609-08-5 Archives - Page 5 of 9 - Esters-buliding-blocks

Xiao, Pan’s team published research in Journal of Organic Chemistry in 2019 | CAS: 609-08-5

Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Recommanded Product: 609-08-5

The author of 《Fluoroalkylation of Various Nucleophiles with Fluoroalkyl Sulfones through a Single Electron Transfer Process》 were Xiao, Pan; Ni, Chuanfa; Miao, Wenjun; Zhou, Min; Hu, Jingyu; Chen, Dingben; Hu, Jinbo. And the article was published in Journal of Organic Chemistry in 2019. Recommanded Product: 609-08-5 The author mentioned the following in the article:

The fluoroalkylation of various nucleophilic reagents with (phenylsulfonyl)difluoromethyl (PhSO2CF2)-substituted phenanthridines was achieved to give fluorinated phenanthridine derivatives, which enables the construction of both carbon-heteroatom and carbon-carbon bonds via the substitution of the phenylsulfonyl group. Mechanistic studies indicated that these reactions proceed through a unimol. radical nucleophilic substitution (SRN1) mechanism. It is worthwhile noting that in the cases of O-nucleophiles (t-BuO- and PhO-), the addition of t-BuOK/PhCHO could significantly promote the reactions, due to the in situ formation of a highly reactive electron donor species through the interaction of t-BuOK, PhCHO, and the solvent DMF, which can effectively initiate the single electron transfer process. In the part of experimental materials, we found many familiar compounds, such as Diethyl 2-methylmalonate(cas: 609-08-5Recommanded Product: 609-08-5)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tao, Eriko’s team published research in Journal of Organic Chemistry in 2020 | CAS: 609-08-5

《Total Synthesis of (±)-Liphagal via Organic-Redox-Driven Palladium-Catalyzed Hydroxybenzofuran Formation》 was written by Tao, Eriko; Inoue, Masaki; Jeong, Taejoo; Kim, In Su; Yoshimitsu, Takehiko. COA of Formula: C8H14O4 And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

A synthetic route to liphagal, a natural PI3Kα inhibitor isolated from Aka coralliphaga, was established. The present route features an organic redox process where an alkynylquinone undergoes reductive cyclization in the presence of a hydroquinone derivative such as hydroxyquinol (1,2,4-benzenetriol) and catalytic PdCl2 to provide a substituted benzofuran suitable for accessing the natural product. The benzofuran formation takes place via the redox transformation between the alkynylquinone and the electron-rich hydroquinones followed by the concomitant Pd(II)-catalyzed oxycyclization of the resultant alkynylhydroquinone. The experimental part of the paper was very detailed, including the reaction process of Diethyl 2-methylmalonate(cas: 609-08-5COA of Formula: C8H14O4)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kang, Qing-Qing’s team published research in New Journal of Chemistry in 2021 | CAS: 609-08-5

Kang, Qing-Qing; Meng, Ya-Nan; Zhang, Jun-Hao; Li, Long; Ge, Guo-Ping; Zheng, Hongxing; Liu, Hongxin; Wei, Wen-Ting published their research in New Journal of Chemistry in 2021. The article was titled 《Iron-catalyzed oxidative cyclization of olefinic 1,3-dicarbonyls with ketone C(sp3)-H bonds: Facile access to 2,3-dihydrofurans》.Quality Control of Diethyl 2-methylmalonate The article contains the following contents:

Iron-catalyzed oxidative cyclization of olefinic 1,3-dicarbonyls with ketone C(sp3)-H bonds through C-C and C-O bond formations has been described for the first time. A broad substrate scope and ease of scale-up are the attractive features of this synthetic method, which provides a series of potentially bioactive 2,3-dihydrofurans. The reaction pathway is proposed to involve a radical addition of the in situ-formed α-carbonyl radical to the C=C bond of olefinic 1,3-dicarbonyls followed by intramol. 5-endo-trig cyclization. The experimental process involved the reaction of Diethyl 2-methylmalonate(cas: 609-08-5Quality Control of Diethyl 2-methylmalonate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sharifi, Ali’s team published research in Heterocyclic Communications in 2022 | CAS: 609-08-5

In 2022,Sharifi, Ali; Moazami, Maryam; Abaee, Mohammad Saeed; Mirzaei, Mojtaba published an article in Heterocyclic Communications. The title of the article was 《Ionic liquid-catalyzed synthesis of (1,4-benzoxazin-3-yl) malonate derivatives via cross-dehydrogenative-coupling reactions》.Recommanded Product: Diethyl 2-methylmalonate The author mentioned the following in the article:

A convenient C(sp3)-C(sp3) oxidative dehydrogenative coupling reaction of 1,4-benzoxazin-2-ones with malonate esters was developed under mild conditions to obtain the resp. ester malonates in high yields. Reactions take place in [omim]FeCl4, acting as both the solvent and the catalyst. Under [omim]Cl/FeCl3-DDQ conditions, benzoxazin-2-ones derivativescoupled with malonates to give the target mols. within 1-2 h time periods. The ionic liquid was recovered and reused in the next reactions without losing its efficiency.Diethyl 2-methylmalonate(cas: 609-08-5Recommanded Product: Diethyl 2-methylmalonate) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xi, Yumeng’s team published research in Nature (London, United Kingdom) in 2020 | CAS: 609-08-5

《Catalytic asymmetric addition of an amine N-H bond across internal alkenes》 was written by Xi, Yumeng; Ma, Senjie; Hartwig, John F.. HPLC of Formula: 609-08-5 And the article was included in Nature (London, United Kingdom) in 2020. The article conveys some information:

Hydroamination of alkenes, the addition of the N-H bond of an amine across an alkene, is a fundamental, yet challenging, organic transformation that creates an alkylamine from two abundant chem. feedstocks, alkenes and amines, with full atom economy. The reaction is particularly important because amines, especially chiral amines, are prevalent substructures in a wide range of natural products and drugs. Although extensive efforts have been dedicated to developing catalysts for hydroamination, the vast majority of alkenes that undergo intermol. hydroamination have been limited to conjugated, strained, or terminal alkenes; only a few examples occur by the direct addition of the N-H bond of amines across unactivated internal alkenes, including photocatalytic hydroamination, and no asym. intermol. additions to such alkenes are known. In fact, current examples of direct, enantioselective intermol. hydroamination of any type of unactivated alkene lacking a directing group occur with only moderate enantioselectivity. Here we report a cationic iridium system that catalyzes intermol. hydroamination of a range of unactivated, internal alkenes, including those in both acyclic and cyclic alkenes, to afford chiral amines with high enantioselectivity. The catalyst contains a phosphine ligand bearing trimethylsilyl-substituted aryl groups and a triflimide counteranion, and the reaction design includes 2-amino-6-methylpyridine as the amine to enhance the rates of multiple steps within the catalytic cycle while serving as an ammonia surrogate. These design principles point the way to the addition of N-H bonds of other reagents, as well as O-H and C-H bonds, across unactivated internal alkenes to streamline the synthesis of functional mols. from basic feedstocks. The experimental process involved the reaction of Diethyl 2-methylmalonate(cas: 609-08-5HPLC of Formula: 609-08-5)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Baal, Eduard’s team published research in Chemistry – A European Journal in 2021 | CAS: 609-08-5

Baal, Eduard; Klein, Marius; Harms, Klaus; Sundermeyer, Jorg published an article in 2021. The article was titled 《2,9-Diazadibenzoperylene and 2,9-Dimethyldibenzoperylene-1,3,8,10-tetratriflates: Key to Functionalized 2,9-Diazaperopyrenes》, and you may find the article in Chemistry – A European Journal.Reference of Diethyl 2-methylmalonate The information in the text is summarized as follows:

The synthesis of 2,9-diaza-1,3,8,10-tetratriflato-dibenzoperylene and corresponding 2,9-dimethyl-1,3,8,10-tetratriflato-dibenzoperylene I [X = NH, CMe] was developed at multigram scale via reduction of one of industrially most important high-performance dyes, perylene-3,4,9,10-tetracarboxylic diimide (PTCDI) and of corresponding dihydroxy peropyrenequinone precursor. The focus of this paper was on reactivity pattern of compound I [X = NH] as key intermediate toward highly functionalized 2,9-diazadibenzopyrelenes (DDPs) II [R = 2-thienyl, C≡CSiMe3, piperidinyl, etc.] obtained via catalytic substitution of four triflate by aryl, heteroaryl, alkynyl, aminyl, and O-phosphanyl substituents. The influence of electron-donating substituents (OSiMe3, OPt-Bu2, N-piperidinyl), electron-withdrawing (OTf, 3,5-bis-trifluoromethyl-phenyl) and of electron-rich π-conjugated (2-thienyl, 4-tert-butylphenyl, trimethylsilyl-ethynyl) substituents on optoelectronic and structural properties of these functionalized DDPs II was investigated via XRD analyzes, UV/Vis, PL spectroscopy, and by electroanal. CV. These results were correlated to results of DFT and TD-DFT calculations Thus, functionalized DPPs II with easily tunable HOMO and LUMO energies and gap became available via a new and reliable synthetic strategy starting from readily available PTCDI. In the experiment, the researchers used Diethyl 2-methylmalonate(cas: 609-08-5Reference of Diethyl 2-methylmalonate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Xiao, Xinsheng’s team published research in Journal of Organic Chemistry in 2019 | CAS: 609-08-5

Synthetic Route of C8H14O4In 2019 ,《Ligand-Free, Quinoline N-Assisted Copper-Catalyzed Nitrene Transfer Reaction To Synthesize 8-Quinolylsulfimides》 appeared in Journal of Organic Chemistry. The author of the article were Xiao, Xinsheng; Huang, Sanping; Tang, Shanshan; Jia, Guokai; Ou, Guangchuan; Li, Yangyan. The article conveys some information:

In the presence of CuCN, 8-quinolinyl thioethers underwent regioselective imination via nitrene transfer reactions with sulfonyl azides to yield 8-quinolinyl sulfimides such as I (R = 4-MeC6H4, Ph, 4-ClC6H4, 4-BrC6H4, 4-F3CC6H4, 4-MeOC6H4, 4-MeCONHC6H4, 2-MeC6H4, 3-MeC6H4, 2,3,5,6-Me4C6H, 1-naphthyl, 2-thienyl, PhCH2, Me). I (R = 4-MeC6H4) was an effective ligand for allylic alkylation reactions of (E)-PhCH(OAc)CH:CHPh with 1,3-dicarbonyl compounds in the presence of PdCl2, N,O-bis(trimethylsilyl)acetamide, and KOAc. In the part of experimental materials, we found many familiar compounds, such as Diethyl 2-methylmalonate(cas: 609-08-5Synthetic Route of C8H14O4)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fujita, Hikaru’s team published research in Journal of Organic Chemistry in 2019 | CAS: 609-08-5

Product Details of 609-08-5In 2019 ,《Substitution of the Dimethylamino Group in Gramines and One-Pot Cyclization to Tetrahydro-β-carbolines Using a Triazine-Based Activating Agent》 was published in Journal of Organic Chemistry. The article was written by Fujita, Hikaru; Nishikawa, Riho; Sasamoto, Ozora; Kitamura, Masanori; Kunishima, Munetaka. The article contains the following contents:

A new method for the substitution of 3-[(dimethylamino)methyl]indoles (gramines) with malonate-based nucleophiles was developed using 2-chloro-4,6-dimethoxy-1,3,5-triazine (CDMT) as the activating agent for the dimethylamino group. The reaction was completed in 1.5-6 h at room temperature in the presence of a tert-amine base and lithium salt. CDMT afforded superior results to Me iodide, a common activating agent for the dimethylamino group in Mannich bases, particularly in the reactions of 1-substituted gramines. The reactivity of the possible intermediates, bis(indol-3-ylmethyl)dimethylammonium salts, was examined to obtain mechanistic insights on the reaction. This substitution method with CDMT enabled the sequential transformation of gramines: substitution with (N-alkylidene)aminomalonates followed by the Pictet-Spengler reaction under acidic conditions afforded 1,2,3,4-tetrahydro-β-carboline derivatives in one pot. In the experiment, the researchers used Diethyl 2-methylmalonate(cas: 609-08-5Product Details of 609-08-5)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Schmatz, Brian’s team published research in Advanced Functional Materials in 2019 | CAS: 609-08-5

The author of 《Fully Printed Organic Electrochemical Transistors from Green Solvents》 were Schmatz, Brian; Lang, Augustus W.; Reynolds, John R.. And the article was published in Advanced Functional Materials in 2019. Quality Control of Diethyl 2-methylmalonate The author mentioned the following in the article:

To achieve the full potential of scalable and cost-effective organic electronic devices, developments are being made in both academic and industry environments to move toward continuous solution-processing techniques that make use of safe and environmentally benign “”green”” solvents. In this work, the first example of a transistor device that is fully solution processed using only green solvents is demonstrated. This achievement is enabled through a novel multistage cleavable side chain process that provides aqueous solubility for semiconducting conjugated polymers, paired with aqueous inkjet printing of PEDOT:PSS electrodes, and a solution deposited ion gel electrolyte as the dielec. layer. The resulting organic electrochem. transistor devices operate in accumulation mode and reach maximum transconductance values of 1.1 mS at a gate voltage of – 1 V. Normalizing the transconductance value to the channel dimensions yields gm/W = 2200 S m-1 (μC* = 22 F cm-1 V-1 s-1), making these devices suitable for a range of applications requiring small signal amplification such as transistors, biosensors, and ion pumps. This new material design and device process paves the way toward scalable, safe, and efficient production of organic electronic devices. In the experiment, the researchers used many compounds, for example, Diethyl 2-methylmalonate(cas: 609-08-5Quality Control of Diethyl 2-methylmalonate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ehm, Christian’s team published research in Polymers (Basel, Switzerland) in 2020 | CAS: 609-08-5

《An integrated high throughput experimentation/predictive QSAR modeling approach to ansa-zirconocene catalysts for isotactic polypropylene》 was written by Ehm, Christian; Vittoria, Antonio; Goryunov, Georgy P.; Izmer, Vyatcheslav V.; Kononovich, Dmitry S.; Samsonov, Oleg V.; Girolamo, Rocco Di; Budzelaar, Peter H. M.; Voskoboynikov, Alexander Z.; Busico, Vincenzo; Uborsky, Dmitry V.; Cipullo, Roberta. Safety of Diethyl 2-methylmalonate And the article was included in Polymers (Basel, Switzerland) in 2020. The article conveys some information:

Compared to heterogeneous Ziegler-Natta systems (ZNS), ansa-metallocene catalysts for the industrial production of isotactic polypropylene feature a higher cost-to-performance balance. In particular, the C2-sym. bis(indenyl) ansa-zirconocenes disclosed in the 1990s are complex to prepare, less stereo- and/or regioselective than ZNS, and lose performance at practical application temperatures The golden era of these complexes, though, was before High Throughput Experimentation (HTE) could contribute significantly to their evolution. Herein, we illustrate a Quant. Structure – Activity Relationship (QSAR) model trained on a robust and highly accurate HTE database. The clear-box QSAR model utilizes, in particular, a limited number of chem. intuitive 3D geometric descriptors that screen various regions of space in and around the catalytic pocket in a modular way thus enabling to quantify individual substituent contributions. The main focus of the paper is on the methodol., which should be of rather broad applicability in mol. organometallic catalysis. Then again, it is worth emphasizing that the specific application reported here led us to identify in a comparatively short time novel zirconocene catalysts rivaling or even outperforming all previous homologues which strongly indicates that the metallocene story is not over yet.Diethyl 2-methylmalonate(cas: 609-08-5Safety of Diethyl 2-methylmalonate) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics