Category: 60705-25-1

Ogawa, Toshihisa; Matsumoto, Keita; Yoshimura, Misa; Hatayama, Katsuo; Kitamura, Kunihiro; Kita, Yasuyuki published the artcile< Stereochemistry of the 2-hydroxy-1,2,3,4-tetrahydropyridine intermediate of Hantzsch cyclization>, Computed Properties of 60705-25-1, the main research area is crystal structure nitrophenyl hydroxytetrahydropyridine; mol structure nitrophenyl hydroxytetrahydropyridine; cyanoethyl aminocrotonate Hantzsch cyclization dialkoxymethylbenzylidene acetoacetate.

Hantzsch cyclization of cyanoethyl 3-aminocrotonate and (E,Z)-4-dialkoxymethyl-2-benzylideneacetoacetates (alkoxy = Me, Et) afforded 3,4-trans-2-hydroxy-1,2,3,4-tetrahydropyridines, e.g., I, in high stereoselectivity.

Tetrahedron Letters published new progress about Crystal structure. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Computed Properties of 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ohuchida, Shuichi; Hamanaka, Nobuyuki; Hayashi, Masaki published the artcile< Synthesis of thromboxane A2 analogs - 4. (±)-Dithiathromboxane A2 sodium salt>, Quality Control of 60705-25-1, the main research area is thia thromboxane platelet.

(±)-(9α,11α),11A-dithia-TXA2 (I) was prepared in 26 steps from (MeO)2CHCOCH2CO2Me and Cl(CH2)3CCCH2I via key intermediate thiopyranylheptenoate ester acetal II, whose cyclization gave an acetal which decomposed on attempted deacetalization, and its 6-[3-methoxycarbonyl)ethyl analog (III), which was ω-alkylated and then cyclized to give I, a very potent agonist. 15β-I caused rapid and irreversible human platelet aggregation.

Tetrahedron published new progress about Blood platelet. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Quality Control of 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Wang, Qian; Chen, Jiean; Huang, Yong published the artcile< Aerobic Oxidation/Annulation Cascades through Synergistic Catalysis of RuCl3 and N-Heterocyclic Carbenes>, Computed Properties of 60705-25-1, the main research area is polysubstituted lactone enantioselective synthesis synergistic catalysis ruthenium heterocyclic carbene; synergistic catalysis ruthenium heterocyclic carbene oxidation annulation enal carbonyl; N-heterocyclic carbenes; cooperative effects; oxidation; ruthenium; synergistic catalysis.

Cooperative catalysis combining a transition metal with an N-heterocyclic carbene is challenging due to strong binding of NHCs towards late transition metals. We report the first example of synergistic catalysis by a chiral NHC and a coordinatively unsaturated ruthenium compound RuCl3 was found to mediate efficient aerobic oxidation of homoenolates generated from enals and the N-heterocyclic carbene. The resulting ��unsaturated acylazolium intermediate reacts selectively with 1,3-dicarbonyl compounds or ketones at either the � or �carbon, yielding polysubstituted chiral lactones in high yield and with excellent enantioselectivity (up to 98 % yield, 94 % ee). This protocol can be applied to structurally sophisticated substrates.

Chemistry – A European Journal published new progress about 1,3-Dicarbonyl compounds Role: RCT (Reactant), RACT (Reactant or Reagent). 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Computed Properties of 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Zhu, Yi-Qiang; Tang, Hui-Tong; Zhang, Pang published the artcile< Formation of pyrrolidin-1-ylcyclopentadienes via cyclization of alkyl 2-dimethoxyacetyl- and 2-ethoxalyl-4-oxopentanoates>, Computed Properties of 60705-25-1, the main research area is pyrrolidinylcyclopentadiene preparation; cyclopentadiene pyrrolidinyl preparation; oxopentanoate cyclization; pentanoate oxo cyclization.

The cyclizations of alkyl 2-dimethoxyacetyl- and 2-ethoxalyl-4-oxopentanoates were only effected by means of pyrrolidine with the formation of appropriately substituted 1-pyrrolidin-1-ylcyclopentadienes.

Chemical Research in Chinese Universities published new progress about Cyclization. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Computed Properties of 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Lin, Yu; Li, Zhanhui; Xu, Chen; Xia, Kaijiang; Wu, Shuwei; Hao, Yongjin; Yang, Qing; Ma, Haikuo; Zheng, Jiyue; Luo, Lusong; Zhu, Fang; He, Sudan; Zhang, Xiaohu published the artcile< Design, synthesis, and evaluation of novel CXCR4 antagonists based on an aminoquinoline template>, Category: esters-buliding-blocks, the main research area is CXCR4 antagonists chemokine CXCL12 GPCR aminoquinoline binding affinity migration; Aminoquinoline; Antagonist; CXCL12; CXCR4; Chemokine; GPCR.

The chemokine receptor CXCR4 has been explored as a drug target due to its involvement in pathol. conditions such as HIV infection and cancer metastasis. Here we report the structure-activity relationship study of novel CXCR4 antagonists based on an aminoquinoline template. This template is devoid of the chiral center in the classical tetrahydroquinoline (THQ) ring moiety and therefore can be easily synthesized. A number of potent CXCR4 antagonists were identified, exemplified by compound 3(I), which demonstrated excellent binding affinity with CXCR4 receptor (IC50 = 57 nM) and inhibited CXCL12 induced cytosolic calcium increase (IC50 = 0.24 nM). Furthermore, compound 3 potently inhibited CXLC12/CXCR4 mediated cell migration in a transwell invasion assay. The simplified synthetic approach combined with good physicochem. properties (e.g. MW 362, clogP 2.1, PSA 48, pKa 7.0 for compound 3) demonstrate the potential of this aminoquinoline template as a novel scaffold to develop CXCR4 antagonists.

Bioorganic Chemistry published new progress about Cell migration. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ohuchida, Shuichi; Hamanaka, Nobuyuki; Hayashi, Masaki published the artcile< Synthesis of thromboxane A2 analogs: DL-9,11:11,12-dideoxa-9,11:11,12-diepithiothromboxane A2>, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate, the main research area is thromboxane A2 analog; dideoxadiepithiothromboxane A2.

Thromboxane A2(TXA2), one of the major products formed from arachidonic acid, possesses powerful biol. effects, i.e., platelet aggregation and vasoconstriction. In spite of these very important biol. actions, this substance is too unstable to be isolated. Therefore synthesis of the stable TXA2 analogs with potent biol. activities is of great importance in thromboxane research. However, only a few stable analogs of TXA2 have been reported because of its chem. unusual structure. The total synthesis of the stable TXA2 analogs, dl-9,11:11,12-dideoxa-9,11:11,12-diepithiothromboxane A2 Me ester (I; R = Me) and the Na salt (I; R = Na), has been achieved starting from (MeO)2CHCOCH2CO2Me. The ester was converted to the key intermediate II in high yield, which was efficiently transformed into the precursor III leading to the main framework, 2,6-dithiabicyclo[3.1.1]heptane, via the compound IV. III was treated with base to afford the desired bicyclic product. The TXA2 analogs thus obtained showed very potent biol. activities.

Journal of the American Chemical Society published new progress about Blood platelet. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Morita, Iwao; Haruta, Yuko; Tomita, Toshio; Tsuda, Masami; Kandori, Kazuhisa; Kise, Masahiro; Kimura, Kiyoshi published the artcile< Syntheses and antihypertensive activities of 1,4-dihydropyridine-5-phosphonate derivatives. III>, COA of Formula: C7H12O5, the main research area is cyclocondensation arylideneacetonylphosphonate aminocrotonate; hydropyridinephosphonate preparation antihypertensive activity; pyridinephosphonate phenyldihydro preparation antihypertensive activity.

Phenyldihydropyridinephosphonates I [RR = (CH2)3, CH2CMe2CH2; R = CO2Me, allyl; R1 = 2-NO2, 2-CF3, 2-OCHF2, 3-NO2; R2 = Me, CH2CHMe2, CH2CH2OCH2Ph, CH2CH2OMe, CH2CH2NMeCH2Ph, allyl; R3 = Me, Et, Pr, allyl, CH2Ph, CH2CH2OMe, NMe2; R4 = Me] were prepared by the cyclocondensation reaction of R3NHCMe:CHCO2R2 with R1C6H4CH:CAcP(O)(OR)2 (II). I [R = allyl, RR = (CH2)3; R1 = 2-NO2, 3-NO2, 2-CF3; R2 = Me; R3 = H; R4 = CH(OMe)2] were prepared similarly by the reaction of II with (MeO)2CHC(NH2):CHCO2Me. I [R4 = CH(OMe)2] was deprotected to give I (same R-R3; R4 = CHO). The latter were converted to I (R4 = CH2OH, CH:NOH, cyano). I were all tested for antihypertensive activity in normotensive and spontaneously hypertensive rats. I [RR = (CH2)3, R1 = 2-NO2, R2 = Me, R3 = R4 = Me] shows higher antihypertensive activity than nifedipine, but lower than DHP-218.

Chemical & Pharmaceutical Bulletin published new progress about Antihypertensives. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, COA of Formula: C7H12O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Drouillat, Bruno; Poupardin, Olivia; Bourdreux, Yann; Greck, Christine published the artcile< Diastereoselective syntheses of α-amino-β-hydroxyesters precursors of the ribosyl-diazepanone core of the liposidomycins>, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate, the main research area is amino hydroxyester glycoside chiral synthon preparation liposidomycin; ribosyl hydroxy amino ester diastereoselective preparation.

The diastereoselective syntheses of the O-protected ribosyl-β-hydroxy-α-amino esters, precursors of α-ribosyl-diazepanone core analogs of the liposidomycins, resp., from the β-ketoesters are described. The anti relationship between the two adjacent aminated and hydroxylated carbons was controlled by sequential hydrogenation of the β-ketoesters in the presence of chiral ruthenium catalysts and electrophilic amination of the resulting β-hydroxyesters.

Tetrahedron Letters published new progress about Chiral synthons. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Drouillat, Bruno; Poupardin, Olivia; Bourdreux, Yann; Greck, Christine published the artcile< Diastereoselective syntheses of α-amino-β-hydroxyesters precursors of the ribosyl-diazepanone core of the liposidomycins>, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate, the main research area is amino hydroxyester glycoside chiral synthon preparation liposidomycin; ribosyl hydroxy amino ester diastereoselective preparation.

The diastereoselective syntheses of the O-protected ribosyl-β-hydroxy-α-amino esters, precursors of α-ribosyl-diazepanone core analogs of the liposidomycins, resp., from the β-ketoesters are described. The anti relationship between the two adjacent aminated and hydroxylated carbons was controlled by sequential hydrogenation of the β-ketoesters in the presence of chiral ruthenium catalysts and electrophilic amination of the resulting β-hydroxyesters.

Tetrahedron Letters published new progress about Chiral synthons. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Morita, Iwao; Haruta, Yuko; Tomita, Toshio; Tsuda, Masami; Kandori, Kazuhisa; Kise, Masahiro; Kimura, Kiyoshi published the artcile< Syntheses and antihypertensive activities of 1,4-dihydropyridine-5-phosphonate derivatives. III>, COA of Formula: C7H12O5, the main research area is cyclocondensation arylideneacetonylphosphonate aminocrotonate; hydropyridinephosphonate preparation antihypertensive activity; pyridinephosphonate phenyldihydro preparation antihypertensive activity.

Phenyldihydropyridinephosphonates I [RR = (CH2)3, CH2CMe2CH2; R = CO2Me, allyl; R1 = 2-NO2, 2-CF3, 2-OCHF2, 3-NO2; R2 = Me, CH2CHMe2, CH2CH2OCH2Ph, CH2CH2OMe, CH2CH2NMeCH2Ph, allyl; R3 = Me, Et, Pr, allyl, CH2Ph, CH2CH2OMe, NMe2; R4 = Me] were prepared by the cyclocondensation reaction of R3NHCMe:CHCO2R2 with R1C6H4CH:CAcP(O)(OR)2 (II). I [R = allyl, RR = (CH2)3; R1 = 2-NO2, 3-NO2, 2-CF3; R2 = Me; R3 = H; R4 = CH(OMe)2] were prepared similarly by the reaction of II with (MeO)2CHC(NH2):CHCO2Me. I [R4 = CH(OMe)2] was deprotected to give I (same R-R3; R4 = CHO). The latter were converted to I (R4 = CH2OH, CH:NOH, cyano). I were all tested for antihypertensive activity in normotensive and spontaneously hypertensive rats. I [RR = (CH2)3, R1 = 2-NO2, R2 = Me, R3 = R4 = Me] shows higher antihypertensive activity than nifedipine, but lower than DHP-218.

Chemical & Pharmaceutical Bulletin published new progress about Antihypertensives. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, COA of Formula: C7H12O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics