Category: 617-55-0

Wang, Xiaoqin; Zhu, Derong; He, Minghua published the artcile< Study on synthesis of drug intermediates (S)-3-hydroxytetrahydrofuran>, Computed Properties of 617-55-0, the main research area is hydroxytetrahydrofuran synthesis malic acid drug intermediate esterification reduction cyclization.

(S)-3-hydroxytetrahydrofuran was synthesized from L-malic acid by esterification, reduction, and cyclization. The chem. structure of the target compound was identified by element anal., IR, NMR and MS spectra. The total yield and the purity of the product were 41% and 99.2%, and the optical purity was 95.8%. This optimal synthetic procedure with lower cost and mild reaction conditions is worthy to have a further pilot manufacture

Huaxue Yanjiu Yu Yingyong published new progress about Cyclization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Computed Properties of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Critcher, Douglas J.; Connolly, Stephen; Mahon, Mary F.; Wills, Martin published the artcile< Synthesis and x-ray crystallographic structure of the right-hand hemisphere of halicholactone and neohalicholactone>, Synthetic Route of 617-55-0, the main research area is halicholactone cyclopropyl lactone preparation crystal structure; neohalicholactone cyclopropyl lactone preparation crystal structure; crystal structure halicholactone cyclopropyl lactone.

The synthesis and X-ray crystallog. structure of the right-hand hemisphere, cyclopropyl lactone I, of the marine natural products halicholactone and neohalicholactone, which contains a nine-membered lactone and cyclopropane ring, is reported.

Journal of the Chemical Society, Chemical Communications published new progress about Crystal structure. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wroblewski, A. E.; Applequist, J.; Takaya, A.; Honzatko, R.; Kim, S. S.; Jacobson, R. A.; Reitsma, B. H.; Yeung, E. S.; Verkade, J. G. published the artcile< Experimental and theoretical study of the structures and optical rotations of chiral bicyclic ortho esters>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is chiral bicyclic ortho ester preparation; optical rotation chiral trioxabicyclooctane preparation; crystal structure chiral trioxabicyclooctane; mol structure chiral trioxabicyclooctane; induced dipole moment chiral trioxabicyclooctane; asym synthesis bicyclic ortho ester; classical dipole interaction theory trioxabicyclooctane.

Three rigid (-)-1-R-2,7,8-trioxabicyclo[3.2.1]octanes I [R = H (II), Me (III), Ph (IV)] were prepared in high enantiomeric purity from (S)-1,2,4-butanetriol and RC(OMe)3 (same R). The structure of (-)-IV was determined by x-ray crystallog. From the crystallog. data, 4 refined structural models of IV were generated, which differed only in their degree of geometric optimization. Whereas one model is unrestrained, the other models are increasingly restrained to ideal geometry in order to correct the systematically short bonds associated with an unrestrained refinement. Molar rotations were calculated from classical dipole interaction theory with the structural parameters from the 4 models of IV and atom polarizabilities derived earlier. The calculated molar rotations from IV were correct in sign and insensitive to rotations of the Ph group about the C-C bond. The differences between the calculated values and the exptl. rotation decreased to within a factor of 4 concomitantly with the increased level of geometric optimization of the models. The difference between the theor. and exptl. values is attributable to small uncertainties in atom coordinates and atom polarizabilities. Similar results were obtained for II and III with the structural models obtained for IV. The identical signs and similar magnitudes of rotations for II-IV stem primarily from the chiral gauche arrangement of the butane fragment.

Journal of the American Chemical Society published new progress about Crystal structure. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Valeev, R. F.; Davletbaev, A. M.; Talipov, R. F.; Miftakhov, M. S. published the artcile< Synthesis of a chiral building block for the C6-C9fragment of epothilones>, HPLC of Formula: 617-55-0, the main research area is dimethyl trimethylsilyl butynyl dioxolane diastereoselective epothilone preparation.

A procedure for the synthesis of 1,3-dioxolane I was developed via multistep reaction sequence starting from L-malic acid. Compound I could be employed as a chiral building block in the construction of C6-C9 fragment of epothilone analogs. Diastereoselective preparation of dimethyl[(trimethylsilyl)butynyl]dioxolane as chiral building block for epothilone analogs.

Russian Journal of Organic Chemistry published new progress about Acetalization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, HPLC of Formula: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Henrot, Serge; Larcheveque, Marc; Petit, Yves published the artcile< Amino acids as chiral synthons: preparation of enantiomerically pure (R)- and (S)-malic acids and its application to the synthesis of 3-hydroxy-4-butanolide>, Related Products of 617-55-0, the main research area is aspartic acid deamination nitrous acid; malic acid conversion hydroxybutanolide; enantiomeric purity hydroxybutanolide malic acid; amino acid chiral synthon.

Nitrous acid deamination of (S)-aspartic acid gave (S)-malic acid, which dissolved in AcCl to give anhydride I. Reaction of I with MeOH gave the half ester which was chemoselectively reduced by borohydride to hydroxybutanolide II of high optical purity.

Synthetic Communications published new progress about Chiral synthons. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Related Products of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thi Ngo, Men; Han, Jae Woo; Van Nguyen, Minh; Le Dang, Quang; Kim, Hun; Choi, Gyung Ja published the artcile< Antifungal properties of natural products from Pterocarya tonkinensis against phytopathogenic fungi>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is Pterocarya antifungal phytopathogenic fungus.

The objectives of this article were (i) to isolate and identify the antifungal substances from the Pterocarya tonkinensis extract based on a bioassay-guided fractionation and (ii) to investigate their potential as a biocontrol agent with their antifungal activities in vitro and in vivo. Eighteen compounds were identified from methanol extract of Pterocarya tonkinensis, including two new natural products 1 and 2: 1, pterocaryalactone; 2, pterocaryafuranone; 3, (1S, 6R)-9-hydroxymegastigm-7-en-3-one; 4, (S)-di-Me malate; 5, α-linolenic acid; 6-8, α-tetralones; 9, (R)-methyl-2-hydroxyl-3-phenyl-propanoate; 10, (E)-4-hydroxycinnamic acid Me ester; 11-14, diarylheptanoids, and 15-18, pentacyclic triterpenoids. Based on results of in vitro antifungal assay, Magnaporthe oryzae and Phytophthora infestans were most sensitive to isolated compounds among tested phytopathogenic fungi. When ten active compounds were applied onto plants at concentration of 100 or 500 μg mL-1, compounds 1 and 8 effectively suppressed rice blast disease, and compounds 15 and 16 not only strongly reduced development of blast on rice but also effectively controlled the development of late blight on tomatoes. This is first report to evaluate the in vitro and in vivo antifungal activities of the isolated compounds from a methanol extract of Pterocarya tonkinensis against phytopathogenic fungi, and our results suggest that Pterocarya tonkinensis and its substances can be used as source to develop natural fungicides.

Pest Management Science published new progress about Alternaria brassicicola. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zampella, Angela; Bassarello, Carla; Bifulco, Giuseppe; Gomez-Paloma, Luigi; D’Auria, Maria Valeria published the artcile< Stereochemistry of sphinxolides and reidispongiolides. Asymmetric synthesis of the C17-C22 fragment of reidispongiolide A>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is reidispongiolide absolute stereochem fragment preparation ozonolysis; asym synthesis hexanetetraol derivative.

Five fragments, [I (R = α, β-OH), II, III (R = α, β-OH)] embedding all the stereogenic centers of reidispongiolide A (IV), have been prepared by a controlled ozonolysis of the IV. The absolute stereochem. of the asym. centers of II, corresponding to the C17-C22 portion of IV, was determined by enantioselective synthesis and application of the advanced Mosher method.

European Journal of Organic Chemistry published new progress about Absolute configuration. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Frelek, Jadwiga; Geiger, Marcela; Voelter, Wolfgang published the artcile< Absolute configurational assignment of α-hydroxy acids and α-hydroxy esters from their Cupra A circular dichroism spectra>, Formula: C6H10O5, the main research area is chiral alpha hydroxy acid absolute configuration Cotton effect; CD spectra Cupra A hydroxy acid chiral complex.

The in situ formed complexes of cuprammonium solution (Cupra A) with optically active α-hydroxy acids and α-hydroxy esters show CD spectra suitable for determination of the absolute configuration of both groups of compounds In the long wavelength spectral region, compounds of R configuration at the α carbon atom display a pos. Cotton effect of around 600 nm and a neg. one at ca. 720 nm, whereas (S)-α-hydroxy acids and esters exhibit neg. and pos. Cotton effects, resp., in the same spectral range.

Tetrahedron: Asymmetry published new progress about Absolute configuration. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Xiaoqin; Zhu, Derong; He, Minghua published the artcile< Study on synthesis of drug intermediates (S)-3-hydroxytetrahydrofuran>, Computed Properties of 617-55-0, the main research area is hydroxytetrahydrofuran synthesis malic acid drug intermediate esterification reduction cyclization.

(S)-3-hydroxytetrahydrofuran was synthesized from L-malic acid by esterification, reduction, and cyclization. The chem. structure of the target compound was identified by element anal., IR, NMR and MS spectra. The total yield and the purity of the product were 41% and 99.2%, and the optical purity was 95.8%. This optimal synthetic procedure with lower cost and mild reaction conditions is worthy to have a further pilot manufacture

Huaxue Yanjiu Yu Yingyong published new progress about Cyclization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Computed Properties of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Critcher, Douglas J.; Connolly, Stephen; Mahon, Mary F.; Wills, Martin published the artcile< Synthesis and x-ray crystallographic structure of the right-hand hemisphere of halicholactone and neohalicholactone>, Synthetic Route of 617-55-0, the main research area is halicholactone cyclopropyl lactone preparation crystal structure; neohalicholactone cyclopropyl lactone preparation crystal structure; crystal structure halicholactone cyclopropyl lactone.

The synthesis and X-ray crystallog. structure of the right-hand hemisphere, cyclopropyl lactone I, of the marine natural products halicholactone and neohalicholactone, which contains a nine-membered lactone and cyclopropane ring, is reported.

Journal of the Chemical Society, Chemical Communications published new progress about Crystal structure. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics