Related Products of 6138-26-7,Some common heterocyclic compound, 6138-26-7, name is Trimethyl propane-1,2,3-tricarboxylate, molecular formula is C9H14O6, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a reactor equipped with a stirrer, a thermometer, a condensing tube, and a Dean-Stark trap, 4-hydroxy-2,2,6,6-tetramethylpiperidine (4.32 g), 1,2,3-propanetricarboxylic acid trimethyl ester (2.00 g), and dibutyl tin oxide (0.28 g) were dissolved in xylene (28 mL), and the resulting solution was refluxed under heating for 48 hours in a nitrogen atmosphere. During the course, generated methanol was removed by molecular sieves. The resulting product was cooled to room temperature and then washed by adding water. The resulting product was purified by recrystallization, and (I-1-a) was obtained as colorless powder. The yield was 1.12 g. The melting point was 110 C.1H-NMR (400 MHz, CDCl3): 1.05-1.16 (m, 24H), 1.21 (s, 18H), 1.87-1.92 (m, 6H), 2.54 (dd, J=6.2 Hz, 16.6 Hz, 2H), 2.70 (dd, J=7.1 Hz, 16.6 Hz, 2H), 3.16-3.23 (m, 1H), 5.13-5.23 (m, 3H).GC-MS (EI): m/z 594 [M+H+], 578 [M-15+]
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Trimethyl propane-1,2,3-tricarboxylate, its application will become more common.
Reference:
Patent; DIC CORPORATION; Iwakubo, Masayuki; Nose, Sayaka; Takachi, Manabu; Aoki, Yoshio; (13 pag.)US10336939; (2019); B2;,
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