Category: 617-55-0

Zhang, Chunying; Ishige, Ryohei; Yasumatsu, Ryou; Kang, Sungmin; Tokita, Masatoshi; Watanabe, Junji published the artcile< Regular undulation and polarization modulation on the film surface of a planarly aligned SmC* polymer>, Product Details of C6H10O5, the main research area is smectic C polymer regular undulation polarization modulation planarly aligned.

Chiral smectic C (SmC*) in a main-chain type of polymer exhibits undulations on its glassy film surface; these undulations are produced by the helical assembly of polymer conforming to the helical field of SmC*. In this study, we have found a polarization modulation superimposed on the undulation from the combined observations of Kelvin force microscopy (KFM) and at. force microscopy (AFM) images. This modulation is caused by the spontaneous polarization of each smectic layer; its direction is parallel to the layer and perpendicular to the tilt direction of mols. within a layer, and rotates around the helical axis. The polarization modulation length corresponds perfectly to the undulation length, i.e., helical pitch of SmC*. By clarifying the relative direction of the spontaneous polarization to the tilt direction of mesogens, we described how the polymers are accommodated to produce such a regular undulation and polarization modulation.

Soft Matter published new progress about Electrooptical switches. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Product Details of C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Meyhoff, Ulrich; Riber, Ulla; Boas, Ulrik published the artcile< Convergent synthesis of degradable dendrons based on L-malic acid>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is polyester dendrimer degradable dendron malic acid convergent preparation.

New degradable polyester dendrons based on the cellular tricarboxylic acid cycle component L-malic acid were synthesized up to the third generation by convergent synthesis. The dendron wedges could be introduced in a stepwise, highly regioselective fashion. HMBC-NMR revealed that the C1-carbonyl on malic acid was exclusively esterified, before the reaction of the second dendron wedge at C4 took place. Degradation studies on a first generation dendron analyzed by HPLC showed that hydrolytic degradation of the dendron most profoundly takes place at pH 4 and pH 9 with the highest degradation rate at alk. pH. NMR shows that the dendron degrades to malic acid and fumaric acid derivatives Preliminary studies performed in the cell culture show low toxicity of the dendrons in concentrations of up to 50 μg mL-1.

New Journal of Chemistry published new progress about Biodegradable medical goods. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thomas, Eric J.; Williams, Andrew C. published the artcile< A stereoselective approach to the δ-lactone fragment of the lankacidin antibiotics>, Application In Synthesis of 617-55-0, the main research area is lankacidin lactone fragment stereoselective preparation.

The lactone fragment I of the lankacidins was prepared from dibenzyl aspartate via the azetidinones II (R = SiMe2CMe3, COEt, R1 = R2 = H, R3 = SiMe2CMe3, CH2OCH2Ph). II (R = R3= SiMe2CMe3, R1 = Me, R2 = OCH2OCH2Ph) was similarly prepared

Journal of the Chemical Society, Chemical Communications published new progress about 617-55-0. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dahlgren, Anders; Johansson, Per-Ola; Kvarnstrom, Ingemar; Musil, Djordje; Nilsson, Ingemar; Samuelsson, Bertil published the artcile< Novel Morpholinone-Based D-Phe-Pro-Arg Mimics as Potential Thrombin Inhibitors: Design, Synthesis, and X-ray Crystal Structure of an Enzyme Inhibitor Complex>, Synthetic Route of 617-55-0, the main research area is morpholinone tripeptide analog preparation thrombin inhibitor MSBAR; reductive amination ring closure preparation morpholinone tripeptide thrombin inhibitor; crystal structure thrombin morpholinone tripeptide inhibitor.

A morpholinone structural motif derived from D(+)- and L(-)-malic acid has been used as a mimic of D-Phe-Pro in the thrombin inhibiting tripeptide D-Phe-Pro-Arg. In place of Arg the more rigid P1 truncated p-amidinobenzylamine (Pab) or 2-amino-5-aminomethyl-3-methyl-pyridine have been utilized. The synthetic strategy developed readily delivers these novel thrombin inhibitors used to probe the α-thrombin inhibitor binding site. The best candidate (I) in this series of thrombin inhibitors exhibits an in vitro IC50 of 720 nM.3. The X-ray crystal structure of I co-crystallized with α-thrombin is discussed.

Bioorganic & Medicinal Chemistry published new progress about Crystal structure. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Delso, Ignacio; Marca, Eduardo; Mannucci, Vanni; Tejero, Tomas; Goti, Andrea; Merino, Pedro published the artcile< Tunable Diastereoselection of Biased Rigid Systems by Lewis Acid Induced Conformational Effects: A Rationalization of the Vinylation of Cyclic Nitrones En Route to Polyhydroxylated Pyrrolidines>, Application In Synthesis of 617-55-0, the main research area is tunable diastereoselective vinylation cyclic nitrone Lewis acid conformational effect; pyrrolidine polyhydroxylated diastereoselective preparation.

The diastereofacial selection in addition reactions to biased rigid systems can be modulated by the action of Lewis acids. As an example, the stereoselectivity of the nucleophilic addition of vinylmagnesium bromide (VMB) to cyclic nitrones in the presence of diethylaluminum chloride (DEAC) shows a strong dependence on the temperature and the carbon substituent adjacent at the reaction center; it is remarkable that whereas a high selectivity is obtained at higher temperatures, in the presence of DEAC, a trend to invert the stereochem. course of the reaction is observed at lower temperatures, provided the substituent at C3 of the pyrrolidine ring allows delivery of the vinyl moiety. This behavior and difference in selectivity is to be attributed to the high conformational barriers of the intermediate nitrone-DEAC-VMB complex. A clear inversion of the selectivity is observed at -78 °C for the reaction of the nitrone protected as an O-Me derivative The present study provides a rationalization for the stereocontrolled addition of nucleophiles to rigid systems (cyclic nitrones).

Chemistry – A European Journal published new progress about Conformational barrier (of nitrone-Grignard-Al complex). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bloomer, James L.; Kappler, Francis E. published the artcile< Total synthesis of a α-carboxymethyltetronic acid. (S)-Carlosic acid>, HPLC of Formula: 617-55-0, the main research area is carlosic acid; tetronic acid mold.

The total synthesis of a naturally occurring mold tetronic acid (I) with correct absolute configuration is described, as well as a possible biogenetic precursor for the entire family.

Journal of Organic Chemistry published new progress about 617-55-0. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, HPLC of Formula: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Henrot, Serge; Larcheveque, Marc; Petit, Yves published the artcile< Amino acids as chiral synthons: preparation of enantiomerically pure (R)- and (S)-malic acids and its application to the synthesis of 3-hydroxy-4-butanolide>, Related Products of 617-55-0, the main research area is aspartic acid deamination nitrous acid; malic acid conversion hydroxybutanolide; enantiomeric purity hydroxybutanolide malic acid; amino acid chiral synthon.

Nitrous acid deamination of (S)-aspartic acid gave (S)-malic acid, which dissolved in AcCl to give anhydride I. Reaction of I with MeOH gave the half ester which was chemoselectively reduced by borohydride to hydroxybutanolide II of high optical purity.

Synthetic Communications published new progress about Chiral synthons. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Related Products of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Thi Ngo, Men; Han, Jae Woo; Van Nguyen, Minh; Le Dang, Quang; Kim, Hun; Choi, Gyung Ja published the artcile< Antifungal properties of natural products from Pterocarya tonkinensis against phytopathogenic fungi>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is Pterocarya antifungal phytopathogenic fungus.

The objectives of this article were (i) to isolate and identify the antifungal substances from the Pterocarya tonkinensis extract based on a bioassay-guided fractionation and (ii) to investigate their potential as a biocontrol agent with their antifungal activities in vitro and in vivo. Eighteen compounds were identified from methanol extract of Pterocarya tonkinensis, including two new natural products 1 and 2: 1, pterocaryalactone; 2, pterocaryafuranone; 3, (1S, 6R)-9-hydroxymegastigm-7-en-3-one; 4, (S)-di-Me malate; 5, α-linolenic acid; 6-8, α-tetralones; 9, (R)-methyl-2-hydroxyl-3-phenyl-propanoate; 10, (E)-4-hydroxycinnamic acid Me ester; 11-14, diarylheptanoids, and 15-18, pentacyclic triterpenoids. Based on results of in vitro antifungal assay, Magnaporthe oryzae and Phytophthora infestans were most sensitive to isolated compounds among tested phytopathogenic fungi. When ten active compounds were applied onto plants at concentration of 100 or 500 μg mL-1, compounds 1 and 8 effectively suppressed rice blast disease, and compounds 15 and 16 not only strongly reduced development of blast on rice but also effectively controlled the development of late blight on tomatoes. This is first report to evaluate the in vitro and in vivo antifungal activities of the isolated compounds from a methanol extract of Pterocarya tonkinensis against phytopathogenic fungi, and our results suggest that Pterocarya tonkinensis and its substances can be used as source to develop natural fungicides.

Pest Management Science published new progress about Alternaria brassicicola. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zampella, Angela; Bassarello, Carla; Bifulco, Giuseppe; Gomez-Paloma, Luigi; D’Auria, Maria Valeria published the artcile< Stereochemistry of sphinxolides and reidispongiolides. Asymmetric synthesis of the C17-C22 fragment of reidispongiolide A>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is reidispongiolide absolute stereochem fragment preparation ozonolysis; asym synthesis hexanetetraol derivative.

Five fragments, [I (R = α, β-OH), II, III (R = α, β-OH)] embedding all the stereogenic centers of reidispongiolide A (IV), have been prepared by a controlled ozonolysis of the IV. The absolute stereochem. of the asym. centers of II, corresponding to the C17-C22 portion of IV, was determined by enantioselective synthesis and application of the advanced Mosher method.

European Journal of Organic Chemistry published new progress about Absolute configuration. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Frelek, Jadwiga; Geiger, Marcela; Voelter, Wolfgang published the artcile< Absolute configurational assignment of α-hydroxy acids and α-hydroxy esters from their Cupra A circular dichroism spectra>, Formula: C6H10O5, the main research area is chiral alpha hydroxy acid absolute configuration Cotton effect; CD spectra Cupra A hydroxy acid chiral complex.

The in situ formed complexes of cuprammonium solution (Cupra A) with optically active α-hydroxy acids and α-hydroxy esters show CD spectra suitable for determination of the absolute configuration of both groups of compounds In the long wavelength spectral region, compounds of R configuration at the α carbon atom display a pos. Cotton effect of around 600 nm and a neg. one at ca. 720 nm, whereas (S)-α-hydroxy acids and esters exhibit neg. and pos. Cotton effects, resp., in the same spectral range.

Tetrahedron: Asymmetry published new progress about Absolute configuration. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Formula: C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics