Preparation of 2-(mono-, di-, and trichloromethyl)phenyl isocyanates was written by Klauke, Erich;Oehlmann, Linthard. And the article was included in Synthesis in 1978.SDS of cas: 60221-81-0 This article mentions the following:
The title compounds were prepared by chlorination of o-tolyl isocyanates I (Rn = H, Cl, F, Cl2, Cl3, Cl4, CF3) under UV irradiation at 100-200°. II (Rn = H, Cl, F, 3,4-Cl2, 5-CF3) were prepared by UV chlorination of I with 0.5 mol-equivalent Cl2 at 110°. Passing Cl2 through I under UV irradiation 4 h at 120-35° gave III (Rn = H, Cl, 3-F, Cl2, Cl3, Cl4, 5-CF3), whereas IV (Rn = H, 4-, 5-Cl, 3-F) were prepared by chlorination of I under intensive UV irradiation In the experiment, the researchers used many compounds, for example, 1-Fluoro-3-isocyanato-2-methylbenzene (cas: 60221-81-0SDS of cas: 60221-81-0).
1-Fluoro-3-isocyanato-2-methylbenzene (cas: 60221-81-0) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.SDS of cas: 60221-81-0
Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics