Expedient synthesis of biologically important sulfonylmethyl pyrimidines was written by Blades, Kevin;Demeritt, Julie;Fillery, Shaun;Foote, Kevin M.;Greenwood, Ryan;Gregson, Clare;Hassall, Lorraine A.;McGuire, Thomas M.;Pike, Kurt G.;Williams, Emma. And the article was included in Tetrahedron Letters in 2014.Safety of Methyl 2-(methylsulfonyl)acetate This article mentions the following:
Two novel synthetic strategies that allow rapid diversification of the sulfone moiety in sulfonylmethyl pyrimidines, a class of compounds with a wide range of biol. activity, which are of interest in a wide variety of drug discovery programs, are described. In the experiment, the researchers used many compounds, for example, Methyl 2-(methylsulfonyl)acetate (cas: 62020-09-1Safety of Methyl 2-(methylsulfonyl)acetate).
Methyl 2-(methylsulfonyl)acetate (cas: 62020-09-1) belongs to esters. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of Methyl 2-(methylsulfonyl)acetate
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics