Category: 609-14-3

SDS of cas: 609-14-3In 2020 ,《Unified Total Synthesis of Pentacyclic Stemoamide-type Alkaloids》 was published in Organic Letters. The article was written by Soda, Yasuki; Sugiyama, Yasukazu; Yoritate, Makoto; Tajima, Hayato; Shibuya, Kana; Ogihara, Chisato; Oishi, Takeshi; Sato, Takaaki; Chida, Noritaka. The article contains the following contents:

The collective synthesis of pentacyclic stemoamide-type alkaloids is recognized as a daunting task despite high demand for a comprehensive biol. profiling of these natural products. In this Letter, the authors report a unified synthesis of seven pentacyclic alkaloids and two unnatural derivatives The keys to success are (1) the chemoselective assembly of four five-membered building blocks, (2) the direct oxidation of pyrrolidine natural products to pyrrole derivatives, and (3) the stereodivergent construction of totally E- or Z-substituted butenolides. In the experiment, the researchers used many compounds, for example, Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3SDS of cas: 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.SDS of cas: 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application In Synthesis of Ethyl 2-methyl-3-oxobutanoateIn 2021 ,《Palladium-catalyzed Tsuji-Trost-type reaction of benzofuran-2-ylmethyl acetates with nucleophiles》 was published in RSC Advances. The article was written by Arcadi, Antonio; Fabrizi, Giancarlo; Fochetti, Andrea; Ghirga, Francesca; Goggiamani, Antonella; Iazzetti, Antonia; Marrone, Federico; Mazzoccanti, Giulia; Serraiocco, Andrea. The article contains the following contents:

The palladium-catalyzed benzylic-like nucleophilic substitution of benzofuran-2-ylmethyl acetates with N, S, O and C soft nucleophiles was investigated. The success of the reaction was dramatically influenced by the choice of catalytic system: with nitrogen based nucleophiles the reaction worked well with Pd2(dba)3/dppf, while with sulfur, oxygen and carbo-nucleophiles [Pd(η3-C3H5)Cl]2/XPhos was more efficient. The regiochem. outcome showeds that the nucleophilic substitution occurs only on the benzylic position of the η3-(benzofuryl)methyl complex. The high to excellent yields and the simplicity of the exptl. procedure made this protocol a versatile synthetic tool for the preparation of 2-substituted benzofurans I [R = CH2N(Me)(Ph), CH2SO2Ph, 4-MeOC6H4OCH2, etc.; R1 = H, 7-OMe, 5-NO2]. The experimental process involved the reaction of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Alkaline-earth Metal-Catalyzed Dehydrative Allylic Alkylation》 was published in Organic Letters in 2020. These research results belong to Xie, Peizhong; Li, Shuangshuang; Liu, Yanan; Cai, Xinying; Wang, Jinyu; Yang, Xiaobo; Loh, Teck-Peng. HPLC of Formula: 609-14-3 The article mentions the following:

An alk.-earth metal catalytic system for environmentally benign allylic alkylation was developed. Allylic alcs. can be utilized directly at room temperature in this transition metal-free process, producing water as the only byproduct. A variety of allylic compounds, including the ones containing all-carbonyl quaternary centers, can be obtained with high yields. In the experimental materials used by the author, we found Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3HPLC of Formula: 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.HPLC of Formula: 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

In 2022,Hu, Jingcheng; Zeng, Li; Hu, Jiayu; Ma, Rui; Liu, Xue; Jiao, Ying; He, Haoyu; Chen, Siyu; Xu, Zhexi; Wang, Hongfei; Lei, Aiwen published an article in Organic Letters. The title of the article was 《Electrochemical Difunctionalization of Terminal Alkynes: Access to 1,4-Dicarbonyl Compounds》.Recommanded Product: 609-14-3 The author mentioned the following in the article:

Herein, a feasible electrosynthesis method to access 1,4-dicarbonyl compounds such as I [R = Ph, 4-MeC6H4, 2-thienyl, etc.; R1 = Me, OMe, OEt, Oi-Pr; R2 = Me; R3 = Me; R2R3 = (CH2)3, (CH2)4, (CH2)5] had been developed from simple alkynes and 1,3-dicarbonyl compounds When the undivided cell was combined with the constant current mode, aryl alkynes containing numerous medicinal motifs with 1,3-dicarbonyl esters or ketones reacted smoothly. External oxidant and catalyst-free conditions conformed to the requirements of green synthesis. After reading the article, we found that the author used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Recommanded Product: 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Recommanded Product: 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Direct Catalytic Asymmetric Synthesis of Oxindole-Derived δ-Hydroxy-β-ketoesters by Aldol Reactions》 was written by Zhang, Dongxin; Chen, Yan; Cai, Hu; Yin, Lei; Zhong, Junchao; Man, Jingjing; Zhang, Qian-Feng; Bethi, Venkati; Tanaka, Fujie. HPLC of Formula: 609-14-3 And the article was included in Organic Letters in 2020. The article conveys some information:

Direct asym. synthesis of δ-hydroxy-β-ketoesters was accomplished via regio- and enantioselective aldol reactions of β-ketoesters with isatins catalyzed by cinchona alkaloid thiourea derivatives The C-C bond formation of the reactions occurred only at the γ-position of the β-ketoesters. Reaction progress monitoring and product stability analyses under the conditions that included the catalyst indicated that the γ-position reaction products were formed kinetically. Various δ-hydroxy-β-ketoesters bearing 3-alkyl-3-hydroxyoxindole cores relevant to the development of bioactive mols. were synthesized. In the experimental materials used by the author, we found Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3HPLC of Formula: 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.HPLC of Formula: 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Pu, Xiang; Dang, Qiu-Di; Yang, Lei; Zhang, Xia; Niu, Dawen published an article in 2022. The article was titled 《Doubly stereoconvergent construction of vicinal all-carbon quaternary and tertiary stereocenters by Cu/Mg-catalyzed propargylic substitution》, and you may find the article in Nature Communications.HPLC of Formula: 609-14-3 The information in the text is summarized as follows:

Here a doubly stereoconvergent, Cu/Mg-catalyzed asym. propargylic substitution reaction to convert simple starting materials to products with vicinal tertiary and all-carbon quaternary stereocenters in high yields and excellent diastereo- and enantioselectivities was reported. Both the nucleophiles and the electrophiles employed in this transformation were racemic. This reaction uses earth abundant metal catalysts, operates under ambient conditions and demonstrated broad substrate scope. The products of this reaction were functional group rich and synthetically versatile. Key to the success of this development was the devise of a Cu/Mg dual catalytic system and the identification of a bulky tridentate pyridinebisimidazoline (PyBim) ligand. The experimental part of the paper was very detailed, including the reaction process of Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3HPLC of Formula: 609-14-3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.HPLC of Formula: 609-14-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Zheng-Xin; Li, Jia-Wei; Wang, Liang-Neng; Li, Ming; Liu, Yue-Jin; Zeng, Ming-Hua published an article in 2021. The article was titled 《Cooperative Ligand-Promoted P(III)-Directed Ruthenium-Catalyzed Remote Meta-C-H Alkylation of Tertiary Phosphines》, and you may find the article in Organic Letters.Reference of Ethyl 2-methyl-3-oxobutanoate The information in the text is summarized as follows:

Herein, the authors disclose a Ru-catalyzed meta-selective C-H activation of phosphines by using intrinsic P(III) as a directing group. 2,2,6,6-Tetramethylheptane-3,5-dione acts as the ligand and exhibits an excellent performance in boosting the meta-alkylation. The protocol allows an efficient and straightforward synthesis of meta-alkylated tertiary phosphines. Several meta-alkylated phosphines were evaluated for Pd-catalyzed Suzuki coupling and are superior to com. available ortho-substituted phosphines. The practicability of this methodol. is further demonstrated by the synthesis of difunctionalized phosphines. After reading the article, we found that the author used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Reference of Ethyl 2-methyl-3-oxobutanoate)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.Reference of Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Catalytic 1,2-Rearrangements: Organocatalyzed Michael/Semi-Pinacol-like Rearrangement Cascade of 1,3-Diones and Nitroolefins》 was written by Jao, Tsung-Jung; Akula, Pavan Sudheer; Hong, Bor-Cherng; Lee, Gene-Hsiang. COA of Formula: C7H12O3 And the article was included in Organic Letters in 2020. The article conveys some information:

New types of organocatalytic 1,2-rearrangements, which resemble the Smiles-like or semi-pinacol-like rearrangement, of Michael adducts of 1,3-dicarbonyl-2-alkyl compounds and nitroalkenes have been realized. Unlike the well-known conjugate addition, the reaction affords the 1-phenyl-1-nitroalkanes via unprecedented rearrangement and cascade reactions. Structures of the appropriate products were unambiguously characterized by X-ray crystallog. In the experiment, the researchers used Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3COA of Formula: C7H12O3)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. They are most widely used as solvents, especially in industries manufacturing explosives, lacquers, paints, and textiles. Ketones are also used in tanning, as preservatives, and in hydraulic fluids.COA of Formula: C7H12O3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Cheng; Xuan, Yang; Chen, Qi; Ni, Guo-Wei; Pan, Jiang; Xu, Jian-He published their research in Molecular Catalysis in 2021. The article was titled 《Asymmetric reduction of 2-chloro-3-oxo-ester into enantiomerically high pure diltiazem precursor by a Candida ketoreductase》.Category: esters-buliding-blocks The article contains the following contents:

Me (2R,3S)-3-(4-methoxyphenyl)glycidate [(2R,3S)-MPGM] is an advanced chiral synthon for the synthesis of the cardiovascular drug diltiazem. It can be easily accessed by cyclizing the reduction products of Me 2-chloro-3-(4-methoxyphenyl)-3-oxo-propanoate. Herein, we report an identified carbonyl reductase (CpKR) from Candida parapsilosis that displayed an excellent stereoselectivity toward the keto substituent at the C3-position of the 2-chloro-3-oxo-ester. The engineered Escherichia coli cells harboring CpKR gene were directly applied for the asym. reduction of keto ester 1a with a space-time yield of 46 g L-1 d-1, which represents the highest productivity in bio-reduction reported so far. The isolated chiral alc. products were then applied to the chem. synthesis of (2R,3S)-MPGM in 99% ee and a total yield of 76% in the two-step chemo-enzymic reactions, which far exceeded the maximum theor. yield (50%) of the existing industrial process based on a lipase-catalyzed resolution of racemic MPGM. This work provides a promising eco-friendly and cost-effective route toward industrial synthesis of pharmaceutically relevant diltiazem. In the experiment, the researchers used many compounds, for example, Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Category: esters-buliding-blocks)

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

《Asymmetric Total Synthesis of the Naturally Occurring Antibiotic Anthracimycin》 was published in Organic Letters in 2020. These research results belong to Davison, Emma K.; Freeman, Jared L.; Zhang, Wanli; Wuest, William M.; Furkert, Daniel P.; Brimble, Margaret A.. Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate The article mentions the following:

The first total synthesis of the potent antibiotic anthracimycin (I) was achieved in 20 steps. The synthesis features an intramol. Diels-Alder reaction to forge the trans-decalin moiety, and an unprecedented aldol reaction using a complex β-ketoester to provide the tricarbonyl motif. A Stork-Zhao olefination and Grubbs ring closing metathesis delivered the E/Z-diene and forged the macrocycle. The C2 configuration was set with a base-mediated epimerization, providing access to (-)-anthracimycin.Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate) was used in this study.

Ethyl 2-methyl-3-oxobutanoate(cas: 609-14-3) belongs to ketone compounds. Ketones are highly reactive, although less so than aldehydes, to which they are closely related. Much of their chemical activity results from the nature of the carbonyl group. Ketones readily undergo a wide variety of chemical reactions.Application In Synthesis of Ethyl 2-methyl-3-oxobutanoate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics