Category: 609-14-3

《Electrochemical-Induced Ring Transformation of Cyclic α-(ortho-Iodophenyl)-β-oxoesters》 was published in Chemistry – A European Journal in 2020. These research results belong to Strehl, Julia; Kahrs, Christoph; Mueller, Thomas; Hilt, Gerhard; Christoffers, Jens. Electric Literature of C7H12O3 The article mentions the following:

Cyclic α-(ortho-iodophenyl)-β-oxoesters R3-2-IC6H3CH(R2)(C(O)OR)C(O)R1 (R = Me, Et; R1 = Me, Ph; R2 = H, Me; R1R2 = -(CH2)3-, -(CH2)4-, -(CH2)5-, -(CH2)6-; R3 = 2-Me, 3-Br, 4-methoxycarbonyl, etc.) and Me 2-(2-iodophenyl)-1-oxoindane-2-carboxylate, Et 2-(2-iodophenyl)-1-oxo-1,2,3,4-tetrahydronaphthalene-2-carboxylate were converted in a ring-expanding transformation to furnish benzannulated cycloalkanone carboxylic esters R3-2-R1C(O)C6H3CH(R2)C(O)OR and Et 12-oxo-5,6,7,12-tetrahydrodibenzo[a,d]cyclooctadiene-5-carboxylate. The reaction sequence started by electrochem. reduction of the iodoarene moiety. In a mechanistic rationale, the resulting carbanionic species was added to the carbonyl group under formation of a strained, tricyclic benzocyclobutene intermediate, which underwent carbon-carbon bond cleavage and rearrangement of the carbon skeleton by retro-aldol reaction. The scope of the reaction sequence was investigated by converting cyclic oxoesters with different ring sizes yielding benzocycloheptanone, -nonanone and -decanone derivatives in moderate to good yields. Furthermore, acyclic starting materials and cyclic compounds carrying addnl. substituents on the iodophenyl ring were submitted to this reaction sequence. The starting materials for this transformation are straightforwardly obtained by conversion of β-oxoesters R1C(O)CH(R2)C(O)OR with phenyliodobis(trifluoroacetate) R3C6H4I((O)OCCF3)2. In addition to this study using Ethyl 2-methyl-3-oxobutanoate, there are many other studies that have used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Electric Literature of C7H12O3) was used in this study.

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Electric Literature of C7H12O3

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Li, Shuangshuang; Qiu, Ju; Li, Bowen; Sun, Zuolian; Xie, Peizhong; Loh, Teck-Peng published their research in Organic Chemistry Frontiers in 2021. The article was titled 《Practical allylation with unactivated allylic alcohols under mild conditions》.Category: esters-buliding-blocks The article contains the following contents:

A practical palladium/calcium catalytic system was developed for dehydrative allylation with unactivated allylic alcs. EtOH solvent with a H2O additive was identified as powerful medium to accelerate proton transfer. This catalytic system and environmentally benign medium enabled a variety of soft carbonic nucleophiles and allylic alcs. to react smoothly at room temperature with water as the only byproduct. A wide spectrum of allylic compounds bearing a variety of functional groups I [R = Me, CN, CO2Et, etc.; R1 = CO2Me, CO2Et; R2 = CN, NO2, CO2Me, CO2Et; R3 = H, Me; R4 = H, Me; R5 = Ph, 2-FC6H4, 2-thienyl, etc.] could be obtained with high to excellent yields. After reading the article, we found that the author used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Category: esters-buliding-blocks)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Majewski, Arkadiusz; Przychodzen, Witold published their research in Synthetic Communications in 2021. The article was titled 《Atom-economic thiophosphoroselenenylations of C-H acid esters and amides》.Computed Properties of C7H12O3 The article contains the following contents:

Three improved thiophosphoroselenenylation procedures of CH-acids, including derivatives of malonic and acetyl-, phosphono-, 4-nitrophenyl- and 3-pyridylacetic acids, have been described and compared to previously reported thiophosphoroselenylation of di-Et malonate using bis(disopropoxyphosphinothioyl)diselenide alone or with the aid of Me iodide. The use of iodine makes it possible to utilize both equivalent of the selenenylating agent. The procedures work well for the majority of nucleophiles in a pKa range between more acidic malononitrile or Meldrum acid and less acidic phenylacetates. The reaction carried out on di-Et malonate in boiling rectified ethanol yields selenoacetate, which cannot be obtained by direct phosphoroselenenylation. Crystal structure of one of the selenomalonamides confirms the stabilization effects of both carbonyl oxygens on selenium atom. The P-Se bond splitting, using TBAF in 3-M excess in the presence of alkylating agent yields the resp. C,Se-dialkyl derivatives In the experiment, the researchers used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Computed Properties of C7H12O3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Computed Properties of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Fayed, Eman A.; Mohsen, Marwa; El-Gilil, Shimaa M. Abd; Aboul-Magd, Dina S.; Ragab, Ahmed published an article in Journal of Molecular Structure. The title of the article was 《Novel cyclohepta[b]thiophene derivative incorporating pyrimidine, pyridine, and chromene moiety as potential antimicrobial agents targeting DNA gyrase》.Category: esters-buliding-blocks The author mentioned the following in the article:

To cultivate novel and effectual antimicrobial agents, the triumphant synthesis of a novel class of cyclohepta-thieno-pyrimidines, I, II [R = Me, 4-MeC6H4, 4-ClC6H4, etc.; R1 = Me, NC, H2OC], cyclohepta[b]thiophene appended 2-imino-2H-chromene-3-carboxamide and 3-imino-3H-benzo[f]chromene-2-carboxamide derivatives , III [R2 = H; R3 = H, Br; R2R3 = C4H4] were presented to enrich their biol. behavior. The desired mols. underwent in-vitro appraisal for their antimicrobial activity, demonstrating encouraging results. Besides, the time-kill kinetics, antibiofilm activity and the DNA gyrase inhibition of the active thiophene compounds were evaluated. The DNA gyrase inhibition by the active thiophenes was also determined with IC50 values to range between (5.3-18.7μM) compared with Levofloxacin and Ciprofloxacin. Also, the sum of the Fractional Inhibitory Concentration Index (ΣFICI) was used to assess synergy between thiophenes and Levofloxacin. Addnl., the antimicrobial activity of the most active thiophene derivative was analyzed after γ-irradiation Moreover, the in-silico prediction methodol. was contemplated for foretelling the physicochem., pharmacokinetic and ADME traits of the most active synthesized compounds and the standard reference drugs: Levofloxacin and Ciprofloxacin. The docking examination was carried out for the most promising derivatives, I, III [R2 = R3 = H] IV [R4 = H2N, (2-cyanoacetyl)amino, (2-chloroacetyl)amino], Novobiocin, and Levofloxacin inside the active site of DNA gyrase, and their resp. docking scores were contrasted with the scores of the above-mentioned standard drugs. In the experiment, the researchers used many compounds, for example, Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Category: esters-buliding-blocks)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Copper-catalyzed enantioselective direct α-C-H amination of β-dicarbonyl derivatives with aryl hydroxylamines and mechanistic insights》 was published in Molecular Catalysis in 2020. These research results belong to Rajmani Singh, Rahul Kumar; Karsili, Tolga N. V.; Srivastava, Radhey. Product Details of 609-14-3 The article mentions the following:

Authors report a novel and efficient Cu-catalyzed direct asym. amination of tertiary β-carbonyl compounds using aryl hydroxylamine as electrophilic nitrogen donor. The process facilitates the convenient and direct synthesis of chiral α-amino carbonyl derivatives, without the need for any post-reaction manipulation. This method reveals an effective strategy for the synthesis of enantioenriched α-C-H aminated derivatives which is hitherto challenging. The choice of the robust chiral indabox ligand was ascertained to be very crucial for the desired enantioselectivity in the contemporary transformation. The reaction mechanism is fully supported by ab initio electronic structure calculations The reaction is facile, efficient and performs well at room temperature with an enantiomeric excess (ee) up to 93%. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Product Details of 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Product Details of 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pacifico, Roberta; Destro, Dario; Gillick-Healy, Malachi W.; Kelly, Brian G.; Adamo, Mauro F. A. published an article in 2021. The article was titled 《Preparation of acidic 5-hydroxy-1,2,3-triazoles via cycloaddition of aryl azides with β-ketoesters》, and you may find the article in Journal of Organic Chemistry.Product Details of 609-14-3 The information in the text is summarized as follows:

A series of 1,2,3-triazoles I (R = H, Me, benzyl; Ar = 3-pyridyl, Ph, 1-naphthyl, etc.) or II (R1 = 2-pyridyl, 3-pyridyl, 4-pyridyl) via cycloaddition reation of β-ketoesters EtOC(O)CH(R)C(O)Me and azides ArN3 and R1N3 in high yields were reported. The reactions employing 2-unsubstituted β-ketoesters EtOC(O)CH2C(O)Me were found to provide 5-Me 1,2,3-triazoles II; whereas 2-alkyl-substituted β-ketoesters provided 5-hydroxy 1,2,3-triazoles I (shown to be relatively acidic) in high yields and as single regioisomers. Several novel compounds were reported and characterized. The synthetic utility of the protocol has been exemplified by the preparation of long-chain 5-hydroxy 1,2,3-triazoles III (R2 = Me, Et; n = 1, 2, 3) with a potentially bioisosteric relationship to hydroxamic acids. In the part of experimental materials, we found many familiar compounds, such as Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Product Details of 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Product Details of 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cai, Mao; Xu, Kaini; Li, Yuze; Nie, Zongxiu; Zhang, Long; Luo, Sanzhong published their research in Journal of the American Chemical Society in 2021. The article was titled 《Chiral Primary Amine/Ketone Cooperative Catalysis for Asymmetric α-Hydroxylation with Hydrogen Peroxide》.Quality Control of Ethyl 2-methyl-3-oxobutanoate The article contains the following contents:

Carbonyls and amines are yin and yang in organocatalysis as they mutually activate and transform each other. These intrinsically reacting partners tend to condense with each other, thus depleting their individual activity when used together as cocatalysts. Though widely established in many prominent catalytic strategies, aminocatalysis and carbonyl catalysis do not coexist well, and, as such, a cooperative amine/carbonyl dual catalysis remains essentially unknown. Here we report a cooperative primary amine and ketone dual catalytic approach for the asym. α-hydroxylation of β-ketocarbonyls with H2O2. Besides participating in the typical enamine catalytic cycle, the chiral primary amine catalyst was found to work cooperatively with a ketone catalyst to activate H2O2 via an oxaziridine intermediate derived from an in-situ-generated ketimine. Ultimately, this enamine-oxaziridine coupling facilitated the highly controlled α-hydroxylation of several β-ketocarbonyls in excellent yield and enantioselectivity. Notably, late-stage hydroxylation for peptidyl amide or chiral esters can also be achieved with high stereoselectivity. In addition to its operational simplicity and mild conditions, this cooperative amine/ketone catalytic approach also provides a new strategy for the catalytic activation of H2O2 and expands the domain of typical amine and carbonyl catalysis to include this challenging transformation. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Quality Control of Ethyl 2-methyl-3-oxobutanoate)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Quality Control of Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Ding, Lu; Song, Hao; Zheng, Chao; You, Shu-Li published an article in Journal of the American Chemical Society. The title of the article was 《Enantioselective Synthesis of Medium-Sized-Ring Lactones via Iridium-Catalyzed Z-Retentive Asymmetric Allylic Substitution Reaction》.Safety of Ethyl 2-methyl-3-oxobutanoate The author mentioned the following in the article:

An enantioselective synthesis of medium-sized-ring lactones, e.g., I, by iridium-catalyzed Z-retentive asym. allylic substitution reaction was reported. The reaction features mild conditions and a broad substrate scope. Various eight- to 11-membered-ring lactones can be afforded in moderate to excellent yields (up to 88%) and excellent enantioselectivity (up to 99% ee). The utilization of both Z-allyl precursors and Ir catalyst is critical for the medium-sized ring formation. The experimental process involved the reaction of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Safety of Ethyl 2-methyl-3-oxobutanoate)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Safety of Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhang, Shuguang; Tan, Xin; Liang, Chaogen; Zhang, Weihua published their research in Journal of Heterocyclic Chemistry in 2021. The article was titled 《Design, synthesis, and antifungal evaluation of novel coumarin-pyrrole hybrids》.Recommanded Product: 609-14-3 The article contains the following contents:

A series of coumarin derivatives I [R1 = H, CH3, CH2CH3, Cl; R2 = H, CH3, CF3, CH2Cl, (CH2)2CH3; R3 = H, CH3, OH; R4 = H, CH3; R5 = H, CH3; R1R2 = -(CH2)3-] bearing a pyrrole scaffold was designed, prepared, and assessed for their in vitro antifungal activities against six phytopathogenic fungi. The antifungal activity screening results suggest that some synthesized hybrids exhibited potential fungicidal activities against the tested fungi. In particular, compounds I (R1 = R5 = H, R2 = CH3, R3 = OH, R4 = CH3; R1 = R5 = H, R2 = (CH2)2CH3, R3 = OH, R4 = CH3; R1 = R4 = H, R2 = R3 = R5 = CH3; R1 = R4 = H, R3 = R5 = CH3, R2 = CF3; R1 = R4 = H, R3 = R5 = CH3, R2 = (CH2)2CH3) displayed significant antifungal effects against Rhizoctonia solani, and possessed EC50 values of 3.94, 7.75, 6.38, 6.25, and 7.67μg/ mL, resp. The above activities are more potent than the commercialized fungicide Boscalid (11.52μg/mL) and Osthole (9.79μg/mL). These results provide a significant reference for further rational design of coumarin-based fungicides. The experimental process involved the reaction of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Recommanded Product: 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Three-Component Reaction for the Synthesis of Highly Functionalized Propargyl Ethers》 was written by Pisella, Guillaume; Gagnebin, Alec; Waser, Jerome. Related Products of 609-14-3 And the article was included in Chemistry – A European Journal in 2020. The article conveys some information:

Copper-catalyzed three-component reaction of diazo compounds, alcs. and ethynyl benziodoxole (EBX) reagents for the synthesis of propargyl ethers was reported. Extensive variations of the three partners of the reaction was possible, led to highly functionalized and structurally diverse products under mild conditions. Alkynylation of a copper ylide intermediate was postulated as key step for this transformation. In the experiment, the researchers used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Related Products of 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Related Products of 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics