Category: 617-52-7

Gao, Yu published the artcileOrganic glass with superior optical properties based on dimethyl itaconate and diethyl itaconate, Quality Control of 617-52-7, the publication is Polymer Testing (2021), 107363, database is CAplus.

High light transmittance material was synthesized by di-Me itaconic acid and di-Et itaconic acid via piecewise bulk polymerization, using benzoyl peroxide (BPO) as catalyst. Its chem. structure was characterized by gel permeation chromatog. (GPC), NMR spectroscopy (NMR) and fourier transform IR spectroscopy (FTIR). The thermal performance of polymer was characterized by differential scanning calorimetry (DSC) and thermogravimetric anal. (TGA), showing its glass transition temperature (T_g) was between 52° and 72°, thermal decomposition temperature above 230°, suitable for processing. The transmittance of the polymer is as high as 92% and d. of 1.1 g/cm³, which has the optical device application potential. The authors also tested the hydrophilicity of the material surface by the contact angle test, combined with the data of simulated calculation to explore the influence factors of hydrophilic change on the material surface.

Polymer Testing published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Quality Control of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wu, Di published the artcile4D Printing of a Fully Biobased Shape Memory Copolyester via a UV-Assisted FDM Strategy, Application of Dimethyl itaconate, the publication is ACS Sustainable Chemistry & Engineering (2022), 10(19), 6304-6312, database is CAplus.

The emergence of 4D-printing technol. provides a new opportunity for the development of shape memory polymers (SMPs) with sophisticated or individualized architectures in the most material-saving way. Fused deposition modeling (FDM) has been regarded as a feasible and facile printing technol. to print thermoplastics, but the low adhesion between interlayers of the obtained objects is an unavoidable problem caused by its printing principle. Fortunately, abundant biobased chems. with a variety of reactive groups make it easy to design ecofriendly linear SMPs with active sites, which are ready for in situ reactions during FDM printing. Herein, we developed fully biobased shape memory copolyesters (PBSe-co-PBIs) by polycondensation of di-Me itaconate, di-Me sebacate, and 1,4-butanediol. The flexible and crystalline PBSe may serve as a mol. switch to ensure the desirable shape memory effect (SME) of the materials, and the PBI moiety with double bonds forming crosslinking points between layers during the printing process under UV irradiation acts as net points for SMPs and enhances interlayer adhesion. The shape memory performance and the enhanced interlayer adhesion of printed materials by this strategy were verified by DMA anal. and tensile tests. Finally, a 4D-printed “Sanxingdui bronze mask” and an overheating protection cover were demonstrated, which indicated a great potential in high-temperature protection devices.

ACS Sustainable Chemistry & Engineering published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C18H35NO, Application of Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Park, Seung Yeon published the artcileDimethyl itaconate attenuates palmitate-induced insulin resistance in skeletal muscle cells through the AMPK/FGF21/PPARδ-mediated suppression of inflammation, Application In Synthesis of 617-52-7, the publication is Life Sciences (2021), 120129, database is CAplus and MEDLINE.

Itaconate (ITA), a derivative of the tricarboxylic acid cycle, has been documented to have a direct antimicrobial effect by inhibiting isocitrate lyase and suppressing proinflammatory cytokines in LPS-treated macrophages. However, the effects of di-Me ITA (DITA), a membrane-permeable derivative of ITA, on insulin signaling and inflammation in skeletal muscle in an obese state remain to be elucidated. Thus, this study was designed to investigate the effects of DITA on the impairment of insulin signaling and inflammation in palmitate-treated C2C12 myocytes. Western blotting was used to determine the expression of insulin signaling associated genes, inflammatory markers, fibroblast growth factor 21 (FGF21), and PPARδ expression, as well as AMPK phosphorylation in mouse skeletal muscle cells. Secreted proinflammatory cytokine levels were detected by ELISA. Insulin signaling was assessed by glucose uptake assay. Treating C2C12 myocytes with DITA attenuated palmitate-induced aggravation of insulin signaling markers, such as insulin receptor substrate-1 (IRS-1) and Akt phosphorylation and inflammatory markers, such as NFκB and IκB phosphorylation. AMPK phosphorylation, as well as PPARδ and myokine FGF21 expression, were enhanced in C2C12 myocytes by DITA treatment. siRNA-mediated suppression of AMPK or FGF21 expression abolished the effects of DITA on insulin resistance and inflammation in palmitate-treated C2C12 myocytes. In sum, DITA suppresses inflammation through the AMPK/FGF21/PPARδ signaling, thereby alleviating insulin resistance in palmitate-treated C2C12 myocytes. The current study appears to be an essential basis for performing animal experiments to develop insulin resistance therapeutics.

Life Sciences published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Application In Synthesis of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sen, Anirban published the artcileMechanistically Guided One Pot Synthesis of Phosphine-Phosphite and Its Implication in Asymmetric Hydrogenation, Related Products of esters-buliding-blocks, the publication is European Journal of Organic Chemistry (2022), 2022(2), e202101447, database is CAplus.

Although hybrid bidentate ligands are known to yield highly enantioselective products in asym. hydrogenation (AH), synthesis of these ligands is an arduous process. Herein, a one pot, atom-economic synthesis of a hybrid phosphine-phosphite (L1) is reported. After understanding the reactivity difference between an O-nucleophile vs. C-nucleophile, one pot synthesis of Senphos (L1) was achieved (72%). When L1 was treated with [Rh], ³¹P NMR revealed bidentate coordination to Rh. Senphos, in the presence of rhodium, catalyzes the AH of Methyl-2-acetamido-3-phenylacrylate and discloses an unprecedented turn over frequency of 2289, along with excellent enantio-selectivity (92%). The generality is demonstrated by hydrogenating an array of alkenes. The AH operates under mild conditions of 1-2 bar H₂ pressure, at room temperature The practical relevance of L1 is demonstrated by scaling-up the reaction to 1 g and by synthesizing DOPA, a drug widely employed for the treatment of Parkinson’s disease. Computational insights indicate that the R isomer is preferred by 3.8 kcal/mol over the S isomer.

European Journal of Organic Chemistry published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C12H15NO, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gautam, Anurag Kumar published the artcilePreclinical evaluation of dimethyl itaconate against hepatocellular carcinoma via activation of the e/iNOS-mediated NF-κB-dependent apoptotic pathway, COA of Formula: C7H10O4, the publication is Frontiers in Pharmacology (2021), 823285, database is CAplus and MEDLINE.

Hepatocellular carcinoma (HCC) is one of the most common tumors affecting a large population worldwide, with the fifth and seventh greatest mortality rates among men and women, resp., and the third prime cause of mortality among cancer victims. Di-Me itaconate (DI) has been reported to be efficacious in colorectal cancer by decreasing IL-1β release from intestinal epithelial cells. In this study, diethylnitrosamine (DEN)-induced HCC in male albino Wistar rats was treated with DI as an anticancer drug. The function and mol. mechanism of DI against HCC in vivo were assessed using histopathol., ELISA (ELISA), and Western blot studies. Metabolomics using 1H-NMR was used to investigate metabolic profiles. As per mol. insights, DI has the ability to trigger mitochondrial apoptosis through iNOS- and eNOS-induced activation of the NF-κB/Bcl-2 family of proteins, CytC, caspase-3, and caspase-9 signaling cascade. Serum metabolomics investigations using 1H-NMR revealed that aberrant metabolites in DEN-induced HCC rats were restored to normal following DI therapy. Furthermore, our data revealed that the DI worked as an anti-HCC agent. The anticancer activity of DI was shown to be equivalent to that of the com. chemotherapeutic drug 5-fluorouracil.

Frontiers in Pharmacology published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, COA of Formula: C7H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Mateliene, Lauryna published the artcileBenign Arylations of Dimethyl Itaconate via Heck-Matsuda Reaction Utilizing in-Situ Generated Palladium on Aluminum Oxide, Recommanded Product: Dimethyl itaconate, the publication is European Journal of Organic Chemistry (2020), 2020(1), 127-135, database is CAplus.

In situ generated palladium on aluminum oxide provides an active and efficient catalytic system for the preparation of arylmethylidene succinates using the Heck-Matsuda reaction. Beside the monoarylation the first examples of the biarylation of these monomers will be described.

European Journal of Organic Chemistry published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Recommanded Product: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Papadopoulos, Lazaros published the artcileStraightforward synthetic protocol to bio-based unsaturated poly(ester amide)s from itaconic acid with thixotropic behavior, Application In Synthesis of 617-52-7, the publication is Polymers (Basel, Switzerland) (2020), 12(4), 980, database is CAplus and MEDLINE.

In the field of polymer chem., tremendous efforts have been made over the last decade to replace petrochem. monomers with building blocks from renewable resources. In this respect, itaconic acid has been used as an alternative to acrylic acid or maleic acid in unsaturated polyesters for thermal or UV-curing applications. However, examples of poly(ester amide)s from itaconic acid are scarce. Under standard polycondensation reactions, the presence of free amines leads to aza-Michael addition reactions at the α,β-unsaturated double bond of the itaconic acid and isomerization reactions to mesaconic acid. Both reactions make the resulting materials useless as UV-curing polymer resins. To avoid these undesired side reactions, we herein report the use of preformed, well-defined diols containing internal amide bonds. The resulting unsaturated poly(ester amide) resins were analyzed before and after UV-induced crosslinking. Viscosity measurements revealed a strong thixotropic behavior induced by the amide groups, which is usually not detected in structurally similar polyester resins.

Polymers (Basel, Switzerland) published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Application In Synthesis of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ali, Mohammad Asif published the artcileHigh-Performance BioNylons from Itaconic and Amino Acids with Pepsin Degradability, SDS of cas: 617-52-7, the publication is Advanced Sustainable Systems (2022), 6(2), 2100052, database is CAplus.

The use of renewable feedstock for polymers has led to poor thermomech. properties with high production costs. Herein, the production of novel chiral dicarboxylic acids derived from renewable itaconic and amino acids (D- or L-leucine) is reported. In this study, rigid chiral heterocyclic dicarboxylic acid monomers are obtained with high purity from itaconic acid-derived di-Me itaconate as a starting material. Chirally interactive polyamides are prepared via melt polycondensation of hexamethylenediamine with heterocyclic diacid monomers. Further studies are conducted on D- or L-leucine-derived polyamides with homochirality that are fully amorphous. In contrast, the crystallization degree of the composite of D-leucine-derived polymer chains with L-leucine-derived chains increases to 36%, presumably due to enhanced interaction between polymer chains with different chiralities. The chirally-interacting composite shows a glass transition temperature, T_g, of approx. 117°C and a melting temperature, T_m, of approx. 213°C, which are higher than those of conventional polyamides such as polyamide 11 (T_g of approx. 57°C). The composite also shows high Young’s moduli, E, and mech. strengths σ, ranging from 2.2-3.8 GPa and 86-108 MPa, resp. In addition, the polyamides show degradability with a digestive enzyme, pepsin.

Advanced Sustainable Systems published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, SDS of cas: 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Nepal, Prabin published the artcilePolycationic Rh-JosiPhos Polymers Supported on Phosphotungstic Acid/Al₂O₃ by Multiple Electrostatic Attractions, Category: esters-buliding-blocks, the publication is ACS Catalysis (2022), 12(3), 2034-2044, database is CAplus.

Cationic Rh-JosiPhos complexes were tethered to crowded, ring-opening olefin metathesis (ROMP)-active norbornene groups. These monomers underwent facile, alternating ROMP (alt-ROMP) with cyclooctene as the co-monomer catalyzed by RuCl₂(:CHPh)(PCy₃)₂ to form linear, polycationic copolymers. The polymers were readily absorbed by phosphotungstic acid (PTA) on Al₂O₃ via multiple electrostatic attractions between the cationic Rh centers in the polymer and the PTA anions on the Al₂O₃ support. The enantioselective hydrogenation of di-Me itaconate occurred with 100% conversion, 5000 turnovers per run, with up to 96% ee, and without significant Rh leaching over 10 reuses of the catalyst.

ACS Catalysis published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Sheng published the artcileDimethyl Itaconate Alleviates the Inflammatory Responses of Macrophages in Sepsis, Safety of Dimethyl itaconate, the publication is Inflammation (2021), 44(2), 549-557, database is CAplus and MEDLINE.

Sepsis is an inflammatory disease characterized by dysregulation of inflammation. Macrophage-mediated inflammation has been implicated in the pathophysiol. of sepsis. Itaconate is a metabolite produced in activated macrophages which has anti-inflammatory activities. In the present study, we investigated the potential effects of a cell-permeable itaconate derivative di-Me itaconate on inflammation in sepsis. We established a lipopolysaccharide (LPS)-induced septic mouse model and administered di-Me itaconate to the septic mice. The survival rate, serum level of pro-inflammatory cytokines, and lung pathol. were evaluated. We also administered di-Me itaconate to LPS-treated bone marrow-derived macrophages (BMDMs), and measured the cytokine production and Nrf2 expression. We also evaluated the effects of di-Me itaconate on Nrf2-deficient mice. Administration of di-Me itaconate enhanced survival rate, decreased serum level of TNF-α and IL-6, and ameliorated lung injury in septic mice. Di-Me itaconate also suppressed LPS-induced production of TNF-α, IL-6, and NOS2 in BMDMs. Di-Me itaconate activated Nrf2 and promoted the expression of Nrf2 and its downstream factor HO-1 and NQO-1. The regulatory activities of di-Me itaconate on inflammatory cytokine production, mouse survival rate were abolished in septic Nrf2^-/- mice. Di-Me itaconate suppressed the inflammatory responses of macrophages in sepsis.

Inflammation published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C5H5NO3S, Safety of Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics