In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 620-72-4 as follows. Quality Control of Phenyl 2-bromoacetate
To a solution of phenylbromoacetate (18.58 g, 86 mmol) in CH3CN under nitrogen was added a solution of (R)-phenylglycinol (10.17 g, 74 mmol) and di-isopropylethylamine (34 ml_, 195 mmol) in CH3CN. The volatiles were removed under reduced pressure keeping the bath temperature below 25 0C to obtain an oil that was treated with EtOAc (120 mL) and stirred for 15 min. The resulting white precipitate was removed by filtration. The filtrate was concentrated under reduced pressure and the desired product was isolated using column chromatography (SiO2) with a step gradient of 10 percent to 50 percent [v/v] EtOAc in cyclohexane to give after evaporation (f?)-5-phenylmorpholin-2- one EBE 06134 (3.17 g, 24 percent yield) as a white solid.MW: 177.2; Yield: 24 percent; White Solid; Mp (0C): 50.3Rf\ 0.30 (EtOAc:cyclohexane = 50:50). 1H-NMR (CDCI3, delta): 1.99 (s, 1 H, NH), 3.89 (q, 2H, J = 17.8 Hz, N-CH2), 4.18(dd, 1 H, J = 3.7 Hz, J = 10.3 Hz, 0-CH), 4.29 (t, 1 H, J = 10.5 Hz, N-CH), 4.40(dd, 1 H, J = 3.7 Hz, J = 10.5 Hz, 0-CH), 7.30-7.45 (m, 5H, ArH).13C-NMR (CDCI3, delta): 46.8, 54.8, 72.8, 125.3 (2xC), 127.0, 127.3 (2xC), 135.9,166.0. [G]22D = + 30.3 ¡ã (c = 1.00, MeOH).
According to the analysis of related databases, 620-72-4, the application of this compound in the production field has become more and more popular.
Reference:
Patent; ALLERGAN, INC.; WO2008/11478; (2008); A2;,
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