623-47-2 Archives - Page 4 of 12 - Esters-buliding-blocks

Annes, Sesuraj Babiola’s team published research in Green Chemistry in 2020 | CAS: 623-47-2

Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Safety of Ethyl propiolate

《Solvent-free and montmorillonite K10-catalyzed domino reactions for the synthesis of pyrazoles with alkynylester as a dual synthon》 was written by Annes, Sesuraj Babiola; Saritha, Rajendhiran; Subramanian, Saravanan; Shankar, Bhaskaran; Ramesh, Subburethinam. Safety of Ethyl propiolateThis research focused ontrisubstituted pyrazole regioselective preparation; disubstituted pyrazole regioselective preparation; pyrazole alkynyl ester domino ring closing montmorillonite K10 catalyst. The article conveys some information:

A highly regioselective, solvent-free and montmorillonite K10 clay-catalyzed domino process with an unprecedented ring-closing C-C bond-formation reaction was described for the synthesis of a new class of 1,3,4-trisubstituted I [R = H, 4-Me, 3-Cl, etc.; R1 = R2 = CO2Me, CO2Et, CO2Bn, etc.] and 1,4-disubstituted pyrazole derivatives I [R2 = H]. The reaction proceeded via nucleophilic attack of enamine from an intermediate on the β-carbon of an amino acrylate. Exptl. outcomes clearly revealed that organic solvents had an adverse effect upon pyrazole formation and that an oxidative condition in the presence of the reusable clay favored formation of the 1,3,4-trisubstituted pyrazole. The clay in the presence of a N-bromosuccinamide catalyst gave the 1,4-disubstituted pyrazole after pyrolytic cleavage at elevated temperature The experimental process involved the reaction of Ethyl propiolate(cas: 623-47-2Safety of Ethyl propiolate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fan, Qiangwen’s team published research in Chemical Physics Letters in 2021 | CAS: 623-47-2

Application In Synthesis of Ethyl propiolateIn 2021 ,《A new metal-organic framework of 3,9-diazatetraasterane-1,5,7,11-tetracarboxylic acid-3,6,9,12-tetraphenyl with sodium ion: Synthesis, characterization and DFT calculations》 was published in Chemical Physics Letters. The article was written by Fan, Qiangwen; Zhu, Longwei; Ren, Huijun; Lin, Hailu; Wu, Guorong. The article contains the following contents:

A new three-dimensional metal-organic framework with regular 1-dimensional channel, [Na2(DATA)1/2(H2O)2·H2O]n, NaTADA, was synthesized by solvothermal reaction of 3,9-diazatetraasterane-1,5,7,11-tetracarboxylic acid-3,6,9,12-tetraphenyl (DATAH4) with sodium hydroxide, and characterized by x-ray single-crystal diffraction, TGA and FTIR spectroscopy. Besides, electronic structures anal., including mol. frontier orbitals, mol. electrostatic potential surface distribution, were also performed basing on electronic wavefunction obtained at the same calculated level for revealing intrinsic mol. structural characteristics. The experimental process involved the reaction of Ethyl propiolate(cas: 623-47-2Application In Synthesis of Ethyl propiolate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Lu’s team published research in Advanced Synthesis & Catalysis in 2020 | CAS: 623-47-2

《Organocatalytic Hantzsch Type Reaction Using Aryl Hydrazines, Propiolic Acid Esters and Enals: Enantioselective Synthesis of Paroxetine》 was written by Chen, Lu; Zhang, Zhi; Zu, Liansuo. Safety of Ethyl propiolateThis research focused onunsubstituted hydropyridine preparation enantioselective diastereoselective; aryl hydrazine propiolic acid ester enal Hantzsch reaction organocatalyst. The article conveys some information:

Aryl hydrazines, propiolic acid esters and enals served as a viable substrate combination for an organocatalytic enantioselective Hantzsch type reaction. The method converted readily available starting materials into important chiral heterocycles with good to excellent yields and enantioselectivities, and addressed the longstanding scope limitation of the classic Hantzsch reaction in the asym. synthesis of 2,6-unsubstituted hydropyridines. The synthetic utility was demonstrated by the concise enantioselective synthesis of paroxetine. In addition to this study using Ethyl propiolate, there are many other studies that have used Ethyl propiolate(cas: 623-47-2Safety of Ethyl propiolate) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Elkanzi, Nadia Ali Ahmed’s team published research in Pharma Chemica in 2019 | CAS: 623-47-2

HPLC of Formula: 623-47-2In 2019 ,《Design, efficient synthesis and antimicrobial evaluation of some novel pyrano[2,3-b][1,8]naphthyridine and pyrrolo [2,3-f][1,8] naphth-yridine derivatives》 was published in Pharma Chemica. The article was written by Elkanzi, Nadia Ali Ahmed; Ghoneim, Amira A.; Bakr, Rania B.. The article contains the following contents:

The synthesis of naphthyridine derivatives by the reaction of 4,11-diamino-1,6,6a,8,9,10-hexahydropyrano[2,3-b]pyrrolo[2,3-f][1,8]naphthyridine-3-carboxylic acid with aminobenzamidine dihydrochloride, benzotriazol-1yloxytris(pyrrolidino)phosphonium hexafluorophosphate and N-ethyldiisopropylamine afforded I and with Benzotriazol-1-yloxytris(pyrrolidino)phosphonium hexafluorophosphate, 4-cyanoaniline and N-ethyldiisopropylamine gave II with good and satisfied yield. The structures of synthesized compounds were established by IR, 1H-NMR, 13C-NMR and mass spectra. Antimicrobial activity of these compounds was evaluated against B. subtilis, S. aureus, E. coli, P. aeruginosa bacteria, A. flavus and C. albicans. The results revealed that the candidate III was found to be the most active against all the tested microorganisms. In the experiment, the researchers used many compounds, for example, Ethyl propiolate(cas: 623-47-2HPLC of Formula: 623-47-2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zare Davijani, Neda’s team published research in Molecular Diversity in 2022 | CAS: 623-47-2

In 2022,Zare Davijani, Neda; Kia-Kojoori, Reza; Abdolmohammadi, Shahrzad; Sadegh-Samiei, Sepehr published an article in Molecular Diversity. The title of the article was 《Employing of Fe3O4/CuO/ZnO@MWCNT MNCs in the solvent-free synthesis of new cyanopyrroloazepine derivatives and investigation of biological activity》.Electric Literature of C5H6O2 The author mentioned the following in the article:

In this research, authors synthesized the Fe3O4/CuO/ZnO@MWCNT magnetic nanocomposites using water extract of Petasites hybridus rhizome, and the high performance of synthesized catalyst was confirmed by using in the solvent-free multicomponent reactions of isatoic anhydride, N-methylimidazole, alkyl bromides, activated acetylenic compounds and 2-aminoacetonitrile at ambient temperature for the production of new cyanopyrroloazepine derivatives in high yields. This catalyst could be used several times in these reactions and have main role in the yield of product. The synthesized cyanopyrroloazepines have NH groups in their structure and for this reason have good antioxidant activity. Also, employing Gram-pos. and Gram-neg. bacteria in the disk diffusion procedure confirmed some cyanopyrroloazepines antimicrobial effect. The results showed that synthesized cyanopyrroloazepine prevented the bacterial growth. This used process for preparation of new cyanopyrroloazepine has some improvements such as low reaction time, product with high yields, simple separation of catalyst and products. The experimental process involved the reaction of Ethyl propiolate(cas: 623-47-2Electric Literature of C5H6O2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Hwu, Jih Ru’s team published research in Journal of Organic Chemistry in 2020 | CAS: 623-47-2

Reference of Ethyl propiolateIn 2020 ,《Domino Reaction for the Synthesis of Polysubstituted Pyrroles and Lamellarin R》 was published in Journal of Organic Chemistry. The article was written by Hwu, Jih Ru; Roy, Animesh; Panja, Avijit; Huang, Wen-Chieh; Hu, Yu-Chen; Tan, Kui-Thong; Lin, Chun-Cheng; Hwang, Kuo-Chu; Hsu, Ming-Hua; Tsay, Shwu-Chen. The article contains the following contents:

Treatment of α-silylaryl triflates, Schiff bases, and alkynes was generated polysubstituted pyrroles in good yields (61-86%) with regioselectivity. This domino reaction involved completion of five sequential steps in a single flask, which comprised aryne formation through 1,2-elimination, their alkylation by Schiff bases through 1,2-addition, 1,4-intramol. proton transfer, Huisgen 1,3-dipolar cycloaddition, and dehydrogenative aromatization. It was then successfully applied as the key step in the synthesis of the natural product lamellarin R. This new reaction represented an efficient, sustainable process for the production of chem. materials. The experimental process involved the reaction of Ethyl propiolate(cas: 623-47-2Reference of Ethyl propiolate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jahanshad, Milad’s team published research in Monatshefte fuer Chemie in 2020 | CAS: 623-47-2

Synthetic Route of C5H6O2In 2020 ,《A copper-catalyzed reaction between terminal alkynes, acetylenic esters, and oxiranes: efficient synthesis of 2H-pyran-4-carboxylate》 appeared in Monatshefte fuer Chemie. The author of the article were Jahanshad, Milad; Manafi, Mohammadreza; Mousavi-Safavi, Seyed Mahmoud; Homami, Seyed Saied; Ghazanfarpour-Darjani, Majid. The article conveys some information:

A catalytic reaction between terminal alkynes, acetylenic esters, and oxiranes has been described. This domino transformation serves as a useful sequential and one-pot method for the synthesis of 2H-pyran-4-carboxylate skeletons from the readily available starting materials. In situ-generated copper acetylides treated initially with oxiranes in the presence of copper catalysts and tetrabutylphosphonium salts, followed by addition of propiolates after 60 min to form synthetically important heterocycles. The experimental part of the paper was very detailed, including the reaction process of Ethyl propiolate(cas: 623-47-2Synthetic Route of C5H6O2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Kun’s team published research in Chemistry – A European Journal in 2019 | CAS: 623-47-2

The author of 《Synthetic Diversity from a Versatile and Radical Nitrating Reagent》 were Zhang, Kun; Jelier, Benson; Passera, Alessandro; Jeschke, Gunnar; Katayev, Dmitry. And the article was published in Chemistry – A European Journal in 2019. Computed Properties of C5H6O2 The author mentioned the following in the article:

A new methodol. was described for the activation of N-nitrosuccimide for the direct synthesis of β-nitroalkenes, β-nitrohydrins, β-nitroethers, isoxazolines I [R = Me, cyclopropyl; R1 = n-heptyl, Bn, CH2OPh; R2 = H, R1R2 = (CH2)4, (CH2)9, (CH2)10C(O)(CH2)3; R3 = H, Me] and isoxazoles II [R4 = CO2Et, CH2CH2Br, cyclohexyl, etc.]. Detailed mechanistic studies strongly suggested that a mesolytic N-N bond fragmentation liberates a nitryl radical. Using in situ photo-sensitized, ESR spectroscopy, direct evidence of a nitryl radical in solution by nitrone spin-trapping was observed To further exhibit versatility of N-nitrosuccinimide under photoredox conditions, the late-stage diversification of an extensive number of C-H partners to prepare isoxazolines I and isoxazoles II was presented. This approach allowed for the formation of an in situ nitrile oxide from a ketone partner, the presence of which was detected by the formation of the corresponding furoxan when conducted in the absence of a dipolarophile. This 1,3-dipolar cycloaddition with nitrile oxides and alkenes or alkynes proceeded in a single-operational step using a mild, regioselective and general protocol with broad chemoselectivity. After reading the article, we found that the author used Ethyl propiolate(cas: 623-47-2Computed Properties of C5H6O2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liu, Zhaohong’s team published research in Organic Chemistry Frontiers in 2019 | CAS: 623-47-2

In 2019,Organic Chemistry Frontiers included an article by Liu, Zhaohong; Raveendra Babu, Kaki; Wang, Feng; Yang, Yang; Bi, Xihe. Computed Properties of C5H6O2. The article was titled 《Influence of sulfonyl substituents on the decomposition of N-sulfonylhydrazones at room temperature》. The information in the text is summarized as follows:

A detailed study of the dissociation performance of structurally varied N-sulfonylhydrazones was described and N-tfsylhydrazone was proved to be the best substrate to give the corresponding diazo compound R1C(N2)R2 [R1 = Ph, 2-FC6H4, 2,4-di-ClC6H3, etc.; R2 = H, Me, Ph] at room temperature N-tfsylhydrazone was capable of releasing non-stabilized aryldiazomethane in a wide range of solvents in the presence of various commonly used bases under mild reaction conditions (-25° to 40°). The utility of the strategy was established by late-stage derivatization of bioactive mols. and several typically sensitive reactions, in which highly purified diazo compounds were required. The experimental process involved the reaction of Ethyl propiolate(cas: 623-47-2Computed Properties of C5H6O2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Xiaowei’s team published research in Advanced Synthesis & Catalysis in 2020 | CAS: 623-47-2

《Rhodium-Catalyzed Cascade Reactions of Indoles with 4-Hydroxy-2-Alkynoates for the Synthesis of Indole-Fused Polyheterocycles》 was written by Wu, Xiaowei; Li, Pinyi; Lu, Yangbin; Qiao, Jin; Zhao, Jingwei; Jia, Xiuwen; Ni, Hangcheng; Kong, Lichun; Zhang, Xiaoning; Zhao, Fei. Related Products of 623-47-2 And the article was included in Advanced Synthesis & Catalysis in 2020. The article conveys some information:

Herein, the authors describe an efficient and regioselective Rh(III)-catalyzed [4+2]-annulation/lactonization cascade of indoles with 4-hydroxy-2-alkynoates at room temperature to access the furo[3′,4′:4,5]pyrimido[1,6-a]indole-1,5(3H,4H)-diones I [R1 = H, 10-OMe, 9-CN, 8-F, etc., R2 = H, Me, Ph, CH2CN, etc., R3 = H, Me, (CH2)2Ph, etc., R4 = H, Me, Et, R3R4 = (CH2)4, (CH2)5, (CH2)6] and II. This method features mild reaction conditions, operational simplicity, excellent regioselectivity, broad substrate scope with good functional group tolerance, and good to excellent yields. The results came from multiple reactions, including the reaction of Ethyl propiolate(cas: 623-47-2Related Products of 623-47-2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics