Category: 609-14-3

《Ruthenium-catalyzed benzylic substitution of benzyl esters with stabilized carbon nucleophiles》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Suzuki, Koki; Tsuji, Hiroaki; Kawatsura, Motoi. Product Details of 609-14-3 The article mentions the following:

A [Cp*RuCl2]2/picolinic acid catalyst system promoted the reaction of 2-naphthylmethyl-2,3,4,5,6-pentafluorobenzoates with a series of stabilized carbon nucleophiles such as malonates, β-ketoesters, and diketones to give the corresponding benzylic alkylation products in moderate to high yields. A plausible reaction mechanism that could involve a (π-benzyl)ruthenium intermediate is proposed. In the experiment, the researchers used many compounds, for example, Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Product Details of 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Product Details of 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Wang, Yi-Feng; Wang, Chao-Jie; Feng, Qing-Zhou; Zhai, Jing-Jing; Qi, Suo-Suo; Zhong, Ai-Guo; Chu, Ming-Ming; Xu, Dan-Qian published an article in Chemical Communications (Cambridge, United Kingdom). The title of the article was 《Copper-catalyzed asymmetric 1,6-conjugate addition of in situ generated para-quinone methides with β-ketoesters》.Related Products of 609-14-3 The author mentioned the following in the article:

A Cu-catalyzed asym. 1,6-conjugate addition of in situ generated para-quinone methides (p-QMs) with β-ketoester has been developed to construct a ketoester skeleton bearing an adjacent tertiary-quaternary carbon stereocenter in good yields and high enantioselectivities. This is the first example of metal-catalyzed asym. transformations of the in situ generated p-QMs, avoiding using pre-synthesized p-QMs requiring bulky 2,6-substitutions and highlighting a new dual catalytic activation with the chiral bis(oxazoline)-metal complex acting as a normal Lewis acid to activate the β-ketoesters and a source of Bronsted acid responsible for generating the p-QMs in situ. In the experiment, the researchers used many compounds, for example, Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Related Products of 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Related Products of 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Budnikov, Alexander S.; Lopat’eva, Elena R.; Krylov, Igor B.; Segida, Oleg O.; Lastovko, Andrey V.; Ilovaisky, Alexey I.; Nikishin, Gennady I.; Glinushkin, Alexey P.; Terent’ev, Alexander O. published an article in Journal of Agricultural and Food Chemistry. The title of the article was 《4-Nitropyrazolin-5-ones as Readily Available Fungicides of the Novel Structural Type for Crop Protection: Atom-Efficient Scalable Synthesis and Key Structural Features Responsible for Activity》.Recommanded Product: Ethyl 2-methyl-3-oxobutanoate The author mentioned the following in the article:

The development of new types of fungicides for agriculture and medicine is highly desirable due to the uprising fungal resistance against commonly used compounds Herein, 4-substituted-4-nitropyrazolin-5-ones (nitropyrazolones) were proposed as highly active fungicides of the novel structural type. The first scalable and practical method for the nitropyrazolone synthesis was proposed, which is atom-efficient, is applicable for the multigram scale synthesis, and allows for production of a wide variety of nitropyrazolones with high yields and purity. The synthesized compounds demonstrated high fungicidal activity against the broad spectrum of phytopathogenic fungi (Venturia inaequalis, Rhizoctonia solani, Fusarium oxysporum, Fusarium moniliforme, Bipolaris sorokiniana, and Sclerotinia sclerotiorum). Their mycelium growth inhibiting activity was comparable or superior to that of kresoxim-Me. In vitro activity against Staphyloccocus aureus, Candida albicans, and Aspergillus niger revealed that nitropyrazolones are promising candidates against human pathogens. The key factors for the manifestation of high fungicidal activity were established to be an aromatic substituent on the N1 atom and small substituents, such as Me, at the C3 and C4 positions of the pyrazolone ring. The experimental process involved the reaction of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Recommanded Product: Ethyl 2-methyl-3-oxobutanoate)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Recommanded Product: Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Supramolecularly regulated copper-bisoxazoline catalysts for the efficient insertion of carbenoid species into hydroxyl bonds》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Iniesta, Ester; Vidal-Ferran, Anton. Recommanded Product: 609-14-3 The article mentions the following:

The catalytic insertion of copper carbenoids into O-H bonds affords synthetically useful α-alkyl/aryl-α-alkoxy/aryloxy derivatives Herein, the design, preparation and application of supramolecularly regulated copper(I) complexes of bisoxazoline ligands is reported. The catalytic performance of these systems can be modulated using an external mol. (i.e. the regulation agent), which interacts with a polyethyleneoxy chain on the ligand (i.e. the regulation site) via supramol. interactions. This approach was applied to an array of structurally diverse alcs. (cycloalkyl, alkyl and aryl derivatives). Moreover, the authors used this methodol. to synthesize advanced synthetic intermediates of biol. relevant compoundsEthyl 2-methyl-3-oxobutanoate(cas: 609-14-3Recommanded Product: 609-14-3) was used in this study.

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Profiling structural diversity and activity of 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Szamosvari, David; Prothiwa, Michaela; Dieterich, Cora Lisbeth; Boettcher, Thomas. Reference of Ethyl 2-methyl-3-oxobutanoate The article mentions the following:

We synthesized all major saturated and unsaturated 2-alkyl-4(1H)-quinolone N-oxides of Pseudomonas and Burkholderia, quantified their native production levels and characterized their antibiotic activities against competing Staphylococcus aureus. We demonstrate that quinolone core methylation and position of unsaturation in the alkyl-chain dictate antibiotic potency which supports the proposed mechanism of action. In addition to this study using Ethyl 2-methyl-3-oxobutanoate, there are many other studies that have used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Reference of Ethyl 2-methyl-3-oxobutanoate) was used in this study.

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Reference of Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Fuentes-Aguilar, Alma; Merino-Montiel, Penelope; Montiel-Smith, Sara; Meza-Reyes, Socorro; Vega-Baez, Jose Luis; Puerta, Adrian; Fernandes, Miguel X.; Padron, Jose M.; Petreni, Andrea; Nocentini, Alessio; Supuran, Claudiu T.; Lopez, Oscar; Fernandez-Bolanos, Jose G. published an article in Journal of Enzyme Inhibition and Medicinal Chemistry. The title of the article was 《2-Aminobenzoxazole-appended coumarins as potent and selective inhibitors of tumour-associated carbonic anhydrases》.COA of Formula: C7H12O3 The author mentioned the following in the article:

We have carried out the design, synthesis, and evaluation of a small library of 2-aminobenzoxazole-appended coumarins as novel inhibitors of tumor-related CAs IX and XII. Substituents on C-3 and/or C-4 positions of the coumarin scaffold, and on the benzoxazole moiety, together with the length of the linker connecting both units were modified to obtain useful structure-activity relationships. CA inhibition studies revealed a good selectivity towards tumor-associated CAs IX and XII (Ki within the mid-nanomolar range in most of the cases) in comparison with CAs I, II, IV, and VII (Ki > 10 μM); CA IX was found to be slightly more sensitive towards structural changes. Docking calculations suggested that the coumarin scaffold might act as a prodrug, binding to the CAs in its hydrolyzed form, which is in turn obtained due to the esterase activity of CAs. An increase of the tether length and of the substituents steric hindrance was found to be detrimental to in vitro antiproliferative activities. Incorporation of a chlorine atom on C-3 of the coumarin moiety achieved the strongest antiproliferative agent, with activities within the low micromolar range for the panel of tumor cell lines tested. In the experiment, the researchers used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3COA of Formula: C7H12O3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.COA of Formula: C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kizhakkayil Mangadan, Arun Raj; Liu, Ji; Aponick, Aaron published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Enantioselective Lactonization by π-Acid-Catalyzed Allylic Substitution: A Complement to π-Allylmetal Chemistry》.Name: Ethyl 2-methyl-3-oxobutanoate The article contains the following contents:

Asym. allylic alkylation (AAA) is a powerful method for the formation of highly useful, non-racemic allylic compounds A complementary enantioselective process that generates allylic lactones via π-acid catalysis was presented. More specifically, a catalytic enantioselective dehydrative lactonization of allylic alcs. using a novel PdII-catalyst containing the imidazole-based P,N-ligand (S)-StackPhos is reported. The high-yielding reactions are operationally simple to perform with enantioselectivities up to 99% ee. This strategy facilitates the replacement of a poor leaving group with what would ostensibly be a better leaving group in the product avoiding complications arising from racemization by equilibration. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Name: Ethyl 2-methyl-3-oxobutanoate)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Name: Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Synthesis of 2-[2-(hydroxyimino)alkyl]-1,2-oxazol-5(2H)-ones》 was written by Nikolaenkova, Elena B.; Bagryanskaya, Irina Yu.; Tikhonov, Alexsei Ya.. Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2020. The article conveys some information:

The reaction of α-hydroxyamino oximes with Et acetoacetate and Et α-methylacetoacetate yields 2-[2-(hydroxyimino)alkyl]-1,2-oxazol-5(2H)-ones. In the reaction of alkylarom. α-hydroxyamino oximes with Et acetoacetate, the intermediate imidazo[1,2-b]-[1,2]oxazolones were isolated, which then convert to the target compoundsEthyl 2-methyl-3-oxobutanoate(cas: 609-14-3Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate) was used in this study.

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics