623-47-2 Archives - Page 3 of 12 - Esters-buliding-blocks

Ivan, Beatrice-Cristina’s team published research in Molecules in 2021 | CAS: 623-47-2

Ethyl propiolate(cas: 623-47-2) is a clear colorless to pale yellow liquid that is soluble in ethanol, ether and chloroform. It an important organic chemical raw material and pharmaceutical intermediate. Ethyl propargylate is obtained by oxidation of propargyl alcohol to propargylic acid followed by esterification.Synthetic Route of C5H6O2

Synthetic Route of C5H6O2In 2021 ,《Synthesis and Toxicity Evaluation of New Pyrroles Obtained by the Reaction of Activated Alkynes with 1-Methyl-3-(cyanomethyl)benzimidazolium Bromide》 appeared in Molecules. The author of the article were Ivan, Beatrice-Cristina; Dumitrascu, Florea; Anghel, Adriana Iuliana; Ancuceanu, Robert Viorel; Shova, Sergiu; Dumitrescu, Denisa; Draghici, Constantin; Olaru, Octavian Tudorel; Nitulescu, George Mihai; Dinu, Mihaela; Barbuceanu, Stefania-Felicia. The article conveys some information:

A series of new pyrrole derivatives I (R = H, methoxycarbonyl, ethoxycarbonyl; R1 = Bz, methoxycarbonyl, ethoxycarbonyl, (propan-2-yloxy)carbonyl) were designed as chem. analogs of the 1,4-dihydropyridines drugs in order to develop future new calcium channel blockers. The new tri- and tetra-substituted N-arylpyrroles I were synthesized by the one-pot reaction of 1-methyl-3-cyanomethyl benzimidazolium bromide with substituted alkynes RCCR1 having at least one electron-withdrawing substituent, in 1,2-epoxybutane, acting both as the solvent and reagent to generate the corresponding benzimidazolium N3-ylide. The structural characterization of the new substituted pyrroles I was based on IR, NMR spectroscopy as well as on single crystal X-ray anal. The toxicity of the new compounds was assessed on the plant cell using Triticum aestivum L. species and on the animal cell using Artemia franciscana Kellogg and Daphnia magna Straus crustaceans. The compounds showed minimal phytotoxicity on Triticum rootlets and virtually no acute toxicity on Artemia nauplii, while on Daphnia magna, it induced moderate to high toxicity, similar to nifedipine. This research indicates that the newly synthesized pyrrole derivatives are promising mols. with biol. activity and low acute toxicity. The experimental part of the paper was very detailed, including the reaction process of Ethyl propiolate(cas: 623-47-2Synthetic Route of C5H6O2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Devleshova, Natalia A.’s team published research in Tetrahedron in 2019 | CAS: 623-47-2

The author of ãReactions of alkyl 4-hydroxybut-2-ynoates with arenes under superelectrophilic activation with triflic acid or HUSY zeolite: Alternative propargylation or allenylation of arenes, and synthesis of furan-2-onesã?were Devleshova, Natalia A.; Lozovskiy, Stanislav V.; Vasilyev, Aleksander V.. And the article was published in Tetrahedron in 2019. Safety of Ethyl propiolate The author mentioned the following in the article:

Reactions of alkyl 4-aryl(or 4,4-diaryl)-4-hydroxybut-2-ynoates [Ar(H or Ar’)(OH)C4-C3â¡C2-CO2Alk], (Ar = Ar’ = Ph, 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4, etc.; Alk = Me, Et) with arenes under the action of triflic acid TfOH or HUSY zeolite result in the formation of two main compounds, aryl substituted furan-2-ones I (Ar1 = Ar2 = Ph, 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4, etc.; Ar3 = 2,5-di-MeC6H3, 3,4-di-MeC6H3, 3-F,4-MeC6H3, etc.) or products of propargylation II (Ar1 = Ph, 4-MeC6H4, 4-MeOC6H4, 4-BrC6H4, etc.; Ar3 = 2,5-di-MeC6H3, 3,4-di-MeC6H3, 3-F,4-MeC6H3, etc.; Alk = Me, Et) of electron rich arenes. Key reactive intermediates in these transformations are the corresponding O,O-diprotonated forms of starting butynoates, Ar(H or Ar’)(+OH2)C4-C3â¡C2-C(=O+H)(OAlk), dehydration of which gives rise to mesomeric propargyl-allenyl cations Ar(H or Ar’)(OH)4C+-C3â¡C2-C(=O+H)(OAlk) â?Ar(H or Ar’)(OH)4C = C3 = 2C+-C(=O+H)(OAlk), having two electrophilic centers on the carbons C4 and C2 resp. Reactions of these species with arenes at C4 lead to products of arene propargylation, alternatively, reactions at C2 result in allenylation of arenes, followed by further transformation into furan-2-ones. Using quantum chem. calculations by the DFT method, it has been shown that the reactivity of such propargyl-allenyl cations is mainly explained by orbital factors. Plausible reaction mechanism is discussed.Ethyl propiolate(cas: 623-47-2Safety of Ethyl propiolate) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Provis-Evans, Cei B.’s team published research in ACS Catalysis in 2020 | CAS: 623-47-2

Related Products of 623-47-2In 2020 ,ãRegioselective Alkyne Cyclotrimerization with an In Situ-Generated [Fe(II)H(salen)]Â·Bpin Catalystã?was published in ACS Catalysis. The article was written by Provis-Evans, Cei B.; Lau, Samantha; Krewald, Vera; Webster, Ruth L.. The article contains the following contents:

A mild, efficient, and regiospecific catalytic cyclotrimerization of alkynes to form 1,2,4-substituted arenes has been discovered. From a cheap and air-stable [Fe(salen)]2-μ-oxo complex and readily available pinacol borane (HBpin), a monomeric [FeH(salen)]·Bpin species formed in situ acts as the active catalyst. This species is shown to feature a hemilabile salen ligand stabilized via interactions with the boron entity. The formation, identity, and reaction mechanism of the active species are supported by complementary kinetic, spectroscopic, and computational data. The active catalyst undergoes hydrometallation of a coordinated alkyne to form a vinyl iron species, stepwise additions of two more alkynes across the Fe-C bond to form a pendant triene, which upon ring-closure forms the arene product. The catalytic cycle is closed by substitution of the product with the alkyne substrate. With the active [FeH(salen)]·Bpin catalyst, atom-efficient, intermol. trimerization is shown with high regioselectivity for a diverse range of substrate substitution patterns and presence of functional groups. In addition to this study using Ethyl propiolate, there are many other studies that have used Ethyl propiolate(cas: 623-47-2Related Products of 623-47-2) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bhaskaran, Rasmi P.’s team published research in ChemistrySelect in 2020 | CAS: 623-47-2

ãMetal-Free Synthesis of Pyrazoles and Chromenopyrazoles from Hydrazones and Acetylenic Estersã?was published in ChemistrySelect in 2020. These research results belong to Bhaskaran, Rasmi P.; Janardhanan, Jith C.; Babu, Beneesh P.. Safety of Ethyl propiolate The article mentions the following:

An efficient, metal-free synthesis of pyrazoles and chromenopyrazoles from aldehyde hydrazones and acetylenic esters was developed. A library of mols. with diverse functional groups was synthesized using substituted hydrazones and alkynes, both sym. and unsym. ones. The derivatives were isolated in moderate to good yields. The experimental part of the paper was very detailed, including the reaction process of Ethyl propiolate(cas: 623-47-2Safety of Ethyl propiolate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Beerhues, Julia’s team published research in Dalton Transactions in 2019 | CAS: 623-47-2

《A dicopper(I)-dimesoionic carbene complex as a click catalyst: mechanistic implications》 was written by Beerhues, Julia; Fauche, Kevin; Cisnetti, Federico; Sarkar, Biprajit; Gautier, Arnaud. Recommanded Product: 623-47-2This research focused ontriazole copper mesoionic binuclear carboxylate bridged complex preparation; click reaction catalyst copper mesoionic binuclear ditriazolylmethane carboxylate complex; cycloaddition kinetics catalyst copper mesoionic carbene ditriazolylmethane carboxylate complex; crystal mol structure copper mesoionic carbene ditriazolylmethane carboxylate complex. The article conveys some information:

A dicopper(I) complex comprising a dimesoionic carbene, bis(triazolyl)methane, and an acetate-bridge is synthesized and fully characterized. This complex is a potent pre-catalyst for the azide-alkyne cycloaddition reaction. A full kinetic investigation shows a first order in azide and a catalyst order smaller than one due to an equilibrated dimerization of the catalyst. In addition to this study using Ethyl propiolate, there are many other studies that have used Ethyl propiolate(cas: 623-47-2Recommanded Product: 623-47-2) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Baldassari, Lucas L.’s team published research in Green Chemistry in 2019 | CAS: 623-47-2

Reference of Ethyl propiolateIn 2019 ,《Triple copper catalysis for the synthesis of vinyl triazoles》 appeared in Green Chemistry. The author of the article were Baldassari, Lucas L.; Cechinatto, Eduardo A.; Moro, Angelica V.. The article conveys some information:

Synthesis of vinyl 1,2,3-triazoles through a one-pot sequence, enabled by the same copper catalyst of three different reactions: hydroboration involving an alkyne, azidation for a vinyl boronate and azide-alkyne cycloaddition was reported. In the part of experimental materials, we found many familiar compounds, such as Ethyl propiolate(cas: 623-47-2Reference of Ethyl propiolate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Al Matarneh, Cristina Maria’s team published research in Molecules in 2020 | CAS: 623-47-2

《Design, synthesis, molecular modelling and anticancer activities of new fused phenanthrolines》 was published in Molecules in 2020. These research results belong to Al Matarneh, Cristina Maria; Amarandi, Roxana Maria; Craciun, Anda Mihaela; Mangalagiu, Ionel I.; Zbancioc, Gheorghita; Danac, Ramona. Electric Literature of C5H6O2 The article mentions the following:

Three series of fused pyrrolophenanthroline derivatives were designed as analogs of phenstatin and synthesized in two steps starting with 1,7-phenanthroline, 4,7-phenanthroline and 1,10-phenanthroline, resp. Two (Compounds 8a and 11c) of the four compounds tested against a panel of sixty human cancer cell lines of the National Cancer Institute (NCI) exhibited significant growth inhibition activity on several cell lines. Compound 11c showed a broad spectrum in terms of antiproliferative efficacy with GI50 values in the range of 0.296 to 250μM. Mol. docking studies indicated that Compounds 8a and 11c are accommodated in the colchicine binding site of tubulin in two different ways. The experimental part of the paper was very detailed, including the reaction process of Ethyl propiolate(cas: 623-47-2Electric Literature of C5H6O2)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sun, Yu’s team published research in ACS Applied Polymer Materials in 2020 | CAS: 623-47-2

《Activated Isobutylene-Isoprene Rubber-Synthesis, Peroxide Cure, and Mechanical Properties》 was written by Sun, Yu; Fan, Chengkai; Wei, Benqian; Wesdemiotis, Chrys; Jia, Li. Name: Ethyl propiolate And the article was included in ACS Applied Polymer Materials in 2020. The article conveys some information:

EIIR, a derivative of isobutylene-isoprene rubber (IIR) with geminal vinylidene-acrylate motifs, has been synthesized by grafting Et propiolate to IIR via EtAlCl2-catalyzed Alder-ene reaction. Methods to cure EIIR using dicumyl peroxide (DCP) with m-phenylene-N,N’-bismaleimide (BMI) as the coagent have been successfully developed. The strength, extensibility, and overall toughness of the peroxide-cured EIIR significantly exceed those of previously reported peroxide-cured IIR derivatives The role of the germinal vinylidene-acrylate moiety in curing has been investigated via model reactions using small-mol. surrogates of the functionalities present in EIIR. Evidence from mass spectrometry suggests that the germinal vinylidene-acrylate moiety undergoes both radical addition and hydrogen abstraction. Its importance for the curing process is further demonstrated by the ability of its small-mol. surrogate, Et 4,5-dimethyl-(E-2),5-hexdienoate (EDHEX), to reduce chain scission when used as a coagent in conjunction with BMI. The excellent mech. properties and the simplicity of the curing package make the peroxide-cured EIIR a strong candidate for pharmaceutical closure applications.Ethyl propiolate(cas: 623-47-2Name: Ethyl propiolate) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Ming’s team published research in Organic Chemistry Frontiers in 2022 | CAS: 623-47-2

In 2022,Yang, Ming; Xu, Xue-Cen; Gong, Yue; Zhao, Yu-Long published an article in Organic Chemistry Frontiers. The title of the article was 《Rhodium-catalyzed coupling-cyclization reaction of isocyanides and 2-azidophenyloxyacrylates: synthesis of N-(3-substituted benzo[d]oxazol-2(3H)-ylidene)amines and dihydrobenzo[d]oxazoles》.Related Products of 623-47-2 The author mentioned the following in the article:

A rhodium-catalyzed coupling cyclization of isocyanides with 2-azidophenyloxyacrylates has been developed for the first time. This reaction allows divergent syntheses of two significant N-heterocycles, five-membered N-(3-substituted benzo[d]oxazol-2(3H)-ylidene)amines and dihydrobenzo[d]oxazoles, from readily available starting materials in a single step.Ethyl propiolate(cas: 623-47-2Related Products of 623-47-2) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Biffis, Andrea’s team published research in Inorganica Chimica Acta in 2021 | CAS: 623-47-2

Biffis, Andrea; Baron, Marco; Tubaro, Cristina; Rancan, Marzio; Armelao, Lidia; Marchenko, Anatoliy; Koidan, Georgyi; Hurieva, Anastasiia N.; Kostyuk, Aleksandr published an article in 2021. The article was titled 《Gold(I) complexes with multifunctional phosphane ligands: Synthesis and catalysis》, and you may find the article in Inorganica Chimica Acta.Recommanded Product: Ethyl propiolate The information in the text is summarized as follows:

Two novel gold(I) complexes with a phosphoguanidine ligand and with a novel cationic phosphane ligand have been prepared and structurally characterized. The phosphoguanidine ligand supports oxidative addition of biphenylene to the gold(I) center, though the yield of the reaction is low. The phosphoguanidine gold(I) complexes is also able to efficiently catalyze the hydroamination of phenylacetylene with mesitylamine, whereas the gold(I) complex with the cationic phosphane ligand, due to its more electron-poor character, promotes the hydroarylation of Et propiolate with mesitylene. In the experiment, the researchers used many compounds, for example, Ethyl propiolate(cas: 623-47-2Recommanded Product: Ethyl propiolate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics