Category: 617-52-7

Singh, Sukhvinder published the artcileIntegrative metabolomics and transcriptomics identifies itaconate as an adjunct therapy to treat ocular bacterial infection, SDS of cas: 617-52-7, the publication is Cell Reports Medicine, database is CAplus and MEDLINE.

The eye is highly susceptible to inflammation-mediated tissue damage evoked during bacterial infection. However, mechanisms regulating inflammation to protect the eye remain elusive. Here, we used integrated metabolomics and transcriptomics to show that the immunomodulatory metabolite itaconate and immune-responsive gene 1 (Irg1) are induced in bacterial (Staphylococcus aureus)-infected mouse eyes, bone-marrow-derived macrophages (BMDMs), and Muller glia. Itaconate levels are also elevated in the vitreous of patients with bacterial endophthalmitis. Irg1 deficiency in mice led to increased ocular pathol. Conversely, intraocular administration of itaconate protects both Irg1-/- and wild-type mice from bacterial endophthalmitis by reducing inflammation, bacterial burden, and preserving retinal architecture and visual function. Notably, itaconate exerts synergistic effects with antibiotics. The protective, anti-inflammatory effects of itaconate are mediated via activation of NRF2/HO-1 signaling and inhibition of NLRP3 inflammasome. Collectively, our study demonstrates the Irg1/itaconate axis is a regulator of intraocular inflammation and provides evidence for using itaconate, along with antibiotics, to treat bacterial infections.

Cell Reports Medicine published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C24H20Ge, SDS of cas: 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Spasojevic, Pavle published the artcileOptimization of Reactive Diluent for Bio-Based Unsaturated Polyester Resin: A Rheological and Thermomechanical Study, Related Products of esters-buliding-blocks, the publication is Polymers (Basel, Switzerland) (2021), 13(16), 2667, database is CAplus and MEDLINE.

Nowadays, unsaturated polyester resins (UPR) are mainly obtained from non-renewable resources. The ever-increasing regulations and the continuous demand for more sustainability have led to extensive research towards more environmentally suitable alternatives to petroleum-based materials. However, one of the main disadvantages of bio-based UPR is their relatively high viscosity compared to petrochem. ones. In order to overcome this drawback, in this work, we investigated the possibility to lower the resin viscosity utilizing a mixture of di-Me itaconate (DMI) and Me methacrylate (MMA) as a reactive diluent. The effect of the DMI and MMA ratio on resin rheol. properties was investigated. The optimal curing parameters were determined and all UPRs had a high gel content, which was shown to be dependent on the DMI and MMA ratio in the formulation. Furthermore, thermomech. and mech. properties of the resulting network were also found to be affected by the used reactive diluent mixture A small substitution of DMI by MMA proved to be advantageous since it offers lower resin viscosity and improved mech. properties.

Polymers (Basel, Switzerland) published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C11H21BF4N2O2, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Wypysek, Sarah K. published the artcileTailoring the Cavity of Hollow Polyelectrolyte Microgels, Related Products of esters-buliding-blocks, the publication is Macromolecular Rapid Communications (2020), 41(1), 1900422, database is CAplus and MEDLINE.

The authors demonstrate how the size and structure of the cavity of hollow charged microgels may be controlled by varying pH and ionic strength. Hollow charged microgels based on N-isopropylacrylamide with ionizable comonomers (itaconic acid) combine advanced structure with enhanced responsiveness to external stimuli. Structural advantages accrue from the increased surface area provided by the extra internal surface. Extreme sensitivity to pH and ionic strength due to ionizable moieties in the polymer network differentiates these soft colloidal particles from their uncharged counterparts, which sustain a hollow structure only at cross-link densities sufficiently high that stimuli sensitivity is reduced. Using small-angle neutron and light scattering, increased swelling of the network in the charged state accompanied by an expanded internal cavity is observed Upon addition of salt, the external fuzziness of the microgel surface diminishes while the internal fuzziness grows. These structural changes are interpreted via Poisson-Boltzmann theory in the cell model.

Macromolecular Rapid Communications published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C6H12F3NO5S, Related Products of esters-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Hu, Keling published the artcileOrganocatalyzed Living Radical Polymerization of Itaconates and Self-Assemblies of Rod-Coil Block Copolymers, SDS of cas: 617-52-7, the publication is Macromolecular Rapid Communications (2020), 41(9), 2000075, database is CAplus and MEDLINE.

Organocatalyzed living radical polymerizations of itaconates are studied, yielding low-dispersity linear and star polymers (D = Mw/Mn = 1.28-1.46) up to Mn = 20 000 and monomer conversion = 62%, where Mn and Mw are the number- and weight-average molar masses, resp. The block polymerization with functional methacrylates, an acrylate, and styrene yields various rod-coil block copolymers. Linear A-B diblock, linear B-A-B triblock, and 3-arm star A-B diblock copolymers generate spherical micelles (nanoparticles) and vesicles (nanocapsules), depending on the polymer structures. Itaconates can be derived from bioresources, and thus the obtained polymers may serve as green polymers. Because of the biocompatibility of polyitaconates, the assemblies may serve as biocompatible nanocarriers.

Macromolecular Rapid Communications published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, SDS of cas: 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Sendra, M. published the artcileImmune-responsive gene 1 (IRG1) and dimethyl itaconate are involved in the mussel immune response, Recommanded Product: Dimethyl itaconate, the publication is Fish & Shellfish Immunology (2020), 645-655, database is CAplus and MEDLINE.

Immune-responsive gene 1 (irg1) is a gene that is well-conserved among different taxa and is highly expressed in the mussel Mytilus galloprovincialis at the constitutive level. The expression of this gene increases after a bacterial infection, primarily in haemocytes. Irg1 catalyzes the production of itaconic acid from cis-aconitic acid in the Krebs cycle. Recently, itaconate has been revealed as an immune metabolite involved in macrophage polarization. In this work, we studied the effects of exogenous di-Me itaconate (DI) on mussels in vitro and in vivo at relevant previously described endogenous concentrations and in mussels infected with Vibrio splendidus. DI did not have adverse effects on the haemocytes viability, apoptotic cells, proliferation and phagocytic activity; however, haemocyte size, velocity and accumulated distance were decreased. The antibacterial activity of DI in vitro and in vivo was observed with high concentrations of DI, i.e., 30 and 50 mM, resp. Furthermore, DI inhibited total ROS, increased mitochondrial ROS and modulated antioxidant genes, such as SOD and CAT, related to Nrf2 activation. In this research, we have demonstrated some important pathways in haemocytes in which itaconate can be involved after its production in a bacterial infection.

Fish & Shellfish Immunology published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C16H24BF4Ir, Recommanded Product: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Xiong, Haigen published the artcileIron-catalyzed carboazidation of alkenes and alkynes, Quality Control of 617-52-7, the publication is Nature Communications (2019), 10(1), 1-7, database is CAplus.

An iron-catalyzed rapid carboazidation of alkenes e.g., 1-tert-butyl-4-ethenylbenzene and alkynes RCCH (R = Ph, 3-chlorophenyl, n-C₆H₁₃, etc.), enabled by the oxidative radical relay precursor t-Bu perbenzoate were described. This strategy enjoys success with a broad scope of alkenes under mild conditions, and it can also work with aryl alkynes which are challenging substrates for carboazidation. A large number of diverse structures, including many kinds of amino acid precursors, fluoroalkylated vinyl azides e.g., 1-(1-azido-3,4,4,4-tetrafluoro-3-trifluoromethyl-butyl)-4-tert-butyl-benzene, other specific organoazides R¹CH₂CH(N₃)CH₂(CF₂)₃CF₃ (R¹ = 5-bromopentyl, 8-(benzyloxy)octyl, 8-hydroxyoctyl, etc.), and 2H-azirines I (R² = n-C₄F₉, C₂F₅, c-C₆F₁₁, etc.) can be easily produced.

Nature Communications published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C3H7NO2, Quality Control of 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Crotti, Antonio E. M. published the artcileReal-time monitoring of a cobalt-mediated one-pot transition metal-catalyzed multicomponent reaction, Formula: C7H10O4, the publication is Inorganica Chimica Acta (2020), 119654, database is CAplus.

In this paper, pressurized sample infusion electrospray ionization mass spectrometry (PSI-ESI-MS) and FTIR spectroscopy were used to investigate the mechanism of a like-Barbier cobalt-mediated one-pot transition metal-catalyzed multicomponent reaction (MCR). The use of charge-tagged aryl halides allowed for the detection of cobalt(II)-promoted hydrodehalogenation products. Although these products were also detected in the off-line ESI-MS monitoring, the ability of PSI-ESI-MS to track real-time changes in the reaction mixture composition proved cobalt(II) was responsible for the undesired transformation. The occurrence of cobalt(II)-promoted hydrodehalogenation as a side reaction in this MCR had not been considered in previous mechanistic proposals and represents an important mechanistic consideration. In this paper, pressurized sample infusion electrospray ionization mass spectrometry (PSI-ESI-MS) and FTIR spectroscopy was used to investigate the mechanism of a like-Barbier cobalt-mediated one-pot transition metal-catalyzed multicomponent reaction (MCR). The use of charge-tagged aryl halides allowed for the detection of cobalt(II)-promoted hydrodehalogenation products. Although these products were also detected in the off-line ESI-MS monitoring, the ability of PSI-ESI-MS to track real-time changes in the reaction mixture composition proved cobalt(II) was responsible for the undesired transformation. The occurrence of cobalt(II)-promoted hydrodehalogenation as a side reaction in this MCR had not been considered in previous mechanistic proposals and represents an important mechanistic consideration.

Inorganica Chimica Acta published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Formula: C7H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Lefebvre, Quentin published the artcileOne Amine-3 Tasks: Reductive Coupling of Imines with Olefins in Batch and Flow, Recommanded Product: Dimethyl itaconate, the publication is Chemistry – A European Journal (2020), 26(6), 1363-1367, database is CAplus and MEDLINE.

An iridium-based photocatalyst promotes the direct reductive cross-coupling of imines Ar¹CH=NAr² (Ar¹ = C₆H₅, 2-CH₃OC₆H₄, 4-FC₆H₄, etc.; Ar² = C₆H₅, 4-FC₆H₄, 4-ClC₆H₄, 4-CH₃OC₆H₄) with olefins R¹R²C=CH₂ (R¹ = H, CH₃, NHC(O)CH₃, CH₂C(O)₂CH₃; R² = C(O)₂Me, S(O)₂Ph, C(O)₂(t-Bu), etc.) upon irradiation with visible light to give GABA derivatives Ar¹CH(NHAr²)CH₂CH(R¹)R² in good yields and selectivities. By enabling triple role of tributylamine additive in this process, the advantages of strategies based on proton-coupled electron transfer (PCET) and the scale-up of this reaction in continuous flow have been achieved.

Chemistry – A European Journal published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, Recommanded Product: Dimethyl itaconate.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Riadi, Yassine published the artcileEfficient novel eutectic-mixture-mediated synthesis of benzoxazole-linked pyrrolidin-2-one heterocycles, COA of Formula: C7H10O4, the publication is Journal of Molecular Liquids (2021), 115011, database is CAplus.

In this study, new benzoxazole-linked pyrrolidinone heterocyclic compounds I [R = H, 2-Me, 3-Cl-4-F, etc.] were synthesized by an eco-efficient strategy using substituted benzylamines and 2-aminophenol under ultrasonic irradiation in the presence of a newly designed metal-free deep eutectic solvent (DES). This DES was prepared by using a eutectic mixture of urea and a synthesized glycine-derived ionic liquid X-ray diffraction and IR spectroscopy were employed to investigate the structure of the ionic liquid and characterize the DES, resp. This method exhibited key advantages of high productivity, a short reaction time, and simple processing. Moreover, this DES was easily separated from reaction mixtures and could be recycled for multiple reactions.

Journal of Molecular Liquids published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, COA of Formula: C7H10O4.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics

Geesi, Mohammed H. published the artcileMetal-doped TiO₂ nanocatalysts in an MX₂/urea mixture for the synthesis of benzothiazoles bearing substituted pyrrolidin-2-ones: enhanced catalytic performance and antibacterial activity, SDS of cas: 617-52-7, the publication is Journal of Environmental Chemical Engineering (2021), 9(4), 105344, database is CAplus.

Pyrrolidinone derivatives I (R = Ph, 2-MeC₆H₄, 4-HOC₆H₄, 3-Cl-4-FC₆H₃, etc.) were synthesized by reacting various arylamines RNH₂ with di-Me itaconate using water as the solvent in a microwave. The obtained pyrrolidinone derivatives I were further reacted with 2-aminothiophenol under microwave irradiation with the assistance of a deep eutectic mixture (CuCl₂ or NiCl₂/urea) and Cu- or Ni-doped TiO₂ nanoparticles to afford the final derivatives II incorporating both pyrrolidin-2-one and benzothiazole rings. To determine the optimum reaction conditions, the effects of temperature, solvent nature, and reaction time were investigated. Under the optimal operation conditions, high reaction yields were achieved. The developed strategy exhibited advantages of a short reaction time, eco-friendliness, and high productivity. Finally, the obtained derivatives II were examined in terms of their antibacterial potential against selected Gram-neg. and Gram-pos. bacterial strains: all the derivatives II, except for II (R = 4-MeOC₆H₄), exhibited activity against the tested bacteria.

Journal of Environmental Chemical Engineering published new progress about 617-52-7. 617-52-7 belongs to esters-buliding-blocks, auxiliary class Alkenyl,Aliphatic hydrocarbon chain,Ester, name is Dimethyl itaconate, and the molecular formula is C7H10O4, SDS of cas: 617-52-7.

Referemce:
https://en.wikipedia.org/wiki/Ester,
Ester – an overview | ScienceDirect Topics