Category: 587-88-2

Identification of new shikonin derivatives as STAT3 inhibitors was written by Qiu, Han-Yue;Fu, Jiang-Yan;Yang, Min-Kai;Han, Hong-Wei;Wang, Peng-Fei;Zhang, Ya-Han;Lin, Hong-Yan;Tang, Cheng-Yi;Qi, Jin-Liang;Yang, Rong-Wu;Wang, Xiao-Ming;Zhu, Hai-Liang;Yang, Yong-Hua. And the article was included in Biochemical Pharmacology (Amsterdam, Netherlands) in 2017.Safety of Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:

The signal transducer and activator of transcription 3 is a constitutively activated oncogenic protein in various human tumors and represents a valid target for anticancer drug design. In this study, the authors have achieved a new type of STAT3 inhibitors based on structural modifications on shikonin scaffold, guided by computational modeling. By tests, PMMB-187 exhibited a more outstanding profile than shikonin on a small panel of human breast cancer cells, especially for the MDA-MB-231 cells. For the cellular mechanisms research, PMMB-187 was found to induce cell apoptosis in MDA-MB-231 cells, associated with the reduction of mitochondrial membrane potential, production of ROS and alteration of the levels of apoptosis-related proteins. Furthermore, PMMB-187 inhibited constitutive/inducible STAT3 activation, transcriptional activity, nuclear translocation and downstream target genes expression in STAT3-dependent breast cancer cells MDA-MB-231. Besides, no obvious inhibitory effect on activation of STAT1 and STAT5 was observed with PMMB-187 treatment. Most notably, the in vivo studies further revealed that PMMB-187 could dramatically suppress the MDA-MB-231 cells xenografted tumor growth. The in vitro and in vivo results collectively suggest that PMMB-187 may serve as a promising lead compound for the further development of potential therapeutic anti-neoplastic agents. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Safety of Ethyl 2-(4-fluorophenyl)acetate).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Safety of Ethyl 2-(4-fluorophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Discovery of isoxazolinone antibacterial agents. Nitrogen as a replacement for the stereogenic center found in oxazolidinone antibacterials was written by Snyder, Lawrence B.;Meng, Zhaoxing;Mate, Robert;D’Andrea, Stanley V.;Marinier, Anne;Quesnelle, Claude A.;Gill, Patrice;DenBleyker, Kenneth L.;Fung-Tomc, Joan C.;Frosco, MaryBeth;Martel, Alain;Barrett, John F.;Bronson, Joanne J.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2004.SDS of cas: 587-88-2 This article mentions the following:

A series of potential antimicrobial derivatives possessing bioisosteric replacements for the central oxazolidinone ring found in oxazolidinone antibacterials have been prepared The design concept involved replacement of the requisite sp³-hybridized stereogenic center found at the 5-position of the oxazolidinone with a nitrogen atom. The synthesis and antibacterial activity of three such ring systems, the benzisoxazolinones, e.g., I, pyrroles, e.g., II, and isoxazolinones, e.g., III, is described. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2SDS of cas: 587-88-2).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.SDS of cas: 587-88-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Copper-Mediated Deuterotrifluoromethylation of 浼?Diazo Esters was written by Hu, Mingyou;Xie, Qiqiang;Li, Xinjin;Ni, Chuanfa;Hu, Jinbo. And the article was included in Chinese Journal of Chemistry in 2016.Name: Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:

A copper-mediated deuterotrifluoromethylation of 浼?diazo esters RC(=N₂)CO₂CH₂CH₃ (R = C₆H₅, 4-BrC₆H₄CH₂, octanyl, naphth-1-yl, etc.) under the promotion of deuterium oxide (D₂O) has been developed for the synthesis of deuterium-labeled trifluoromethyl compounds RC(CF₃)(D)(CO₂CH₂CH₃). This deuterotrifluoromethylation reaction is of broad scope and can afford the deuterated products with higher than 99% isotopic purity. Moreover, the results of this investigation also provide some exptl. evidences to support the previously proposed trifluoromethylation mechanism. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Name: Ethyl 2-(4-fluorophenyl)acetate).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Name: Ethyl 2-(4-fluorophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Transition-Metal-Free Regiospecific Aroylation of Nitroarenes Using Ethyl Arylacetates at Room Temperature was written by Kumar, Promod;Sharma, Anup Kumar;Guntreddi, Tirumaleswararao;Singh, Rahul;Singh, Krishna Nand. And the article was included in Organic Letters in 2018.SDS of cas: 587-88-2 This article mentions the following:

A novel regiospecific C(sp³)-C(sp²) coupling between Et arylacetates and nitroarenes was developed to deliver biaryl ketones in excellent yields. The protocol is metal-free, mild, and compatible with a number of functional groups on both of the reacting partners. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2SDS of cas: 587-88-2).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120鎺?C閳ユ弲閳ユ彊 and O閳ユ弲閳ユ彊 angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C閳ユ彊閳ユ弲 bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. SDS of cas: 587-88-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

High Affinity Central Benzodiazepine Receptor Ligands: Synthesis and Biological Evaluation of a Series of Phenyltriazolobenzotriazindione Derivatives was written by Primofiore, Giampaolo;Da Settimo, Federico;Taliani, Sabrina;Salerno, Silvia;Novellino, Ettore;Greco, Giovanni;Cosimelli, Barbara;Besnard, Francois;Costa, Barbara;Montali, Marina;Martini, Claudia. And the article was included in Journal of Medicinal Chemistry in 2005.Application In Synthesis of Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:

A series of 2-phenyl[1,2,3]triazolo[1,2-a][1,2,4]benzotriazin-1,5(6H)-diones (PTBTs), were prepared and tested at the central benzodiazepine receptor (BzR). The skeleton of these compounds was designed by formally combining the N-C:O moieties of the known BzR ligands, triazoloquinoxalines and triazinobenzimidazoles (ATBIs). Most of the PTBTs displayed submicromolar/nanomolar potency at the BzR. The 9-chloro derivatives were generally found to be more potent than their 9-unsubstituted counterparts. Compound (I) turned out to be the most potent of the PTBTs (K_i 2.8 nM). A subset of compounds when tested for their affinity on recombinant rat 浼?灏?绾?, 浼?灏?绾?, and 浼?灏?绾? GABA_A/Bz receptor subtypes, showed enhanced affinities for the 浼?灏?绾? isoform, with compounds I and (II) exhibiting the highest selectivity. Moreover, compounds I and II were found to display a full agonist efficacy profile at 浼? and 浼? receptor subtypes, and an antagonist efficacy at 浼?-containing receptors. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Application In Synthesis of Ethyl 2-(4-fluorophenyl)acetate).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is 绾?valerolactone.Application In Synthesis of Ethyl 2-(4-fluorophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Synthesis of α-Aryl Nitriles through Palladium-Catalyzed Decarboxylative Coupling of Cyanoacetate Salts with Aryl Halides and Triflates was written by Shang, Rui;Ji, Dong-Sheng;Chu, Ling;Fu, Yao;Liu, Lei. And the article was included in Angewandte Chemie, International Edition in 2011.SDS of cas: 587-88-2 This article mentions the following:

The synthesis of α-aryl nitriles through palladium-catalyzed decarboxylative coupling of cyanoacetate salts with aryl halides and triflates is reported. The reaction was extended to the preparation of α-aryl esters. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2SDS of cas: 587-88-2).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.SDS of cas: 587-88-2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

4-(4-Fluorophenyl)-2-methyl-3-(1-oxy-4-pyridyl)isoxazol-5(2H)-one was written by Margutti, Simona;Schollmeyer, Dieter;Laufer, Stefan. And the article was included in Acta Crystallographica, Section E: Structure Reports Online in 2008.Quality Control of Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:

The crystal structure of 4-(4-fluorophenyl)-2-methyl-3-(1-oxy-4-pyridyl)isoxazol-5(2H)-one, C₁₅H₁₁FN₂O₃, was determined as part of a study on the biol. activity of isoxazolone derivatives as p38 mitogen-activated protein kinase (MAPK) inhibitors. The dihedral angles between rings are isoxazole/benzene = 55.0(3)°, isoxazole/pyridine = 33.8(2)° and benzene/pyridine = 58.1(2)°. Crystallog. data are given. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Quality Control of Ethyl 2-(4-fluorophenyl)acetate).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Quality Control of Ethyl 2-(4-fluorophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Isoxazolone Based Inhibitors of p38 MAP Kinases was written by Laufer, Stefan A.;Margutti, Simona. And the article was included in Journal of Medicinal Chemistry in 2008.Category: esters-buliding-blocks This article mentions the following:

SAR of N-alkylated isoxazolones as p38 MAP kinase inhibitors was realized. The data herein show the possibility of transferring the SAR study and evaluation from N-1-substituted imidazole to isoxazolones. Optimization of substituent was realized. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Category: esters-buliding-blocks).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Category: esters-buliding-blocks

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Non-metal Lewis acid-catalyzed cross-Claisen condensation for β-keto esters was written by Zhang, Tianyu;Yang, Zhenkun;Zhou, Dapeng;Meng, Fuliang;Han, Zhengyu;Huang, Hai. And the article was included in Organic & Biomolecular Chemistry in 2021.COA of Formula: C10H11FO2 This article mentions the following:

A new catalytic and highly chemoselective cross-Claisen condensation of esters was disclosed. In the presence of TBSNTf₂ as a non-metal Lewis acid, various esters can undergo cross-Claisen condensation to for/m β-keto esters which are important building blocks. Compared with the traditional Claisen condensation, this process, employing silyl ketene acetals (SKAs) as carbonic nucleophiles to achieve cross-Claisen condensation, requires mild conditions and has good tolerance of functional groups. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2COA of Formula: C10H11FO2).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.COA of Formula: C10H11FO2

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Amination of Diazocarbonyl Compounds: N-H Insertion under Metal-Free Conditions was written by Luo, Xuesong;Chen, Gui;He, Lin;Huang, Xueliang. And the article was included in Journal of Organic Chemistry in 2016.Quality Control of Ethyl 2-(4-fluorophenyl)acetate This article mentions the following:

Transition-metal-free intermol. N-H insertion of α-diazocarbonyl compounds is reported. Among the series of nitrogen sources examined, dibenzenesulfonimide was found to be the choice in terms of the yields and the reaction time. Primary mechanistic experiments suggest that a pathway involving a sequence of protonation and nucleophilic substitution was preferred. In the experiment, the researchers used many compounds, for example, Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2Quality Control of Ethyl 2-(4-fluorophenyl)acetate).

Ethyl 2-(4-fluorophenyl)acetate (cas: 587-88-2) belongs to esters. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Quality Control of Ethyl 2-(4-fluorophenyl)acetate

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics