Category: 61644-18-6

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 61644-18-6, name is Chloromethyl isobutyrate, A new synthetic method of this compound is introduced below., Recommanded Product: 61644-18-6

General procedure: To a solution of Compound 54B (150 mg, 0.24 mmol) in DMF (10 mL) was added chloromethyl isobutyrate (36 mg, 0.24 mmol) and Na2CO3 (50 mg, 0.48 mmol). The reaction mixture was stirred at 50 C for 3 hour. After cooling down to room temperature, the mixture was diluted with water (50 mL) and extracted with ethyl acetate (20 mL x 3). The combined extracts were washed with brine (50 mL), dried over anhydrous sodium sulfate, filtered, and concentrated to furnish Compound 54C. LC-MS (ESI) m/z: non-ionizable compound under routine conditions used.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHAO, Qi; (737 pag.)WO2019/133770; (2019); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 61644-18-6, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61644-18-6, name is Chloromethyl isobutyrate, This compound has unique chemical properties. The synthetic route is as follows.

A 1-L jacketed glass reactor equipped with a nitrogen pad, overhead stirrer motor, down-pumping 45 pitched 4-blade impeller, “h” baffle, West condenser, and thermowell was charged sequentially with solid UK-2A (56.10 g, 0.109 mol, 1.0 equiv), anhydrous Na2C03(23.09 g, 0.218 mol, 2.0 equiv), solid Nal (0.979 g, 0.0065 mol, 6 mol%), nonyl phenyl ketone (1.5022 g, nonreactive internal standard for HPLC analysis), 15-crown-5 (2.444 g, 0.0109 mol, 10 mol%), neat chloromethyl isobutyrate (16.47 g, 0.120 mol, 1.1 equiv), and ethyl acetate (361 g). The 1-L reactor was placed under an atmosphere of nitrogen, agitation was initiated, and the reaction mixture was heated to 65 C. Samples of the reaction mixture (approximately 1 mL) were removed at 5 h and 10 h. Each sample was added to fresh ethyl acetate (5 mL), syringe filtered, and diluted approximately 6: 1 (v/v) with 0.1% formic acid in N,N-dimethylformamide. The resulting samples were analyzed by HPLC (UV detection, 270 nm) and the molar concentrations of unreacted UK-2A (Formula IV), Formula (VI), and the by-product of Formula (VII) were determined based on the known quantity of internal standard (nonyl phenyl ketone). The conversion of Formula (IV) and the yields of Formula (VI) and Formula (VII) could be calculated on the basis of this information (see for example Entry 4 of Table 1).

The chemical industry reduces the impact on the environment during synthesis Chloromethyl isobutyrate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; DOW AGROSCIENCES LLC; JANSMA, Matthew; ADAWAY, Timothy; TRIPPEER, Michael; (19 pag.)WO2017/62362; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 61644-18-6, name is Chloromethyl isobutyrate, A new synthetic method of this compound is introduced below., Computed Properties of C5H9ClO2

General procedure: Carboxylic acid (±)-9 (5.18 mmol) was dissolved in N,N-dimethylformamide (15.5 mL). Cesium carbonate (4.14 mmol) was added to the solution and the suspension was stirred during 2-3 min after which chloromethyl 2-methylpropanoate (6.73 mmol) was added. After stirring at room temperature during 18-24 h, dichloromethane (30 mL) was added to the mixture and the resulting organic phase was successively washed with water (3×20 mL) and brine (3×20 mL). Organic solvent was eliminated and the residue was submitted to flash chromatography (hexane/ethyl acetate mixtures) to yield the corresponding diester (±)-5.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Torres, Susana Y.; Ochoa, Estael; Verdecia, Yamila; Rebolledo, Francisca; Tetrahedron; vol. 70; 31; (2014); p. 4675 – 4684;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 61644-18-6, name is Chloromethyl isobutyrate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 61644-18-6, Product Details of 61644-18-6

In a reactor equipped with a distillation device, add toluene,100 g (0.55 mol) of ethyl 1-ethyl-3-methylpyrazole-5-carboxylate and 95 g (0.55 mol) of p-tert-butylbenzoacetonitrile, after dehydration under reflux,224g (0.66mol) of sodium ethoxide solution was added dropwise, and the addition was completed within 5h.Low-boiling by-products are separated from the top of the column.After the reaction was completed, the solvent and other boilables were distilled off under reduced pressure, and toluene was recovered.To the residue were added anhydrous acetonitrile and 4.5 g (0.03 mol) of sodium iodide.Add 77.8g (0.57mol) of 1-chloromethyl isobutyrate,Warm to reflux.After the reaction is completed, cool and separate the liquid phase.The solvent was distilled off under reduced pressure,Get 213.7g1- (2- (4- (tert-butyl) phenyl) -2-cyano-1- (1-ethyl-3-methyl-1H-5-pyrazolyl) ethoxy) isobutyric acid Methyl ester,The yield was 95%, in which the content of the E formula was 88.4%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Chloromethyl isobutyrate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Zhejiang Chemical Institute Co., Ltd.; Sinochem Lantian Group Co., Ltd.; Zhong Liangkun; Xu Tianming; Huang Hongying; Wei Youchang; (16 pag.)CN110003111; (2019); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 61644-18-6, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 61644-18-6 as follows.

General procedure: Carboxylic acid (±)-9 (5.18 mmol) was dissolved in N,N-dimethylformamide (15.5 mL). Cesium carbonate (4.14 mmol) was added to the solution and the suspension was stirred during 2-3 min after which chloromethyl 2-methylpropanoate (6.73 mmol) was added. After stirring at room temperature during 18-24 h, dichloromethane (30 mL) was added to the mixture and the resulting organic phase was successively washed with water (3×20 mL) and brine (3×20 mL). Organic solvent was eliminated and the residue was submitted to flash chromatography (hexane/ethyl acetate mixtures) to yield the corresponding diester (±)-5.

According to the analysis of related databases, 61644-18-6, the application of this compound in the production field has become more and more popular.

Reference:
Article; Torres, Susana Y.; Ochoa, Estael; Verdecia, Yamila; Rebolledo, Francisca; Tetrahedron; vol. 70; 31; (2014); p. 4675 – 4684;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 61644-18-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 61644-18-6, name is Chloromethyl isobutyrate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

To a stirred solution of (S)-1 -(((3-cyanopyridin-2-yl)oxy)methyl)-4- ((1 R,3aS,5aR,5bR,7aR,1 1 aS,1 1 bR,13aR,13bR)-3a-((2-((1 s,4R)-1 -hydroxy-4- (methylsulfonyl)cyclohexyl)ethyl)amino)-5a,5b,8,8, 1 1 a-pentamethyl-1 -(prop-1 -en-2-yl)- 2,3,3a,4,5,5a,5b,6,7,7a,8,1 1 ,1 1 a,1 1 b,12,13,13a,13b-octadecahydro-1 H- cyclopenta[a]chrysen-9-yl)cyclohex-3-ene-1 -carboxylic acid (200 mg, 0.230 mmol) and chloromethyl isobutyrate (62.8 mg, 0.460 mmol) in DMF (5.0 ml_) were added potassium carbonate (159 mg, 1 .149 mmol) followed by sodium iodide (6.89 mg, 0.046 mmol) at 0 C under Nitrogen atmosphere. The reaction mixture was allowed to warm to 27 C and stirred for 16 hr. The progress of the reaction was monitored by TLC (Si02, 5% MeOH/DCM, Rf = 0.4, KMn04-active). The reaction mixture was quenched with ice water (50 ml_) and extracted with EtOAc (2 c 30 ml_). The combined organic layers were washed with brine (50 ml_), dried over Na2S04, filtered and concentrated under reduced pressure to give the crude residue as sticky oil. The crude compound was triturated with chilled n-pentane (3 x 10 ml_) filtered and dried under high vacuum to afford (isobutyryloxy)methyl (S)-1 -(((3-cyanopyridin-2-yl)oxy)methyl)-4- ((1 R,3aS,5aR,5bR,7aR,1 1 aS,1 1 bR,13aR,13bR)-3a-((2-((1 s,4R)-1 -hydroxy-4- (methylsulfonyl)cyclohexyl)ethyl)amino)-5a,5b,8,8, 1 1 a-pentamethyl-1 -(prop-1 -en-2-yl)- 2,3,3a,4,5,5a,5b,6,7,7a,8,1 1 ,1 1 a,1 1 b,12,13,13a,13b-octadecahydro-1 H- cyclopenta[a]chrysen-9-yl)cyclohex-3-ene-1 -carboxylate (93 mg, Yield: 40%, white solid. NMR (400 MHz, CDCI3) d = 8.32 (dd, J = 2.0, 5.0 Hz, 1 H), 7.86 (dd, J = 2.0, 7.5 Hz, 1 H), 6.98 (dd, J = 5.0, 7.6 Hz, 1 H), 5.81-5.77 (m, 2H), 5.36-5.33 (m, 1 H), 5.19-5.17 (m, 1 H), 4.74-4.71 (m, 1 H), 4.61 -4.55 (m, 3H), 2.84-2.64 (m, 7H), 2.57-2.50 (m, 1 H), 2.25- 1 .82 (m, 12H), 1 .72-1 .38 (m, 22H), 1 .32-1 .22 (m, 6H), 1 .13 (d, J = 7.0 Hz, 6H), 1 .07-1 .01 (m, 6H), 0.98-0.94 (m, 6H), 0.93-0.88 (m, 3H), 0.86-0.82 (m, 3H). LCMS: RT = 7.1 1 mins, (M+H) = 970.4, Purity = 97%, HPLC Purity = 96%, Chiral HPLC Purity = 94%.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Chloromethyl isobutyrate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; VIIV HEALTHCARE UK (NO.5) LIMITED; KADOW, John F.; NAIDU, B. Narasimhulu; (61 pag.)WO2019/207460; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 61644-18-6, A common heterocyclic compound, 61644-18-6, name is Chloromethyl isobutyrate, molecular formula is C5H9ClO2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Carboxylic acid (±)-9 (5.18 mmol) was dissolved in N,N-dimethylformamide (15.5 mL). Cesium carbonate (4.14 mmol) was added to the solution and the suspension was stirred during 2-3 min after which chloromethyl 2-methylpropanoate (6.73 mmol) was added. After stirring at room temperature during 18-24 h, dichloromethane (30 mL) was added to the mixture and the resulting organic phase was successively washed with water (3×20 mL) and brine (3×20 mL). Organic solvent was eliminated and the residue was submitted to flash chromatography (hexane/ethyl acetate mixtures) to yield the corresponding diester (±)-5.

The synthetic route of 61644-18-6 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Torres, Susana Y.; Ochoa, Estael; Verdecia, Yamila; Rebolledo, Francisca; Tetrahedron; vol. 70; 31; (2014); p. 4675 – 4684;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 61644-18-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 61644-18-6 name is Chloromethyl isobutyrate, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Carboxylic acid (±)-9 (5.18 mmol) was dissolved in N,N-dimethylformamide (15.5 mL). Cesium carbonate (4.14 mmol) was added to the solution and the suspension was stirred during 2-3 min after which chloromethyl 2-methylpropanoate (6.73 mmol) was added. After stirring at room temperature during 18-24 h, dichloromethane (30 mL) was added to the mixture and the resulting organic phase was successively washed with water (3×20 mL) and brine (3×20 mL). Organic solvent was eliminated and the residue was submitted to flash chromatography (hexane/ethyl acetate mixtures) to yield the corresponding diester (±)-5.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, Chloromethyl isobutyrate, and friends who are interested can also refer to it.

Reference:
Article; Torres, Susana Y.; Ochoa, Estael; Verdecia, Yamila; Rebolledo, Francisca; Tetrahedron; vol. 70; 31; (2014); p. 4675 – 4684;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 61644-18-6, name is Chloromethyl isobutyrate, A new synthetic method of this compound is introduced below., Application In Synthesis of Chloromethyl isobutyrate

General procedure: To a solution of Compound 54B (150 mg, 0.24 mmol) in DMF (10 mL) was added chloromethyl isobutyrate (36 mg, 0.24 mmol) and Na2CO3 (50 mg, 0.48 mmol). The reaction mixture was stirred at 50 C for 3 hour. After cooling down to room temperature, the mixture was diluted with water (50 mL) and extracted with ethyl acetate (20 mL x 3). The combined extracts were washed with brine (50 mL), dried over anhydrous sodium sulfate, filtered, and concentrated to furnish Compound 54C. LC-MS (ESI) m/z: non-ionizable compound under routine conditions used.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; BIOMARIN PHARMACEUTICAL INC.; WANG, Bing; CHAO, Qi; (737 pag.)WO2019/133770; (2019); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 61644-18-6, name is Chloromethyl isobutyrate, This compound has unique chemical properties. The synthetic route is as follows., Computed Properties of C5H9ClO2

A 1-L jacketed glass reactor equipped with a nitrogen pad, overhead stirrer motor, down-pumping 45 pitched 4-blade impeller, “h” baffle, West condenser, and thermowell was charged sequentially with solid UK-2A (56.09 g, 0.109 mol, 1.0 equiv), anhydrous Na2C03(23.09 g, 0.218 mol, 2.0 equiv), solid Nal (0.973 g, 0.0065 mol, 6 mol%), nonyl phenyl ketone (1.5269 g, nonreactive internal standard for HPLC analysis), benzo-15-crown- 5 (1.454 g, 0.0054 mol, 5 mol%), neat chloromethyl isobutyrate (16.48 g, 0.120 mol, 1.1 equiv), and ethyl acetate (317 g). The 1-L reactor was placed under an atmosphere of nitrogen, agitation was initiated, and the reaction mixture was heated to 55 C. Samples of the reaction mixture (approximately 1 mL) were removed at 5 h, 10 h, and 24 h. Each sample was added to fresh ethyl acetate (5 mL), syringe filtered, and diluted approximately 6: 1 (v/v) with 0.1% formic acid in N,N-dimethylformamide. The resulting samples were analyzed by HPLC (UV detection, 270 nm) and the molar concentrations of unreacted UK-2A (Formula IV), Formula (VI), and the by-product of Formula (VII) were determined based on the known quantity of internal standard (nonyl phenyl ketone). The conversion of Formula (IV) and the yields of Formula (VI) and Formula (VII) could be calculated on the basis of this information (see for example, Entry 8 of Table 1).

According to the analysis of related databases, 61644-18-6, the application of this compound in the production field has become more and more popular.

Reference:
Patent; DOW AGROSCIENCES LLC; JANSMA, Matthew; ADAWAY, Timothy; TRIPPEER, Michael; (19 pag.)WO2017/62362; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics