Category: 617-55-0

Listowsky, Irving; Avigad, Gad; Englard, Sasha published the artcile< Conformational equilibria and stereochemical relations among carboxylic acids>, HPLC of Formula: 617-55-0, the main research area is acyclic acid conformation; conformation acyclic acid; circular dichroism acyclic acid.

The CO spectra of certain acyclic carboxylic acids were surveyed in an effort to study their conformation in solution In aqueous solution the spectra of many α-hydroxy acids were characterized by two overlapping ellipticity bands; a weak one in the 240-mμ spectral region and a more intense one of opposite sign near 210 mμ. At elevated temperatures or in solvents of low dielec. constant, the band of longer wavelength increased in intensity with an attendant decrease in the short-wavelength band. These properties are compatible with the presence of two structural species in equilibrium, and could be related to the contributions of specific rotational isomers of the acids. Conformations with the hydroxyl and carbonyl groups in an eclipsed alignment are designated as preferred. In contrast to the α-hydroxy acids, carboxylic acids with α-alkyl substituents generally showed only a single dichroic band centered near 210 mμ. In general, coplanarity of the carboxyl group and α-substituents was assumed, and interpretations in terms of the preferred orientation of substituents adjacent to the carboxyl group are suggested. The proposed population of rotational isomers was consistent with the observed effects of solvent polarity, temperature, polarity of substituents, and predicted steric interactions. An empirical rule relating the sign of ellipticity and the conformation of these classes of carboxylic acids was applied.

Journal of Organic Chemistry published new progress about Acids Role: PRP (Properties). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, HPLC of Formula: 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Muraoka, Osamu; Toyooka, Naoki; Ohshima, Yumiko; Narita, Norihiko; Momose, Takefumi published the artcile< Synthesis of natural (S)-(-)-tulipalin B starting from L-malic acid as a chiral pool>, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate, the main research area is tulipalin B total synthesis enantioselectivity; malic acid chiral synthon tulipalin B.

Naturally occurring tulipalin B (I) was prepared enantioselectively from chiral synthon L-malic acid (II) in 15% yield.

Heterocycles published new progress about Chiral synthons. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Recommanded Product: (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Regano, Celia; Alla, Abdellilah; De Ilarduya, Antxon Martinez; Munoz-Guerra, Sebastian published the artcile< Linear polyamides from L-malic acid and alkanediamines>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is malic acid linear polyamide synthesis optical thermal mech property.

A series of linear polyamides (PnMLM) derived from O-methyl-protected L-malic acid and 1,n-alkanediamines with even n values ranging from 4 to 12 were prepared and fully characterized. L-Malic acid entered in the chain with a random orientation rendering essentially aregic polymers. PnMLM displayed optical rotation consistent with the content of the polymer in malic units, and they all were crystalline with m.ps. ranging from 158 to 188 °C and glass-transition temperatures varying from 37 to 70 °C. PnMLM appeared to be fairly stable to heat with thermal decomposition starting close to 300 °C. Hydrolytic degradation of PnMLM at 37 °C was slow, but the process was significantly faster at 70 °C. Thermal degradation took place with the formation of cyclic malimides in the residual polymer and released the 1,n-alkanediamine. However, hydrolytic degradation took place in a first stage with the formation of open chains of carboxylic- and amine-ended oligomers.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about Hydrolytic polymer degradation. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Bertus, Philippe; Zhang, Jing-Heng; Sir, Geoffroy; Weibel, Jean-Marc; Pale, Patrick published the artcile< Asymmetric synthesis of the cyclopentanones related to NCS and N1999A2 antitumor antibiotics>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is hydroxylated cyclopentanone Bestmann cyclization preparation; NCS N1999A2 hydroxylated cyclopentanone core preparation.

Optically pure protected mono- or dihydroxylated cyclopentanones, precursors for the core of the antitumor antibiotics NCS and N1999A2 were obtained in six to eight steps via a key Bestmann cyclization with excellent overall yields (up to 52%).

Tetrahedron Letters published new progress about Cyclization. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wada, Kojiro; Ishida, Tatsuyoshi published the artcile< A steroid hydroxylase inhibitor, diplodialide A, and related metabolites from Diplodia pinea>, Electric Literature of 617-55-0, the main research area is diplodialide Diplodia lactone structure; steroid hydroxylase inhibition diplodialide.

The structures of diplodialide A (I; RR1 = O), B (I; R = OH, R1 = H), C (II), and D (III) from Diplodia pinea were determined from chem. and spectral data.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Diplodia pinea. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Electric Literature of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jain, R.; Sundram, A.; Lopez, S.; Neckermann, G.; Wu, C.; Hackbarth, C.; Chen, D.; Wang, W.; Ryder, N. S.; Weidmann, B.; Patel, D.; Trias, J.; White, R.; Yuan, Z. published the artcile< α-Substituted hydroxamic acids as novel bacterial deformylase inhibitor-based antibacterial agents. [Erratum to document cited in CA140:128630]>, Synthetic Route of 617-55-0, the main research area is erratum hydroxamic acid preparation bacterial deformylase inhibitor antibacterial agent; proline hydroxamic preparation bacterial deformylase inhibitor antibacterial agent erratum.

The corrected version of Table 2 is given.

Bioorganic & Medicinal Chemistry Letters published new progress about Antibacterial agents. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Synthetic Route of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Papageorgiou, Christos; Benezra, Claude published the artcile< Synthesis of potentially allergenic chiral α-(hydroxyalkyl)acrylates>, Category: esters-buliding-blocks, the main research area is asym synthesis hydroxylalkylacrylate; acrylate hydroxyalkyl asym synthesis; sulfoxide optically active asym induction.

Treating (R)- or (S)-4-MeC6H4S(O)CHMeCO2CMe3 with Me3CMgBr and aldehydes RCH2CHO (R = Me, Bu, octyl), followed by thermal elimination, gave title compounds (R)- or (S)-Me3CO2CC(:CH2)CH(OH)CHR, resp., in 75% enantiomeric excess.

Tetrahedron Letters published new progress about Esters Role: SPN (Synthetic Preparation), PREP (Preparation). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Papageorgiou, Christos; Benezra, Claude published the artcile< Use of enzymic hydrolysis of dimethyl malates for a short synthesis of tulipalin B and of its enantiomer>, Safety of (S)-Dimethyl 2-hydroxysuccinate, the main research area is dimethyl malate regiochem esterase hydrolysis; tulipalin B.

Pig liver esterase hydrolyzes the ester function α to the hydroxyl group in di-Me malate. This regiospecific reaction was used to synthesize (+)- and (-)-tulipalin B.

Journal of Organic Chemistry published new progress about Regiochemistry. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Safety of (S)-Dimethyl 2-hydroxysuccinate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Griffiths, Jon-Paul; Nie, Hui; Brown, R. James; Day, Peter; Wallis, John D. published the artcile< Synthetic strategies to chiral organosulfur donors related to bis(ethylenedithio)tetrathiafulvalene>, Application In Synthesis of 617-55-0, the main research area is tetrathiafulvalene nonracemic preparation oxidation potential; dithiolodithiinylidene dithiolodithiinacetate nonracemic preparation oxidation potential; spirodioxolanedithiolodithiepinylidene spirodioxolanedithiolodithiepine nonracemic preparation oxidation potential; cyclopropadithiolobenzodithiinylidene cyclopropadithiolobenzodithiin stereoselective nonracemic preparation oxidation potential; fused dithiolodithiin stereoselective nonracemic preparation crystal structure; stereoselective Diels Alder cycloaddition dithioletrithione alkene; mol crystal structure nonracemic fused dithiolodithiin; oxidation potential nonracemic tetrathiafulvalene.

Nonracemic tetrathiafulvalenes such as I, II, and III are prepared from nonracemic starting materials. Me (dithiolodithiinylidene)dithiolodithiinacetate I is prepared in six steps from di-Me malate using a double nucleophilic substitution reaction with a dithiolethionedithiolate as the key step. (spirodioxolanedithiolodithiepinylidene)spirodioxolanedithiolodithiepine II is prepared in four steps from trans-stilbene and a thioxodithiolodithiepinone using a ketalization reaction to incorporate absolute stereochem. into the tetrathiafulvalene system. (cyclopropadithiolobenzodithiinylidene)cyclopropadithiolobenzodithiin III (and its double bond stereoisomer) are prepared in three steps from (+)-2-carene using the stereoselective Diels-Alder cycloaddition with dithioletrione IV as the key step. Other nonracemic alkenes undergo stereoselective Diels-Alder reactions with IV to yield nonracemic fused dithiolodithiins. The oxidation potentials of I, II, and III and related tetrathiafulvalenes are determined; the oxidation potential of III differs from that of related racemic compounds The crystal structures of fused dithiolethiones generated by Diels-Alder cycloaddition of (-)-α-pinene, (-)-β-pinene, and (+)-2-carene with IV are determined by X-ray crystallog. and discussed.

Organic & Biomolecular Chemistry published new progress about Alkenes Role: RCT (Reactant), RACT (Reactant or Reagent). 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application In Synthesis of 617-55-0.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Phukan, Prodeep published the artcile< Iodine as an extremely powerful catalyst for the acetylation of alcohols under solvent-free conditions>, Application of C6H10O5, the main research area is alc acetylation acetic anhydride solvent free; acetate preparation.

Iodine was found to promote quant. acetylation of alcs. in a very short time with an equimolar amount of acetic anhydride under solvent-free conditions at room temperature

Tetrahedron Letters published new progress about Acetylation. 617-55-0 belongs to class esters-buliding-blocks, and the molecular formula is C6H10O5, Application of C6H10O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics