Category: 6149-41-3

In 2015,Rioux, Vincent; Choque, Benjamin; Ezanno, Helene; Duby, Cecile; Catheline, Daniel; Legrand, Philippe published 《Influence of the cis-9, cis-12 and cis-15 double bond position in octadecenoic acid (18:1) isomers on the rat FADS2-catalyzed Δ6-desaturation》.Chemistry and Physics of Lipids published the findings.Computed Properties of C4H8O3 The information in the text is summarized as follows:

Oleic (cis9-18:1), linoleic (cis9,cis12-18:2) and α-linolenic (cis9,cis12,cis15-18:3) acids are well described substrates of the Δ6-desaturase encoded by the mammalian fatty acid desaturase 2 (FADS2) gene. In addition, at least 9 other very structurally different fatty acids have been shown to be Δ6- or even Δ8-desatd. by the FADS2 protein. A better characterization of the substrate specificity of this enzyme is therefore needed. By using com. cis9-18:1 and chem. synthesized cis12- and cis15-18:1 (sharing the n-6 double bond with 18:2 n-6 and the n-3 double bond with 18:3 n-3, resp.), we tried to decrypt the fatty acid structure driving the FADS2 substrate affinity. We first showed that both recombinant and native rat FADS2 were able to Δ6-desaturate not only the cis9- but also the cis12- and cis15-18:1 isomers. Next, the inhibitory effect of increasing concentrations of each 18:1 isomer was investigated in vitro on the Δ6-desaturation of α-linolenic acid. At equimolar inhibitor/substrate ratio (60 μM), the cis9-18:1 exhibited a significantly higher inhibition (25%) than the cis12- (8%) and cis15-18:1 (5%). This study shows that a single cis double bond in 12- or 15-position in 18:1 is enough to make them low Δ6-desaturable substrates. If a preexisting cis9-double bond is not absolutely required for the Δ6-desaturation of octadecenoic acids, its presence is however crucial to explain the higher enzyme affinity. Compared with oleic acid, the addnl. presence of a cis12-double bond in linoleic acid increased ilts inhibitory effect on the Δ6-desaturation of α-linolenic acid at low concentration (30 μM) but not at higher concentrations (60 and 120 μM). In this classification of the decreasing impact of the double bond when it comes closer to the Me end of octadecenoic acids, the cis11-18:1 (cis-vaccenic acid) should be considered apart since it is itself not Δ6-desatd. but still a good competitive inhibitor of the α-linolenic acid Δ6-desaturation In the experiment, the researchers used many compounds, for example, Methyl 3-hydroxypropanoate(cas: 6149-41-3Computed Properties of C4H8O3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C4H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Cobalt-Catalysed Reductive Etherification Using Phosphine Oxide Promoters under Hydroformylation Conditions》 was written by Delolo, Fabio G.; Fessler, Johannes; Neumann, Helfried; Junge, Kathrin; dos Santos, Eduardo N.; Gusevskaya, Elena V.; Beller, Matthias. Recommanded Product: 6149-41-3This research focused onunsym ether chemoselective preparation; benzaldehyde alc reductive etherification phosphine oxide hydroformylation cobalt catalyst; base-metal catalysis; cobalt; etherification; hydrogenation; phosphine oxides. The article conveys some information:

A phosphine-oxide-promoted, cobalt-catalyzed reductive etherification using syngas as a reductant was reported. This novel methodol. was successfully used to prepare a broad range of unsym. ethers R1CH2OR2 [R1 = Ph, 1-naphthyl, 2-naphthyl, etc.; R2 = Me, i-Pr, cyclohexyl, etc.] from various aldehydes and alcs. containing diverse functional groups, and was scaled-up to multigram scale under comparably mild conditions. Mechanistic experiments supported an acetalization-hydrogenation sequence. In the experiment, the researchers used many compounds, for example, Methyl 3-hydroxypropanoate(cas: 6149-41-3Recommanded Product: 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2001,Ladame, Sylvain; Bardet, Michel; Perie, Jacques; Willson, Michele published 《Selective inhibition of Trypanosoma brucei GAPDH by 1,3-bisphospho-D-glyceric acid (1,3-diPG) analogues》.Bioorganic & Medicinal Chemistry published the findings.Quality Control of Methyl 3-hydroxypropanoate The information in the text is summarized as follows:

Various phosphono-phosphates and diphosphonates were synthesized as 1,3-diphosphoglycerate (1,3-diPG) analogs by using a β-ketophosphonate, an α-fluoro,β-ketophosphonate or a β-ketophosphoramidate to mimic the unstable carboxyphosphate part of the natural substrate. The inhibitory effect of these analogs on glyceraldehyde-3-phosphate dehydrogenases (GAPDH) from Trypanosoma brucei (Tb) and rabbit muscle were measured with respect to both substrates, glyceraldehyde-3-phosphate (GAP) and 1,3-diPG. Interestingly, all 1,5-diphosphono,2-oxopentanes without substitution at the C-3 position selectively inhibit the Tb GAPDH with respect to 1,3-diPG and are without effect on Rm GAPDH. All 1-phospho,3-oxo,4-phosphonobutanes show themselves to be non-selective inhibitors either with regard to substrates or organisms, but they will be of a great interest as 1,3-diPG stable models for structural studies of co-crystals with GAPDHs. In the experiment, the researchers used many compounds, for example, Methyl 3-hydroxypropanoate(cas: 6149-41-3Quality Control of Methyl 3-hydroxypropanoate)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of Methyl 3-hydroxypropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2006,Parkkari, Teija; Savinainen, Juha R.; Raitio, Katri H.; Saario, Susanna M.; Matilainen, Laura; Sirvioe, Tuomas; Laitinen, Jarmo T.; Nevalainen, Tapio; Niemi, Riku; Jaervinen, Tomi published 《Synthesis, cannabinoid receptor activity, and enzymatic stability of reversed amide derivatives of arachidonoyl ethanolamide》.Bioorganic & Medicinal Chemistry published the findings.Recommanded Product: Methyl 3-hydroxypropanoate The information in the text is summarized as follows:

Retroanandamide (2f) and its 10 analogs (1a-e, 2a-e) were synthesized and evaluated for the cannabinoid receptor activation by a [35S]GTPγS binding assay using rat cerebellar membranes, and Chinese hamster ovary cell membranes expressing human CB2 receptors. The primary goal of the study was to develop cannabinoid receptor agonists having improved enzymic stability compared to endogenous N-arachidonoyl ethanolamide (AEA). Furthermore, by reversing the amide bond of AEA, the formation of arachidonic acid would be prevented. Finally, an effect of the carbonyl carbon position on the cannabinoid receptor activity was explored by synthesizing retroanandamide analogs having different chain lengths (1a-e, C19; 2a-f, C20). All the synthesized compounds, except one, behaved as partial agonists for the both cannabinoid receptors. In rat brain homogenate, the reversed amides possessed significantly higher stability against FAAH induced degradation than AEA. Therefore, the reversed amide analogs of AEA may serve as enzymically stable structural basis for the drug design based on the endogenous cannabinoids. In addition to this study using Methyl 3-hydroxypropanoate, there are many other studies that have used Methyl 3-hydroxypropanoate(cas: 6149-41-3Recommanded Product: Methyl 3-hydroxypropanoate) was used in this study.

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: Methyl 3-hydroxypropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2011,Guo, Zhenmei; Wang, Hengsheng; Lv, Zhiguo; Wang, Zhihui; Nie, Tao; Zhang, Weiwei published 《Catalytic performance of [Bmim][Co(CO)4] functional ionic liquids for preparation of 1,3-propanediol by coupling of hydroesterification-hydrogenation from ethylene oxide》.Journal of Organometallic Chemistry published the findings.Computed Properties of C4H8O3 The information in the text is summarized as follows:

In this paper, synthesis of 1,3-propanediol (1,3-PDO) through coupling of hydroesterification-hydrogenation from ethylene oxide (EO) catalyzed by 1-butyl-3-methylimidazolium cobalt tetracarbonyl [Bmim][Co(CO)4] functional ionic liquid which was prepared by metathesis reaction between [Bmim]Cl and KCo(CO)4 has been studied. The structure of [Bmim][Co(CO)4] was characterized by FT-IR and 1H NMR. Using [Bmim][Co(CO)4] as catalyst and [Bmim]PF6 as solvent, 1,3-PDO was prepared for the first time by coupling of hydroesterifaction of EO and hydrogenation of Me 3-hydroxypropionate (3-HPM). The yield of 3-HPM can reach 90.8%, while the yield of 1,3-PDO up to 82.9%. The catalyst can be separated from the product mixture by extraction with deionized water and recycled several times without significant loss of catalytic efficiency. A possible reaction mechanism has also been proposed. The results came from multiple reactions, including the reaction of Methyl 3-hydroxypropanoate(cas: 6149-41-3Computed Properties of C4H8O3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Computed Properties of C4H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2016,Rosi, Luca; Frediani, Marco; Frediani, Piero; Bartoli, Mattia published 《a simple protocol for quantitative analysis of bio-oils through gas-chromatography/mass spectrometry》.European Journal of Mass Spectrometry published the findings.Related Products of 6149-41-3 The information in the text is summarized as follows:

A new and simple protocol for quant. anal. of bio-oils using gas-chromatog./mass spectrometry is suggested. Compounds were identified via their mass spectra, and then unavailable response factors were calculated with respect to di-Ph as the internal standard using a modified method previously suggested for gas chromatog. with flame ionization detection. This new protocol was applied to the characterization of bio-oils obtained from the pyrolysis of woods of different sources or using different pyrolysis procedures. This protocol allowed evaluation of the yields of products from poplar pyrolysis (among 50% and 99%), while a reduced amounts of products were identified from the pyrolysis of cellulose (between 46% and 58%). The main product was always acetic acid, but it was formed in very large yields from poplar while lower yields were obtained from cellulose. The experimental part of the paper was very detailed, including the reaction process of Methyl 3-hydroxypropanoate(cas: 6149-41-3Related Products of 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Related Products of 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2007,Cordeiro, Alessandra; Jimeno, Maria Luisa; Maestro, Miguel A.; Camarasa, Maria-Jose; Quesada, Ernesto; San-Felix, Ana published 《Synthesis of Highly Condensed Polycyclic Carbohydrates by Reaction of a Spiro-Cyclic Enamino Sulfonate Derived from D-Xylofuranose with Bifunctional Reagents》.Journal of Organic Chemistry published the findings.HPLC of Formula: 6149-41-3 The information in the text is summarized as follows:

The appropriately substituted 5-O-tosyl derivative I, easily prepared from 1,2-O-isopropylidene-α-D-xylofuranose, serves as a useful precursor for the preparation of highly condensed cyclic carbohydrates. The synthesis involves a first cyclization of the 5-O-tosyl sugar derivative I to a highly reactive cyclic enamine, which subsequently undergoes the nucleophilic attack of a bifunctional reagent X(CH2)nZ in a regio- and stereospecific way. Finally, a spontaneous cyclization step allows the formation of a stereochem. defined extra ring, fused to the sugar backbone. The functionalization and size of this ring can be varied by the proper choice of the bifunctional reagent. X-ray diffraction anal. and intensive NMR studies with one of these carbohydrates II were performed to highlight the strained nature of these compounds The results came from multiple reactions, including the reaction of Methyl 3-hydroxypropanoate(cas: 6149-41-3HPLC of Formula: 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. HPLC of Formula: 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2014,Tamiaki, Hitoshi; Isoda, Yasuaki; Tanaka, Takuya; Machida, Shinnosuke published 《Synthesis of chlorophyll-amino acid conjugates as models for modification of proteins with chromo/fluorophores》.Bioorganic & Medicinal Chemistry published the findings.Safety of Methyl 3-hydroxypropanoate The information in the text is summarized as follows:

A chlorophyll-a derivative bonded directly with epoxide at the peripheral position of the chlorin π-system was reacted with N-urethane and C-ester protected amino acids bearing an alc. or phenolic hydroxy group as well as a carboxy group at the residue to give chlorophyll-amino acid conjugates. The carboxy residues of N,C-protected aspartic and glutamic acids were esterified with the epoxide in high yields. The synthetic conjugates in dichloromethane had absorption bands throughout the visible region including intense red-side Qy and blue-side Soret bands. By their excitation at the visible bands, strong and efficient fluorescence emission was observed up to the near-IR region. The chromo/fluorophores are promising for preparation of functional peptides and modification of proteins. In the experimental materials used by the author, we found Methyl 3-hydroxypropanoate(cas: 6149-41-3Safety of Methyl 3-hydroxypropanoate)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Safety of Methyl 3-hydroxypropanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

HPLC of Formula: 6149-41-3In 2013 ,《Assessment of the chemical composition and in vitro antimicrobial potential of extracts of the liverwort Scapania aspera》 was published in Natural Product Communications. The article was written by Bukvicki, Danka R.; Tyagi, Amit K.; Gottardi, Davide G.; Veljic, Milan M.; Jankovic, Snezana M.; Guerzoni, Maria E.; Marin, Petar D.. The article contains the following contents:

The chem. composition of Scapania aspera extracts was determined by solid phase micro extraction gas chromatog.-mass spectrometry (SPME GC-MS) and 96 constituents were identified. The dominant compounds in the methanol extract were β-barbatene (25.1%), o-cymene (14.0%), α-barbatene (5.7%), allo-aromadendrene (4.9%) and β-bourbonene, while in the ethanol extract, o-cymene (17.8%), β-barbatene (17.6%), α-thujene (6.7%), octen-1-ol acetate (4.9%) and β-bazzanene (2.4%) were the major components. In the Et acetate extract, β-barbatene (14.3%), undecane (11.8%), 2-methyldecane (11.2%), decane (10.9%) and o-cymene (3.6%) were major components. The antimicrobial activity of the different extracts was evaluated against pathogenic and food spoilage microorganisms using disk diffusion and micro-broth dilution methods. The minimal inhibitory concentration (MIC) of extracts of S. aspera varied from 0.4 to 1.5 mg/mL and 1 to 3 mg/mL for yeast and bacterial strains, resp. The zone of inhibition of the methanol extract for yeast strains was higher than that for bacterial strains. The results suggest that S. aspera extracts have potential as natural antimicrobial agents. In the experiment, the researchers used many compounds, for example, Methyl 3-hydroxypropanoate(cas: 6149-41-3HPLC of Formula: 6149-41-3)

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. HPLC of Formula: 6149-41-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2013,D’Agostino, Carmine; Kotionova, Tatyana; Mitchell, Jonathan; Miedziak, Peter J.; Knight, David W.; Taylor, Stuart H.; Hutchings, Graham J.; Gladden, Lynn F.; Mantle, Mick D. published 《Solvent Effect and Reactivity Trend in the Aerobic Oxidation of 1,3-Propanediols over Gold Supported on Titania: NMR Diffusion and Relaxation Studies》.Chemistry – A European Journal published the findings.Formula: C4H8O3 The information in the text is summarized as follows:

In recent work, it was reported that changes in solvent composition, precisely the addition of water, significantly inhibits the catalytic activity of Au/TiO2 catalyst in the aerobic oxidation of 1,4-butanediol in methanol due to changes in diffusion and adsorption properties of the reactant. In order to understand whether the inhibition mechanism of water on diol oxidation in methanol is generally valid, the solvent effect on the aerobic catalytic oxidation of 1,3-propanediol and its two methyl-substituted homologues, 2-methyl-1,3-propanediol and 2,2-dimethyl-1,3-propanediol, over a Au/TiO2 catalyst has been studied here using conventional catalytic reaction monitoring in combination with pulsed-field gradient NMR (PFG-NMR) diffusion and NMR relaxation time measurements. Diol conversion is significantly lower when water is present in the initial diol/methanol mixture A reactivity trend within the group of diols was also observed Combined NMR diffusion and relaxation time measurements suggest that mol. diffusion and, in particular, the relative strength of diol adsorption, are important factors in determining the conversion. These results highlight NMR diffusion and relaxation techniques as novel, non-invasive characterization tools for catalytic materials, which complement conventional reaction data.Methyl 3-hydroxypropanoate(cas: 6149-41-3Formula: C4H8O3) was used in this study.

Methyl 3-hydroxypropanoate(cas: 6149-41-3) belongs to esters with low molecular weight are commonly used as fragrances and found in essential oils and pheromones. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Formula: C4H8O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics