Category: 6038-19-3

On May 15, 2010, Zhang, Xiaotong; Bao, Ye; Huang, Ke; Barnett-Rundlett, Kimber L.; Armstrong, Daniel W. published an article.Computed Properties of 6038-19-3 The title of the article was Evaluation of dalbavancin as chiral selector for HPLC and comparison with teicoplanin-based chiral stationary phases. And the article contained the following:

Dalbavancin is a new compound of the macrocyclic glycopeptide family. It was covalently linked to 5 μm silica particles using two different binding chemistries. Approx. 250 racemates including (a) heterocyclic compounds, (b) chiral acids, (c) chiral amines, (d) chiral alcs., (e) chiral sulfoxides and sulfilimines, (f) amino acids and amino acid derivatives, and (g) other chiral compounds were tested on the two new chiral stationary phases (CSPs) using three different mobile phases. As dalbavancin is structurally related to teicoplanin, the same set of chiral compounds was screened on two com. available teicoplanin CSPs for comparison. The dalbavancin CSPs were able to sep. some enantiomers that were not separated by the teicoplanin CSPs and also showed improved separations for many racemates. However, there were other compounds only separated or better separated on teicoplanin CSPs. Therefore, the dalbavancin CSPs are complementary to the teicoplanin CSPs. Chirality, 2010. © 2009 Wiley-Liss, Inc. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Computed Properties of 6038-19-3

The Article related to dalbavancin chiral selector hplc teicoplanin stationary phase, Pharmaceutical Analysis: General and other aspects.Computed Properties of 6038-19-3

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Valverde, David; Munoz, Ivan; Garcia-Verdugo, Eduardo; Altava, Belen; Luis, Santiago V. published an article in 2021, the title of the article was Preparation of Nanofibers Mats Derived from Task-Specific Polymeric Ionic Liquid for Sensing and Catalytic Applications.Safety of 3-Aminodihydrothiophen-2(3H)-one hydrochloride And the article contains the following content:

Nanofibers mats derived from the task-specific functionalized polymeric ionic liquids based on homocysteine thiolactone are obtained by electrospinning them as blends with polyvinylpyrrolidone. The presence of this functional moiety allowed the post-functionalization of these mats through the aminolysis of the thiolactone ring in the presence of an amine by a thiol-alkene “click” reaction. Under controlled exptl. conditions the modification can be performed introducing different functionalization and crosslinking of the electrospun fibers, while maintaining the nanostructure obtained by the electrospinning. Initial studies suggest that the nanofibers based on these functionalized polymeric ionic liquids can be used in both sensing and catalytic applications. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Safety of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

The Article related to polymeric ionic liquid nanofiber mat sensing catalytic application, catalysis, electrospinning, nanofibers, poly(homocysteine thiolactone), sensing, Textiles and Fibers: Preparation Of Fibers and other aspects.Safety of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

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On October 11, 2021, Mommer, Stefan; Gehlen, David; Akagi, Takami; Akashi, Mitsuru; Keul, Helmut; Moeller, Martin published an article.Electric Literature of 6038-19-3 The title of the article was Thiolactone-Functional Pullulan for In Situ Forming Biogels. And the article contained the following:

Gelation in the presence of cells with min. cytotoxicity is highly desirable for materials with applications in tissue engineering. Herein, the naturally occurring polysaccharide pullulan is functionalized with thiolactones that undergo ring-opening addition of amines. As a result, the modified pullulan can be crosslinked with diamines and/or amine-containing biol. substrates enhancing the system′s versatility (e.g., gelatin and cell-binding ligands GHK/GRGDS). Thiolactone degrees of substitution of 2.5 or 5.0 mol % are achieved, and resp. hydrogels exhibit mesh sizes of 27.8 to 49.1 nm. Cell proliferation studies on chosen gels (G′ ≃ 500 Pa, over 14 days) demonstrate that for normal human dermal fibroblasts (NHDFs), both gelatin and GRGDS equally support cell proliferation, while in the case of hepatocytes (HepG2), the presence of GRGDS and GHK improve cell proliferation 10-fold compared to gelatin. Cells remain viable and in one instance were successfully encapsulated by in situ gelation, altogether confirming the mild and biocompatible nature of this strategy to produce biogels using biol. active substrates as crosslinkers. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Electric Literature of 6038-19-3

The Article related to thiolactone pullulan in situ biogel, Placeholder for records without volume info and other aspects.Electric Literature of 6038-19-3

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Chattaway, Claire; Magnin, Delphine; Ferain, Etienne; Demoustier-Champagne, Sophie; Glinel, Karine published an article in 2019, the title of the article was Spatioselective functionalization of gold nanopillar arrays.Related Products of 6038-19-3 And the article contains the following content:

A process combining electrochem. nanofabrication by hard templating with the use of a masking strategy and surface functionalization methods, is developed to produce arrays of gold nanopillars of spatially-controlled surface chem. Therefore, a gold nanopillar array is first fabricated by performing metal electrochem. deposition into a track-etched membrane supported on a gold substrate. After dissolution of the membrane, a protective polymer layer is deposited on the array and partially etched to specifically reveal the top of the nanopillars. Then, a polythiolactone-based copolymer is grafted on the upper part of the nanopillars. Afterwards, the sacrificial polymer layer is dissolved to reveal the non-functionalized surface corresponding to the lower part of the gold nanopillars and the background surface. This surface is subsequently modified by a self-assembled monolayer (SAM) of alkylthiol mols. which leads to nanostructured surfaces with spatio-selective surface chem. The grafting of gold nanoparticles and of a bioadhesive peptide on the top and on the background of the nanopillar array, resp., is performed to prove the versatility of the approach to produce bifunctionalized nanopillar arrays for biol., biosensing or (bio)catalysis applications. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Related Products of 6038-19-3

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On October 11, 2022, Aljuaid, Mohammed; Houck, Hannes A.; Efstathiou, Spyridon; Haddleton, David M.; Wilson, Paul published an article.COA of Formula: C4H8ClNOS The title of the article was Photocrosslinking of Polyacrylamides Using [2 + 2] Photodimerisation of Monothiomaleimides. And the article contained the following:

The [2 + 2] photocycloaddition of monothiomaleimides (MTMs) has been exploited for the photocrosslinking of polyacrylamides. Polymer scaffolds composed of dimethylacrylamide and varying amounts of D,L-homocysteine thiolactone acrylamide (5, 10, and 20 mol %) were synthesized via free-radical polymerization, whereby the latent thiol functionality was exploited to incorporate MTM motifs. Subsequent exposure to UV light (λ = 365 nm, 15 mW cm-2) triggered intermol. crosslinking via the photodimerization of MTM side chains, thus resulting in the formation of polyacrylamide gels. The polymer scaffolds were characterized using Fourier transform IR spectroscopy, UV-visible spectroscopy, 1H NMR spectroscopy, and size exclusion chromatog., confirming the occurrence of the [2 + 2] photocycloaddition between the MTM moieties. The mech. and phys. properties of the resulting gels containing various MTM mol % were evaluated by rheol., compression testing, and swelling experiments In addition, SEM was used to characterize the xerogel morphol. of 5 and 10 mol % MTM hydro- and organo-gels. The macro-porous morphol. obtained for the hydrogels was attributed to phase separation due to the difference in solubility of the PDMA modified with thiolactone side chains, provided that a more homogeneous morphol. was obtained when the photo-gels were prepared in DMF as the solvent. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).COA of Formula: C4H8ClNOS

The Article related to photocrosslinking polyacrylamide photodimerization monothiomaleimide, Placeholder for records without volume info and other aspects.COA of Formula: C4H8ClNOS

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On July 31, 2020, Li, Chunmei; Su, Zhengzhou; Tan, Jiaojun; Xue, Ying; Yang, Yumin; Yin, Hangyu; Zhang, Guoxian; Zhang, Qiuyu published an article.COA of Formula: C4H8ClNOS The title of the article was Autocatalyzed interfacial thiol-isocyanate click reactions for microencapsulation of ionic liquids. And the article contained the following:

Abstract: In recent years, ionic liquids (ILs) have received increasing attention because of low vapor pressure, environment friendliness, good thermal and chem. stability and strong solubility However, the liquid nature and high viscosity restrict their applications in some fields. Encapsulation of ILs is an attractive way to handle them easily. Herein, we proposed a facile method to prepare IL-loaded microcapsules using IL-in-oil emulsion as template, poly(amide-thioether) as surfactant and interfacial thiol-isocyanate click reaction for shell formation. In this system, core materials ILs were proved to be able to catalyze thiol-isocyanate reaction without side products, which significantly simplified the preparation process of microcapsules. The shell of the microcapsules was composed of polythiourethane and poly(amide-thioether), which provided a strong protection for ILs. In addition, compared with IL-in-water emulsion, the application of IL-in-oil emulsion avoided the side reactions of the highly active isocyanate. The IL content of the resulted microcapsules could reach as high as 70 weight%. It was also demonstrated that the proposed encapsulation technol. was suitable for ILs with different polarities. This work provides an efficient way to encapsulate ILs using emulsion template, which will make ILs find widespread applications across various fields. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).COA of Formula: C4H8ClNOS

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On April 10, 2020, Phan, Quoc Thang; Patil, Maheshkumar Prakash; Tu, Trang T. K.; Le, Cuong M. Q.; Kim, Gun-Do; Lim, Kwon Taek published an article.HPLC of Formula: 6038-19-3 The title of the article was Polyampholyte-grafted single walled carbon nanotubes prepared via a green process for anticancer drug delivery application. And the article contained the following:

We report a novel process for surface modified single-walled carbon nanotubes (SWCNTs) as drug nanocarriers by using facile and green synthetic methods. Firstly, polyampholytic alternating polymers having furfuryl amine and 3-(dimethylamino)-1-propylamine as functional groups were prepared via one-pot thiol-ene chem. in sustainable conditions. The obtained polymers were then used to a direct functionalization onto the surface of SWCNTs through Diels-Alder click reaction conducted in aqueous media under ultrasonication. The resulting hybrid was characterized by 1H NMR, FT-IR, TGA and UV-vis measurements. The hybrid improved the drug loading content up to 150 wt%, indicating that they are potential doxorubicin (DOX) delivery nano-vehicles. Furthermore, the in-vitro drug release profiles showed that there was a burst release of DOX at pH 5.5 under an acidic condition in microenvironment of tumor cells, in contrast with a lower release rate at pH 7.4 in the physiol. condition. Cell viability assays demonstrated the low cytotoxicity against the normal HEK293 cell of SWCNT hybrids, while they exhibited a high cytotoxic activity towards HeLa cancer cells. These evidences revealed the promising SWCNT-based drug carrier for tumor-targeting chemotherapy release in the cancer therapy. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).HPLC of Formula: 6038-19-3

The Article related to polyampholyte grafted carbon nanotube anticancer drug ph controlled release, Placeholder for records without volume info and other aspects.HPLC of Formula: 6038-19-3

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Su, Yajuan; Tian, Liang; Yu, Meng; Gao, Qiang; Wang, Dehui; Xi, Yuewei; Yang, Peng; Lei, Bo; Ma, Peter X.; Li, Peng published an article in 2017, the title of the article was Cationic peptidopolysaccharides synthesized by ′click′ chemistry with enhanced broad-spectrum antimicrobial activities.SDS of cas: 6038-19-3 And the article contains the following content:

The emergence and spread of multidrug-resistant (MDR) bacteria is a serious clin. problem, and a challenge for the medical research community. There is an urgent need to explore novel effective antimicrobial mols. Here, we report on a series of cationic peptidopolysaccharides that have a bacterial peptidoglycan-mimetic structure and have been synthesized using a facile thiol-ene ′click′ chem. to graft antimicrobial peptides, ε-poly-L-lysine (EPL), onto a polysaccharide (chitosan, CS) backbone. These CS-g-EPL copolymers demonstrated enhanced, selective, broad-spectrum antibacterial and antifungal activities towards Gram-neg. bacteria (Escherichia coli and Pseudomonas aeruginosa), Gram-pos. bacteria (Enterococcus faecalis and methicillin-resistant Staphylococcus aureus (MRSA)), and fungi (Candida albicans and Fusarium solani). Mechanistic studies proved that the CS-g-EPL likely disrupts the anionic microbial membrane leading to cell death, and is less likely to disrupt the mammalian cell membrane. In addition, CSL-g-EPL50% exhibits good in vitro biocompatibility with mammalian cells, and very little evidence of in vivo toxicity. Most importantly, CS-g-EPL demonstrated a strong antimicrobial efficacy with a log reduction of 4.66 in a rat MRSA infection model. These excellent biol. properties present a promising prospect for CS-g-EPL in biomedical applications. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).SDS of cas: 6038-19-3

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On July 5, 2021, Churusova, Svetlana G.; Aleksanyan, Diana V.; Rybalkina, Ekaterina Yu.; Susova, Olga Yu.; Peregudov, Alexander S.; Brunova, Valentina V.; Gutsul, Evgenii I.; Klemenkova, Zinaida S.; Nelyubina, Yulia V.; Glushko, Valentina N.; Kozlov, Vladimir A. published an article.Recommanded Product: 6038-19-3 The title of the article was Palladium(II) Pincer Complexes of Functionalized Amides with S-Modified Cysteine and Homocysteine Residues: Cytotoxic Activity and Different Aspects of Their Biological Effect on Living Cells. And the article contained the following:

In the search for potential new metal-based antitumor agents, two series of nonclassical palladium(II) pincer complexes based on functionalized amides with S-modified cysteine and homocysteine residues have been prepared and fully characterized by 1D and 2D NMR (1H, 13C, COSY, HMQC or HSQC, 1H-13C, and 1H-15N HMBC) and IR spectroscopy and, in some cases, X-ray diffraction. Most of the resulting complexes exhibit a high level of cytotoxic activity against several human cancer cell lines, including colon (HCT116), breast (MCF7), and prostate (PC3) cancers. Some of the compounds under consideration are also efficient in both native and doxorubicin-resistant transformed breast cells HBL100, suggesting the prospects for the creation of therapeutic agents based on the related compounds that would be able to overcome drug resistance. An anal. of different aspects of their biol. effects on living cells has revealed a remarkable ability of the S-modified derivatives to induce cell apoptosis and efficient cellular uptake of their fluorescein-conjugated counterpart, confirming the high anticancer potential of Pd(II) pincer complexes derived from functionalized amides with S-donor amino acid pendant arms. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Recommanded Product: 6038-19-3

The Article related to palladium pincer complex cysteine homocysteine residue antitumor agent cytotoxicity, Placeholder for records without volume info and other aspects.Recommanded Product: 6038-19-3

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Espeel, Pieter; Carrette, Lieselot L. G.; Bury, Katarzyna; Capenberghs, Sven; Martins, Jose C.; Du Prez, Filip E.; Madder, Annemieke published an article in 2013, the title of the article was Multifunctionalized Sequence-Defined Oligomers from a Single Building Block.Safety of 3-Aminodihydrothiophen-2(3H)-one hydrochloride And the article contains the following content:

A thiolactone-based approach for the solid-supported preparation of multifunctionalized sequence-defined oligomers was successfully developed. The elaborated two-step iterative method, consisting of an on-resin aminolysis and subsequent chain extension through Michael addition, does not require protecting groups and relies on the use of a single, readily available thiolactone acrylamide building block. Several functionalized short (up to tetrameric) sequences were obtained by consecutive use of a variety of com. available amines. The obtained sequence-defined motifs featuring a unique backbone and a preprogrammed organization of functionalized side chains were fully characterized by NMR spectroscopy and HRMS. These species could potentially exhibit tunable folding and self-association properties, predominantly determined by the nature of the functionalized amines. In this regard, high-throughput automation and control over the stereochem., induced by the use of enantiomerically pure building blocks, will be further explored. Moreover, through further application of thiolactones as latent thiol functionalities and installation of appropriate functional end groups, these short heterotelechelic fragments are susceptible to periodic polymerization, a process expected to afford larger sequence-controlled polymers. The experimental process involved the reaction of 3-Aminodihydrothiophen-2(3H)-one hydrochloride(cas: 6038-19-3).Safety of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

The Article related to thiolactone oligomer solid phase synthesis self association, chemoselectivity, sequence-defined oligomers, solid-phase synthesis, synthetic methods, thiolactone, Chemistry of Synthetic High Polymers: Other and other aspects.Safety of 3-Aminodihydrothiophen-2(3H)-one hydrochloride

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