Category: 617-52-7

Chiloeches, A. published the artcileAntibacterial and compostable polymers derived from biobased itaconic acid as environmentally friendly additives for biopolymers, Application In Synthesis of 617-52-7, the publication is Polymer Testing (2022), 107541, database is CAplus.

In this work, a series of antibacterial cationic copolymers derived from bio-sourced itaconic acid was studied as potential biobased active components in biodegradable formulations based on poly(butylene adipate-co-terephthalate) (PBAT) for packaging applications. These copolymers were first characterized by testing their antimicrobial activity against resistant bacterial strains, their biodegradability in compost conditions, and their thermal properties by differential scanning calorimetry (DSC) and thermogravimetric anal. (TGA). The antibacterial properties showed potent activity against Methicillin-resistant Staphylococcus aureus (MRSA), with MIC values as low as 78μg mL^-1. Related to their biodegradability, the cationic polymers biodegraded fast under compost conditions and even a priming effect was observed in the compost. Thermal properties, characterized by DSC and TGA, showed that the copolymers thermally degraded at temperature relatively low; nevertheless, they are able to be processed at temperatures up to _~150°C. Subsequently, these antibacterial polymers were successfully blended as minor active component (10 wt%) with PBAT by melt-extrusion and press-compression molding. The resulting biopolymeric films exhibit potent antibacterial activity. Therefore, these antibacterial biobased polymers derived from itaconic acid seem to be good candidates for applications related to active food packaging or even for biomedical devices.

Polymer Testing published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Application In Synthesis of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Joseph Srinivasan, Shiny published the artcileE. coli Nickel-Iron Hydrogenase 1 Catalyses Non-native Reduction of Flavins: Demonstration for Alkene Hydrogenation by Old Yellow Enzyme Ene-reductases, HPLC of Formula: 617-52-7, the publication is Angewandte Chemie, International Edition (2021), 60(25), 13824-13828, database is CAplus and MEDLINE.

A new activity for the [NiFe] uptake hydrogenase 1 of Escherichia coli (Hyd1) is presented. Direct reduction of biol. flavin cofactors FMN and FAD is achieved using H₂ as a simple, completely atom-economical reductant. The robust nature of Hyd1 is exploited for flavin reduction across a broad range of temperatures (25-70°C) and extended reaction times. The utility of this system as a simple, easy to implement FMNH₂ or FADH₂ regenerating system is then demonstrated by supplying reduced flavin to Old Yellow Enzyme “ene-reductases” to support asym. alkene reductions with up to 100% conversion. Hyd1 turnover frequencies up to 20.4 min^-1 and total turnover numbers up to 20 200 were recorded during flavin recycling.

Angewandte Chemie, International Edition published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, HPLC of Formula: 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Vaghi, Luca published the artcilePHANE-TetraPHOS, the First D₂ Symmetric Chiral Tetraphosphane. Synthesis, Metal Complexation, and Application in Homogeneous Stereoselective Hydrogenation, HPLC of Formula: 617-52-7, the publication is European Journal of Organic Chemistry (2021), 2021(17), 2367-2374, database is CAplus.

PHANE-TetraPHOS, a new D₂ sym. tetraphosphane based on the [2.2]paracyclophane scaffold, was synthesized and characterized. The peculiarity of this system was the presence of four homotopic diphenylphosphane groups, exchangeable through C₂ symmetry operations and consequently indistinguishable. Their spatial arrangement allows the simultaneous complexation of two metal atoms. Enantiomeric purity were attained at tetra-phosphane oxide level by fractional crystallization of the diastereomeric adducts obtained from the racemate with enantiopure dibenzoyltartaric acids. Alk. treatment of diastereomerically pure adducts followed by exhaustive P-O groups reduction with HSiCl₃ gave both PHANE-TetraPHOS antipodes in an enantiopure state. They were tested as rhodium ligands in the homogeneous enantioselective hydrogenation of some benchmark unsaturated compounds Catalytic activity and enantiodiscrimination ability were found comparable to those exhibited by the complexes of the parent bidentate ligand PHANEPHOS, but only half a mole of precious chiral ligand were employed.

European Journal of Organic Chemistry published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C5H10N2OS, HPLC of Formula: 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Ondono, Raul published the artcileDesign of novel small molecule base-pair recognizers of toxic CUG RNA transcripts characteristics of DM1, Application of Dimethyl itaconate, the publication is Computational and Structural Biotechnology Journal (2021), 51-61, database is CAplus and MEDLINE.

Myotonic Dystrophy type 1 (DM1) is an incurable neuromuscular disorder caused by toxic DMPK transcripts that carry CUG repeat expansions in the 3′ untranslated region (3′UTR). The intrinsic complexity and lack of crystallog. data makes noncoding RNA regions challenging targets to study in the field of drug discovery. In DM1, toxic transcripts tend to stall in the nuclei forming complex inclusion bodies called foci and sequester many essential alternative splicing factors such as Muscleblind-like 1 (MBNL1). Most DM1 phenotypic features stem from the reduced availability of free MBNL1 and therefore many therapeutic efforts are focused on recovering its normal activity. For that purpose, herein we present pyrido[2,3-d]pyrimidin-7-(8H)-ones, a privileged scaffold showing remarkable biol. activity against many targets involved in human disorders including cancer and viral diseases. Their combination with a flexible linker meets the requirements to stabilize DM1 toxic transcripts, and therefore, enabling the release of MBNL1. Therefore, a set of novel pyrido[2,3-d]pyrimidin-7-(8H)-ones derivatives (1a-e) were obtained using click chem. 1a exerted over 20% MBNL1 recovery on DM1 toxic RNA activity in primary cell biol. studies using patient-derived myoblasts. 1a promising anti DM1 activity may lead to subsequent generations of ligands, highlighting a new affordable treatment against DM1.

Computational and Structural Biotechnology Journal published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Application of Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gu, Lingwen published the artcileDimethyl itaconate protects against fungal keratitis by activating the Nrf2/HO-1 signaling pathway, Quality Control of 617-52-7, the publication is Immunology & Cell Biology (2020), 98(3), 229-241, database is CAplus and MEDLINE.

Di-Me itaconate (DI) is a membrane-permeable itaconate derivative with anti-inflammatory functions. However, the anti-inflammatory effect of DI has never been studied in fungal keratitis. In this study, we tested the protective effect of DI against fungal keratitis and assessed the role of Nrf2/HO-1 signaling in this process. Eyes of C57BL/6 (B6) mice were treated with 2 mm DI after infection with Aspergillus fumigatus. HCECs were pretreated with 0.25 mm DI and then incubated with A. fumigatus. Clin. scoring, slit-lamp photog., myeloperoxidase determination, flow cytometry and immunostaining were used to assess the disease response and treatment efficacy. PCR, Western blot and ELISA were used to assess the expression of IL-1β, chemokine (C-X-C motif) ligand 1, IL-6, IL-8, Nrf2 and HO-1. In addition, quantification of viable fungi, absorbance assays and fluorimetry were used to measure DI fungistatic activity. We observed that DI-treated eyes showed decreased clin. scores, fungal loads, PMN infiltration and cytokine expression, compared with phosphate-buffered saline-treated infected eyes. Moreover, DI treatment increased Nrf2 and HO-1 expression in corneas and nuclear Nrf2 accumulation in HCECs. Finally, DI treatment reduced the A. fumigatus absorbance and fungal mass. These data indicate that DI protects against fungal keratitis by limiting inflammation via the Nrf2/HO-1 signaling pathway and that DI inhibits the growth of A. fumigatus.

Immunology & Cell Biology published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Quality Control of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Li, Shuailong published the artcileRhodium-Catalyzed Enantioselective Anti-Markovnikov Hydroformylation of α-Substituted Acryl Acid Derivatives, Category: esters-buliding-blocks, the publication is Organic Letters (2020), 22(3), 1108-1112, database is CAplus and MEDLINE.

Rhodium-catalyzed asym. anti-Markovnikov hydroformylation of α-substituted acrylates/acrylamides has been developed. By employing the Rh/(S,S)-DTBM-YanPhos complex, a series of β-chiral linear aldehydes were obtained in high yields (up to 94% yield) and high enantioselectivities (up to 96% ee). The utility of this methodol. is demonstrated by a gram-scale reaction and a concise synthetic route to chiral γ-butyrolactone.

Organic Letters published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Gao, Min published the artcilePhase-Transfer-Catalyzed Asymmetric Annulations of Alkyl Dihalides with Oxindoles: Unified Access to Chiral Spirocarbocyclic Oxindoles, Category: esters-buliding-blocks, the publication is Organic Letters (2022), 24(3), 875-880, database is CAplus and MEDLINE.

A general phase-transfer-catalyzed asym. (n+1) (n = 4 or 5) annulation reaction, featuring the direct coupling of simple oxindoles I (R¹ = H, 5-Me, 6-OMe, 6-Cl, etc.) with alkyl dihalides R²(R³)C=C(CH₂I)(CH₂)₂I (R² = R³ = H, Me, Et, Ph n-pentyl; R²R³ = -(CH₂)₅) and e.g., 1-(2-iodoethyl)-2-(iodomethyl)benzene that are allylic/benzylic and non-allylic/benzylic, has been developed to provide previously inaccessible cyclopentane- II and III and cyclohexane-fused spirooxindole IV (R⁴ = H, 6,7-(OMe)₂, 6-Cl) scaffolds with high yields and enantioselectivities (88-95% ee). Along with a broad scope and mild conditions, the new protocol also enables a two-step and gram-scale synthesis of the core of the drug ubrogepant.

Organic Letters published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Category: esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wang, Qian published the artcileThe anti-inflammatory drug dimethyl itaconate protects against colitis-associated colorectal cancer, Application of Dimethyl itaconate, the publication is Journal of Molecular Medicine (Heidelberg, Germany) (2020), 98(10), 1457-1466, database is CAplus and MEDLINE.

Abstract: Colorectal cancer (CRC) is the third most common diagnosed cancer of which risk factors include unhealthy diet, smoking, and chronic inflammation. Weakening the inflammatory response emerges as an effective therapeutic strategy to prevent the progression of CRC. Inflammatory macrophages produce substantial amounts of immunoregulatory metabolite itaconate, which is synthesized by the immune response gene 1 (Irg1). In this study, we use a membrane-permeable itaconate derivative, di-Me itaconate (DI), for the protection against CRC in mouse model. DI decreased the high inflammatory state of ulcerative colitis and reduced the colitis-associated cancer (CAC) risk. Mechanistically, DI inhibited the secretion of the cytokines IL-1β and CCL2 from intestinal epithelial cells, and therefore reduced the recruitment of macrophages into tumor microenvironment. Meanwhile, the decrease of macrophage infiltration was accompanied by a decrease of myeloid-derived suppressor cell (MDSC) infiltration and the differentiation of T cell subsets into cytotoxic T cells. Our findings demonstrate the potential application of DI for the prevention of colitis-associated CRC. Key messages: Di-Me itaconate (DI) suppresses ulcerative colitis and colitis-associated colorectal cancer DI decreases infiltration of macrophages and myeloid-derived suppressor cells into tumor DI weakens the inflammatory response via inhibiting the secretion of IL-1β and CCL2.

Journal of Molecular Medicine (Heidelberg, Germany) published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C11H11BFNO4, Application of Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Dai, ZengHui published the artcileReactive Diluent Derived from Ferulic Acid for the Preparation of a Fully Biobased Unsaturated Polyester Resin, Recommanded Product: Dimethyl itaconate, the publication is ACS Sustainable Chemistry & Engineering (2020), 8(47), 17379-17386, database is CAplus.

A reactive diluent for the preparation of a fully biobased unsaturated polyester resin (UPR) was developed and is presented here. The diluent, 4-vinylguaiacol acetyl ester (AC4VG), was obtained via a simple two-step synthesis: decarboxylation from ferulic acid (FA) and acetylation of the decarboxylated product, 4-vinylguaiacol (4VG). This diluent shows excellent miscibility with biobased unsaturated polyester prepolymer (UPP) that had been synthesized from succinic acid (SA), 1,3-dihydroxypropane (PD), and itaconic acid (IA). A mixed solution of these possessed a very low viscosity at 174 mPa·s at room temperature when 40 wt% AC4VG was added. Moreover, its vinyl group brought high reactivity for free radical copolymerization with the UPP, and the benzene ring structure enabled a high glass transition temperature (T_g) of the cured UPR. When the fully biobased UPR was reinforced by cotton fabric, a strong tensile strength at the break of approx. 65.8 MPa, a T_g of 135°C, and a T_d5% of 276°C were achieved. This work suggests that the fully biobased UPR reported here is a promising candidate for replacing petroleum-based ones, and the diluent AC4VG played an important role in the performance of this biobased UPR. A biobased reactive diluent, 4-vinylguaiacol acetyl ester, was developed for the preparation of a fully biobased unsaturated polyester resin.

ACS Sustainable Chemistry & Engineering published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Recommanded Product: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Zhang, Xiaohua published the artcileSystematically Controlling Acceptor Fluorination Optimizes Hierarchical Morphology, Vertical Phase Separation, and Efficiency in Non-Fullerene Organic Solar Cells, Name: Dimethyl itaconate, the publication is Advanced Energy Materials (2022), 12(1), 2102172, database is CAplus.

Non-fullerene acceptor (NFA) end group (EG) functionalization, especially by fluorination, affects not only the energetics but also the morphol. of bulk-heterojunction (BHJ) organic solar cell (OSC) active layers, thereby influencing the power conversion efficiency (PCE) and other metrics of NFA-based OSCs. However, a quant. understanding of how varying the degrees of NFA fluorination influence the blend morphol. and photovoltaic properties remains elusive. Here a series of three A-DAD-A type NFAs (D = π-donor group and A = π-acceptor EG) which systematically increase the degree of EG fluorination and comprehensively investigate the resulting blends with the polymer donor PM6 in terms of optical properties, electronic structure, film crystallinity, charge carrier transport, and OSC performance is reported. The results indicate that the most highly fluorinated NFA, BT-BO-L4F, achieves an optimal BHJ hierarchical morphol. where enhanced NFA mol. intermol. π-π stacking and optimal vertical phase gradation are achieved in the BHJ blend. These factors also promote optimum NFA-cathode contact, more balanced electron and hole mobility, and suppress both monomol. and bimol. recombination. As a result, both the short-circuit c.d. and fill factor in this OSC series progressively increase with increasing EG fluorine d., and the resulting PCEs increase from 9 to 16.8%.

Advanced Energy Materials published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H8BFO2, Name: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics