Category: 60705-25-1

Watanabe, Hidenori; Onoda, Takahiro; Kitahara, Takeshi published the artcile< Tandem intermolecular alkylation-intramolecular Robinson annulation: a novel and stereoselective construction of the octalin skeleton. Expeditious synthesis of (-)-tanabalin>, Application In Synthesis of 60705-25-1, the main research area is tanabalin octalin skeleton preparation; tandem intermol alkylation intramol Robinson annulation.

Tanabalin (I), an insect antifeedant, was synthesized in optically active form employing a known δ-lactone II as the only source of chirality. The key step is a tandem intermol. alkylation-intramol. Robinson annulation to construct the trans-octalin skeleton.

Tetrahedron Letters published new progress about Cyclization (Robinson). 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Application In Synthesis of 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Voigt, Benjamin; Mahrwald, Rainer published the artcile< Organocatalyzed cascade reactions of carbohydrates - a direct access to C-glycosides>, Electric Literature of 60705-25-1, the main research area is C glycoside preparation; proline catalyzed Knoevenagel oxa Michael cascade monosaccharide ketoester.

An organocatalyzed transformation to elongate unprotected carbohydrates is described. This operationally simple methodol. is based on a Knoevenagel-oxa-Michael cascade. This reaction is catalyzed by proline and DBU. Products were obtained with exceptional high degrees of stereoselectivity.

Chemical Communications (Cambridge, United Kingdom) published new progress about C-Glycosides Role: SPN (Synthetic Preparation), PREP (Preparation). 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Electric Literature of 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Voigt, Benjamin; Mahrwald, Rainer published the artcile< Organocatalyzed cascade reactions of carbohydrates - a direct access to C-glycosides>, Electric Literature of 60705-25-1, the main research area is C glycoside preparation; proline catalyzed Knoevenagel oxa Michael cascade monosaccharide ketoester.

An organocatalyzed transformation to elongate unprotected carbohydrates is described. This operationally simple methodol. is based on a Knoevenagel-oxa-Michael cascade. This reaction is catalyzed by proline and DBU. Products were obtained with exceptional high degrees of stereoselectivity.

Chemical Communications (Cambridge, United Kingdom) published new progress about C-Glycosides Role: SPN (Synthetic Preparation), PREP (Preparation). 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Electric Literature of 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Marchalin, Stefan; Chudik, Miloslav; Cvopova, Katarina; Kozisek, Jozef; Lesko, Jan; Daich, Adam published the artcile< Conformationally constrained 1,4-DHPs. A convenient route to bis-1,4-DHPs as a novel class of nitrogen compounds>, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate, the main research area is pyridine dihydro preparation tandem Knoevenagel condensation aminonitrile cyclization; indolizine preparation; dihydropyridine bis preparation; active methylene compound dihydropyridine Knoevenagel condensation aminonitrile cyclization.

On heating in glacial AcOH, 2-formyl-1,4-dihydropyridines I (R1 = MeCO, Me2CHO2C; R2 = 3-O2NC6H4, 5-nitro-2-furyl) underwent the tandem Knoevenagel condensation/aminonitrile cyclization with activated methylene reagents, such as Me acetoacetate or benzoylacetonitrile, to afford highly functionalized indolizines II (R3 = CN, MeO2C) in 65-88% yields. However, treatment of I (R1 = CN, MeCO, MeO2C, Me2CHO2C; R2 = 3-O2NC6H4, 5-cyano-2-furyl, 2-thienyl, etc.) with 3-aminocrotonitrile gave the Knoevenagel condensation products, bis-1,4-dihydropyridines III, as the major products in 50-82% yields.

Tetrahedron published new progress about Crystal structure. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Poupardin, Olivia; Greck, Christine; Genet, Jean Pierre published the artcile< Efficient asymmetric synthesis of a functionalized Δ2-pyrazoline>, Category: esters-buliding-blocks, the main research area is pyrazolinecarboxylate asym synthesis.

The asym. synthesis of Me (4S,5R)-4-hydroxy-3-pyrazoline-5-carboxylate in 4 steps is described starting from 4,4-dimethoxy-3-oxobutanoate by sequential catalytic hydrogenation and electrophilic amination.

Tetrahedron Letters published new progress about Stereoselective synthesis. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Category: esters-buliding-blocks.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

de Ancos, Begona; Maestro, M. Carmen; Martin, M. Rosario; Mateo, Ana I. published the artcile< Reactions of pyrrolidine enamines of cyclic and acyclic 3,4-dioxobutanoic acid derivatives with dimethyl acetylenedicarboxylate. A new case of atropisomerism>, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate, the main research area is pyrrolidine enamine reaction acetylenedicarboxylate atropisomerism.

Reaction conditions and structure of the starting enamines (cyclic or open-chain) determine greatly the final products of the title reactions. Whereas in benzene and acetonitrile, MeO2CCCCO2Me and pyrrolidinylbutanoate I give a mixture of the diastereoisomeric dienamines II, in methanol I affords pyrrolizine III. Enaminofuranones IV (R = Me, menthyl, R1 = H) furnish the corresponding “”Michael adducts”” (E)- and (Z)-IV and V but fail to yield pyrrolizines.

Tetrahedron published new progress about Atropisomers. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Victory, Pedro; Sempere, Julian; Borrell, Jose I.; Crespo, Ana published the artcile< Synthesis of 4-dimethoxymethyl-6-hydroxy-2-methoxynicotinonitrile: a suggested mechanism revision>, Application In Synthesis of 60705-25-1, the main research area is nicotinonitrile dimethoxymethylhydroxymethoxy.

Me 4,4-dimethoxy-3-oxobutyrate condenses with malonodinitrile in methanolic sodium methoxide to form 4-dimethoxymethyl-2-methoxypyridine-3-carbonitrile. A previously proposed interpretation of this reaction is shown to be only one of several which allow the formation of one isomer or another [6-alkoxy-2-hydroxy- or 2-alkoxy-6-hydroxy-3-cyano-pyridines] depending on the pH of the medium.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Knoevenagel reaction. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Application In Synthesis of 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Colombo, Maria I.; Zinczuk, Juan; Mischne, Mirta P.; Ruveda, Edmundo A. published the artcile< Studies directed toward the preparation of key intermediates for the synthesis of trisporic acids and cassiol>, Application of C7H12O5, the main research area is asym synthesis trisporic acid White intermediate preparation; cassiol intermediate preparation asym synthesis trisporic acid; resolution chiral auxiliary asym synthesis trisporic acid intermediate preparation; Michael addition asym synthesis trisporic acid White intermediate preparation; aldol condensation asym synthesis trisporic acid White intermediate preparation; olefination asym synthesis trisporic acid White intermediate preparation.

An enantioselective synthesis and resolution of the key White intermediate I for the synthesis of trisporic acids are described. Attempts to develop a synthetic route toward the antiulcerogenic compound cassiol (II) by an olefination reaction of I and an alternative sequence involving a Michael addition followed by an aldol condensation of an open substrate, are also reported.

Pure and Applied Chemistry published new progress about Aldol condensation. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Application of C7H12O5.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Terinek, Miroslav; Vasella, Andrea published the artcile< Synthesis of tetrahydro-pyrido-imidazole-2-acetates: Effect of carboxy and methoxycarbonyl groups at C(2) on the inhibition of some 尾- and 伪-glycosidases>, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate, the main research area is hydropyridoimidazoleacetate monosaccharide hydrophobic effect preparation structure property inhibition glycosidase.

The gluco- and manno-tetrahydro-pyrido-imidazole-2-acetates and -acetic acids, e.g. I, were synthesized by condensation, in the presence of HgCl2, of the known thiono-lactam II with the 尾-amino ester III that was obtained by addition of AcOMe to the imine, followed by debenzylation. Title imidazoles were tested as inhibitors of the 尾-glucosidase from Caldocellum saccharolyticum, the 伪-glucosidase from brewer’s yeast, the 尾-mannosidase from snail, and the 伪-mannosidase from Jack beans. There is a similar dependence of the Ki values on the nature of the C(2)-substituent in the gluco- and manno-series. Manno-imidazoles are in general weaker inhibitors than the gluco-analogs. The Me acetates are 3-4 times weaker than the Me propionates, in agreement with the hydrophobic effect. Structure activity of title compounds as inhibitors of glycosidases is reported. The Me propionates proved the strongest inhibitors of the 伪-glucosidase (IC50(5) = 25 渭M) and the 伪-mannosidase (Ki(11) = 0.60 渭M).

Helvetica Chimica Acta published new progress about Condensation reaction. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, Recommanded Product: Methyl 4,4-dimethoxy-3-oxobutanoate.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Secrist, John A. III; Hickey, Charles J.; Norris, Robert E. published the artcile< A convenient total synthesis of (±)-(7E,9E)-trisporic acid B methyl ester>, SDS of cas: 60705-25-1, the main research area is total synthesis methyl trisporate; trisporic acid B total synthesis.

The title compound I was totally synthesized using as a key step a Michael-aldol sequence on MeO2CCHMeCOCH(OMe)2 to give cyclohexenone II.

Journal of Organic Chemistry published new progress about 60705-25-1. 60705-25-1 belongs to class esters-buliding-blocks, and the molecular formula is C7H12O5, SDS of cas: 60705-25-1.

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics