Category: 59227-79-1

Application of 59227-79-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59227-79-1, name is Ethyl 4-(4-chlorophenoxy)butanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

General procedure: Hydrazine hydrate (0.060 mol) was added to the solution of compounds 3a-h (0.045 mol) in ethanol (25 ml), and the reaction mixture was stirred at room temperature for 4 h. Reaction completion was monitored by thin-layer chromatography using hexane: ethyl acetate (2:1) as the mobile phase and allowed to stand overnight. Formed white crystals 4a-h were filtered, washed, and after drying recrystallized from ethanol to give 4a-h.

The synthetic route of Ethyl 4-(4-chlorophenoxy)butanoate has been constantly updated, and we look forward to future research findings.

Reference:
Article; Al-Ghorbani, Mohammed M. Abdullah; Indian Journal of Heterocyclic Chemistry; vol. 28; 3; (2018); p. 379 – 384;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 59227-79-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 59227-79-1, name is Ethyl 4-(4-chlorophenoxy)butanoate belongs to esters-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step 1 : To a solution of ethyl-4-(4-chlorophenoxy)butanoate (6.0 g, 24.721 mmol, 1 .0 equiv) in dry tetrahydrofuran (10 mL) was added lithium diisopropylamide solution (2.0 M in THF/heptane/ethylbenzene (18.5 mL, 4.944 mmol, 1 .5 equiv) slowly at -78 C. The reaction mixture was stirred for 2 h at -78 C. A solution of carbon tetrabromide (12.3 g, 37.083 mmol, 1 .5 equiv) in dry tetrahydrofuran (15 mL) was added at -78 C and the reaction was stirred for 10 min and was then allowed to stir at room temperature for 1 h. The mixture was then quenched with a saturated aqueous ammonium chloride solution (100 mL) and extracted with ethyl acetate (3 x 100 mL). The combined organic layer was dried over anhydrous sodium sulfate, filtered and concentrated. The crude product was purified by flash column chromatography using a silica gel column and the product eluted at 2% ethyl acetate in hexane to yield ethyl-2-bromo-4-(4-chlorophenoxy)butanoate (0.6 g crude, 7.59 % yield) as a gum. NMR (400 MHz, CDCI3): delta ppm 1 .30 (t, J = 7.2 Hz, 3 H), 2.34 – 2.43 (m, 1 H), 2.52 – 2.61 (m, 1 H), 4.04 – 4.13 (m, 2 H), 4.22 – 4.28 (m, 2 H), 4.52 – 4.56 (m, 1 H), 6.81 (d, J = 8.8 Hz, 2 H), 7.23 (d, J = 8.8 Hz, 2 H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-(4-chlorophenoxy)butanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED; CHEUNG, Mui; DEMARTINO, Michael P.; KALITA, Biswajit; KRISTAM, Rajendra; (128 pag.)WO2019/8507; (2019); A1;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Reference of 59227-79-1,Some common heterocyclic compound, 59227-79-1, name is Ethyl 4-(4-chlorophenoxy)butanoate, molecular formula is C12H15ClO3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: Hydrazine hydrate (0.045 mol) was added to the solution of compounds 3a-l (0.03 mol) in ethanol (20 ml) and stirred the reaction mixture at room temperature for 5 h. Reaction completion was monitored by thin layer chromatography using hexane:ethylacetate (2:1) as the mobile phase and allowed to stand overnight. The white crystals 4a-l formed were filtered, washed and after drying recrystallized from ethanol. 4-(4-Chloro-phenoxy)-butyric acid hydrazide (4b) Yield 90%; mp 85-87 C; FT-IR (KBr, cm-1): 3315 (NH2), 3220 (NH), 1672 (C=O); 1H NMR (CDCl3): delta 2.26 (m, 2H, CH2), 2.75 (t, 2H, COCH2), 3.85 (d, 2H, NH2), 4.07 (t, 2H, OCH2), 6.88 (d, J = 8.80 Hz, 2H, Ar-H), 7.27 (d, J = 8.85 Hz, 2H, Ar-H), 8.40 (t, 1H, NH); LC-MS m/z 229 (M + 1). Anal. Calcd. for C10H13ClN2O2: C, 52.52; H, 5.73; N, 12.25. Found: C, 52.43; H, 5.75; N, 12.39%.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 4-(4-chlorophenoxy)butanoate, its application will become more common.

Reference:
Article; Al-Ghorbani, Mohammed; Vigneshwaran; Ranganatha, V. Lakshmi; Prabhakar; Khanum, Shaukath Ara; Bioorganic Chemistry; vol. 60; (2015); p. 136 – 146;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics