Category: 6197-30-4

On February 10, 2020, Azaroff, Alyssa; Miossec, Carole; Lanceleur, Laurent; Guyoneaud, Remy; Monperrus, Mathilde published an article.Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Priority and emerging micropollutants distribution from coastal to continental slope sediments: A case study of Capbreton Submarine Canyon (North Atlantic Ocean). And the article contained the following:

Incising continental margins, submarine canyons are key issue for understanding shelf/deep sea exchange of particulate pollutant, impact on marine ecosystem and global geochem. cycling. The occurrence and distribution of 100 priority and emerging micropollutants were investigated in sediments within the first 25 km of the Capbreton submarine area. The most predominant compounds were polycyclic aromatic hydrocarbons (PAHs), trace metals and metalloid (TMs) (e.g. mercury, lead and arsenic), synthetical musks (e.g. musk ketone, galaxolide), UV filters (e.g. octocrylene and 2-ethylhexyl 4-methoxycinnamate, EHMC) as well as some pharmaceuticals (e.g. azithromycin, acetaminophen). Highest concentrations were measured in submarine canyon sediments, distant from the coast and were correlated with both organic carbon and fine fraction contents, where PAHs, EHMC and musk ketone concentrations up to 7116, 32 and 7 ng g-1 dry weight, resp. Those results likely demonstrate, that atm. inputs of pyrogenic PAHs, and both trapping and transporting of polluted particles along the continuum shore/deep sea by the Capbreton Canyon, might lead to an accumulation of anthropogenic micropollutants. The ecol. risk assessment indicates that priority pollutants raise a potentially high risk for benthic organisms (e.g. PAHs, TMs). This might raised a specific concern about how the human can impact this ecosystem. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to micropollutant submarine canyon sediment pollution atlantic ocean, inorganic pollutants, marine strategy framework directive, persistent organic pollutants, submarine canyon sediments, toxicity risk assessment and other aspects.Safety of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On January 15, 2022, Prakash, Ved; Jain, Veena; Chauhan, Shweta Singh; Parthasarathi, Ramakrishnan; Roy, Somendu K.; Anbumani, Sadasivam published an article.Application of 6197-30-4 The title of the article was Developmental toxicity assessment of 4-MBC in Danio rerio embryo-larval stages. And the article contained the following:

Enormous production of cosmetic products and its indiscriminate use tends to discharge into the aquatic environment and might threaten non-target organisms inhabiting aquatic ecosystems. In the present study, developmental toxicity of 4-methylbenzylidene camphor (4-MBC), a widely used organic UV filter in personal care products has been evaluated using zebrafish embryo-larval stages. Waterborne exposure induced developmental toxicity and deduced 2.71 mg/L as 96 h LC50 whereas embryos exposed to sub-lethal concentrations (50 and 500μg/L) caused a significant delay in hatching rate, heart rate, reduced larval length, and restricted hatchlings motility besides the axial curvature. Chronic exposure to 10 dpf resulted in significant decrease in SOD activity at 500μg/L with no changes in CAT level besides a significant increase in GST enzyme at 5μg/L concentration in 5 dpf sampled larvae. However, all the three enzymes were significantly elevated in 10 dpf larvae indicating differential oxidative stress during the stages of development. Similar trend is noticed for acetylcholine esterase enzyme activity. A concentration dependent increase in malondialdehyde content was noted in larvae sampled at 5 and 10 dpf. In addition, multixenobiotic resistance (MXR) activity inhibition, and elevated oxidative tissue damage were noticed at 5 dpf with no significant changes in 10 dpf larvae. Furthermore, immunoblot anal. confirms 4-MBC induced apoptosis in zebrafish larvae with promoted cleaved Caspase-3, Bax and inhibited Bcl-2 proteins expression. Subsequently, docking studies revealed the binding potential of 4-MBC to zebrafish Abcb4 and CYP450 8A1 proteins with the binding energy of -8.1 and -8.5 kcal/mol representing target proteins interaction and toxicity potentiation. Our results showed that 4-MBC exposure triggers oxidative stress at sub-lethal concentrations leading to apoptosis, deformities and locomotion perturbations in developing zebrafish. This is first of its kind in systematically demonstrating developmental toxicity of 4-MBC and the information shall be used for aquatic toxicity risk assessment. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Application of 6197-30-4

The Article related to danio developmental toxicity 4 mbc, 4-methylbenzylidene camphor, apoptosis, developmental toxicity, embryo-larval stage, multi-xenobiotics resistance activity, senescence associated β-galactosidase activity and other aspects.Application of 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 1, 2022, Ko, Hyejin; An, Seungchan; Ahn, Sungjin; Park, In Guk; Gong, Junpyo; Hwang, Seok Young; Oh, Soyeon; Ki, Min Won; Jin, Sun Hee; Choi, Won Jun; Noh, Minsoo published an article.Computed Properties of 6197-30-4 The title of the article was Sunscreen filter octocrylene is a potential obesogen by acting as a PPARγ partial agonist. And the article contained the following:

Octocrylene (OC) is an extensively prescribed organic UV B filter used in sunscreen products. Due to its extensive use, a significant level of OC is detected in marine and freshwater environments. Notably, the bioaccumulation of OC in aquatic biota may affect human health. In this study, the effect of OC on metabolism was investigated using the adipogenesis model of human bone marrow mesenchymal stem cells (hBM-MSCs). OC promoted adiponectin production during adipogenesis in hBM-MSCs compared to the vehicle-treated control (EC50, 29.6 μM). In target identification, OC directly bound to peroxisome proliferator-activated receptor (PPAR) γ (Ki, 37.8 μM). OC-bound PPARγ also significantly recruited nuclear receptor coactivator proteins SRC-1 (EC50, 54.1 μM) and SRC-2 (EC50, 58.6 μM). In the mol. docking simulation study, the optimal ligand-binding mode of OC suggested that OC is a PPARγ partial agonist. A competitive anal. with a PPARγ full agonist pioglitazone revealed that OC acted as a PPARγ partial agonist. OC altered the gene transcription profile of lipid-metabolism associated enzymes in normal human keratinocytes, primarily exposed human cells after the application of sunscreens. In conclusion, OC is a potential metabolic disrupting obesogen. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Computed Properties of 6197-30-4

The Article related to octocrylene obesogen peroxisome proliferator activated receptor adipogenesis, human bone marrow mesenchymal stem cells, obesogen, octocrylene, peroxisome proliferator-activated receptor gamma, uv b filter and other aspects.Computed Properties of 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On November 1, 2020, Liu, Guifeng; Liu, Huan; Tong, Yuanjun; Xu, Linyan; Ye, Yu-Xin; Wen, Cheng; Zhou, Ningbo; Xu, Jianqiao; Ouyang, Gangfeng published an article.HPLC of Formula: 6197-30-4 The title of the article was Headspace solid-phase microextraction of semi-volatile ultraviolet filters based on a superhydrophobic metal-organic framework stable in high-temperature steam. And the article contained the following:

Herein, a superhydrophobic metal-organic framework (MOF) derived from decorating the metal-oxo nodes of the amino-functionalized UiO-66(Zr) with phenylsilane was prepared and successfully developed into a novel SPME fiber coating. The highest extraction efficiencies towards the semi-volatile UV filters were achieved when the aqueous samples were heated up to 100°C. It was notable that the lab-made coating exhibited extraordinary stability towards hot water steam, probably because the hydrophobic groups capped on the MOF prevented water mols. from entering and deconstructing its lattice. Even after being treated with water steam under 100°C for 21 h, the extraction performance of the coating remained unchanged, and the crystal structure of the MOF maintained. Furthermore, a negligible matrix effect was observed even in the samples containing humic acid. Under the optimal extraction and thermal desorption conditions, a method for determining UV filters in aqueous samples was established, which possessed low detection limits (0.6-2.1 ng L-1), wide linear ranges (10-50000 ng L-1), good inter-fiber reproducibility (2.3-6.0%, n = 6), and satisfying intra-fiber repeatability (1.8-5.8%, n = 3). The method was successfully applied in quantifying UV filters in environmental water samples. In addition, the lab-made NH2-UiO-66(Zr)-shp-coated fiber was also suitable for the anal. of polycyclic aromatic hydrocarbons (PAHs). The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).HPLC of Formula: 6197-30-4

The Article related to semi volatile uv filter superhydrophobic metal organic framework spme, headspace solid-phase microextraction, hydrothermal, semi-volatile organic contaminants, super-hydrophobic metal–organic frameworks and other aspects.HPLC of Formula: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liao, Fang-Yi; Su, Yu-Lin; Weng, Jing-Ru; Lin, Ying-Chi; Feng, Chia-Hsien published an article in 2020, the title of the article was Ultrasound-vortex-assisted dispersive liquid-liquid microextraction combined with high performance liquid chromatography-diode array detection for determining UV filters in cosmetics and the human stratum corneum.Computed Properties of 6197-30-4 And the article contains the following content:

This study explores the amounts of common chem. UV filters (i.e., avobenzone, bemotrizinol, ethylhexyl triazone, octocrylene, and octyl methoxycinnamate) in cosmetics and the human stratum corneum. An ultrasound-vortex-assisted dispersive liquid-liquid microextraction (US-VA-DLLME) method with a high-performance liquid chromatog.-diode array detector was used to analyze UV filters. A bio-derived solvent (i.e., anisole) was used as the extractant in the US-VA-DLLME procedure, along with methanol as the dispersant, a vortexing time of 4 min, and ultrasonication for 3 min. The mass-transfer rate of the extraction process was enhanced due to vortex-ultrasound combination. Various C18 end-capped columns were used to investigate the separation characteristics of the UV filters, with XBridge BEH or CORTECS selected as the separation column. Calibration curves were constructed in the 0.05-5μg/mL (all filters except octocrylene) and 0.1-10μg/mL (octocrylene) ranges, and excellent anal. linearities with coefficients of determination (r2) above 0.998. The developed method was successfully used to analyze sunscreen. Moreover, experiments were designed to simulate the sunscreen-usage habits of consumers, and the cup method was used to extract UV filters from the human stratum corneum. The results suggest that a makeup remover should be employed to remove water-in-oil sunscreens from skin. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Computed Properties of 6197-30-4

The Article related to ultrasound vortex assisted dispersive liquid microextraction uv filter hplc, uv filters, bio-derived solvent, cup method, human stratum corneum, ultrasound–vortex-assisted dispersive liquid–liquid microextraction and other aspects.Computed Properties of 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On December 1, 2021, Falfushynska, Halina; Sokolov, Eugene P.; Fisch, Kathrin; Gazie, Hatem; Schulz-Bull, Detlef E.; Sokolova, Inna M. published an article.Application of 6197-30-4 The title of the article was Biomarker-based assessment of sublethal toxicity of organic UV filters (ensulizole and octocrylene) in a sentinel marine bivalve Mytilus edulis. And the article contained the following:

The global occurrence of organic UV filters in the marine environment is of increasing ecotoxicol. concern. Here we assessed the toxicity of UV filters ensulizole and octocrylene in the blue mussels Mytilus edulis exposed to 10 or 100μg l-1 of octocrylene and ensulizole for two weeks. An integrated battery of biochem. and mol. biomarkers related to xenobiotics metabolism and cellular toxicity (including oxidative stress, DNA damage, apoptosis, autophagy and inflammation) was used to assess the toxicity of these UV filters in the mussels. Octocrylene (but not ensulizole) accumulated in the mussel tissues during the waterborne exposures. Both studied UV filters induced sublethal toxic effects in M. edulis at the investigated concentrations These effects involved induction of oxidative stress, genotoxicity (indicated by upregulation of DNA damage sensing and repair markers), upregulation of apoptosis and inflammation, and dysregulation of the xenobiotic biotransformation system. Octocrylene induced cellular stress in a concentration-dependent manner, whereas ensulizole appeared to be more toxic at the lower (10μg l-1) studied concentration than at 100μg l-1. The different concentration-dependence of sublethal effects and distinct toxicol. profiles of ensulizole and octocrylene show that the environmental toxicity is not directly related to lipophilicity and bioaccumulation potential of these UV filters and demonstrate the importance of using bioassays for toxicity assessment of emerging pollutants in coastal marine ecosystems. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Application of 6197-30-4

The Article related to mytilus biomarker ensulizole octocrylene, 2-ethylhexyl 2-cyano-3,3-diphenyl-2-propanoate (octocrylene), apoptosis, inflammation, organic uv filters, oxidative stress, phenylbenzimidazole sulfonic acid (ensulizole) and other aspects.Application of 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Umeoka, Eduardo H. L.; van Leeuwen, Judith M. C.; Vinkers, Christiaan H.; Joels, Marian published an article in 2021, the title of the article was The Role of Stress in Bipolar Disorder.HPLC of Formula: 6197-30-4 And the article contains the following content:

Stress is a major risk factor for bipolar disorder. Even though we do not completely understand how stress increases the risk for the onset and poorer course of bipolar disorder, knowledge of stress physiol. is rapidly evolving. Following stress, stress hormones – including (nor)adrenaline and corticosteroid – reach the brain and change neuronal function in a time-, region-, and receptor-dependent manner. Stress has direct consequences for a range of cognitive functions which are time-dependent. Directly after stress, emotional processing is increased at the cost of higher brain functions. In the aftermath of stress, the reverse is seen, i.e., increased executive function and contextualization of information. In bipolar disorder, basal corticosteroid levels (under non-stressed conditions) are generally found to be increased with blunted responses in response to exptl. stress. Moreover, patients who have bipolar disorder generally show impaired brain function, including reward processing. There is some evidence for a causal role of (dysfunction of) the stress system in the etiol. of bipolar disorder and their effects on brain system functionality. However, longitudinal studies investigating the functionality of the stress systems in conjunction with detailed information on the development and course of bipolar disorder are vital to understand in detail how stress increases the risk for bipolar disorder. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).HPLC of Formula: 6197-30-4

The Article related to beta adrenoceptor 11betahsd2 bipolar disorder, blunted response, cognition, cortisol awakening response (car), hypercortisolemia, hypothalamus-pituitary-adrenal (hpa) axis, network, trier social stress test (tsst) and other aspects.HPLC of Formula: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Abughrin, Suad E.; Alshana, Usama; Bakirdere, Sezgin published an article in 2022, the title of the article was Magnetic Nanoparticle-Based Dispersive Solid-Phase Microextraction of Three UV Blockers Prior to Their Determination by HPLC-DAD.Category: esters-buliding-blocks And the article contains the following content:

The need for proper handling of environmental samples is significant, owing to their environmental effects on both humans and animals, as well as their immediate surroundings. In the current study, magnetic nanoparticle-based dispersive solid-phase microextraction was combined with high-performance liquid chromatog. using a diode array as the detector (HPLC-DAD) for both the separation and determination of three different UV blockers, namely octocrylene, ethylhexyl methoxycinnamate, and avobenzone. The optimum conditions for the extraction were found to be as follows: Stearic acid magnetic nanoparticles (20 mg) as the sorbent, acetonitrile (100 μL) as the eluent, as well as a sample pH of 2.50, adsorption and desorption time of 1.0 min, with a 3.0 mL sample volume The limits of detection were as low as 0.05 μg mL-1. The coefficient of determination (R2) was above 0.9950, while the percentages of relative recoveries (%RR) were between 81.2 and 112% for the three UV blockers from the environmental water samples and sunscreen products. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Category: esters-buliding-blocks

The Article related to sunscreen environmental water uv blocker, magnetic nanoparticle dispersive solid phase microextraction hplcdad, hplc-dad, uv blockers, dispersive solid-phase microextraction, magnetic nanoparticles, sunscreen products and other aspects.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On February 15, 2021, Hascup, Kevin N.; Findley, Caleigh A.; Britz, Jesse; Esperant-Hilaire, Nahayo; Broderick, Sarah O.; Delfino, Kristin; Tischkau, Shelley; Bartke, Andrzej; Hascup, Erin R. published an article.Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate The title of the article was Riluzole attenuates glutamatergic tone and cognitive decline in AβPP/PS1 mice. And the article contained the following:

We have previously demonstrated hippocampal hyperglutamatergic signaling occurs prior to plaque accumulation in AβPP/PS1 mice. Here, we evaluate 2-Amino-6-(trifluoromethoxy) benzothiazole (riluzole) as an early intervention strategy for Alzheimers disease (AD), aimed at restoring glutamate neurotransmission prior to substantial Beta amyloid (Aβ) plaque accumulation and cognitive decline. Male AβPP/PS1 mice, a model of progressive cerebral amyloidosis, were treated with riluzole from 2-6 mo of age. Morris water maze, in vivo electrochem., and immunofluorescence were performed to assess cognition, glutamatergic neurotransmission, and pathol., resp., at 12 mo. Four months of prodromal riluzole treatment in AβPP/PS1 mice resulted in long-lasting procognitive effects and attenuated glutamatergic tone that was observed six months after discontinuing riluzole treatment. Riluzole-treated AβPP/PS1 mice had significant improvement in long-term memory compared to vehicle-treated AβPP/PS1 mice that was similar to normal aging C57BL/6J control mice. Furthermore, basal glutamate concentration and evoked-glutamate release levels, which were elevated in vehicle-treated AβPP/PS1 mice, were restored to levels observed in age-matched C57BL/6J mice in AβPP/PS1 mice receiving prodromal riluzole treatment. Aβ plaque accumulation was not altered with riluzole treatment. This study supports that interventions targeting the glutamatergic system during the early stages of AD progression have long-term effects on disease outcome, and importantly may prevent cognitive decline. Our observations provide preclin. support for targeting glutamate neurotransmission in patients at risk for developing AD. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

The Article related to riluzole nmda receptor glutamatergic tone ps1 alzheimers disease, alzheimer’s disease (ad), alpha-7 nicotinic acetylcholine receptor (α7nachr), amyloid-beta (aβ), biosensor, learning and memory, prodromal intervention and other aspects.Name: 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On March 31, 2020, Celeiro, Maria; Acerbi, Ruben; Kabir, Abuzar; Furton, Kenneth G.; Llompart, Maria published an article.SDS of cas: 6197-30-4 The title of the article was Development of an analytical methodology based on fabric phase sorptive extraction followed by gas chromatography-tandem mass spectrometry to determine UV filters in environmental and recreational waters. And the article contained the following:

A novel method based on fabric phase sorptive extraction (FPSE) followed by gas chromatog.-tandem mass spectrometry (GC-MS/MS) has been validated for the simultaneous determination of 11 UV filters (ethylhexyl salicylate, benzyl salicylate, homosalate, benzophenone-3, isoamylmethoxycinnamate, 4-methylbenzylidenecamphor, Me anthranilate, etocrylene, 2-ethylhexylmethoxycinnamate, 2-ethylhexyl p-dimethylaminobenzoate, and octocrylene), in natural and recreational waters. Major exptl. parameters affecting FPSE procedure have been optimized to obtain the highest extraction efficiency. Different types and sizes of sol-gel coated FPSE media, sample volume, extraction time, and type and volume of desorption solvent were evaluated. The optimal conditions involved the use of a (2.0 x 2.5) cm2 FPSE device with PDMS based coating for the extraction of 20 mL of water for 20 min. The quant. desorption of the target compounds was performed with 0.5-1 mL of Et acetate. The method was satisfactorily validated in terms of linearity, precision, repeatability and reproducibility. Recovery studies were performed at different concentration levels in real water matrixes to show its suitability, obtaining mean values about 90% and satisfactory precision. LODs were at the low ng L-1 in all cases. Finally, the validated FPSE-GC-MS/MS method was applied to different real samples, including environmental water (lake, river, seawater) and recreational water (swimming-pool), where 8 out of the 11 studied compounds were detected at concentrations between 0.12-123μg L-1. FPSE is proposed as an efficient and simple alternative to other extraction and microextraction techniques for the anal. of UV filters in waters. Since no matrix effects were observed, quantification could be carried out by conventional calibration with standard solutions, without the need to perform the complete FPSE procedure, thus allowing a higher throughput in comparison with other microextraction techniques. The experimental process involved the reaction of 2-Ethylhexyl 2-cyano-3,3-diphenylacrylate(cas: 6197-30-4).SDS of cas: 6197-30-4

The Article related to uv filter sorptive extraction gas chromatog tandem mass spectrometry, environmental water, fabric phase sorptive extraction, gas chromatography-tandem mass spectrometry, microextraction, sample preparation, uv filters and other aspects.SDS of cas: 6197-30-4

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics