Category: 5941-55-9

Related Products of 5941-55-9,Some common heterocyclic compound, 5941-55-9, name is Ethyl (E)-3-Ethoxyacrylate, molecular formula is C7H12O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of ethyl-(E)-3-ethoxyacrylate (21 mmol) and 2N NaOH (12 mL) was refluxed for 2 h. The solution was then evaporated to dryness. The residue was redissolved in toluene (7 mL), the solution stirred for 3 min and the solvent evaporated. This was repeated 5 times until water was removed from the solid which was used directly in the next step. S?um (E)-3- ethoxyacrylate (3.30 mmol) (20) was added to thionyl chloride (15.2 mmol) and the mixture was refluxed for 90 min. The solution was evaporated and the residue was dissolved in dry THF, 2 mL).4′-met’oxy-[1,1′-biphenyl]-2-amine (2.19 mmol) and pyridine (5.0 mmol) were added to the solution at 0 C. Resulting mixture was stirred for 18h at room temperature. Next, water/EtOAc was added to the solution and the aqueous phase was separated and washed with EtOAc. The organic phase was dried with Na2SO4, evaporated and the residue was purified on silica chromatography to give the sub-title product. Yield: 43%

The synthetic route of 5941-55-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; YALE UNIVERSITY; JORGENSEN, William L.; DZIEDZIC, Pawel; CISNEROS, Jose; (240 pag.)WO2016/130968; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 5941-55-9, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 5941-55-9 as follows.

Preparation Example 21 Synthesis of 6-cyano-2-heptylthio-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one (intermediate) Eight (8) grams of 2-amino-5-heptylthio-1,3,4-thiadiazole, 5 g of ethyl 3-ethoxy-2-propenoate, 10 g of polyphosphoric acid and 10 ml of xylene were mixed, and the mixture was vigorously agitated at 125C for 30 minutes. After the reaction was finished, the reaction mixture was extracted with water and toluene. The organic layer was washed with a sodium hydrogen carbonate aqueous solution and then with water. The solvent was distilled off and the residue was recrystallized from a n-hexane/ethanol mixture and thus 7.4 g of 2-heptylthio-5H-1,3,4-thiadiazolo[3,2-a]pyrimidin-5-one was obtained. Yield 75%.

According to the analysis of related databases, 5941-55-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; KUMIAI CHEMICAL INDUSTRY CO., LTD.; IHARA CHEMICAL INDUSTRY Co., Ltd.; EP282635; (1989); A3;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5941-55-9, name is Ethyl (E)-3-Ethoxyacrylate, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of Ethyl (E)-3-Ethoxyacrylate

To a mixture of 19 (3.7 g, 21.9 mmol) and (E)-ethyl 3-ethoxyacrylate (4.7 g, 32.8 mmol) in DMF (76 mL) was added Cs2CO3 (10.7 g, 32.8 mmol) and the reaction was heated at 110 C for 15 hours. After cooling to ambient temperature, the solvent was removed in vacuo and the residue was washed with acetic acid to pH 4 and extracted with EA (100 ml) for three times. The extract was dried over Na2SO4. The crude product was purified by flash chromatography to afford the title compound (2.2 g, 45.9 %). 1H NMR (400 MHz, CDCl3) delta 9.56 (br, 1H), 8.01 (d, J = 8.0 Hz, 1H), 6.08 (d, J = 8.0 Hz, 1H), 4.37 (q, J = 7.2 Hz, 2H), 2.50 (s, 1H), 1.39 (t, J = 7.2 Hz, 3H). MS (ESI) m/z 222 [M+H]+.

According to the analysis of related databases, 5941-55-9, the application of this compound in the production field has become more and more popular.

Reference:
Article; Lu, Xiaoyun; Tang, Jian; Liu, Zhiyong; Li, Minke; Zhang, Tianyu; Zhang, Xiantao; Ding, Ke; Bioorganic and Medicinal Chemistry Letters; vol. 26; 24; (2016); p. 5916 – 5919;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Related Products of 5941-55-9, A common heterocyclic compound, 5941-55-9, name is Ethyl (E)-3-Ethoxyacrylate, molecular formula is C7H12O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a cooled (-10 C) solution of (E)-ethyl 3-ethoxyacrylate (1 g, 6.94 mmol) in water (4 mL) and dioxane (4 mL) was added N-bromosuccinamide (NBS, 1.36 g, 7.63 mmol). The reaction was warmed to room temperature and stirred for one hour, at which point 6-chloropyridazin-3-amine (0.899 g, 6.94 mmol) was added reaction mixture was heated 80C for one hour. The reaction was cooled to room temperature and quenched via the addition of water. The product was extracted with ethyl acetate and the combined organic layers were washed with saturated (aq.) sodium chloride, dried over sodium sulfate, filtered, concentrated and purified using automated chromatography to provide ethyl 6-chloroimidazo[l,2-b]pyridazine-3-carboxylate (1 g, 61 % yield). LC retention time 1.42 min [O]. MS (E+) m/z: 226 (MH+).

The synthetic route of 5941-55-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; WEINSTEIN, David S.; MOSLIN, Ryan M.; ZHANG, Yanlei; GARDNER, Daniel S.; SANTELLA, Joseph B.; LANGEVINE, Charles M.; STACHURA, Sylwia; (127 pag.)WO2017/87590; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

5941-55-9, name is Ethyl (E)-3-Ethoxyacrylate, belongs to esters-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: Ethyl (E)-3-Ethoxyacrylate

EXAMPLE 23 6.0 g of ethyl 2-chloro-5-ureidobenzoate and 6.4 g of ethyl 3-ethoxyacrylate are heated at reflux temperature in 100 ml of 1,2-dimethoxyethane and subsequently heated at this temperature with 12 ml of 2N hydrochloric acid for 5 minutes. The reaction mixture is evaporated to dryness under reduced pressure and the residue is purified by chromatography on 300 g of silica gel using ethyl acetate/n-hexane (1:3) as the eluent. There is obtained ethyl 2-chloro-5-{3-[2-(ethoxycarbonyl)vinyl]ureido}-benzoate, m.p. 116-117 C.

The synthetic route of 5941-55-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Hoffmann-La Roche Inc.; US4746352; (1988); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Adding a certain compound to certain chemical reactions, such as: 5941-55-9, name is Ethyl (E)-3-Ethoxyacrylate, belongs to esters-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5941-55-9, HPLC of Formula: C7H12O3

To a mixture of ethyl 5-amino- lH-pyrazole-4-carboxylate (Sigma- Aldrich, 150.00 g, 1.08 mmol) and ethyl (E)-3-ethoxyprop-2-enoate (Sigma- Aldrich, 292.16 g, 2.03 mol) in DMF (3.2 L) was added CS2CO3 (656.77 g, 2.02 mol) in one portion at 20 C under N2. The mixture was stirred at 110 C for 6 h. TLC (PE: EtOAc=l : 1) showed the reaction was completed. The mixture was cooled to 20 C and filtered through a celite pad. The filter cake was washed with ethyl acetate (3X30 mL). The filtrate was added to H20 (2 L) and acidified with HOAc to pH=4. The resultant precipitate was filtered to afford 1-2 (173.00 g, 834.98 mmol, 86.36% yield) as a white solid: 1H NMR (400 MHz, DMSO-d6) delta 8.54 (d, 7=7.91 Hz, 1H), 8.12 (s, 1H), 6.13 (d, 7=7.91 Hz, 1H), 4.27 (q, 7=7.11 Hz, 2H), 1.28 (t, 7=7.09 Hz, 3H).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Patent; TP THERAPEUTICS, INC.; CUI, Jingrong Jean; LI, Yishan; ROGERS, Evan W.; ZHAI, Dayong; DENG, Wei; HUANG, Zhongdong; (120 pag.)WO2017/15367; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthetic Route of 5941-55-9,Some common heterocyclic compound, 5941-55-9, name is Ethyl (E)-3-Ethoxyacrylate, molecular formula is C7H12O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A mixture of ethyl-(E)-3-ethoxyacrylate (21 mmol) and 2N NaOH (12 mL) was refluxed for 2 h. The solution was then evaporated to dryness. The residue was redissolved in toluene (7 mL), the solution stirred for 3 min and the solvent evaporated. This was repeated 5 times until water was removed from the solid which was used directly in the next step. S?um (E)-3- ethoxyacrylate (3.30 mmol) (20) was added to thionyl chloride (15.2 mmol) and the mixture was refluxed for 90 min. The solution was evaporated and the residue was dissolved in dry THF, 2 mL).4′-met’oxy-[1,1′-biphenyl]-2-amine (2.19 mmol) and pyridine (5.0 mmol) were added to the solution at 0 C. Resulting mixture was stirred for 18h at room temperature. Next, water/EtOAc was added to the solution and the aqueous phase was separated and washed with EtOAc. The organic phase was dried with Na2SO4, evaporated and the residue was purified on silica chromatography to give the sub-title product. Yield: 43%

The synthetic route of 5941-55-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; YALE UNIVERSITY; JORGENSEN, William L.; DZIEDZIC, Pawel; CISNEROS, Jose; (240 pag.)WO2016/130968; (2016); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5941-55-9, name is Ethyl (E)-3-Ethoxyacrylate, A new synthetic method of this compound is introduced below., Application In Synthesis of Ethyl (E)-3-Ethoxyacrylate

To a reactor was charged K3PO4 (4104 g granular, 19.3 moles), ethyl 3-amino-lH-pyrazole-4-carboxylate (2000 g, 12.9 moles), and DMF (18.8 kg) and the mixture was agitated. After 20 min, (?)-ethyl 3- ethoxyacrylate, (2230 g, 15.5 moles) was added and the mixture was heated to 110-115 C internal temperature (IT). After the reaction was judged to be complete based on consumption of starting material , heating was ceased. The mixture was allowed to stir and cool overnight. Aqueous hydrochloric acid (3 M, 13 L) was added over ~ 2 h. DI water (6 L) was added and the mixture was allowed to stir overnight. The mixture was filtered through polypropylene filter cloth (PPFC) and the residue was washed with water (3 x 5 vol, 3 x 10 L). The solid was placed in trays and oven dried under vacuum at 55 C for 3 days and then 45 C for 4 days to constant weight of (2553 g 95.6%).

The synthetic route of 5941-55-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZHAO, Qian; SPENCER, Stacey; JIANG, Yutong; HAAS, Julia; EARY, Charles Todd; (335 pag.)WO2018/81417; (2018); A2;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Some common heterocyclic compound, 5941-55-9, name is Ethyl (E)-3-Ethoxyacrylate, molecular formula is C7H12O3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of Ethyl (E)-3-Ethoxyacrylate

To a reactor was charged K3PO4 (4104 g granular, 19.3 moles), ethyl 3-amino-lH-pyrazole-4-carboxylate (2000 g, 12.9 moles), and DMF (18.8 kg) and the mixture was agitated. After 20 min, (?)- ethyl 3-ethoxyacrylate, (2230 g, 15.5 moles) was added and the mixture was heated to 110- 115 C internal temperature (IT). After the reaction was judged to be complete based on consumption of starting material, heating was ceased. The mixture was allowed to stir and cool overnight. Aqueous hydrochloric acid (3 M, 13 L) was added over ~ 2 h. DI water (6 L) was added and the mixture was allowed to stir overnight. The mixture was filtered through polypropylene filter cloth (PPFC) and the residue was washed with water (3 x 5 vol, 3 x 10 L). The solid was placed in trays and oven dried under vacuum at 55 C for 3 days and then 45 C for 4 days to constant wei ht of (2553 g 95.6%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 5941-55-9, its application will become more common.

Reference:
Patent; ZHAO, Qian; SPENCER, Stacey; JIANG, Yutong; HAAS, Julia; EARY, Charles Todd; (352 pag.)WO2019/84285; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 5941-55-9, The chemical industry reduces the impact on the environment during synthesis 5941-55-9, name is Ethyl (E)-3-Ethoxyacrylate, I believe this compound will play a more active role in future production and life.

To a mixture of 5-amino-1H-pyrazole-4-carbonitrile (10.00 g, 92.51 mmol) in DMF (350.00mL) was added ethyl (E)-3-ethoxyacrylate (13.34 g, 92.51 mmol) and Cs2CO3 (60.38 g, 185.02mmol). The mixture was stirred at 100C for 2 hrs. After LCMS showed the reaction was complete, the reaction mixture was cooled to 25C, then added to water (300 mL), acidified by HC1 (1 M) till pH = 4, then filtered. The filter cake was dried in vacuum to give 5-hydroxypyrazolo[1,5- ajpyrimidine-3-carbonitrile (10.00 g, yield: 67.5 1%) as a white solid.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl (E)-3-Ethoxyacrylate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; BLUEPRINT MEDICINES CORPORATION; WENGLOWSKY, Steven, Mark; MIDUTURU, Chandrasekhar, V.; BIFULCO, Neil, Jr; KIM, Joseph, L.; (91 pag.)WO2017/87778; (2017); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics