Category: 60705-25-1

Drouillat, Bruno; Poupardin, Olivia; Bourdreux, Yann; Greck, Christine published the artcile< Diastereoselective syntheses of α-amino-β-hydroxyesters precursors of the ribosyl-diazepanone core of the liposidomycins>, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate, the main research area is amino hydroxyester glycoside chiral synthon preparation liposidomycin; ribosyl hydroxy amino ester diastereoselective preparation.

The diastereoselective syntheses of the O-protected ribosyl-β-hydroxy-α-amino esters, precursors of α-ribosyl-diazepanone core analogs of the liposidomycins, resp., from the β-ketoesters are described. The anti relationship between the two adjacent aminated and hydroxylated carbons was controlled by sequential hydrogenation of the β-ketoesters in the presence of chiral ruthenium catalysts and electrophilic amination of the resulting β-hydroxyesters.

Tetrahedron Letters published new progress about Chiral synthons. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Morita, Iwao; Haruta, Yuko; Tomita, Toshio; Tsuda, Masami; Kandori, Kazuhisa; Kise, Masahiro; Kimura, Kiyoshi published the artcile< Syntheses and antihypertensive activities of 1,4-dihydropyridine-5-phosphonate derivatives. III>, COA of Formula: C7H12O5, the main research area is cyclocondensation arylideneacetonylphosphonate aminocrotonate; hydropyridinephosphonate preparation antihypertensive activity; pyridinephosphonate phenyldihydro preparation antihypertensive activity.

Phenyldihydropyridinephosphonates I [RR = (CH2)3, CH2CMe2CH2; R = CO2Me, allyl; R1 = 2-NO2, 2-CF3, 2-OCHF2, 3-NO2; R2 = Me, CH2CHMe2, CH2CH2OCH2Ph, CH2CH2OMe, CH2CH2NMeCH2Ph, allyl; R3 = Me, Et, Pr, allyl, CH2Ph, CH2CH2OMe, NMe2; R4 = Me] were prepared by the cyclocondensation reaction of R3NHCMe:CHCO2R2 with R1C6H4CH:CAcP(O)(OR)2 (II). I [R = allyl, RR = (CH2)3; R1 = 2-NO2, 3-NO2, 2-CF3; R2 = Me; R3 = H; R4 = CH(OMe)2] were prepared similarly by the reaction of II with (MeO)2CHC(NH2):CHCO2Me. I [R4 = CH(OMe)2] was deprotected to give I (same R-R3; R4 = CHO). The latter were converted to I (R4 = CH2OH, CH:NOH, cyano). I were all tested for antihypertensive activity in normotensive and spontaneously hypertensive rats. I [RR = (CH2)3, R1 = 2-NO2, R2 = Me, R3 = R4 = Me] shows higher antihypertensive activity than nifedipine, but lower than DHP-218.

Chemical & Pharmaceutical Bulletin published new progress about Antihypertensives. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, COA of Formula: C7H12O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Drouillat, Bruno; Poupardin, Olivia; Bourdreux, Yann; Greck, Christine published the artcile< Diastereoselective syntheses of α-amino-β-hydroxyesters precursors of the ribosyl-diazepanone core of the liposidomycins>, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate, the main research area is amino hydroxyester glycoside chiral synthon preparation liposidomycin; ribosyl hydroxy amino ester diastereoselective preparation.

The diastereoselective syntheses of the O-protected ribosyl-β-hydroxy-α-amino esters, precursors of α-ribosyl-diazepanone core analogs of the liposidomycins, resp., from the β-ketoesters are described. The anti relationship between the two adjacent aminated and hydroxylated carbons was controlled by sequential hydrogenation of the β-ketoesters in the presence of chiral ruthenium catalysts and electrophilic amination of the resulting β-hydroxyesters.

Tetrahedron Letters published new progress about Chiral synthons. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Drouillat, Bruno; Poupardin, Olivia; Bourdreux, Yann; Greck, Christine published the artcile< Diastereoselective syntheses of α-amino-β-hydroxyesters precursors of the ribosyl-diazepanone core of the liposidomycins>, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate, the main research area is amino hydroxyester glycoside chiral synthon preparation liposidomycin; ribosyl hydroxy amino ester diastereoselective preparation.

The diastereoselective syntheses of the O-protected ribosyl-β-hydroxy-α-amino esters, precursors of α-ribosyl-diazepanone core analogs of the liposidomycins, resp., from the β-ketoesters are described. The anti relationship between the two adjacent aminated and hydroxylated carbons was controlled by sequential hydrogenation of the β-ketoesters in the presence of chiral ruthenium catalysts and electrophilic amination of the resulting β-hydroxyesters.

Tetrahedron Letters published new progress about Chiral synthons. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Fang; Wang, Yujie; Du, Qian; Ge, Wenxiang; Li, Zhanhui; Wang, Xu; Fu, Chunyan; Luo, Lusong; Tian, Sheng; Ma, Haikuo; Zheng, Jiyue; Zhang, Yi; Sun, Xiaotian; He, Sudan; Zhang, Xiaohu published the artcile< Structural optimization of aminopyrimidine-based CXCR4 antagonists>, Reference of 60705-25-1, the main research area is aminopyrimidine synthesis SAR CXCR4 CXCL12 chemotaxis hERG; Antagonist; CXCR4; Chemokine; GPCR; Structural optimization.

Structural optimization of aminopyrimidine-based CXCR4 antagonists is reported. The optimization is guided by mol. docking studies based on available CXCR4-small mol. crystal complex. The optimization identifies a number of compounds with improved receptor binding affinity and functional activity exemplified by compound 23 (inhibition of APC-conjugate clone 12G5 for CXCR4 binding in a cell based assay: IC50 = 8.8 nM; inhibition of CXCL12 induced cytosolic calcium increase: IC50 = 0.02 nM). In addition, compound 23 potently inhibits CXCR4/CXLC12 mediated chemotaxis in a matrigel invasion assay. Furthermore, compound 23 exhibits good physicochem. properties (MW 367, clogP 2.1, PSA 48, pKa 7.2) and in vitro safety profiles (marginal/moderate inhibition of CYP isoenzymes and hERG). These results represent significant improvement over the initial hit from scaffold hybridization and suggest that compound 23 can be used as a starting point to support lead optimization.

European Journal of Medicinal Chemistry published new progress about Cardiotoxicity. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Reference of 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Deb, Barnali; Chakraborty, Ankita; Hossain, Jewel; Majumdar, Swapan published the artcile< A Task-Specific Ionic-Liquid-Mediated Solvent-Free Protocol for Direct Access to Dimethyl Acetal Protected Benzimidazole 2-Carboxaldehydes>, Product Details of C7H12O5, the main research area is dimethyl acetal benzimidazole carboxaldehyde preparation; amino aniline methyl dimethoxyoxobutanoate cyclization imidazolium ionic liquid catalyst.

A robust and straightforward protocol has been developed for the synthesis of a diverse array of di-Me acetal protected benzimidazole-2-carboxaldehydes I (R = H, 6-Me, 5,6-di-Me, 6-Cl, carboxyl; R1 = H, Bn, prop-2-en-1-yl, etc.) by reacting various 2-amino aniline derivatives II with Me 4,4-dimethoxy-3-oxobutanoate using the task-specific imidazolium ionic liquid (HBIm·TFA) as a promoter for N-C/C-N annulation processes. The present protocol offers several advantages over existing protocols, such as single-step process, short reaction times, very mild reaction conditions, high yields, ease of purification, recovery and reusability of the catalyst, and scale-up of the reaction.

SynOpen published new progress about Acetals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Product Details of C7H12O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Deb, Barnali; Chakraborty, Ankita; Hossain, Jewel; Majumdar, Swapan published the artcile< A Task-Specific Ionic-Liquid-Mediated Solvent-Free Protocol for Direct Access to Dimethyl Acetal Protected Benzimidazole 2-Carboxaldehydes>, Product Details of C7H12O5, the main research area is dimethyl acetal benzimidazole carboxaldehyde preparation; amino aniline methyl dimethoxyoxobutanoate cyclization imidazolium ionic liquid catalyst.

A robust and straightforward protocol has been developed for the synthesis of a diverse array of di-Me acetal protected benzimidazole-2-carboxaldehydes I (R = H, 6-Me, 5,6-di-Me, 6-Cl, carboxyl; R1 = H, Bn, prop-2-en-1-yl, etc.) by reacting various 2-amino aniline derivatives II with Me 4,4-dimethoxy-3-oxobutanoate using the task-specific imidazolium ionic liquid (HBIm·TFA) as a promoter for N-C/C-N annulation processes. The present protocol offers several advantages over existing protocols, such as single-step process, short reaction times, very mild reaction conditions, high yields, ease of purification, recovery and reusability of the catalyst, and scale-up of the reaction.

SynOpen published new progress about Acetals Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Product Details of C7H12O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics