623-47-2 Archives - Page 8 of 12 - Esters-buliding-blocks

Sabat, Nazarii’s team published research in European Journal of Medicinal Chemistry in 2020 | CAS: 623-47-2

Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Reference of Ethyl propiolate

《Synthesis and antitumor activities investigation of a C-nucleoside analogue of ribavirin》 was published in European Journal of Medicinal Chemistry in 2020. These research results belong to Sabat, Nazarii; Migianu-Griffoni, Evelyne; Tudela, Tiffany; Lecouvey, Marc; Kellouche, Sabrina; Carreiras, Franck; Gallier, Florian; Uziel, Jacques; Lubin-Germain, Nadege. Reference of Ethyl propiolate The article mentions the following:

SRO-91 is a non-natural ribofuranosyl-1,2,3-triazole C-nucleoside I obtained by a synthetic sequence involving a C-alkynyl glycosylation mediated by metallic indium and a Huisgen cycloaddition for the construction of the triazole. Its structure is close to the one of ribavirin, a drug presenting a broad-spectrum against viral infections. SRO-91 antitumor activities were investigated on 9 strains of tumor cells and IC50 of the order of 1μM were obtained on A431 epidermoid carcinoma cells and B16F10 skin melanoma cells. In addition, studies of ovarian tumor cell inhibitions show an interesting activity in regard to the need for new drugs for this pathol. Finally, cytotoxicity and mouse toxicity studies reveal a favorable therapeutic index for SRO-91. In the experimental materials used by the author, we found Ethyl propiolate(cas: 623-47-2Reference of Ethyl propiolate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Elkanzi, Nadia A. A.’s team published research in Journal of Heterocyclic Chemistry in 2019 | CAS: 623-47-2

Product Details of 623-47-2In 2019 ,《Design, Synthesis, Molecular Modeling Study, and Antimicrobial Activity of Some Novel Pyrano[2,3-b]pyridine and Pyrrolo[2,3-b]pyrano[2.3-d]pyridine Derivatives》 appeared in Journal of Heterocyclic Chemistry. The author of the article were Elkanzi, Nadia A. A.; Bakr, Rania B.; Ghoneim, Amira A.. The article conveys some information:

Novel derivatives of pyrano[2,3-b]pyridine and pyrrolo[2,3-b]pyrano[2.3-d]pyridine were prepared, and their structures were elucidated by spectral and elemental analyses. The newly prepared candidates were evaluated for their antimicrobial activity against Candida sp., Aspergillus multi, Aspergillus niger, Escherichia coli, and Staphylococcus aureus. All the tested compounds revealed potent to moderate activity toward all tested microorganisms; especially, candidate I showed comparable antifungal activity as that showed by the standard drug ketoconazole toward Candida sp., and Et 4-methyl-1,7,8,9-tetrahydropyrano[2,3-b]pyrrolo[2,3-d]pyridine-3-carboxylate II was the most active compound against all the tested bacteria. Furthermore, the newly synthesized compounds are subjected to mol. docking study for the inhibition of the enzyme L-glutamine: D-fructose-6-phosphate amidotransferase [GlcN-6-P], which is a new target for antimicrobials to explain action mode of these target compounds as leads for discovering other antimicrobial agents. After reading the article, we found that the author used Ethyl propiolate(cas: 623-47-2Product Details of 623-47-2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Song, Yaoyao’s team published research in Journal of Agricultural and Food Chemistry in 2021 | CAS: 623-47-2

Song, Yaoyao; Wang, Lei; Liu, Fengjuan; Jiao, Chengjin; Nan, Hao; Shen, Xiao; Chen, Hong; Li, Yifan; Lei, Beilei; Jiang, Jinglong; Chen, Peng; Xu, Quanle published their research in Journal of Agricultural and Food Chemistry in 2021. The article was titled 《β-Cyanoalanine Synthase Regulates the Accumulation of β-ODAP via Interaction with Serine Acetyltransferase in Lathyrus sativus》.Synthetic Route of C5H6O2 The article contains the following contents:

β-N-Oxalyl-L-α,β-diaminopropionic acid (β-ODAP), found in Lathyrus sativus at first, causes a neurol. disease, lathyrism, when over ingested in an unbalanced diet. Our previous research suggested that β-ODAP biosynthesis is related to sulfur metabolism In this study, β-cyanoalanine synthase (β-CAS) was confirmed to be responsible for β-ODAP biosynthesis via in vitro enzymic anal. LsCAS was found to be pyridoxal phosphate (PLP)-dependent via spectroscopic anal. and dual functional via enzymic activity anal. Generation of a M135T/M235S/S239T triple mutant of LsCAS, which are the key sites to control the ratio of CAS/cysteine synthase (CS) activity, switches reaction chem. to that of a CS. LsCAS interactions were further screened and verified via Y2H, BiFC and pull-down assay. It was suggested that LsSAT2 interacts and forms a cysteine regulatory complex (CRC) with LsCAS in mitochondria, which improves LsSAT while reduces LsCAS activities to affect β-ODAP content pos. These results provide new insights into the mol. regulation of β-ODAP content in L. sativus. In the experiment, the researchers used many compounds, for example, Ethyl propiolate(cas: 623-47-2Synthetic Route of C5H6O2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Beltran, Frederic’s team published research in European Journal of Organic Chemistry in 2019 | CAS: 623-47-2

《Surfactant Micelles Enable Metal-Free Spirocyclization of Keto-Ynamides and Access to Aza-Spiro Scaffolds in Aqueous Media》 was written by Beltran, Frederic; Vela-Gonzalez, Andrea V.; Knaub, Tatiana; Schmutz, Marc; Krafft, Marie Pierre; Miesch, Laurence. SDS of cas: 623-47-2This research focused onynamide keto sufactant micelle base spirocyclization; aza spirocycle preparation. The article conveys some information:

Micellar solutions of cetyltrimethylammonium bromide (CTAB) surfactant allow the spirocyclization of keto-ynamides in an aqueous medium without recourse to transition-metal catalysis, enabling access in water to naturally occurring aza-spiro compounds with potential in drug discovery. The reaction was monitored by dynamic light scattering (DLS) and cryogenic transmission electron microscopy (cryo-TEM), which determined the morphol. and change in size of the micelles before and after incorporation of the substrate and achievement of 5-endo-dig cyclization inside the micelles.Ethyl propiolate(cas: 623-47-2SDS of cas: 623-47-2) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Osafune, Yukio’s team published research in Journal of Bioscience and Bioengineering in 2022 | CAS: 623-47-2

In 2022,Osafune, Yukio; Toshida, Kenji; Han, Jinshun; Kishimoto, Toru; Iizuka-Furukawa, Sachiko; Isogai, Atsuko; Mukai, Nobuhiko published an article in Journal of Bioscience and Bioengineering. The title of the article was 《Identification of 2-furanmethanethiol contributing to roast aroma in honkaku shochu and awamori》.Reference of Ethyl propiolate The author mentioned the following in the article:

Honkaku shochu and awamori are traditional Japanese spirits. 2-Furanmethanethiol (2FM), a volatile thiol, was identified as a roast aroma compound in honkaku shochu and awamori. The detection threshold of 2FM in 25% (volume/volume) ethanol water solutions was determined as 1.6 ng/L. The odor activity values, calculated using the detection threshold suggested that 2FM affects the quality of honkaku shochu and awamori. The odor activity values of 2FM were higher in barley shochu distilled at atm. pressure than in sweet potato shochu, rice shochu and awamori; therefore, 2FM is considered to contribute to the characteristics of barley shochu. The experimental part of the paper was very detailed, including the reaction process of Ethyl propiolate(cas: 623-47-2Reference of Ethyl propiolate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Di Martino, Rita Maria Concetta’s team published research in ACS Chemical Neuroscience in 2020 | CAS: 623-47-2

《Novel Curcumin-Diethyl Fumarate Hybrid as a Dualistic GSK-3β Inhibitor/Nrf2 Inducer for the Treatment of Parkinson’s Disease》 was published in ACS Chemical Neuroscience in 2020. These research results belong to Di Martino, Rita Maria Concetta; Pruccoli, Letizia; Bisi, Alessandra; Gobbi, Silvia; Rampa, Angela; Martinez, Ana; Perez, Concepcion; Martinez-Gonzalez, Loreto; Paglione, Maria; Di Schiavi, Elia; Seghetti, Francesca; Tarozzi, Andrea; Belluti, Federica. Synthetic Route of C5H6O2 The article mentions the following:

Common copathogenic factors, including oxidative stress and neuroinflammation, are found to play a vital role in the development of neurodegenerative disorders, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Nowadays, owing to the multifactorial character of the diseases, no effective therapies are available, thus underlying the need for new strategies. Overexpression of the enzyme GSK-3β and downregulation of the Nrf2/ARE pathway are responsible for a decrease in antioxidant defense effects. These pieces of evidence underline the usefulness of dual GSK-3β inhibitors/Nrf2 inducers. In this regard, to design a dual modulator, the structures of a curcumin-based analog, as GSK-3β inhibitor, and a di-Et fumarate fragment, as Nrf2 inducer, were combined. Among the hybrids, 5 and 6 proved to effectively inhibit GSK-3β, while 4 and 5 showed a marked ability to activate Nrf2 together to increase the neuronal resistance to oxidative stress. These last pieces of evidence translated into specific neuroprotective effects of 4 and 5 against PD pathol. events including neurotoxicity elicited by α-synuclein aggregates and 6-hydroxydopamine. Hybrid 5 also showed neuroprotective effects in a C. elegans model of PD where the activation of GSK-3β is intimately involved in Nrf2 regulation. In summary, 5 emerged as an interesting multitarget derivative, valuable to be exploited in a multitarget PD perspective. After reading the article, we found that the author used Ethyl propiolate(cas: 623-47-2Synthetic Route of C5H6O2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Omanakuttan, Vishnu K.’s team published research in Asian Journal of Organic Chemistry in 2022 | CAS: 623-47-2

《Tandem Reaction of 4-Halo-1,3-Dicarbonyl Compounds with Alkynes towards 4-Vinyl-3(2H)-Furanones and 3(2H)-Furanone fused 2-Pyridones》 was written by Omanakuttan, Vishnu K.; Santhini, P. V.; Shaludheen, S.; Varughese, Sunil; Hopf, Henning; John, Jubi. Safety of Ethyl propiolateThis research focused onvinyl furanone preparation; furanone fused pyridone preparation; halo dicarbonyl compound alkyne tandem Michael addition intramol cyclization. The article conveys some information:

A facile synthetic route of 4-vinyl-3(2H)-furanones I [R1 = OMe, OEt, OtBu, Ph; R2 = H, C(O)Ph, CO2Me, CO2tBu; R3 = H, Me; R4 = H, Me, Br; R5 = OMe, OEt, Ph] via tandem Michael addition and intramol. cyclization from the reaction of 4-halo-1,3-dicarbonyl compounds and alkynes was reported. The formation of a side-product (regioisomer) by a stepwise [2+2] cycloaddition between enolate (of the 4-halo-1,3-dicarbonyl compound) and activated alkyne followed by a sequential 4π-ring opening and an intramol. cyclization was also noted. Another interesting observation was the formation of 3(2H)-furanone fused 2-pyridone II [R6 = Me, Et; R7 = Ph, Bn, 4-MeC6H4, etc.] from the reaction of 4-bromo-3-oxo-N-alkyl(aryl)butanamides and activated alkynes with satisfactory to good yields. After reading the article, we found that the author used Ethyl propiolate(cas: 623-47-2Safety of Ethyl propiolate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kuzuhara, Daiki’s team published research in Journal of Porphyrins and Phthalocyanines in 2019 | CAS: 623-47-2

HPLC of Formula: 623-47-2In 2019 ,《2,7,12,17-Tetra(2,5-thienylene)-substituted porphycenes》 was published in Journal of Porphyrins and Phthalocyanines. The article was written by Kuzuhara, Daiki; Nakaoka, Haruka; Matsuo, Kyohei; Aratani, Naoki; Yamada, Hiroko. The article contains the following contents:

Syntheses of thiophene and dithiophene-substituted porphycenes (ThPc and DThPc) at 2,7,12,17-positions by McMurry coupling are reported. The crystal structure of ThPc revealed that the porphycene plane shows a highly planar structure, and the dihedral angles between the porphycene core and thiophene are relatively small at 21deg and 18deg. ThPc and DThPc exhibit red-shifted and broadened absorption because of the extension of π conjugations through porphycene to the substituted thiophenes. It was found that introduction of thiophene units onto porphycene results in decreasing the HOMO-LUMO differences effectively. The results came from multiple reactions, including the reaction of Ethyl propiolate(cas: 623-47-2HPLC of Formula: 623-47-2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hell, Sandrine M.’s team published research in Angewandte Chemie, International Edition in 2020 | CAS: 623-47-2

《Hydrosulfonylation of Alkenes with Sulfonyl Chlorides under Visible Light Activation》 was published in Angewandte Chemie, International Edition in 2020. These research results belong to Hell, Sandrine M.; Meyer, Claudio F.; Misale, Antonio; Sap, Jeroen B. I.; Christensen, Kirsten E.; Willis, Michael C.; Trabanco, Andres A.; Gouverneur, Veronique. Formula: C5H6O2 The article mentions the following:

Sulfonyl chlorides are inexpensive reactants extensively explored for functionalization, but never considered for radical hydrosulfonylation of alkenes. Herein, the authors report that tris(trimethylsilyl)silane is an ideal hydrogen atom donor enabling highly effective photoredox-catalyzed hydrosulfonylation of electron-deficient alkenes with sulfonyl chlorides. To increase the generality of this transformation, polarity-reversal catalysis (PRC) was successfully implemented for alkenes bearing alkyl substituents. This late-stage functionalization method tolerates a remarkably wide range of functional groups, is operationally simple, scalable, and allows access to building blocks which are important for medicinal chem. and drug discovery. In addition to this study using Ethyl propiolate, there are many other studies that have used Ethyl propiolate(cas: 623-47-2Formula: C5H6O2) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Nitisha’s team published research in Chemical Communications (Cambridge, United Kingdom) in 2022 | CAS: 623-47-2

In 2022,Nitisha; Chetti, Prabhakar; Parthasarathy, Venkatakrishnan published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Coronene-embedded ‘super’ coumarins》.Electric Literature of C5H6O2 The author mentioned the following in the article:

A non-planar π-enlarged coronene-embedded coumarin achieved via pyranone annulation and its cyanated derivative possess bright orange to red emission in both solution and solid states, with scope for bioimaging applications. The multiple redox states, frontier MO energy levels and strong cofacial π-stacking ability point towards applications in organic optoelectronics. In addition to this study using Ethyl propiolate, there are many other studies that have used Ethyl propiolate(cas: 623-47-2Electric Literature of C5H6O2) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics