide ions at the electron-deficient olefins and the approach of the tropylium ion to the incipient carbanion. Quantum chem. calculations were performed to elucidate the analogy to the amine- or phosphine-catalyzed Rauhut-Currier reactions. Subsequent synthetic transformations of the bromo-cycloheptatrienylated adducts are reported.Ethyl propiolate(cas: 623-47-2Synthetic Route of C5H6O2) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hussein, Mohanad A.’s team published research in Angewandte Chemie, International Edition in 2020 | CAS: 623-47-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Marsicano, Vincenzo’s team published research in Bioorganic & Medicinal Chemistry Letters in 2021 | CAS: 623-47-2

Application In Synthesis of Ethyl propiolateIn 2021 ,《Design, synthesis and biological evaluation of new thiazole scaffolds as potential TRPM8 antagonists》 was published in Bioorganic & Medicinal Chemistry Letters. The article was written by Marsicano, Vincenzo; Arcadi, Antonio; Bianchini, Gianluca; Tomassetti, Mara; Aramini, Andrea. The article contains the following contents:

The preliminary results on the development of a viable methodol. for the further functionalization of 4-hydroxythiazole derivatives to afford target TRPM8 antagonists are reported. The combined Sonogashira coupling/annulation reactions of the Et 2-(3-fluorophenyl)-4-tifluoromethylsulfonyloxy-1,3-thiazole-5-carboxylate have been applied to the synthesis of analogs of the selective blocker of TRPM8 DFL23448. Among all the synthetised derivatives, the most promising compound resulted to be active as TRPM8 blocker (IC50 = 4.06 μM), showing an excellent metabolic stability and no cytotoxic effects. Finally, in silico characterization of the derivatives showed no violation of the drug-likeness rules. In the part of experimental materials, we found many familiar compounds, such as Ethyl propiolate(cas: 623-47-2Application In Synthesis of Ethyl propiolate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Xiaohu’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2021 | CAS: 623-47-2

Li, Xiaohu; Huang, You published their research in Chemical Communications (Cambridge, United Kingdom) in 2021. The article was titled 《Phosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: access to the synthesis of chromeno[4,3-b]pyrroles》.Recommanded Product: Ethyl propiolate The article contains the following contents:

A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates I (R1 = Me, Et, i-Pr, PhCH2) with aldimine esters II (R2 = 4-Me, 5-Et2N, 6-F, 3,4-benzo, etc.; R3 = Me, Et, i-Pr) has been developed to provide a series of chromeno[4,3-b]pyrroles III that contain three contiguous stereogenic centers. The method gives good yields, excellent chemoselectivity and diastereoselectivity under mild conditions. The experimental process involved the reaction of Ethyl propiolate(cas: 623-47-2Recommanded Product: Ethyl propiolate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fu, Leiqing’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2022 | CAS: 623-47-2

HPLC of Formula: 623-47-2In 2022 ,《Copper-catalyzed C-H/N-H annulation of enaminones and alkynyl esters for densely substituted pyrrole synthesis》 appeared in Chemical Communications (Cambridge, United Kingdom). The author of the article were Fu, Leiqing; Wan, Jie-Ping; Zhou, Liyun; Liu, Yunyun. The article conveys some information:

Herein, the copper-catalyzed annulation of enaminones R1C(O)CH=C(NH2)R2 (R1 = Me, Ph, naphthalen-2-yl, thiophen-2-yl, etc.; R2 = Me, Ph, n-Pr) with alkynyl esters HCCC(O)OR3 and R3C(O)OCCC(O)OR3 (R3 = Et, Me, t-Bu) for the facile synthesis of different pyrroles with 2,3,4,5-tetrasubstituted structures I and II has been developed. With Cu(OAc)2 as the only catalyst, the tunable synthesis of 2-vinyl I and 2,3-dicarboxyl-functionalized pyrroles II has been achieved by using terminal and internal alkynyl esters, resp. The synthesis of 2-vinyl pyrroles I represents the first example accessing 2-vinyl substituted pyrroles I via direct cascade reactions involving vinylation and pyrroles II ring formation. In addition to this study using Ethyl propiolate, there are many other studies that have used Ethyl propiolate(cas: 623-47-2HPLC of Formula: 623-47-2) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Al-Matarneh, Cristina M.’s team published research in Journal of the Serbian Chemical Society in 2021 | CAS: 623-47-2

Product Details of 623-47-2In 2021 ,《Synthesis and properties of new fused pyrrolo-1,10-phenanthroline type derivatives》 appeared in Journal of the Serbian Chemical Society. The author of the article were Al-Matarneh, Cristina M.; Rosca, Irina; Shova, Sergiu; Danac, Ramona. The article conveys some information:

New fused pyrrolo-phenanthroline type derivatives were synthesized, in two steps, from 1,10-phenanthroline and evaluated for antimicrobial activity and fluorescence properties. Synthetic approach involved a 3 + 2 dipolar-cycloaddition of some selected N-substituted 1,10-phenanthrolin-1-ium ylides, (m)ethoxycarbonyl and cyano (1,2-di)substituted acetylenes and alkenes, resp. The structures of compounds were supported by anal. and spectroscopic data. The mol. structures of four selected compounds was determined by monocrystal XRD analyses. All synthesized compounds were then evaluated for their potential antimicrobial activity against Staphylococcus aureus ATCC25923, Escherichia coli ATCC25922 and Candida albicans ATCC10231. Two of the compounds demonstrated significant activity against the above tested strains. In the experimental materials used by the author, we found Ethyl propiolate(cas: 623-47-2Product Details of 623-47-2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fritzemeier, Russell G.’s team published research in Angewandte Chemie, International Edition in 2020 | CAS: 623-47-2

《Organocatalytic trans Phosphinoboration of Internal Alkynes》 was written by Fritzemeier, Russell G.; Nekvinda, Jan; Vogels, Christopher M.; Rosenblum, Carol Ann; Slebodnick, Carla; Westcott, Stephen A.; Santos, Webster L.. Recommanded Product: 623-47-2 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

We report the first trans phosphinoboration of internal alkynes. With an organophosphine catalyst, alkynoate esters and the phosphinoboronate Ph2P-Bpin are efficiently converted into the corresponding trans-α-phosphino-β-boryl acrylate products in moderate to good yield with high regio- and Z-selectivity. This reaction operates under mild conditions and demonstrates good atom economy, requiring only a modest excess of the phosphinoboronate. X-ray crystallog. experiments allowed structural assignment of the unprecedented and densely functionalized (Z)-α-phosphino-β-boryl acrylate products. After reading the article, we found that the author used Ethyl propiolate(cas: 623-47-2Recommanded Product: 623-47-2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Devarahosahalli Veeranna, Kirana’s team published research in Organic & Biomolecular Chemistry in 2021 | CAS: 623-47-2

Devarahosahalli Veeranna, Kirana; Kanti Das, Kanak; Baskaran, Sundarababu published their research in Organic & Biomolecular Chemistry in 2021. The article was titled 《Reversal of polarity by catalytic SET oxidation: synthesis of azabicyclo[m.n.0]alkanes via chemoselective reduction of amidines》.HPLC of Formula: 623-47-2 The article contains the following contents:

A one-pot catalytic method has been developed for the stereoselective synthesis of cyclopropane-fused cyclic amidines using CuBr2/K2S2O8 as an efficient single electron transfer (SET) oxidative system. The generality of this mild method is demonstrated with a wide variety of substrates to furnish pharmaceutically important amidines containing aza-bicyclic and novel aza-tricyclic frameworks in very good yields. A chemoselective reduction of cyclic amidines to 2-/3-azabicyclo[m.n.0]alkanes and octahydroindoles has been developed using a NaBH4/I2 reagent system. The synthetic scope of the chemoselective reduction of the amidine functionality has been exemplified in the stereoselective synthesis of an iminosugar based (±)-epiquinamide analog. In the experiment, the researchers used Ethyl propiolate(cas: 623-47-2HPLC of Formula: 623-47-2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chiu, Po-Hao’s team published research in Journal of the Taiwan Institute of Chemical Engineers in 2021 | CAS: 623-47-2

Chiu, Po-Hao; Yang, Yan-Lin; Tsao, Heng-Kwong; Sheng, Yu-Jane published an article in 2021. The article was titled 《Deep learning for predictions of hydrolysis rates and conditional molecular design of esters》, and you may find the article in Journal of the Taiwan Institute of Chemical Engineers.COA of Formula: C5H6O2 The information in the text is summarized as follows:

The hydrolysis rate of an ester is essential for the choice of materials in sustainable and eco-friendly applications. In this work, the autoencoder (AE) model has been constructed to predict the hydrolysis rate by inputting SMILES and partial charges. Moreover, the conditional autoencoder (CAE) model has been developed to design chem. structures of esters that possess hydrolysis rates close to the desired value. By implementing the SMILES enumeration technique and the attention mechanism, our AE model exhibits significantly better performance than SPARC based on the root mean square error. For six biodegradable esters that have no exptl. rate constants, the predictions of our AE model are in agreement with those based on the activation energies calculated from Dmol3. To design an ester satisfying the desired conditions, our CAE model demonstrates its capability of providing the best candidates of esters and their rate constants based on structural similarity and the least difference of hydrolysis rates. The derived structures are similar to the desired structure and their rate constants are close to the targeted value. The results came from multiple reactions, including the reaction of Ethyl propiolate(cas: 623-47-2COA of Formula: C5H6O2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics