609-08-5 Archives - Page 4 of 9 - Esters-buliding-blocks

Arai, Shigeru’s team published research in Tetrahedron Letters in 2019 | CAS: 609-08-5

Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.Recommanded Product: 609-08-5

In 2019,Tetrahedron Letters included an article by Arai, Shigeru; Kawata, Yuna; Amako, Yuka; Nishida, Atsushi. Recommanded Product: 609-08-5. The article was titled 《Nickel-catalyzed [2 + 2] cycloaddition reaction using bisallenes》. The information in the text is summarized as follows:

A nickel-catalyzed [2 + 2] cycloaddition of bisallenes was described for the synthesis of bicyclic compounds I [R1 = H, Me; R2 = H, Ph; X = NTs, C(CO2Et)2, C(CO2Me)(CN); Y = CH2, C(CH2)5, CHPh] and tricyclic compounds II [R3 = Me, i-Pr]. Simple bisallenes were employed for the formation of “”head to head”” cycloadducts in the presence of Ni(0) with xantphos. The dienyl moiety in a product was applicable for various [4 + 2] cycloaddition reactions. Allene-allenamides under Ni-xantphos system gave the tricyclic compounds II through sequential [2 + 2]-[4 + 2] cycloaddition reaction in highly stereoselective manner. In addition to this study using Diethyl 2-methylmalonate, there are many other studies that have used Diethyl 2-methylmalonate(cas: 609-08-5Recommanded Product: 609-08-5) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Panda, Sanjib’s team published research in Dalton Transactions in 2021 | CAS: 609-08-5

Panda, Sanjib; Baliyan, Rupal; Dhara, Suman; Huang, Kuo-Wei; Lahiri, Goutam Kumar published their research in Dalton Transactions in 2021. The article was titled 《Redox induced oxidative C-C coupling of non-innocent bis(heterocyclo)methanides》.Electric Literature of C8H14O4 The article contains the following contents:

Redox driven C-C bond formation has gained recent attention over the traditional sequence of oxidative addition, insertion and reductive elimination reactions. In this regard, the transient radical mediated diverse reactivity profile of bis(heterocyclo)methanes (H-BHM: HL1-HL4) has been demonstrated as a function of varying metal ions and ligand backbones. It highlighted the following events: (a) redox induced homocoupling of deprotonated HL1 and HL4 on coordination to M(OAc)2 precursors (M = CuII, ZnII, PdII, AgI), including the effective role of mol. oxygen in the transformation process; (b) steric inhibition of C-C coupling of HL1 or HL4 on inserting the substituent at the bridged methylene center (Ph in HL2 or CH3 in HL3); (c) competitive C-C coupling vs. oxygenation of free HL1 with varying concentrations of PdII(OAc)2 as the ease of oxygenation over dimerization of the deprotonated HL1 was corroborated by the DFT calculated lower activation barrier and greater thermodn. stability of the former; and (d) redox non-innocence of BHMs on a coordinatively inert ruthenium platform, which in turn favored the involvement of a radical pathway for the aforestated coupling or oxygenation process. A combined structural, spectroscopic and DFT calculated transition state anal. demonstrated the mechanistic outline for the metal assisted oxidative coupling of BHMs. In addition to this study using Diethyl 2-methylmalonate, there are many other studies that have used Diethyl 2-methylmalonate(cas: 609-08-5Electric Literature of C8H14O4) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Chen, Jing’s team published research in Analytical Biochemistry in 2020 | CAS: 609-08-5

ãSynthesis and mass spectra of rearrangement bio-signature metabolites of anaerobic alkane degradation via fumarate additionã?was published in Analytical Biochemistry in 2020. These research results belong to Chen, Jing; Zhou, Lei; Liu, Yi-Fan; Hou, Zhao-Wei; Li, Wei; Mbadinga, Serge Maurice; Zhou, Jing; Yang, Tao; Liu, Jin-Feng; Yang, Shi-Zhong; Wu, Xiao-Lin; Gu, Ji-Dong; Mu, Bo-Zhong. Recommanded Product: Diethyl 2-methylmalonate The article mentions the following:

Metabolite profiling in anaerobic alkane biodegradation plays an important role in revealing activation mechanisms. Apart from alkylsuccinates, which are considered to be the usual biomarkers via fumarate addition, the downstream metabolites of C-skeleton rearrangement can also be regarded as biomarkers. However, it is difficult to detect intermediate metabolites in both environmental samples and enrichment cultures, resulting in lacking direct evidence to prove the occurrence of fumarate addition pathway. A synthetic method of rearrangement metabolites was established. Four compounds, namely, propylmalonic acid, 2-(2-methylbutyl)malonic acid, 2-(2-methylpentyl)malonic acid and 2-(2-methyloctyl)malonic acid, were synthesized and determined by four derivatization approaches. Besides, their mass spectra were obtained. Four characteristic ions were observed at m/z 133 + 14n, 160 + 28n, 173 + 28n and [M – (45 + 14n)]+ (n = 0 and 2 for Et and Bu esters, resp.). For Me esterification, mass spectral features were m/z 132, 145 and [M – 31]+, while for silylation, fragments were m/z 73, 147, 217, 248, 261 and [M – 15]+. These data provide basis on identification of potential rearrangement metabolites in anaerobic alkane biodegradation via fumarate additionDiethyl 2-methylmalonate(cas: 609-08-5Recommanded Product: Diethyl 2-methylmalonate) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tsuji, Hiroaki’s team published research in Tetrahedron Letters in 2021 | CAS: 609-08-5

Tsuji, Hiroaki; Takahashi, Yoshiyuki; Kawatsura, Motoi published their research in Tetrahedron Letters in 2021. The article was titled ãNickel-catalyzed hydroalkylation of 1,3-dienes with malonates using a homoallyl carbonate as the 1,3-diene and hydride sourceã?Product Details of 609-08-5 The article contains the following contents:

The nickel-catalyzed hydroalkylation of 1,3-dienes with malonates using homoallyl carbonates RCH(OCOOCH3)CH2CH=CH2 (R = 4-chlorophenyl, piperonyl, cyclohexyl, etc.) as the 1,3-diene and hydride source was reported. A broad range of homoally carbonates and malonate derivatives R1CH(COOR2)2 (R1 = H, Ph, Me, i-Bu, etc.; R2 = Et, i-Pr, Me, Bn, t-Bu) was well tolerated under a Ni/DPEphos catalyst system, providing the corresponding 1,2-hydroalkylation products RCH=CH2CH(CH3)CH((COOCH3)2)CH3 in 40-94% yields with excellent regioselectivity. Also, suggested the possible reaction mechanism for the nickel-catalyzed hydroalkylation of in situ generated 1,3-dienes with malonates is suggested. In addition to this study using Diethyl 2-methylmalonate, there are many other studies that have used Diethyl 2-methylmalonate(cas: 609-08-5Product Details of 609-08-5) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Tsuji, Hiroaki’s team published research in Tetrahedron Letters in 2021 | CAS: 609-08-5

Tsuji, Hiroaki; Suzuki, Koki; Kawatsura, Motoi published an article in 2021. The article was titled ãRuthenium-catalyzed stereospecific benzylic alkylation of optically active benzyl esters with malonate nucleophilesã? and you may find the article in Tetrahedron Letters.Reference of Diethyl 2-methylmalonate The information in the text is summarized as follows:

Herein, the study for the ruthenium-catalyzed benzylic alkylation of chiral benzyl esters with malonates as a carbon nucleophile was described. A combination of [Cp*RuCl2]2 and picolinic acid found to be effective for the title reaction, provided the chiral benzylic alkylation products with retention of stereochem. of the starting material. The ruthenium catalysis was proceed via a double inversion mechanism was proposed. In the experiment, the researchers used Diethyl 2-methylmalonate(cas: 609-08-5Reference of Diethyl 2-methylmalonate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Dai, Yubei’s team published research in Chinese Chemical Letters in 2022 | CAS: 609-08-5

Dai, Yubei; Wang, Fang; Zhu, Shengqing; Chu, Lingling published an article in 2022. The article was titled 《Selective Ni-catalyzed cross-electrophile coupling of alkynes, fluoroalkyl halides and vinyl halides》, and you may find the article in Chinese Chemical Letters.Safety of Diethyl 2-methylmalonate The information in the text is summarized as follows:

A Ni-catalyzed three-component cross-electrophile coupling of alkynes with alkenyl halides and fluoroalkyl halides to generate fluoroalkyl-incorporated 1,3-dienes was reported. This mild and operationally simple protocol was distinguished by its broad substrate scope and excellent chemo-, regio- and stereoselectivity, offering a new and organometallic agent-free platform for the construction of fluoroalkyl-incorporated diene motifs. Preliminary mechanistic studies were conducted to probe the potential reaction pathway. In the part of experimental materials, we found many familiar compounds, such as Diethyl 2-methylmalonate(cas: 609-08-5Safety of Diethyl 2-methylmalonate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhou, Jing-xuan’s team published research in Tetrahedron Letters in 2021 | CAS: 609-08-5

Category: esters-buliding-blocksIn 2021 ,《Polysulfonate supported chiral diamine-nickel catalysts: Synthesis and applications》 appeared in Tetrahedron Letters. The author of the article were Zhou, Jing-xuan; Zhu, Dong-yu; Chen, Jie; Zhang, Xue-jing; Yan, Ming; Chan, Albert S. C.. The article conveys some information:

A series of chiral polysulfonate cyclohexyldiamine-Ni(II) catalysts were prepared via sulfur (VI) fluoride exchange click-reactions. The catalysts exhibited good catalytic activity and enantioselectivity in the Michael addition of malonates to nitroalkenes. The excellent recyclability of the catalysts was demonstrated via the reuse of the privileged catalyst for ten times. The results provided a new strategy for the immobilization of chiral homogeneous catalysts. The experimental process involved the reaction of Diethyl 2-methylmalonate(cas: 609-08-5Category: esters-buliding-blocks)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Daxiong’s team published research in Chinese Chemical Letters in 2021 | CAS: 609-08-5

Li, Daxiong; Zhang, Chunsheng; Ding, Wei; Huang, Siming; Yu, Le; Lu, Nan; Pan, Wenkai; Li, Yiming; De Clercq, Erik; Pannecouque, Christophe; Zhang, Hongbing; Wang, Yueping; He, Yanping; Chen, Fener published their research in Chinese Chemical Letters in 2021. The article was titled 《Structure-based linker optimization of 6-(2-cyclohexyl-1-alkyl)-2-(2-oxo-2-phenylethylsulfanyl)pyrimidin-4(3H)-ones as potent non-nucleoside HIV-1 reverse transcriptase inhibitors》.Name: Diethyl 2-methylmalonate The article contains the following contents:

Most of these new compounds showed moderate to good activities against wild type HIV-1 with IC50 values ranging from 7.55μmol/L to 0.018μmol/L. Most of these new compounds I showed moderate to good activities against wild type HIV-1 with IC50 values ranging from 7.55μmol/L to 0.018μmol/L. Among them, compound I [R1 = Me; R2 = Et; R3 = H] [II] was identified as the most promising inhibitor against HIV-1 replication with an IC50 = 0.018μmol/L, CC50 = 194μmol/L, and SI = 12791, which was much more potent than the reference drugs NVP and DLV and comparable to AZT and EFV. In addition, compound [II] also exhibited improved activity against double mutant HIV-1 strain RES056 compared to that of the reference drugs NVP/DLV and DB02. The preliminary structure-activity relationship (SAR) and mol. modeling studies were also discussed, which provides some useful indications for guiding the further rational design of new S-DACO analogs. In addition to this study using Diethyl 2-methylmalonate, there are many other studies that have used Diethyl 2-methylmalonate(cas: 609-08-5Name: Diethyl 2-methylmalonate) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Sarkar, Ramkrishna’s team published research in Polymer Chemistry in 2019 | CAS: 609-08-5

The author of 《De-symmetrizing periodically grafted amphiphilic copolymers: design, synthesis and generation of Janus folded chains》 were Sarkar, Ramkrishna; Gowd, E. Bhoje; Ramakrishnan, S.. And the article was published in Polymer Chemistry in 2019. Formula: C8H14O4 The author mentioned the following in the article:

Periodically grafted amphiphilic copolymers (PGACs) were earlier shown to fold in a zigzag fashion to enable segregation of the two immiscible segments, namely the backbone and the pendant segments; crystallization of one or both segments led to the formation of a lamellar structure with the two segments located in alternate layers. In the present study two different pendant segments, namely PEG and fluorocarbon, were installed at periodic intervals in an alternating fashion along a polyethylene-like polyester backbone; the mutual immiscibility between the three different segments, namely backbone alkylene (HC), PEG and fluorocarbon (FC), causes the polymer to fold as earlier, but now the zigzag folded chain would carry fluoroalkyl segments on one side and PEG on the other, thereby generating de-symmetrized Janus-type folded chains. Using DSC, SAXS, WAXS, AFM and FT-IR measurements, we demonstrate the self-segregation and independent crystallization of all three segments, and the formation of a lamellar morphol. bearing three different layers. Such layering of three different types of segments in a graft copolymer is unprecedented and could pave the way for interesting applications that require separation of two different functional entities at sub-10 nm length scales. In addition to this study using Diethyl 2-methylmalonate, there are many other studies that have used Diethyl 2-methylmalonate(cas: 609-08-5Formula: C8H14O4) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Li, Dan’s team published research in Journal of Organic Chemistry in 2019 | CAS: 609-08-5

The author of 《Synthesizing 1,23-C60 Adducts with Improved Efficiency: A Type of Stable and Highly Soluble C60 Derivatives》 were Li, Dan; Li, Zong-Jun; He, Fa-Gui; Geng, Chao; Gao, Xiang. And the article was published in Journal of Organic Chemistry in 2019. HPLC of Formula: 609-08-5 The author mentioned the following in the article:

In addition to the 1,9- and 1,7-C60 adducts, the 1,23-C60 adducts are an important type of C60 derivatives, where the property of the fullerene compounds is significantly affected by the addition pattern. However, much less is known on the adducts due to the less availability of the compounds Herein, the hydroxide-promoted reactions of C60 with 2-alkylmalonates are reported, which produce the 1,23-C60 adducts with improved efficiency. The reactions were studied with the in situ vis-NIR spectral measurement in order to probe into the reaction mechanism. The obtained 1,23-C60 adducts exhibited good thermal stability and better solubility with respect to the 1,7-isomers. In the experiment, the researchers used Diethyl 2-methylmalonate(cas: 609-08-5HPLC of Formula: 609-08-5)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics