609-08-5 Archives - Esters-buliding-blocks

Hori, Fuka’s team published research in Synlett in 2022 | CAS: 609-08-5

Diethyl 2-methylmalonate(cas: 609-08-5) belongs to aliphatic hydrocarbons. Aliphatic hydrocarbons belong to the most abundant fraction in crude oil. Aliphatics molecules are linear or branched open-chain structures such as n-alkanes, isoalkanes, cycloalkanes (naphthenes), terpenes and steranes.COA of Formula: C8H14O4

In 2022,Hori, Fuka; Yoshimura, Tomoyuki; Matsuo, Jun-ichi published an article in Synlett. The title of the article was ãConstruction of Indole Skeletons through Direct Catalytic Three-Component Domino Reactions of Vinylarenes, Aldehydes, and Pronucleophilesã?COA of Formula: C8H14O4 The author mentioned the following in the article:

A synthesis of 3-alkyl-2-arylindoles was performed by sequential oxidation and reduction of 2-(2-nitrophenyl)ethanols that were prepared by base-catalyzed three-component reactions of vinylarenes, aldehydes, and various pronucleophiles, including nitroalkanes, thiols, and malonates. In addition to indoles, a selective synthesis of an N-hydroxyindole was accomplished. The highly nucleophilic character of transient benzylic anions in DMSO was also clarified for the three-component reactions.Diethyl 2-methylmalonate(cas: 609-08-5COA of Formula: C8H14O4) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Jung, Joori’s team published research in Catalysts in 2021 | CAS: 609-08-5

Jung, Joori; Shin, Byeong Soo; Kang, Jeong Won; Han, Won-Sik published their research in Catalysts in 2021. The article was titled ãCatalytic Hydrogenation and Dehydrogenation Reactions of N-alkyl-bis(carbazole)-Based Hydrogen Storage Materialsã?Formula: C8H14O4 The article contains the following contents:

Recently, there have been numerous efforts to develop hydrogen-rich organic materials because hydrogen energy is emerging as a renewable energy source. In this regard, we designed and prepared four new materials based on N-alkyl-bis(carbazole), 9,9â?(2-methylpropane-1,3-diyl)bis(9Hcarbazole) (MBC), 9,9â?(2-ethylpropane-1,3-diyl)bis(9H-carbazole) (EBC), 9,9â?(2-propylpropane-1,3- diyl)bis(9H-carbazole) (PBC), and 9,9â?(2-butylpropane-1,3-diyl)bis(9H-carbazole) (BBC), to investigate their hydrogen adsorption/hydrogen desorption reactivity depending on the length of the alkyl chain. The gravimetric densities of MBC, EBC, PBC, and BBC were 5.86, 5.76, 5.49, and 5.31 H2 wt%, resp., again depending on the alkyl chain length. All materials showed complete hydrogenation reactions under ruthenium on an alumina catalyst at 190 Â°C, and complete reverse reactions and dehydrogenation reactions were observed under palladium on an alumina catalyst at <280 Â°C. At this temperature, all the prepared compounds were thermally stable, and no decomposition was observed After reading the article, we found that the author used Diethyl 2-methylmalonate(cas: 609-08-5Formula: C8H14O4)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mino, Takashi’s team published research in Synlett in 2021 | CAS: 609-08-5

Mino, Takashi; Yamaguchi, Daiki; Kumada, Manami; Youda, Junpei; Saito, Hironori; Tanaka, Junya; Yoshida, Yasushi; Sakamoto, Masami published their research in Synlett in 2021. The article was titled ãChiral P,Olefin Ligands with Rotamers for Palladium-Catalyzed Asymmetric Allylic Substitution Reactionsã?Application In Synthesis of Diethyl 2-methylmalonate The article contains the following contents:

A series of phosphine-olefin-type chiral aminophosphines, was synthesized and confirmed that these each exists as two rotamers at the C(aryl)-N(amine) bond. The ability of these aminophosphines to act as chiral ligands for Pd-catalyzed asym. allylic substitution reactions, such as the alkylation of allylic acetates with malonates or indoles with high enantioselectivities (up to 98% ee) was also investigated. The results came from multiple reactions, including the reaction of Diethyl 2-methylmalonate(cas: 609-08-5Application In Synthesis of Diethyl 2-methylmalonate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yi, Xiaoqing’s team published research in ACS Nano in 2021 | CAS: 609-08-5

Yi, Xiaoqing; Hu, Jing-Jing; Dai, Jun; Lou, Xiaoding; Zhao, Zujin; Xia, Fan; Tang, Ben Zhong published an article in 2021. The article was titled ãSelf-Guiding Polymeric Prodrug Micelles with Two Aggregation-Induced Emission Photosensitizers for Enhanced Chemo-Photodynamic Therapyã? and you may find the article in ACS Nano.Reference of Diethyl 2-methylmalonate The information in the text is summarized as follows:

Nowadays, aggregation-induced emission luminogens (AIEgens) with reactive oxygen species (ROS) generating ability have been used as photosensitizers for imaging guided photodynamic therapy (PDT). To achieve enhanced antitumor outcomes, combining AIEgens-based PDT with chemotherapy is an efficient strategy. However, the therapeutic efficiency is hampered by the limited cellular uptake efficiency and the appropriate light irradiation occasion. In this paper, a self-guiding polymeric micelle (TB@PMPT) composed of two AIE photosensitizers and a reduction-sensitive paclitaxel prodrug (PTX-SS-N3) was established for enhanced chemo-photodynamic therapy by a dual-stage light irradiation strategy. When the micelles were accumulated in tumor tissues, the first light irradiation (L1, 6 min) was utilized to facilitate cellular uptake by “”photochem. internalization”” (PCI). Then, the intracellular glutathione (GSH) would induce the PTX release, micelles disassembly and the aggregation state change of AIEgens. The fluorescence signal change of two AIEgens-based ratiometric fluorescent probe could not only precisely guide the second light irradiation (L2, 18 min) for sufficient ROS production, but also monitor the nonfluorescent drug PTX release in turn. Both in vivo and in vitro studies demonstrated that the dual-stage light irradiation strategy employed for TB@PMPT micelles exhibited a superior therapeutic effect over only 24 min continuous light irradiationDiethyl 2-methylmalonate(cas: 609-08-5Reference of Diethyl 2-methylmalonate) was used in this study.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Kokel, Anne’s team published research in Molecules in 2022 | CAS: 609-08-5

In 2022,Kokel, Anne; Kadish, Dora; Torok, Bela published an article in Molecules. The title of the article was ãPreparation of Deuterium Labeled Compounds by Pd/C-Al-D2O Facilitated Selective H-D Exchange Reactionsã?Quality Control of Diethyl 2-methylmalonate The author mentioned the following in the article:

The chemo/regioselective H-D exchange of amino acids and synthetic building blocks by an environmentally benign Pd/C-Al-D2O catalytic system is described. Due to the importance of isotope labeled compounds in medicinal chem. and structural biol., notably their use as improved drug candidates and biol. probes, the efficient and selective deuteration methods are of great interest. The approach is based on selective H-D exchange reactions where the deuterium source is simple D2O. D2 gas is generated in situ from the reaction of aluminum and D2O, while the com. available palladium catalyst assists the H-D exchange reaction. The high selectivity and efficiency, as well as the simplicity and safe nature of the procedure make this method an environmentally benign alternative to current alternatives. In the experiment, the researchers used Diethyl 2-methylmalonate(cas: 609-08-5Quality Control of Diethyl 2-methylmalonate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ishida, Naoki’s team published research in Synlett in 2021 | CAS: 609-08-5

Recommanded Product: 609-08-5In 2021 ,ãNickel-Catalyzed Î±-1,3-Dienylation of 1,3-Dicarbonyl Compounds with Propargylic Carbonatesã?appeared in Synlett. The author of the article were Ishida, Naoki; Kamino, Yuka; Murakami, Masahiro. The article conveys some information:

Herein reported is a nickel-catalyzed α-1,3-dienylation reaction of 1,3-dicarbonyl compounds with substituted propargylic (e.g., but-2-ynyl) carbonates. The propargyl unit changes into a 1,3-dienyl unit, which is incorporated at the α-position of the 1,3-dicarbonyl compounds In the experiment, the researchers used many compounds, for example, Diethyl 2-methylmalonate(cas: 609-08-5Recommanded Product: 609-08-5)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wu, Dunqi’s team published research in Youji Huaxue in 2020 | CAS: 609-08-5

ãA new class of chiral pincer-type PNN ligands for Pd-catalyzed asymmetric allylic alkylationã?was published in Youji Huaxue in 2020. These research results belong to Wu, Dunqi; Cheng, Xuan; Liu, Yankai; Cheng, Guo; Guan, Xiaoyu; Deng, Qinghai. Synthetic Route of C8H14O4 The article mentions the following:

A new class of chiral tridentate P,N,N-donor pincer ligands bearing two or three stereocenters, 1-(4,5-dihydrooxazol-2-yl)-N-(2-(diphenylphosphanyl)benzyl) methanamines (oxpma) I (R1 = i-Pr, t-Bu; R2 = Me, i-Pr, Ph, Bn; R3 = H, Me; R4 = H, i-Pr, Ph), were synthesized starting from readily available amino acids R1CH(NH2)COOH in five or six steps. They were applied in palladium-catalyzed asym. allylic alkylation of allylic acetates ArCH(OAc)CH=CHAr (Ar = Ph, 3-chlorophenyl, 2-naphthyl, etc.) to afford the desired products (R/S,E)-ArCH(R5)CH=CHAr (R5 = CH2COOMe, CH2CC(O)Me, CH2CN, etc.) with high enantioselectivities (up to 96% ee). The results came from multiple reactions, including the reaction of Diethyl 2-methylmalonate(cas: 609-08-5Synthetic Route of C8H14O4)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Liniger, Marc’s team published research in Molecules in 2020 | CAS: 609-08-5

Reference of Diethyl 2-methylmalonateIn 2020 ,《Ring-closing metathesis approaches towards the total synthesis of rhizoxins》 appeared in Molecules. The author of the article were Liniger, Marc; Neuhaus, Christian M.; Altmann, Karl-Heinz. The article conveys some information:

Efforts are described towards the total synthesis of the bacterial macrolide rhizoxin F, which is a potent tubulin assembly and cancer cell growth inhibitor. A significant amount of work was expanded on the construction of the rhizoxin core macrocycle by ring-closing olefin metathesis (RCM) between C(9) and C(10), either directly or by using relay substrates, but in no case was ring-closure achieved. Macrocycle formation was possible by ring-closing alkyne metathesis (RCAM) at the C(9)/C(10) site. The requisite diyne was obtained from advanced intermediates that had been prepared as part of the synthesis of the RCM substrates. While the direct conversion of the triple bond formed in the ring-closing step into the C(9)-C(10) E double bond of the rhizoxin macrocycle proved to be elusive, the corresponding Z isomer was accessible with high selectivity by reductive decomplexation of the biscobalt hexacarbonyl complex of the triple bond with ethylpiperidinium hypophosphite. Radical-induced double bond isomerization, full elaboration of the C(15) side chain, and directed epoxidation of the C(11)-C(12) double bond completed the total synthesis of rhizoxin F. In the experiment, the researchers used Diethyl 2-methylmalonate(cas: 609-08-5Reference of Diethyl 2-methylmalonate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yamamoto, Kosuke’s team published research in Synlett in 2019 | CAS: 609-08-5

In 2019,Synlett included an article by Yamamoto, Kosuke; Ishimaru, Keiko; Mizuta, Satoshi; Minato, Daishirou; Kuriyama, Masami; Onomura, Osamu. Reference of Diethyl 2-methylmalonate. The article was titled 《Diastereodivergent Synthesis of Bromoiminolactones: Electrochemical and Chemical Bromoiminolactonization of α-Allylmalonamides》. The information in the text is summarized as follows:

A diastereodivergent synthesis of N-substituted iminolactones I, II (R1 = Me, Et, Ph, etc.; R2 = Ph, cyclohexyl, benzyl, etc.) by bromoiminolactonization of α-substituted α-allylmalonamides R1C(CH2CH=CH2)(C(O)NHR2)2 is reported. Whereas bromocyclization under conventional chem. conditions provided cis-bromoiminolactones I, and electrochem. conditions exhibited complementary diastereoselectivity to afford the trans-products II. A variety of substituents on the nitrogen atoms and an α-position of the malonamide were tolerated under both sets of conditions to afford the corresponding iminolactones I, II in excellent yields and high diastereoselectivities. In the experiment, the researchers used Diethyl 2-methylmalonate(cas: 609-08-5Reference of Diethyl 2-methylmalonate)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Yang, Dan’s team published research in Organic Letters in 2021 | CAS: 609-08-5

Yang, Dan; Wu, Xiong; Zheng, Xiao-Jie; Xie, Jian-Hua; Zhou, Qi-Lin published their research in Organic Letters in 2021. The article was titled 《Dynamic Kinetic Resolution of γ-Substituted Cyclic β-Ketoesters via Asymmetric Hydrogenation: Constructing Chiral Cyclic β-Hydroxyesters with Three Contiguous Stereocenters》.Product Details of 609-08-5 The article contains the following contents:

An efficient asym. hydrogenation of racemic γ-substituted cyclic β-ketoesters I (R = Ph, 2-naphthyl, 2-furyl, etc.; n = 1, 2) via dynamic kinetic resolution to provide chiral cyclic β-hydroxy esters II with three contiguous stereocenters is reported. Using a chiral spiro iridium catalyst (R)-5 (Ir-SpiroSAP), a series of racemic γ-aryl/alkyl substituted cyclic β-ketoesters I was hydrogenated to the corresponding chiral cyclic β-hydroxy esters II in high yields (84-97%) with good to excellent enantioselectivities (69->99% ee) and cis,cis-selectivities (up to >99:1). In the experiment, the researchers used many compounds, for example, Diethyl 2-methylmalonate(cas: 609-08-5Product Details of 609-08-5)

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics