Category: 61874-04-2

Korman, Arthur published the artcileLight-controlled twister ribozyme with single-molecule detection resolves RNA function in time and space, Safety of Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, the publication is Proceedings of the National Academy of Sciences of the United States of America (2020), 117(22), 12080-12086, database is CAplus and MEDLINE.

Small ribozymes such as Oryza sativa twister spontaneously cleave their own RNA when the ribozyme folds into its active conformation. The coupling between twister folding and self-cleavage has been difficult to study, however, because the active ribozyme rapidly converts to product. Here, we describe the synthesis of a photocaged nucleotide that releases guanosine within microseconds upon photosolvolysis with blue light. Application of this tool to O. sativa twister achieved the spatial (75 μm) and temporal (â‰?0 ms) control required to resolve folding and self-cleavage events when combined with single-mol. fluorescence detection of the ribozyme folding pathway. Real-time observation of single ribozymes after photo-deprotection showed that the precleaved folded state is unstable and quickly unfolds if the RNA does not react. Kinetic anal. showed that Mg2+ and Mn2+ ions increase ribozyme efficiency by making transitions to the high energy active conformation more probable, rather than by stabilizing the folded ground state or the cleaved product. This tool for light-controlled single RNA folding should offer precise and rapid control of other nucleic acid systems.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 61874-04-2. 61874-04-2 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester,Aldehyde, name is Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, and the molecular formula is C10H10O4, Safety of Methyl 2-(3-formyl-4-hydroxyphenyl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wagener, Tobias published the artcileSynthesis of Saturated N-Heterocycles via a Catalytic Hydrogenation Cascade, COA of Formula: C10H10O4, the publication is Advanced Synthesis & Catalysis, database is CAplus.

Herein, a one-pot protocol for the synthesis of octahydroindoles I [R¹ = H, 3-Me, 6-CF₃, etc.], decahydroquinolines II [R² = H, 7-Me, 6-Et, etc.] and octahydroindolizine III•TsOH through a cascade reaction was presented.

Advanced Synthesis & Catalysis published new progress about 61874-04-2. 61874-04-2 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester,Aldehyde, name is Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, and the molecular formula is C9H8O4, COA of Formula: C10H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Jen, Timothy published the artcileAdrenergic agents. 8. Synthesis and β-adrenergic agonist activity of some 3-tert-butylamino-2-(substituted phenyl)-1-propanols, Recommanded Product: Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, the publication is Journal of Medicinal Chemistry (1977), 20(10), 1263-8, database is CAplus and MEDLINE.

Title compounds I-HCl [61874-10-0], II hemifumarate [63857-50-1], III-HCl [61874-03-1], IV hemifumarate [63857-52-3], and V-2HCl [61873-98-1] were prepared and tested in the spontaneously contracted guinea pig tracheal chain preparation and the spontaneously beating guinea pig right atria. The title phenylpropanolamine compounds were less potent in the tracheal chain preparation test than the analogous phenylethanolamine compounds The selectivity for tracheal vs. cardiac muscle of the phenylpropanolamines is greater than for isoproterenol, but less than for the phenylethanolamine analogs, in most cases. Structure-activity relations are discussed.

Journal of Medicinal Chemistry published new progress about 61874-04-2. 61874-04-2 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester,Aldehyde, name is Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, and the molecular formula is C10H10O4, Recommanded Product: Methyl 2-(3-formyl-4-hydroxyphenyl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hansen, Stinne W. published the artcileIdentification of a New Class of Selective Excitatory Amino Acid Transporter Subtype 1 (EAAT1) Inhibitors Followed by a Structure-Activity Relationship Study, Application of Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, the publication is Journal of Medicinal Chemistry (2016), 59(19), 8757-8770, database is CAplus and MEDLINE.

Screening of a small compound library at three excitatory amino acid transporter subtypes 1-3 (EAAT1-3) subtypes resulted in the identification of compound (I) that exhibited a distinct preference as an inhibitor at EAAT1 (IC₅₀ 20 μM) compared to EAAT2 and EAAT3 (IC₅₀ > 300 μM). This prompted us to subject I to an elaborate structure-activity-relationship study through the purchase and synthesis and subsequent pharmacol. characterization of a total of 36 analogs. Although this effort did not result in analogs with substantially improved inhibitory potencies at EAAT1 compared to that displayed by the hit, it provided a detailed insight into structural requirements for EAAT1 activity of this scaffold. The discovery of this new class of EAAT1-selective inhibitors not only supplements the currently available pharmacol. tools in the EAAT field, but also substantiates the notion that EAAT ligands not derived from α-amino acids hold considerable potential in terms of subtype-selective modulation.

Journal of Medicinal Chemistry published new progress about 61874-04-2. 61874-04-2 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester,Aldehyde, name is Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, and the molecular formula is C10H10O4, Application of Methyl 2-(3-formyl-4-hydroxyphenyl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Xiaohu published the artcilePhosphine-catalyzed sequential (2+3)/(2+4) annulation of γ-vinyl allenoates: access to the synthesis of chromeno[4,3-b]pyrroles, Recommanded Product: Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, the publication is Chemical Communications (Cambridge, United Kingdom) (2021), 57(77), 9934-9937, database is CAplus and MEDLINE.

A phosphine-catalyzed cascade (2+3)/(2+4) cyclization reaction of γ-vinyl allenoates I (R¹ = Me, Et, i-Pr, PhCH₂) with aldimine esters II (R² = 4-Me, 5-Et₂N, 6-F, 3,4-benzo, etc.; R³ = Me, Et, i-Pr) has been developed to provide a series of chromeno[4,3-b]pyrroles III that contain three contiguous stereogenic centers. The method gives good yields, excellent chemoselectivity and diastereoselectivity under mild conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 61874-04-2. 61874-04-2 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester,Aldehyde, name is Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, and the molecular formula is C10H10O4, Recommanded Product: Methyl 2-(3-formyl-4-hydroxyphenyl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Bosch, Joan published the artcileStereoselective Syntheses of the Antihistaminic Drug Olopatadine and Its E-Isomer, Application of Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, the publication is Journal of Organic Chemistry (2012), 77(14), 6340-6344, database is CAplus and MEDLINE.

Practical stereoselective synthetic routes to the antihistaminic drug olopatadine (I) and its E-isomer have been developed, the key steps being a trans stereoselective Wittig olefination using a nonstabilized phosphorus ylide and a stereoselective Heck cyclization. The stereoselectivity of the Wittig reaction depends on both the phosphonium salt anion and the cation present in the base used to generate the ylide.

Journal of Organic Chemistry published new progress about 61874-04-2. 61874-04-2 belongs to esters-buliding-blocks, auxiliary class Benzene,Phenol,Ester,Aldehyde, name is Methyl 2-(3-formyl-4-hydroxyphenyl)acetate, and the molecular formula is C10H10O4, Application of Methyl 2-(3-formyl-4-hydroxyphenyl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics