Category: 6038-19-3

On June 13, 2016, Gao, Jingyi; Wang, Mingzhi; Wang, Fangyingkai; Du, Jianzhong published an article.Formula: C4H8ClNOS The title of the article was Synthesis and Mechanism Insight of a Peptide-Grafted Hyperbranched Polymer Nanosheet with Weak Positive Charges but Excellent Intrinsically Antibacterial Efficacy. And the article contained the following:

Antimicrobial resistance is an increasingly problematic issue in the world and there is a present and urgent need to develop new antimicrobial therapies without drug resistance. Antibacterial polymers are less susceptible to drug resistance but they are prone to inducing serious side effects due to high pos. charge. Herein we report a peptide-grafted hyperbranched polymer which can self-assemble into unusual nanosheets with highly effective intrinsically antibacterial activity but weak pos. charges (+ 6.1 mV). The hyperbranched polymer was synthesized by sequential Michael addition-based thiol-ene and free radical mediated thiol-ene reactions, and followed by ring-opening polymerization of N-carboxyanhydrides (NCAs). The nanosheet structure was confirmed by transmission electron microscopy (TEM) and at. force microscopy (AFM) studies. Furthermore, a novel “wrapping and penetrating” antibacterial mechanism of the nanosheets was revealed by TEM and it is the key to significantly decrease the pos. charges but have a very low min. inhibitory concentration (MIC) of 16 μg mL-1 against typical Gram-pos. and Gram-neg. bacteria. Overall, our synthetic strategy demonstrates a new insight for synthesizing antibacterial nanomaterials with weak pos. charges. Moreover, the unique antibacterial mechanism of our nanosheets may be extended for designing next-generation antibacterial agents without drug resistance. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Formula: C4H8ClNOS

The Article related to peptide graft hyperbranched polymer nanosheet antibacterial, Pharmaceuticals: Formulation and Compounding and other aspects.Formula: C4H8ClNOS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 18, 2015, Yan, Yunfeng; Xue, Lian; Miller, Jason B.; Zhou, Kejin; Kos, Petra; Elkassih, Sussana; Liu, Li; Nagai, Atsushi; Xiong, Hu; Siegwart, Daniel J. published an article.Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride The title of the article was One-pot synthesis of functional poly(amino ester sulfide)s and utility in delivering pDNA and siRNA. And the article contained the following:

The development of efficacious carriers is an important long-standing challenge in gene therapy. In the past few decades, tremendous progress has been made toward non-viral vectors for gene delivery including cationic lipids and polymers. However, there continues to be a need for clin. translatable polymer-based delivery carriers because they offer tunable degradation profiles and functional groups, diverse structures/morphologies, and scalability in preparation Herein, we developed a library of 144 degradable polymers with varying amine and hydrophobic content via a facile method that involves thiobutyrolactone aminolysis and consequent thiol-(meth)acrylate or acrylamide addition in one-pot. The polymer platform was evaluated for pDNA and siRNA delivery to HeLa cells in vitro. Hydrophobically modified 5S, 2E1, 6CY1, 5CY2, and 2M1 grafted HEMATL polymers are capable of delivering pDNA depending on the chem. composition and the size of the polyplexes. Hydrophobically modified 5S and 2B grafted HEMATL and 5S grafted ATL polymers exhibit capability for siRNA delivery that approaches the efficacy of com. available transfection reagents. Due to tunable functionality and scalable preparation, this synthetic approach may have broad applicability in the design of delivery materials for gene therapy. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

The Article related to poly amino ester sulfide pdna sirna polyplex preparation, Pharmaceuticals: Formulation and Compounding and other aspects.Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On April 18, 2018, Molla, Mijanur R.; Boeser, Alexander; Rana, Akshita; Schwarz, Karina; Levkin, Pavel A. published an article.Related Products of 6038-19-3 The title of the article was One-pot parallel synthesis of lipid library via thiolactone ring opening and screening for gene delivery. And the article contained the following:

Efficient delivery of nucleic acids into cells is of great interest in the field of cell biol. and gene therapy. Despite a lot of research, transfection efficiency and structural diversity of gene-delivery vectors are still limited. A better understanding of the structure-function relationship of gene delivery vectors is also essential for the design of novel and intelligent delivery vectors, efficient in “difficult-to-transfect” cells and in vivo clin. applications. Most of the existing strategies for the synthesis of gene-delivery vectors require multiple steps and lengthy procedures. Here, we demonstrate a facile, three-component one-pot synthesis of a combinatorial library of 288 structurally diverse lipid-like mols. termed “lipidoids” via a thiolactone ring opening reaction. This strategy introduces the possibility to synthesize lipidoids with hydrophobic tails containing both unsaturated bonds and reducible disulfide groups. The whole synthesis and purification are convenient, extremely fast, and can be accomplished within a few hours. Screening of the produced lipidoids using HEK293T cells without addition of helper lipids resulted in identification of highly stable liposomes demonstrating ∼95% transfection efficiency with low toxicity. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Related Products of 6038-19-3

The Article related to lipid library thiolactone ring opening gene delivery, Pharmaceuticals: Formulation and Compounding and other aspects.Related Products of 6038-19-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mommer, Stefan; Lamberts, Kevin; Keul, Helmut; Moeller, Martin published an article in 2013, the title of the article was A novel multifunctional coupler: the concept of coupling and proof of principle.Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride And the article contains the following content:

A multifunctional coupler with an ethylene carbonate- and a thiolactone ring I was synthesized. As proof of principle the coupler was reacted with four low-mol. weight building blocks to form a multifunctional mol. The reactivity/selectivity of the coupler towards amines, acrylates and acyl halides was evaluated. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

The Article related to multifunctional coupler ethylene carbonate thiolactone preparation, General Organic Chemistry: Synthetic Methods and other aspects.Reference of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Mommer, Stefan; Lamberts, Kevin; Keul, Helmut; Moeller, Martin published an article in 2013, the title of the article was A novel multifunctional coupler: the concept of coupling and proof of principle [Erratum to document cited in CA158:534245].Formula: C4H8ClNOS And the article contains the following content:

An acknowledgments section was omitted from the published manuscript; the omitted section is given. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Formula: C4H8ClNOS

The Article related to erratum multifunctional coupler ethylene carbonate thiolactone preparation, General Organic Chemistry: Synthetic Methods and other aspects.Formula: C4H8ClNOS

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

On August 10, 2020, Ding, Zexuan; Liu, Guhuan; Hu, Jinming published an article.Quality Control of 3-Aminodihydrothiophen-2(3H)-one hydrochloride The title of the article was Ratiometric Fluorescent Mapping of pH and Glutathione Dictates Intracellular Transport Pathways of Micellar Nanoparticles. And the article contained the following:

Visualization of intracellular transport pathways is crucial to investigate the internalization mechanism and understand the intracellular behavior of nanomaterials. Herein, we rationalized the design of micellar nanoparticles (NPs) for ratiometric fluorescent mapping of intracellular pH and glutathione (GSH), two essential parameters for maintaining normal cellular functions. Specifically, pH-sensitive naphthalimide-based probe (NPI) and pH-inert rhodamine B (RhB) were covalently labeled to double hydrophilic block copolymers (DHBCs) using the thiolactone chem., enabling the covalent attachment of NPI and RhB to one mol. with a redox-responsive disulfide linkage. The dually labeled DHBCs exhibited blue/orange dual emissions in acidic pH, which was further converted into green/orange dual emissions in neutral pH because of the deprotonation of NPI moieties and the sole green emission in the presence of GSH at neutral pH because of the decreased Forster resonance energy transfer efficiency between an NPI donor and an RhB acceptor as a result of GSH-mediated cleavage of disulfide bonds. These remarkable ratiometric fluorescence changes allowed for not only the simultaneous mapping of the intracellular pH and GSH but also the intracellular transport pathways of internalized NPs. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Quality Control of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

The Article related to ratiometry fluorescence mapping ph glutathione cell internalization micelle nanoparticle, Pharmaceuticals: Formulation and Compounding and other aspects.Quality Control of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Ganguly, Kumkum; Wu, Ruilian; Ollivault-Shiflett, Morgane; Goodwin, Peter M.; Silks, Louis A. III; Iyer, Rashi published an article in 2011, the title of the article was Design, synthesis, and a novel application of quorum-sensing agonists as potential drug-delivery vehicles.Application In Synthesis of 3-Aminodihydrothiophen-2(3H)-one hydrochloride And the article contains the following content:

Surface adhered bacterial colonies or biofilms are an important problem in medical and food industries. Bacteria use a chem. language to monitor their quorum and to express virulence factors, which eventually help them in colonization and manifestation of an infection. The LasR-LasI and RhlR-RhlI quorum-sensing (QS) systems of Pseudomonas aeruginosa control expression of virulence factors in a population d.-dependent fashion. In this study, we investigated the role of synthetic analogs to RhIR-RhII system of P. aeruginosa strains (PAO-1; wild-type and mutants JP-1, PDO-100, and JP-2) responsible for production of acyl-homoserine lactones-2; butanol homoserine lactone (AHL-2; C4-HSL). We synthesized double (QS1207) and single (QS0108) sulfur analogs against (C4-HSL; AHL-2), an autoinducer of Pseudomonas QS system. Extensive biol. investigation of these analogs suggested a growth promoting activity for these analogs in Pseudomonas controlling biofilm production and exo-protease secretion. We hypothesized that these thiolactone analogs could be potentially utilized as potent drug-delivery vehicles against biofilm-producing pathogens. As a proof of principle we conjugated the single sulfur analog QS0108 with the broad-spectrum antibiotic, ciprofloxacin (QS0108-Cip). The QS analog-antibiotic conjugate was significantly more effective at disrupting both the nascent and mature biofilms of P. aeruginosa than the free antibiotic. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Application In Synthesis of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

The Article related to antibiotic conjugate thiobutyrylhomocysteine thiolactone quorum sensing agonist preparation, Pharmaceuticals: Formulation and Compounding and other aspects.Application In Synthesis of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Moitra, Parikshit; Kumar, Krishan; Sarkar, Sourav; Kondaiah, Paturu; Duan, Wei; Bhattacharya, Santanu published an article in 2017, the title of the article was New pH-responsive gemini lipid derived co-liposomes for efficacious doxorubicin delivery to drug resistant cancer cells.Recommanded Product: 6038-19-3 And the article contains the following content:

A gemini version of the amphiphile palmitoyl homocysteine was synthesized. Co-liposomes were prepared using the gemini along with a natural zwitterionic lipid, DOPE and cholesterol at specified ratios. This afforded pH-responsive co-liposomes which could efficiently transport the anticancer drug, doxorubicin (DOX), across the DOX-resistant HeLa cancer cells in response to low pH of cellular endosomes. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Recommanded Product: 6038-19-3

The Article related to ph responsive gemini lipid liposome doxorubicin delivery, drug resistant cancer cell doxorubicin delivery human, Pharmaceuticals: Formulation and Compounding and other aspects.Recommanded Product: 6038-19-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fan, Zhiping; Zhang, Yemin; Ji, Jinkai; Li, Xinsong published an article in 2015, the title of the article was Hybrid polypeptide hydrogels produced via native chemical ligation.Synthetic Route of 6038-19-3 And the article contains the following content:

Biocompatible crosslinking is a key approach for developing biomedical hydrogels and scaffolds. In this report, native chem. ligation (NCL) was utilized to prepare biocompatible and biodegradable hydrogel using naturally derived poly(γ-glutamic acid) and ε-poly-lysine as the backbone without any additive and byproduct. First, thiolactone grafted poly(γ-glutamic acid) (PGA-HC) and cysteine grafted ε-poly-lysine (EPL-C) precursors were synthesized. Their structure was confirmed by NMR (NMR). After that, NCL crosslinking of PGA-HC and EPL-C precursors was triggered by simply blending their buffer solutions without any additive at room temperature, resulting in a hybrid polypeptide hydrogel. The crosslinking approach was verified by Fourier transform IR spectroscopy (FTIR) anal. The equilibrium water content, morphol., degradation rate and mech. properties of the hybrid hydrogels were characterized in detail. The results revealed the NCL hybrid hydrogels had tunable gelation time, water content and mech. properties by adjusting precursor composition Furthermore, the biocompatibility of hybrid hydrogels was confirmed by MTT assay. These characteristics provide a potential opportunity for the NCL hybrid polypeptide hydrogels as wound dressings, skin fillings, drug delivery vehicles and tissue regeneration matrixes. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Synthetic Route of 6038-19-3

The Article related to hybrid polypeptide hydrogel native chem ligation, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Synthetic Route of 6038-19-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Fan, Zhiping; Cheng, Ping; Liu, Min; Li, Dacheng; Liu, Guiqin; Zhao, Yanna; Ding, Zhuang; Chen, Fang; Wang, Bingquan; Tan, Xiaoxiao; Wang, Zhengping; Han, Jun published an article in 2017, the title of the article was Poly(glutamic acid) hydrogels crosslinked via native chemical ligation.Related Products of 6038-19-3 And the article contains the following content:

Mild crosslinking methods, which have a strong influence on biomedical hydrogels and scaffolds, have attracted wide attention in recent years. In this project, native chem. ligation (NCL) was utilized to prepare biocompatible and biodegradable hydrogels using naturally derived poly(glutamic acid) (PGA) with no additives or byproducts. Firstly, thiolactone-grafted poly(glutamic acid) (PGA-HC) and cysteine-grafted poly(glutamic acid) (PGA-C) precursors were synthesized. Their structure was confirmed by NMR (NMR). Then, hydrogels crosslinked by NCL were formed by blending buffered solutions of PGA-HC and PGA-C with no additives under physiol. conditions. After that, the equilibrium water content, morphol., degradation rate and mech. properties of the hydrogels were characterized in detail. The data showed that the PGA hydrogels had gelation times, water contents and mech. properties that were tunable by adjusting the precursor composition Furthermore, the biocompatibility of the hydrogels was confirmed by an MTT assay. These characteristics provide a potential opportunity for the NCL hydrogels as wound dressings, skin fillings, drug delivery vehicles and tissue regeneration matrixes. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Related Products of 6038-19-3

The Article related to polyglutamic acid hydrogen crosslinking chem ligation biomaterial, Pharmaceuticals: Prosthetics and Medical Goods and other aspects.Related Products of 6038-19-3

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics