Category: 609-14-3

Abdelkawy, Mahmoud A.; Davin, Christopher; Aly, El-Saied A.; El-Badawi, Mahmoud A.; Itsuno, Shinichi published their research in ChemistrySelect in 2021. The article was titled 《Chiral Polyureas Derived Cinchona Alkaloids: Highly Efficient Bifunctional Organocatalysts for the Asymmetric Michael Addition Reaction》.Synthetic Route of C7H12O3 The article contains the following contents:

Repetitive Mizoroki-Heck (MH) coupling polymerization was used to create novel chiral polyureas with cinchona alkaloids in the main chain. Apart from two-component polycondensation of cinchona urea dimers with diiodobenzene via MH reaction conditions, some chiral polyureas were easily polymerized under self polycondensation to yield the chiral polymers. The asym. Michael addition reaction was successfully carried out using chiral polymers derived cinchona urea. Interestingly, phenolic-based chiral polymers served as heterogeneous catalysts for the enantioselective Michael reaction, with high catalytic activity and excellent enantioselectivities (up to 99% ee). These polymeric catalysts were also stable, and they could be recycled and reused. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Synthetic Route of C7H12O3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Synthetic Route of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Zhang, Qi; Shi, Mingying; Mi, Xueling; Luo, Sanzhong published an article in Organic Chemistry Frontiers. The title of the article was 《Catalytic asymmetric oxidative sulfenylation of β-ketocarbonyls using a chiral primary amine》.HPLC of Formula: 609-14-3 The author mentioned the following in the article:

Enantioselective oxidative construction of a C(sp3)-S bond has been achieved using a chiral primary amine catalyst in the presence of tert-Bu hydroperoxide and a catalytic amount of tetrabutylammonium iodide. The distinctive feature of the current reaction is coupling with nucleophilic sulfur reactants under oxidative conditions. This protocol provides facile access to chiral thioethers bearing S-containing quaternary stereocenters with good chemo- and enantiocontrol. The experimental process involved the reaction of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3HPLC of Formula: 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.HPLC of Formula: 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Krakowian, Daniel; Gadarowska, Dominika; Daniel-Wojcik, Anna; Mrzyk, Inga published an article in Toxicology In Vitro. The title of the article was 《Cytotoxicity assay to assess eye irritation – A comparison with other methods and possible strategies for use》.Synthetic Route of C7H12O3 The author mentioned the following in the article:

Many in vitro methods can be used to classify eye irritation or damage caused by exposure to a substance. In this study, a recently described method called the Cytotoxicity Assay to Assess Eye Irritation (CEI) was compared with other selected in vitro methods adopted in the OECD guidelines. Furthermore, the influence of combining more than one in vitro method was investigated. Basic performance indexes were considered and a risk assessment based on the number of correct and incorrect results (overestimated or underestimated) was performed. The CEI results were similar to those of other in vitro tests, however, the CEI can also directly classify substances irritating to the eyes. When the CEI preceded an eye irritation test based reconstructed human corneal-like epithelium, there were fewer underestimates compared with other method combinations. This combination can better protect human health and provides results comparable to those obtained in animal tests. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Synthetic Route of C7H12O3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Synthetic Route of C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of 609-14-3In 2021 ,《Umbelliferyloxymethyl phosphonate compounds-weakly binding zinc ionophores with neuroprotective properties》 appeared in Dalton Transactions. The author of the article were Guesne, Sebastien; Connole, Laura; Kim, Stephanie; Motevalli, Majid; Robson, Lesley; Michael-Titus, Adina T.; Sullivan, Alice. The article conveys some information:

Umbelliferone is a member of the coumarin family of compounds which are known for diverse pharmacol. activity including in targets relevant to Alzheimers disease, AD. The toxicity associated with some forms of the amyloid protein, Aβ, and the role of Zn2+ (and other biometals) dyshomeostasis in this, are of great interest in AD and make metal ionophore capability desirable in so called multi target drug ligands MTDLs. A new series of umbelliferyloxymethyl phosphonic acid diethylester compounds (umbelliferyloxymethyl phosphonates) bearing a phosphonate at the 7-position (compounds 1, 3-6), hydrolysis products 2, 2a and 2b from 1 and analogs 7 and 8 of 1 with 7-O to 7-S and 1-O to 1-NH substitutions, are reported. Single crystal x-ray structures of compounds 1, 2 and 2a were determined In terms of neuroprotective properties, the compounds 1, 2, 3, 4, 5 and 6 at 1μM concentration, inhibited the toxicity of Aβ1-42 (Aβ42) in both toxic Amyloid Derived Diffusible Ligand (ADDL) and fibrillar (fibril) forms towards rat hippocampal cells. Compound 7 displayed cytotoxicity and 8 failed to inhibit Aβ42 toxicity. Concerning compound-metal ionophore activity (assessed using chem. experiments), despite weak binding to Zn2+ determined from 31P NMR titration of 1 and 2 by ZnCl2, compounds 1, 3, 4, 5 and 6 demonstrated ionophore assisted partition of Zn2+ from water to octanol at micromolar concentrations with efficacy on a par with or better than the chelator MTDL clioquinol (5-chloro-7-iodo-8-hydroxyquinoline). Partition was assessed using furnace Atomic Absorption Spectroscopy (AAS). In further experiments interaction of compound 1 with Zn2+ or it’s pathways was inferred by (i) delayed fluorescence response with added Zn2+ in cells treated with FluoZin-3 and (ii) by suppression of Zn2+ promoted aggregation of Aβ42. The results came from multiple reactions, including the reaction of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Application of 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Application of 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Cottrez, Francoise; Leblanc, Virginie; Boitel, Elodie; Groux, Herve; Alepee, Nathalie published an article in 2021. The article was titled 《The EyeIRR-IS assay: Development and evaluation of an in vitro assay to measure the eye irritation sub-categorization of liquid chemicals》, and you may find the article in Toxicology In Vitro.Name: Ethyl 2-methyl-3-oxobutanoate The information in the text is summarized as follows:

Several alternative methods have been developed and regulatory adopted by OECD as in vitro alternatives to the Draize eye irritation assay either to detect chems. not requiring classification (No Category) or inducing serious damage to the eye (Category 1) but none are sensitive enough to identify chems. inducing reversible eye effects (category 2) which are categorised by default. Therefore, the discriminatory power of a genomic approach applied to the SkinEthic Human Corneal Epithelium (HCE) model was investigated to allow subcategorization capacity according to UN GHS classification. An algorithm based on gene expression modulation on a training (62) and a test (31 liquids) chem. set, tested neat and at 30%was evaluated in an assay called EyeIRR-IS. Its accuracy prediction to distinguish Cat1/Cat2 from No Cat was 95% with a specificity of 89% and a sensitivity of 98%. For subcategorization into the 3 GHS classes the accuracy reached 84% with 94% Cat1, 67% Cat2 and 89% No Cat correctly predicted. No Cat.1 chems. were underestimated as neg. with a majority of misclassified Cat2 over predicted as Cat 1. In conclusion, the performance of the assay suggests its added value in a defined approach for liquids to replace the Draize assay. The experimental process involved the reaction of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Name: Ethyl 2-methyl-3-oxobutanoate)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Name: Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Homrani, Yasmina; El Amrani, Mohamed Amin; Loxq, Pauline; Capet, Frederic; Suisse, Isabelle; Sauthier, Mathieu published an article in 2022. The article was titled 《Synthesis and crystal structures of palladium complexes based on α-amino-oximes derived from (R)-limonene and their application in allylic alkylation of 1,3-dioxo compounds》, and you may find the article in Comptes Rendus Chimie.Recommanded Product: Ethyl 2-methyl-3-oxobutanoate The information in the text is summarized as follows:

Coordination compounds Pd(L1)Cl2, Pd(L2)Cl2, and Pd(L3)Cl2 have been synthesized from optically pure α-amino-oxime ligands s L1-L3 b based on (R)-limonene. Structures of the new palladium complexes are characterized and described by NMR spectroscopy and X-rays. These α-amino-oxime ligands were then evaluated in the palladium-catalyzed allylation of 1,3-dioxo compounds In addition to this study using Ethyl 2-methyl-3-oxobutanoate, there are many other studies that have used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Recommanded Product: Ethyl 2-methyl-3-oxobutanoate) was used in this study.

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Thermoresponsive starch hydrogel stabilized Pd nanoparticles: Soft catalyst for the preparation of (±)-α-methylbiphenylalanine in water aiming at bioorthogonal chemistries》 was written by dos Santos, Raquel V.; Vitoi, Vitor Hugo M.; Costa, Marcio V.; da Silva, Lorenna C. L. L. F.; Archanjo, Braulio S.; Achete, Carlos A.; Silva, Raphael S. F.; Aguiar, Lucia C. S.; Malta, Luiz Fernando B.; Senra, Jaqueline D.. Category: esters-buliding-blocks And the article was included in Catalysis Letters in 2021. The article conveys some information:

The corn-starch was able to reduce Pd(II) species under relatively low concentration (5.0 wt/vol) leading to the formation of a thermoresponsive palladium nanoparticles-containing hydrogel with D = 16.1 nm ± 6.4 nm. It was successfully applied to the Suzuki-Miyaura reaction step in neat water involved in the synthesis of (±)-N-acetyl-α-methyl-4-biphenylalanine Et ester, a direct precursor of an unnatural quaternary biarylalanine. In the experiment, the researchers used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Category: esters-buliding-blocks)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Shichao; Hou, Bo; Wang, Jianbo published their research in Journal of Organic Chemistry in 2021. The article was titled 《Palladium-Catalyzed Oxidative Coupling of the Allenic C-H Bond with α-Diazo Esters: Synthesis of [3]Dendralenes》.Formula: C7H12O3 The article contains the following contents:

A palladium-catalyzed highly regio- and stereoselective C-H oxidative coupling of allenes such as I with α-diazo esters such as benzyl 2-diazopropanoate is developed. The reaction pathway involves allylic palladium carbene as the key intermediate, which is followed by a carbene migratory insertion process. The reaction proceeds efficiently under mild conditions without external base, providing substituted [3]dendralenes such as II bearing various functional groups. After reading the article, we found that the author used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Formula: C7H12O3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Formula: C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Petrovicova, Tatiana; Gyuranova, Dominika; Plz, Michal; Myrtollari, Kamela; Smonou, Ioulia; Rebros, Martin published an article in 2021. The article was titled 《Application of robust ketoreductase from Hansenula polymorpha for the reduction of carbonyl compounds》, and you may find the article in Molecular Catalysis.Product Details of 609-14-3 The information in the text is summarized as follows:

Enzyme-catalyzed asym. reduction of ketones is an attractive tool for the production of chiral building blocks or precursors for the synthesis of bioactive compounds Expression of robust ketoreductase (KRED) from Hansenula polymorpha was upscaled and applied for the asym. reduction of 31 prochiral carbonyl compounds (aliphatic and aromatic ketones, diketones and β-keto esters) to the corresponding optically pure hydroxy compounds Biotransformations were performed with the purified recombinant KRED together with NADP+ recycling glucose dehydrogenase (GDH, Bacillus megaterium), both overexpressed in Escherichia coli BL21(DE3). Maximum activity of KRED for biotransformation of ethyl-2-methylacetoacetate achieved by the high cell d. cultivation was 2499.7 ± 234 U g-1DCW and 8.47 ± 0.40 U·mg-1E, resp. The KRED from Hansenula polymorpha is a very versatile enzyme with broad substrate specificity and high activity towards carbonyl substrates with various structural features. Among the 36 carbonyl substrates screened in this study, the KRED showed activity with 31, with high enantioselectivity in most cases. With several ketones, the Hansenula polymorpha KRED catalyzed preferentially the formation of the (R)-secondary alcs., which is highly valued. In addition to this study using Ethyl 2-methyl-3-oxobutanoate, there are many other studies that have used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Product Details of 609-14-3) was used in this study.

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Product Details of 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Naikwadi, Dhanaji R.; Singh, Amravati S.; Biradar, Ankush V. published an article in 2021. The article was titled 《Bronsted acidic cellulose-PO3H: An efficient catalyst for the chemoselective synthesis of fructones and trans-esterification via condensation of acetoacetic esters with alcohols and diols》, and you may find the article in Molecular Catalysis.Recommanded Product: Ethyl 2-methyl-3-oxobutanoate The information in the text is summarized as follows:

Cellulose is the most abundant organic source and has expedient a great deal of interest as renewable and emerged as sustainable feedstock. The functionalization of cellulose as designed catalytic system intriguing furnished to the production of fine chems. Herein, we synthesized an environmental friendly solid acid catalyst by functionalizing cellulose with phosphoric acid (PO3H). The successful functionalization of cellulose with PO3H was confirmed by 31P NMR, ICP-OES, FE-SEM, and XPS anal. ICP-OES revealed the presence of phosphorus content of ~1.0 weight % on the catalyst’s surface while elemental mapping by FESEM and XPS shows a uniform distribution of phosphorus over the material. The synthesized solid acid catalyst was utilized for condensation of diols with acetoacetic esters in solvent-free conditions to synthesize fine chems. The present approach not only circumvented the one-step protection and other products but more fascinatingly provided trans-esterification of acetoacetic esters with diols and n-alcs. The catalyst was successfully used for chemoselective protection on Et acetoacetate with 1,2 diols to essential fructone mol. with ~100% conversion and 99% selectivity. The results suggested that the catalyst has the advantage over com. solid acid heterogeneous and homogeneous catalysts. In the experimental materials used by the author, we found Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Recommanded Product: Ethyl 2-methyl-3-oxobutanoate)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Recommanded Product: Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics