Category: 58677-05-7

Sabbah, Dima A.’s team published research in Molecules in 2020 | CAS: 58677-05-7

Ethyl 2-amino-5-methylbenzoate(cas: 58677-05-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).HPLC of Formula: 58677-05-7

《Molecular modeling, synthesis and biological evaluation of N-phenyl-4-hydroxy-6-methyl-2- quinolone-3-carboxamides as anticancer agents》 was published in Molecules in 2020. These research results belong to Sabbah, Dima A.; Hasan, Shaima’ E.; Abu Khalaf, Reema; Bardaweel, Sanaa K.; Hajjo, Rima; Alqaisi, Khalid M.; Sweidan, Kamal A.; Al-Zuheiri, Aya M.. HPLC of Formula: 58677-05-7 The article mentions the following:

The emergence of phosphatidylinositol 3-kinase (PI3Kα) in cancer development has accentuated its significance as a potential target for anticancer drug design. Twenty one derivatives of N-phenyl-4-hydroxy-6-methyl-2-quinolone-3-carboxamide were synthesized and characterized using NMR (1H and 13C) and HRMS. The derivatives displayed inhibitory activity against human epithelial colorectal adenocarcinoma (Caco-2) and human colon cancer (HCT-116) cell lines: compounds 8 (IC50 Caco-2 = 98μM, IC50 HCT-116 = 337μM) and 16 (IC50 Caco-2 = 13μM, IC50 HCT-116 = 240.2μM). Results showed that compound 16 significantly affected the gene encoding AKT, BAD, and PI3K. The induced-fit docking (IFD) studies against PI3Kα demonstrated that the scaffold accommodates the kinase domains and forms H-bonds with significant binding residues. The experimental process involved the reaction of Ethyl 2-amino-5-methylbenzoate(cas: 58677-05-7HPLC of Formula: 58677-05-7)

Ethyl 2-amino-5-methylbenzoate(cas: 58677-05-7) belongs to anime. In organic chemistry, amines are compounds and functional groups that contain a basic nitrogen atom with a lone pair. Amines are formally derivatives of ammonia (NH3), wherein one or more hydrogen atoms have been replaced by a substituent such as an alkyl or aryl group (these may respectively be called alkylamines and arylamines; amines in which both types of substituent are attached to one nitrogen atom may be called alkylarylamines).HPLC of Formula: 58677-05-7

Referemce:
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Manna, Kartic’s team published research in Organic Letters in 2020 | CAS: 58677-05-7

Ethyl 2-amino-5-methylbenzoate(cas: 58677-05-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.HPLC of Formula: 58677-05-7

HPLC of Formula: 58677-05-7On October 2, 2020 ,《Overcoming the Deallylation Problem: Palladium(II)-Catalyzed Chemo-, Regio-, and Stereoselective Allylic Oxidation of Aryl Allyl Ether, Amine, and Amino Acids》 was published in Organic Letters. The article was written by Manna, Kartic; Begam, Hasina Mamataj; Samanta, Krishanu; Jana, Ranjan. The article contains the following contents:

We report herein a Pd(II)/bis-sulfoxide-catalyzed intramol. allylic C-H acetoxylation of aryl allyl ether, amine, and amino acids with the retention of a labile allyl moiety. Mechanistically, the reaction proceeds through a distinct double-bond isomerization from the allylic to the vinylic position followed by intramol. carboxypalladation and the β-hydride elimination pathway. For the first time, C-H oxidation of N-allyl-protected amino acids to furnish five-membered heterocycles through 1,3-syn-addition is established with excellent diastereoselectivity. In the experiment, the researchers used many compounds, for example, Ethyl 2-amino-5-methylbenzoate(cas: 58677-05-7HPLC of Formula: 58677-05-7)

Ethyl 2-amino-5-methylbenzoate(cas: 58677-05-7) belongs to anime. Primary amines having a tertiary alkyl group (R3CNH2) are difficult to prepare with most methods but are made industrially by the Ritter reaction. In this method a tertiary alcohol reacts with hydrogen cyanide (HCN) in the presence of a concentrated strong acid; a formamide, RNH―CHO, is formed first, which then undergoes hydrolysis.HPLC of Formula: 58677-05-7

Referemce:
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics

Application of Ethyl 2-amino-5-methylbenzoate

Electric Literature of 58677-05-7,Some common heterocyclic compound, 58677-05-7, name is Ethyl 2-amino-5-methylbenzoate, molecular formula is C10H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Electric Literature of 58677-05-7,Some common heterocyclic compound, 58677-05-7, name is Ethyl 2-amino-5-methylbenzoate, molecular formula is C10H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A solution ofethyl 2-nitrobenzoate (917 mg, 4.7 mmol) in MeOH (20 mL) and CH3COOH(0.1 mL) was subjected to two cycles N2/vacuum. Pd(OH)2/C10% wt (66 mg, 0.01 eq.) was added and the reaction mixture stirred at roomtemperature under H2 (1 atm) for 12 h. Propanal (337 muL, 4.7 mmol)and Pd(OH)2/C 10% wt (66 mg, 0.01 eq.) were added, and the reactionstirred at room temperature under H2 (1 atm) for additional 12 h.The suspension was filtered through Celite washing twice with CH2Cl2(20 mL). The solution recovered was evaporated under reduced pressure giving anoil after purification by flash chromatography (PE/AcOEt: 4/1). The oil obtained(1 eq.) was dissolved in dry CH2Cl2, and ethyl malonyl chloride(1 eq.) was added. The reaction mixture was stirred at room temperature under N2overnight. The reaction mixture was diluted with CH2Cl2and washed with a saturated solution of NaHCO3. Organic layers werethen washed with brine, dried over dry Na2SO4, filteredand evaporated under reduced pressure giving the expected compound after flashchromatography purification.

The synthetic route of 58677-05-7 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Manetti, Fabrizio; Petricci, Elena; Gabrielli, Annalisa; Mann, Andre; Faure, Helene; Gorojankina, Tatiana; Brasseur, Laurent; Hoch, Lucile; Ruat, Martial; Taddei, Maurizio; European Journal of Medicinal Chemistry; vol. 121; (2016); p. 747 – 757;,
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Share a compound : 58677-05-7

The synthetic route of Ethyl 2-amino-5-methylbenzoate has been constantly updated, and we look forward to future research findings.

These common heterocyclic compound, 58677-05-7, name is Ethyl 2-amino-5-methylbenzoate, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Product Details of 58677-05-7

Example 51; 2-(6-(3-Methoxyphenyl)-5-methylpyridin-3-ylamino)-5-methylbenzoic acidIn a schlenck tube, a mixture of Intermediate 33 (2.55 mmol, 0.71 g), Intermediate 55 (2.57 mmol, 0.46 g), BINAP (0.25 mmol, 0.158 g), Pd2(dba)3 (0.13 mmol, 0.116 g) and NaO1Bu (6.35 mmol, 0.610 g) in toluene (20 ml) was heated at 11O0C for 12 hours, under argon atmosphere. The solvent was evaporated, the solid residue was suspended in water, the pH was taken to 6.5 and extracted with CHCI3. The crude mixture was purified by flash chromatography over SiO2 eluting with mixtures of hexane/ethyl acetate affording 0.580 g (yield 65%) of the expected compound. delta 1H NMR (300 MHz, CDCI3): 2.28 (s, 3H)1 2.34 (s, 3H), 3.85 (s, 3H), 6.95 (d, 1 H), 7.08(s, 2H), 7.23 (d, 1 H), 7.36 (t, 1H), 7.58 (s, 1 H), 7.83 (s, 1 H), 8.51 (s, 1 H).ESI/MS (m/e, %): 349 [(M+1) 100].

The synthetic route of Ethyl 2-amino-5-methylbenzoate has been constantly updated, and we look forward to future research findings.

Reference:
Patent; LABORATORIOS ALMIRALL, S.A.; WO2009/21696; (2009); A1;,
Ester – Wikipedia,
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Continuously updated synthesis method about 58677-05-7

The synthetic route of 58677-05-7 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 58677-05-7, name is Ethyl 2-amino-5-methylbenzoate, A new synthetic method of this compound is introduced below., name: Ethyl 2-amino-5-methylbenzoate

a) 5-Methyl-2-methylaminobenzyl chloride hydrochloride Ethyl 2-amino-5-methylbenzoate was treated with dimethylsulfuric acid to give a N-methylated product. The N-methylated product was reduced using lithium aluminum hydride to give 5-methyl-2-methylaminobenzyl alcohol.

The synthetic route of 58677-05-7 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Nippon Chemiphar Co., Ltd.; US5082943; (1992); A;,
Ester – Wikipedia,
Ester – an overview | ScienceDirect Topics