Category: 6038-19-3

Marquardt, Fabian; Stoecker, Cornelia; Gartzen, Rita; Heine, Elisabeth; Keul, Helmut; Moeller, Martin published an article in 2018, the title of the article was Novel antibacterial polyglycidols: relationship between structure and properties.Quality Control of 3-Aminodihydrothiophen-2(3H)-one hydrochloride And the article contains the following content:

Antimicrobial polymers are an attractive alternative to low mol. weight biocides, because they are non-volatile, chem. stable, and can be used as non-releasing additives. Polymers with pendant quaternary ammonium groups and hydrophobic chains exhibit antimicrobial properties due to the electrostatic interaction between polymer and cell wall, and the membrane disruptive capabilities of the hydrophobic moiety. Herein, the synthesis of cationic-hydrophobic polyglycidols with varying structures by post-polymerization modification is presented. The antimicrobial properties of the prepared polyglycidols against E. coli and S. aureus are examined Polyglycidol with statistically distributed cationic and hydrophobic groups (cationic-hydrophobic balance of 1:1) is compared to (i) polyglycidol with a hydrophilic modification at the cationic functionality; (ii) polyglycidol with both-cationic and hydrophobic groups-at every repeating unit; and (iii) polyglycidol with a cationic-hydrophobic balance of 1:2. A relationship between structure and properties is presented. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Quality Control of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

The Article related to escherichia staphylococcus erythrocyte polyglycidol antibacterial structure property relationship, antimicrobial polymers, functional polyethers, multifunctional polyglycidol, post-polymerization functionalization, structure-property relationship and other aspects.Quality Control of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On July 8, 2010, Coumar, Mohane Selvaraj; Chu, Chang-Ying; Lin, Cheng-Wei; Shiao, Hui-Yi; Ho, Yun-Lung; Reddy, Randheer; Lin, Wen-Hsing; Chen, Chun-Hwa; Peng, Yi-Hui; Leou, Jiun-Shyang; Lien, Tzu-Wen; Huang, Chin-Ting; Fang, Ming-Yu; Wu, Szu-Huei; Wu, Jian-Sung; Chittimalla, Santhosh Kumar; Song, Jen-Shin; Hsu, John T.-A.; Wu, Su-Ying; Liao, Chun-Chen; Chao, Yu-Sheng; Hsieh, Hsing-Pang published an article.COA of Formula: C4H8ClNOS The title of the article was Fast-Forwarding Hit to Lead: Aurora and Epidermal Growth Factor Receptor Kinase Inhibitor Lead Identification. And the article contained the following:

Furanopyrimidines such as I [R = (S)-HOCH2CHPh; R1 = 3-(H2C:CCONH)C6H4] are prepared as Aurora A kinase and epidermal growth factor receptor (EGFR) inhibitors by preparation of a combinatorial library of approx. 350 furanopyridines and optimization of the inhibitors found from the library. The initial hit compound I (R = HOCH2CH2; R1 = Ph) was modified to better fit the back pocket to produce the potent Aurora A kinase inhibitor I (R = 4-PhNHCONHC6H4; R1 = Ph) with submicromolar antiproliferative activity in the HCT-116 human colon cancer cell line. On the basis of docking studies with EGFR hit I [R = (S)-HOCH2CHPh; R1 = Ph], introduction of an acrylamide Michael acceptor group led to I [R = (S)-HOCH2CHPh; R1 = 3-(H2C:CCONH)C6H4], which inhibited both the wild and mutant EGFR kinases and also showed antiproliferative activity in the gefitinib-resistant HCC827 human lung cancer cells. The X-ray cocrystal structures of I (R = HOCH2CH2, 4-PhNHCONHC6H4; R1 = Ph) bound to Aurora A kinase and the crystal structure of I [R = (S)-HOCH2CHPh; R1 = 3-(H2C:CCONH)C6H4] bound to EGFR confirmed their hypothesized binding modes. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).COA of Formula: C4H8ClNOS

The Article related to furanopyrimidine combinatorial library preparation aurora egfr kinase inhibitor, structure furanopyrimidine activity aurora egfr kinase inhibitor, optimization furanopyrimidine aurora egfr kinase inhibitor activity, mol crystal structure furanopyrimidine bound aurora egfr kinase and other aspects.COA of Formula: C4H8ClNOS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Miura, Tomoya; Fujimoto, Yoshikazu; Funakoshi, Yuuta; Murakami, Masahiro published an article in 2015, the title of the article was A Reaction of Triazoles with Thioesters to Produce β-Sulfanyl Enamides by Insertion of an Enamine Moiety into the Sulfur-Carbonyl Bond.Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride And the article contains the following content:

N-Sulfonyl-1,2,3-triazoles I (R1 = n-Pr, 1-cyclohexenyl, Ph, 4-MeC6H4, 3-thienyl, etc., R2 = 4-MeC6H4; R1 = Ph, R2 = Me, n-Bu, 2-MeC6H4, etc.) react with thioesters R3C(O)SR4 [R3 = Me, R4 = Et, n-Bu, Ph, 4-MeOC6H4, etc.; R3 = t-BuO, R4 = Ph; R3R4 = (CH2)3, CHClCH2CH2, PhCH2CHCH2, etc.] in the presence of a rhodium(II) catalyst to produce β-sulfanyl enamides II in a stereoselective manner. The reaction proceeds through generation of an α-imino rhodium carbene complex, nucleophilic addition of the sulfur atom of a thioester onto the carbenoid carbon atom, and subsequent intramol. migration of the acyl group from the sulfur atom to the imino nitrogen atom. The method is successfully applied to a ring-expansion reaction of thiolactones, thus leading to the formation of sulfur-containing lactams. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

The Article related to triazole sulfonyl stereoselective nucleophilic addition rearrangement thioester rhodium, amide sulfonyl thiovinyl stereoselective preparation, lactam thia sulfonyl preparation, thiolactone ring expansion sulfonyl triazole rhodium catalyst, carbenoids, copper, heterocycles, rhodium, sulfur and other aspects.Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics