Category: 6065-54-9

Continuously updated synthesis method about C7H12O4

Synthetic Route of 6065-54-9, These common heterocyclic compound, 6065-54-9, name is Dimethyl 2,2-dimethylmalonate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Synthetic Route of 6065-54-9, These common heterocyclic compound, 6065-54-9, name is Dimethyl 2,2-dimethylmalonate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Step 2: 2.63 g Mg in 75 ml anhydrous THF are preheated to 55C, treated with 20 mg iodine and 20 mg methyl iodide, 25.7 g of 5-bromo-7-methoxy-2,2-dimethyl-2,3-dihydro-1-benzofuran (see below) are added maintaining reflux of the reaction, and the reaction is heated to reflux for 3 h until most of the Mg disappeared. 20 g dimethyl dimethylmalonate are solved in 40 ml anhydrous THF, cooled to – 6OC, and the freshly prepared Grignard reagent is added drop wise over 1 h at this temperature. The reaction is allowed to warm to 5C and quenched with 250 ml saturated aqueous ammonium chloride solution. The reaction is extracted with ether twice, the combined organic layers are dried over MgSO4, and the solvent is removed under reduced pressure. The crude product may contain some unreacted dimethyl dimethylmalonate, which could largely be distilled off under vacuum. The crude product is used for the cyclisation reaction without further purification.;

Statistics shows that Dimethyl 2,2-dimethylmalonate is playing an increasingly important role. we look forward to future research findings about 6065-54-9.

Reference:
Patent; NYCOMED GMBH; SCHLEMMINGER, Imre; SCHMIDT, Beate; FLOCKERZI, Dieter; TENOR, Hermann; ZITT, Christof; HATZELMANN, Armin; MARX, Degenhard; BRAUN, Clemens; KUeLZER, Raimund; HEUSER, Anke; KLEY, Hans-Peter; STERK, Geert Jan; WO2010/55083; (2010); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some scientific research about Dimethyl 2,2-dimethylmalonate

Electric Literature of 6065-54-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6065-54-9, name is Dimethyl 2,2-dimethylmalonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Electric Literature of 6065-54-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6065-54-9, name is Dimethyl 2,2-dimethylmalonate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A. 2,2-Dimethyl-3-oxo-3-(pentylamino)propionic acid Following the procedure of Example 1A and B except substituting dimethyl 2,2-dimethylmalonate for dimethyl malonate, the title compound is obtained.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Dimethyl 2,2-dimethylmalonate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; E. R. Squibb & Sons, Inc.; US4654356; (1987); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics